HR job title
- Distinguished Professor
- Contact Info
- 1 979 845 5988
Safe, Stephen Distinguished Professor
Positions
- Distinguished Professor, Veterinary Physiology and Pharmacology, School of Veterinary Medicine and Biomedical Sciences
- Syd Kyle Chair, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University
- Distinguished Professor, Biochemistry and Biophysics, College of Agriculture and Life Sciences
The aryl hydrocarbon receptor (AhR) is a nuclear helix-loop-helix transcription factor which forms a ligand-induced nuclear heterodimer with the AhR nuclear translocator (Arnt) protein. Research in this laboratory is focused on the molecular mechanism of crosstalk between the AhR and estrogen receptor (ER) signaling pathways in which the AhR inhibits estrogen-induced gene expression. The antiestrogenic activities of some AhR agonists are also being developed as drugs for clinical treatment of breast and endometrial cancers in women. Research on estrogen-dependent gene expression in various cancer cell lines is focused on analysis of several gene promoters to determine the mechanisms of ERa and ERb action. This includes several genes that are activated through interactions of the ER with Sp1 protein and other DNA-bound transcription factors.
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Overview
Publications
selected publications
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academic article
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Upadhyay, S., Hailemariam, A. E., Mariyam, F., Hafiz, Z., Martin, G., Kothari, J., ... Safe, S.
(2024).
Bis-Indole Derivatives as Dual Nuclear Receptor 4A1 (NR4A1) and NR4A2 Ligands. Biomolecules.
14(3), 284-284.
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Safe, S.
(2023).
Natural products and synthetic analogs as selective orphan nuclear receptor 4A (NR4A) modulators. 18689.
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Mohankumar, K., Wright, G., Kumaravel, S., Shrestha, R., Zhang, L., Abdelrahim, M., Chapkin, R. S., & Safe, S.
(2023).
Bis-indole-derived NR4A1 antagonists inhibit colon tumor and splenic growth and T-cell exhaustion. Cancer Immunology Immunotherapy.
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Zhang, L., Mohankumar, K., Martin, G., Mariyam, F., Park, Y., Han, S. J., & Safe, S.
(2023).
Flavonoids Quercetin and Kaempferol Are NR4A1 Antagonists and Suppress Endometriosis in Female Mice. ENDOCRINOLOGY.
bqad133.
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Lee, M., Upadhyay, S., Mariyam, F., Martin, G., Hailemariam, A., Lee, K., ... Safe, S.
(2023).
Flavone and Hydroxyflavones Are Ligands That Bind the Orphan Nuclear Receptor 4A1 (NR4A1). International Journal of Molecular Sciences.
24(9), 8152-8152.
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Safe, S.
(2023).
Specificity Proteins (Sp) and Cancer. International Journal of Molecular Sciences.
24(6), 5164-5164.
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Madison, C. A., Hillbrick, L., Kuempel, J., Albrecht, G. L., Landrock, K. K., Safe, S., Chapkin, R. S., & Eitan, S.
(2023).
Intestinal epithelium aryl hydrocarbon receptor is involved in stress sensitivity and maintaining depressive symptoms. Behavioural Brain Research.
440, 114256-114256.
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Safe, S., Han, H., Jayaraman, A., Davidson, L. A., Allred, C. D., Ivanov, I., ... Chapkin, R. S.
(2023).
Aryl Hydrocarbon Receptor (AhR) Signaling in Colonic Cells and Tumors. 2(1), 93-99.
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Safe, S., Kothari, J., Hailemariam, A., Upadhyay, S., Davidson, L. A., & Chapkin, R. S.
(2023).
Health Benefits of Coffee Consumption for Cancer and Other Diseases and Mechanisms of Action. 24(3), 2706-2706.
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Madison, C. A., Debler, R. A., Vardeleon, N. I., Hillbrick, L., Jayaraman, A., Safe, S., Chapkin, R. S., & Eitan, S.
(2022).
Sex-dependent differences in the stress mitigating and antidepressant effects of selective aryl hydrocarbon receptor modulators. JOURNAL OF AFFECTIVE DISORDERS.
319, 213-220.
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Safe, S., & Zhang, L.
(2022).
The Role of the Aryl Hydrocarbon Receptor (AhR) and Its Ligands in Breast Cancer. Cancers.
14(22), 5574-5574.
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Park, H., Jin, U., Martin, G., Chapkin, R. S., Davidson, L. A., Lee, K., Jayaraman, A., & Safe, S.
(2022).
Structure-activity relationships among mono- and dihydroxy flavones as aryl hydrocarbon receptor (AhR) agonists or antagonists in CACO2 cells. CHEMICO-BIOLOGICAL INTERACTIONS.
365, 110067-110067.
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Madison, C. A., Kuempel, J., Albrecht, G. L., Hillbrick, L., Jayaraman, A., Safe, S., Chapkin, R. S., & Eitan, S.
(2022).
3,3'-Diindolylmethane and 1,4-dihydroxy-2-naphthoic acid prevent chronic mild stress induced depressive-like behaviors in female mice. JOURNAL OF AFFECTIVE DISORDERS.
309, 201-210.
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Mohankumar, K., Wright, G., Kumaravel, S., Shrestha, R., Zhang, L., Abdelrahim, M., Chapkin, R. S., & Safe, S.
(2022).
Abstract 236: Nuclear receptor 4A1 ligands target T-cell exhaustion in colorectal cancer. Cancer Research.
82(12_Supplement), 236-236.
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Zhang, L., Martin, G., Mohankumar, K., Hampton, J. T., Liu, W. R., & Safe, S.
(2022).
RESVERATROL BINDS NUCLEAR RECEPTOR 4A1 (NR4A1) AND ACTS AS AN NR4A1 ANTAGONIST IN LUNG CANCER CELLS. Molecular Pharmacology.
102(2), 80-91.
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Safe, S.
(2022).
Excited about Receptors. 1(1), 1-2.
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Lee, H., Kim, D. H., Lee, I., Park, J., Martin, G., Safe, S., ... Lee, S.
(2022).
Plant Alkaloid Tetrandrine Is a Nuclear Receptor 4A1 Antagonist and Inhibits Panc-1 Cell Growth In Vitro and In Vivo. International Journal of Molecular Sciences.
23(9), 5280-5280.
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Schoeller, A., Karki, K., Jayaraman, A., Chapkin, R. S., & Safe, S.
(2022).
Short chain fatty acids exhibit selective estrogen receptor downregulator (SERD) activity in breast cancer. American Journal of Cancer Research.
12(7), 3422-3436.
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Han, H., Davidson, L. A., Fan, Y., Landrock, K. K., Jayaraman, A., Safe, S. H., & Chapkin, R. S.
(2022).
Loss of aryl hydrocarbon receptor suppresses the response of colonic epithelial cells to IL22 signaling by upregulating SOCS3. American Journal of Physiology: Gastrointestinal and Liver Physiology.
322(1), G93-G106.
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Mohankumar, K., Shrestha, R., & Safe, S.
(2022).
Nuclear receptor 4A1 (NR4A1) antagonists target paraspeckle component 1 (PSPC1) in cancer cells. Molecular Carcinogenesis.
61(1), 73-84.
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Yang, Y., Osorio, D., Davidson, L. A., Han, H., Mullens, D. A., Jayaraman, A., ... Chapkin, R. S.
(2022).
Single-cell RNA Sequencing Reveals How the Aryl Hydrocarbon Receptor Shapes Cellular Differentiation Potency in the Mouse Colon. Cancer Prevention Research.
15(1), 17-28.
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Safe, S., Shrestha, R., & Mohankumar, K.
(2021).
Orphan nuclear receptor 4A1 (NR4A1) and novel ligands. Essays in Biochemistry.
65(6), 877-886.
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Shrestha, R., Mohankumar, K., Martin, G., Hailemariam, A., Lee, S., Jin, U., Burghardt, R., & Safe, S.
(2021).
Flavonoids kaempferol and quercetin are nuclear receptor 4A1 (NR4A1, Nur77) ligands and inhibit rhabdomyosarcoma cell and tumor growth. Journal of Experimental and Clinical Cancer Research.
40(1), 392.
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Mohankumar, K., Wright, G., Kumaravel, S., Shrestha, R., Abdelrahim, M., Chapkin, R., & Safe, S.
(2021).
A NOVEL NUCLEAR RECEPTOR 4A1 (NR4A1) ANTAGONISTS ATTENUATES T-CELL EXHAUSTION IN COLORECTAL CANCER. Journal for ImmunoTherapy of Cancer.
9(Suppl 2), A761-A762.
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Abdelrahim, M., Mohankumar, K., Karki, K., & Safe, S.
(2021).
IMMUNOMODULATION BY TARGETING PDL-1 IN COLON CANCER USING NUCLEAR RECEPTOR 4A1 (NR4A1) ANTAGONISTS. Journal for ImmunoTherapy of Cancer.
9(Suppl 2), A754-A755.
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Zarei, M., Shrestha, R., Johnson, S., Yu, Z., Karki, K., Vaziri-Gohar, A., ... Safe, S.
(2021).
Nuclear Receptor 4A2 (NR4A2/NURR1) Regulates Autophagy and Chemoresistance in Pancreatic Ductal Adenocarcinoma. Cancer Research Communications.
1(2), 65-78.
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Chapkin, R. S., Davidson, L. A., Park, H., Jin, U., Fan, Y., Cheng, Y., ... Safe, S.
(2021).
Role of the Aryl Hydrocarbon Receptor (AhR) in Mediating the Effects of Coffee in the Colon. Molecular Nutrition and Food Research.
65(20), e2100539-2100539.
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Baron, J. A., Nichols, H. B., & Safe, S.
(2021).
Cigarette Smoking and Estrogen-Related Cancer-Reply. Cancer Epidemiology, Biomarkers and Prevention.
30(10), 1978-1978.
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Safe, S., Shrestha, R., Mohankumar, K., Howard, M., Hedrick, E., & Abdelrahim, M.
(2021).
Transcription factors specificity protein and nuclear receptor 4A1 in pancreatic cancer. WORLD JOURNAL OF GASTROENTEROLOGY.
27(38), 6387-6398.
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Baron, J. A., Nichols, H. B., Anderson, C., & Safe, S.
(2021).
Cigarette Smoking and Estrogen-Related Cancer. Cancer Epidemiology, Biomarkers and Prevention.
30(8), 1462-1471.
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Mohankumar, K., Karki, K., Safe, S., & Abdelrahim, M.
(2021).
Abstract 1149: Nuclear receptor 4A1 (NR4A1) antagonists target PD-L1 in colon cancer. 81(13_Supplement), 1149-1149.
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Mohankumar, K., Shrestha, R., & Safe, S.
(2021).
Abstract 2428: NR4A1 ligands inhibits PSPC1 regulated EMT and stemness markers in breast, lung and liver cancer cells. 81(13_Supplement), 2428-2428.
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Shrestha, R., Mohankumar, K., Martin, G., & Safe, S.
(2021).
Abstract 629: Flavonoids are NR4A1 antagonists and target PAX3-FOXO1 and G9a in alveolar rhabdomyosarcoma cells. 81(13_Supplement), 629-629.
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Han, H., Davidson, L. A., Hensel, M., Yoon, G., Landrock, K., Allred, C., ... Chapkin, R. S.
(2021).
Loss of Aryl Hydrocarbon Receptor Promotes Colon Tumorigenesis in ApcS580/+; KrasG12D/+ Mice. Molecular Cancer Research.
19(5), 771-783.
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Karki, K., Mohankumar, K., Schoeller, A., Martin, G., Shrestha, R., & Safe, S.
(2021).
NR4A1 Ligands as Potent Inhibitors of Breast Cancer Cell and Tumor Growth. Cancers.
13(11), 2682-2682.
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Shrestha, R., Mohankumar, K., Jin, U., Martin, G., & Safe, S.
(2021).
The Histone Methyltransferase Gene G9A Is Regulated by Nuclear Receptor 4A1 in Alveolar Rhabdomyosarcoma Cells. 20(3), 612-622.
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Chidambara Murthy, K. N., Jayaprakasha, G. K., Safe, S., & Patil, B. S.
(2021).
Citrus limonoids induce apoptosis and inhibit the proliferation of pancreatic cancer cells. Food and Function.
12(3), 1111-1120.
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Park, H., Jin, U., Karki, K., Allred, C., Davidson, L. A., Chapkin, R. S., ... Safe, S.
(2021).
Hydroxylated Chalcones as Aryl Hydrocarbon Receptor Agonists: Structure-Activity Effects. TOXICOLOGICAL SCIENCES.
180(1), 148-159.
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Safe, S., & Karki, K.
(2021).
The Paradoxical Roles of Orphan Nuclear Receptor 4A (NR4A) in Cancer. Molecular Cancer Research.
19(2), 180-191.
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Lee, H., Kim, S., Kim, B., Safe, S., & Lee, S.
(2021).
Broussochalcone A Is a Novel Inhibitor of the Orphan Nuclear Receptor NR4A1 and Induces Apoptosis in Pancreatic Cancer Cells. Molecules.
26(8), 2316-2316.
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Han, H., Safe, S., Jayaraman, A., & Chapkin, R. S.
(2021).
Diet-Host-Microbiota Interactions Shape Aryl Hydrocarbon Receptor Ligand Production to Modulate Intestinal Homeostasis. Annual Review of Nutrition.
41(1), 455-478.
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Safe, S., Jayaraman, A., Chapkin, R. S., Howard, M., Mohankumar, K., & Shrestha, R.
(2021).
Flavonoids: structure-function and mechanisms of action and opportunities for drug development. Toxicological research.
37(2), 147-162.
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Nottingham, E., Mazzio, E., Surapaneni, S. K., Kutlehria, S., Mondal, A., Badisa, R., ... Singh, M.
(2021).
Synergistic effects of methyl 2-cyano-3,11-dioxo-18beta-olean-1,-12-dien-30-oate and erlotinib on erlotinib-resistant non-small cell lung cancer cells. Journal of Pharmaceutical Analysis.
11(6), 799-807.
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Yang, F., DeLuca, J., Menon, R., Garcia-Vilarato, E., Callaway, E., Landrock, K. K., ... Jayaraman, A.
(2020).
Effect of diet and intestinal AhR expression on fecal microbiome and metabolomic profiles. Microbial Cell Factories.
19(1), 219.
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Park, H., Jin, U., Karki, K., Jayaraman, A., Allred, C., Michelhaugh, S. K., ... Safe, S.
(2020).
Dopamine is an aryl hydrocarbon receptor agonist. Biochemical Journal.
477(19), 3899-3910.
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Han, H., Davidson, L. A., Fan, Y., Goldsby, J. S., Yoon, G., Jin, U., ... Chapkin, R. S.
(2020).
Loss of aryl hydrocarbon receptor potentiates FoxM1 signaling to enhance self-renewal of colonic stem and progenitor cells. EMBO Journal.
39(19), e104319.
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Jin, U., Michelhaugh, S. K., Polin, L. A., Shrestha, R., Mittal, S., & Safe, S.
(2020).
Omeprazole Inhibits Glioblastoma Cell Invasion and Tumor Growth. Cancers.
12(8), 2097-2097.
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Nottingham, E., Sekar, V., Mondal, A., Safe, S., Rishi, A. K., & Singh, M.
(2020).
The Role of Self-Nanoemulsifying Drug Delivery Systems of CDODA-Me in Sensitizing Erlotinib-Resistant Non-Small Cell Lung Cancer. Journal of Pharmaceutical Sciences.
109(6), 1867-1882.
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Mohankumar, K., Li, X. i., Sung, N., Cho, Y. J., Han, S. J., & Safe, S.
(2020).
Bis-Indole-Derived Nuclear Receptor 4A1 (NR4A1, Nur77) Ligands as Inhibitors of Endometriosis. ENDOCRINOLOGY.
161(4), bqaa027.
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Kumaravel, S., Singh, S., Roy, S., Venkatasamy, L., White, T. K., Sinha, S., ... Chakraborty, S.
(2020).
CXCL11-CXCR3 Axis Mediates Tumor Lymphatic Cross Talk and Inflammation-Induced Tumor, Promoting Pathways in Head and Neck Cancers. American Journal of Pathology.
190(4), 900-915.
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Wu, C., Wei, Q., Wang, H., Kim, D. M., Balderas, M., Wu, G., ... Sun, Y.
(2020).
Protective Effects of Ghrelin on Fasting-Induced Muscle Atrophy in Aging Mice. Journal of Gerontology Series A: Biological Sciences and Medical Sciences.
75(4), 621-630.
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Karki, K., Wright, G. A., Mohankumar, K., Jin, U., Zhang, X., & Safe, S.
(2020).
A Bis-Indole-Derived NR4A1 Antagonist Induces PD-L1 Degradation and Enhances Antitumor Immunity. Cancer Research.
80(5), 1011-1023.
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Garcia-Villatoro, E. L., DeLuca, J., Callaway, E. S., Allred, K. F., Davidson, L. A., Hensel, M. E., ... Allred, C. D.
(2020).
Effects of high-fat diet and intestinal aryl hydrocarbon receptor deletion on colon carcinogenesis. American Journal of Physiology: Gastrointestinal and Liver Physiology.
318(3), G451-G463.
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Safe, S., Jayaraman, A., & Chapkin, R. S.
(2020).
Ah receptor ligands and their impacts on gut resilience: structure-activity effects. Critical Reviews in Toxicology.
50(6), 463-473.
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Safe, S., Jin, U., Park, H., Chapkin, R. S., & Jayaraman, A.
(2020).
Aryl Hydrocarbon Receptor (AHR) Ligands as Selective AHR Modulators (SAhRMs). International Journal of Molecular Sciences.
21(18), 6654-6654.
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Han, H., Jayaraman, A., Safe, S., & Chapkin, R. S.
(2020).
Targeting the aryl hydrocarbon receptor in stem cells to improve the use of food as medicine. Current Stem Cell Reports.
6(4), 109-118.
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Karki, K., Li, X. i., Jin, U., Mohankumar, K., Zarei, M., Michelhaugh, S. K., ... Safe, S.
(2020).
Nuclear receptor 4A2 (NR4A2) is a druggable target for glioblastomas. Journal of Neuro-Oncology.
146(1), 25-39.
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Wang, M., Safe, S., Hearon, S. E., & Phillips, T. D.
(2019).
Strong adsorption of Polychlorinated Biphenyls by processed montmorillonite clays: Potential applications as toxin enterosorbents during disasters and floods. Environmental Pollution.
255(Pt 1), 113210-113210.
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Hedrick, E., Mohankumar, K., Lacey, A., & Safe, S.
(2019).
Inhibition of NR4A1 Promotes ROS Accumulation and IL24-Dependent Growth Arrest in Rhabdomyosarcoma. Molecular Cancer Research.
17(11), 2221-2232.
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Park, H., Jin, U., Orr, A. A., Echegaray, S. P., Davidson, L. A., Allred, C. D., ... Safe, S.
(2019).
Isoflavones as Ah Receptor Agonists in Colon-Derived Cell Lines: Structure-Activity Relationships. CHEMICAL RESEARCH IN TOXICOLOGY.
32(11), 2353-2364.
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Li, X. i., Tjalkens, R. B., Shrestha, R., & Safe, S.
(2019).
Structure-dependent activation of gene expression by bis-indole and quinoline-derived activators of nuclear receptor 4A2. Chemical Biology and Drug Design.
94(4), 1711-1720.
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Hedrick, E., Li, X. i., Cheng, Y., Lacey, A., Mohankumar, K., Zarei, M., & Safe, S.
(2019).
Potent inhibition of breast cancer by bis-indole-derived nuclear receptor 4A1 (NR4A1) antagonists. Breast Cancer Research and Treatment.
177(1), 29-40.
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Jin, U., Karki, K., Cheng, Y., Michelhaugh, S. K., Mittal, S., & Safe, S.
(2019).
The aryl hydrocarbon receptor is a tumor suppressor-like gene in glioblastoma. 294(29), 11342-11353.
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Mohankumar, K., Li, X. i., Sridharan, S., Karki, K., & Safe, S.
(2019).
Nuclear receptor 4A1 (NR4A1) antagonists induce ROS-dependent inhibition of mTOR signaling in endometrial cancer. Gynecologic Oncology.
154(1), 218-227.
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Jung, Y., Lee, H., Cho, H., Kim, K., Kim, J., Safe, S., & Lee, S.
(2019).
Dual targeting of Nur77 and AMPK by isoalantolactone inhibits adipogenesis in vitro and decreases body fat mass in vivo. INTERNATIONAL JOURNAL OF OBESITY.
43(5), 952-962.
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De Miranda, B. R., Miller, J. A., Hansen, R. J., Lunghofer, P. J., Safe, S., Gustafson, D. L., Colagiovanni, D., & Tjalkens, R. B.
(2019).
Correction to "Neuroprotective Efficacy and Pharmacokinetic Behavior of Novel Anti-Inflammatory Para-Phenyl Substituted Diindolylmethanes in a Mouse Model of Parkinson's Disease". Journal of Pharmacology and Experimental Therapeutics.
369(1), 66-66.
-
Safe, S., & van den Berg, M.
(2019).
Editorial overview: Mechanistic toxicology. 14, iii-iv.
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Yoon, K., Chen, C., Orr, A. A., Barreto, P. N., Tamamis, P., & Safe, S.
(2019).
Activation of COUP-TFI by a Novel Diindolylmethane Derivative. Cells.
8(3), 220-220.
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Kasiappan, R., Jutooru, I., Mohankumar, K., Karki, K., Lacey, A., & Safe, S.
(2019).
Reactive Oxygen Species (ROS)-Inducing Triterpenoid Inhibits Rhabdomyosarcoma Cell and Tumor Growth through Targeting Sp Transcription Factors. Molecular Cancer Research.
17(3), 794-805.
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Lacey, A., Hedrick, E., Cheng, Y., Mohankumar, K., Warren, M., & Safe, S.
(2018).
Interleukin-24 (IL24) Is Suppressed by PAX3-FOXO1 and Is a Novel Therapy for Rhabdomyosarcoma. MOLECULAR CANCER THERAPEUTICS.
17(12), 2756-2766.
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Hedrick, E., Mohankumar, K., & Safe, S.
(2018).
TGF-Induced Lung Cancer Cell Migration Is NR4A1-Dependent. Molecular Cancer Research.
16(12), 1991-2002.
-
Safe, S., Han, H., Goldsby, J., Mohankumar, K., & Chapkin, R. S.
(2018).
Aryl Hydrocarbon Receptor (AhR) Ligands as Selective AhR Modulators: Genomic Studies. Current Opinion in Toxicology.
11-12, 10-20.
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Karki, K., Harishchandra, S., & Safe, S.
(2018).
Bortezomib Targets Sp Transcription Factors in Cancer Cells. Molecular Pharmacology.
94(4), 1187-1196.
-
Popichak, K. A., Hammond, S. L., Moreno, J. A., Afzali, M. F., Backos, D. S., Slayden, R. D., Safe, S., & Tjalkens, R. B.
(2018).
Compensatory Expression of Nur77 and Nurr1 Regulates NF-B-Dependent Inflammatory Signaling in Astrocytes. Molecular Pharmacology.
94(4), 1174-1186.
-
Afzali, M. F., Popichak, K. A., Burton, L. H., Klochak, A. L., Wilson, W. J., Safe, S., Tjalkens, R. B., & Legare, M. E.
(2018).
A novel diindolylmethane analog, 1,1-bis(3'-indolyl)-1-(p-chlorophenyl) methane, inhibits the tumor necrosis factor-induced inflammatory response in primary murine synovial fibroblasts through a Nurr1-dependent mechanism. Molecular Immunology.
101, 46-54.
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Draz, H., Goldberg, A. A., Tomlinson Guns, E. S., Fazli, L., Safe, S., & Sanderson, J. T.
(2018).
Autophagy inhibition improves the chemotherapeutic efficacy of cruciferous vegetable-derived diindolymethane in a murine prostate cancer xenograft model. Investigational New Drugs.
36(4), 718-725.
-
Safe, S., Abbruzzese, J., Abdelrahim, M., & Hedrick, E.
(2018).
Specificity Protein Transcription Factors and Cancer: Opportunities for Drug Development. 11(7), 371-382.
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Jin, U., Park, H., Li, X. i., Davidson, L. A., Allred, C., Patil, B., ... Safe, S.
(2018).
Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids. TOXICOLOGICAL SCIENCES.
164(1), 205-217.
-
Boobis, A., Safe, S. H., & Farland, W.
(2018).
Editorial overview: Risk assessment in toxicology. Current Opinion in Toxicology.
9, iii-v.
-
Jin, U., Karki, K., Kim, S., & Safe, S.
(2018).
Inhibition of pancreatic cancer Panc1 cell migration by omeprazole is dependent on aryl hydrocarbon receptor activation of JNK. Biochemical and Biophysical Research Communications.
501(3), 751-757.
-
Hammond, S. L., Popichak, K. A., Li, X. i., Hunt, L. G., Richman, E. H., Damale, P. U., ... Tjalkens, R. B.
(2018).
The Nurr1 Ligand,1,1-bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism. Journal of Pharmacology and Experimental Therapeutics.
365(3), 636-651.
-
Mohankumar, K., Lee, J., Wu, C. S., Sun, Y., & Safe, S.
(2018).
Bis-Indole-Derived NR4A1 Ligands and Metformin Exhibit NR4A1-Dependent Glucose Metabolism and Uptake in C2C12 Cells. ENDOCRINOLOGY.
159(5), 1950-1963.
-
Choudhary, M., Safe, S., & Malek, G.
(2018).
Suppression of aberrant choroidal neovascularization through activation of the aryl hydrocarbon receptor. BBA: Molecular Basis of Disease.
1864(5 Pt A), 1583-1595.
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Wang, B., Wang, L., Li, X. i., Liu, Y., Zhang, Z., Hedrick, E., ... Wang, S.
(2018).
Template-free fabrication of vertically-aligned polymer nanowire array on the flat-end tip for quantifying the single living cancer cells and nanosurface interaction. Manufacturing letters.
16, 27-31.
-
Safe, S., Nair, V., & Karki, K.
(2018).
Metformin-induced anticancer activities: recent insights. Biological Chemistry: official scientific journal of the GBM.
399(4), 321-335.
-
Cheng, Y., Imanirad, P., Jutooru, I., Hedrick, E., Jin, U., Rodrigues Hoffman, A., ... Safe, S.
(2018).
Role of metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1) in pancreatic cancer. PLoS ONE.
13(2), e0192264-e0192264.
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Draz, H., Goldberg, A. A., Titorenko, V. I., Tomlinson Guns, E. S., Safe, S. H., & Sanderson, J. T.
(2017).
Diindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-activated protein kinase (AMPK). Cellular Signalling.
40, 172-182.
-
Safe, S.
(2017).
Carbidopa: a selective Ah receptor modulator (SAhRM). Biochemical Journal.
474(22), 3763-3765.
-
Li, Y., Wang, F., Lu, L. i., Zhu, F., Huang, S., Nomie, K., ... Rui, L.
(2017).
NR4A1 inhibition synergizes with ibrutinib in killing mantle cell lymphoma cells. Blood Cancer Journal.
7(12), 632.
-
Lee, H., Safe, S., & Lee, S.
(2017).
Inactivation of the orphan nuclear receptor NR4A1 contributes to apoptosis induction by fangchinoline in pancreatic cancer cells. TOXICOLOGY AND APPLIED PHARMACOLOGY.
332, 32-39.
-
Hedrick, E., Lee, S., Doddapaneni, R., Singh, M., & Safe, S.
(2017).
Correction for Hedrick et al., "NR4A1 Antagonists Inhibit 1-Integrin-Dependent Breast Cancer Cell Migration". Molecular and Cellular Biology.
37(18), e00197-e00117.
-
Hedrick, E., & Safe, S.
(2017).
Transforming Growth Factor /NR4A1-Inducible Breast Cancer Cell Migration and Epithelial-to-Mesenchymal Transition Is p38 (Mitogen-Activated Protein Kinase 14) Dependent. 37(18), e00306-e00317.
-
Kolluri, S. K., Jin, U., & Safe, S.
(2017).
Erratum to: Role of the aryl hydrocarbon receptor in carcinogenesis and potential as an anti-cancer drug target. Archives of Toxicology.
91(9), 3209-3209.
-
Hedrick, E., Lee, S., & Safe, S.
(2017).
The nuclear orphan receptor NR4A1 regulates 1-integrin expression in pancreatic and colon cancer cells and can be targeted by NR4A1 antagonists. Molecular Carcinogenesis.
56(9), 2066-2075.
-
Jin, U., Cheng, Y., Park, H., Davidson, L. A., Callaway, E. S., Chapkin, R. S., ... Safe, S.
(2017).
Short Chain Fatty Acids Enhance Aryl Hydrocarbon (Ah) Responsiveness in Mouse Colonocytes and Caco-2 Human Colon Cancer Cells. Scientific Reports.
7(1), 10163.
-
Karki, K., Hedrick, E., Kasiappan, R., Jin, U., & Safe, S.
(2017).
Piperlongumine Induces Reactive Oxygen Species (ROS)-Dependent Downregulation of Specificity Protein Transcription Factors. Cancer Prevention Research.
10(8), 467-477.
-
Draz, H., Goldberg, A., Sanderson, T., & Safe, S.
(2017).
Abstract 3298: Diindolylmethane and its halogenated analogues induce autophagy in human prostate cancer cells via induction of the astrocyte-elevated gene-1 (AEG-1). 77(13_Supplement), 3298-3298.
-
Kolluri, S. K., Jin, U., & Safe, S.
(2017).
Role of the aryl hydrocarbon receptor in carcinogenesis and potential as an anti-cancer drug target. Archives of Toxicology.
91(7), 2497-2513.
-
Jin, U., Cheng, Y., Zhou, B., & Safe, S.
(2017).
Bardoxolone Methyl and a Related Triterpenoid Downregulate cMyc Expression in Leukemia Cells. Molecular Pharmacology.
91(5), 438-450.
-
Taoka, R., Jinesh, G. G., Xue, W., Safe, S., & Kamat, A. M.
(2017).
CF3DODA-Me induces apoptosis, degrades Sp1, and blocks the transformation phase of the blebbishield emergency program. Apoptosis: an international journal on programmed cell death.
22(5), 719-729.
-
Bridi, M. S., Hawk, J. D., Chatterjee, S., Safe, S., & Abel, T.
(2017).
Pharmacological Activators of the NR4A Nuclear Receptors Enhance LTP in a CREB/CBP-Dependent Manner. Neuropsychopharmacology.
42(6), 1243-1253.
-
Safe, S., & Li, X. i.
(2017).
Endocrine disruption: Relevance of experimental studies in female animals to human studies. Current Opinion in Toxicology.
3, 12-19.
-
Cheng, Y., Jin, U., Davidson, L. A., Chapkin, R. S., Jayaraman, A., Tamamis, P., ... Safe, S.
(2017).
Editor's Highlight: Microbial-Derived 1,4-Dihydroxy-2-naphthoic Acid and Related Compounds as Aryl Hydrocarbon Receptor Agonists/Antagonists: Structure-Activity Relationships and Receptor Modeling. TOXICOLOGICAL SCIENCES.
155(2), 458-473.
-
Lacey, A., Rodrigues-Hoffman, A., & Safe, S.
(2017).
PAX3-FOXO1A Expression in Rhabdomyosarcoma Is Driven by the Targetable Nuclear Receptor NR4A1. Cancer Research.
77(3), 732-741.
-
Safe, S., Cheng, Y., & Jin, U.
(2017).
The Aryl Hydrocarbon Receptor (AhR) as a Drug Target for Cancer Chemotherapy. Current Opinion in Toxicology.
2, 24-29.
-
Hedrick, E., Li, X. i., & Safe, S.
(2017).
Penfluridol Represses Integrin Expression in Breast Cancer through Induction of Reactive Oxygen Species and Downregulation of Sp Transcription Factors. 16(1), 205-216.
-
Kasiappan, R., Jutooru, I., Karki, K., Hedrick, E., & Safe, S.
(2016).
Benzyl Isothiocyanate (BITC) Induces Reactive Oxygen Species-dependent Repression of STAT3 Protein by Down-regulation of Specificity Proteins in Pancreatic Cancer. 291(53), 27122-27133.
-
Safe, S., & Kasiappan, R.
(2016).
Natural Products as Mechanism-based Anticancer Agents: Sp Transcription Factors as Targets. Phytotherapy Research.
30(11), 1723-1732.
-
Godugu, C., Doddapaneni, R., Safe, S. H., & Singh, M.
(2016).
Novel diindolylmethane derivatives based NLC formulations to improve the oral bioavailability and anticancer effects in triple negative breast cancer. European Journal of Pharmaceutics and Biopharmaceutics.
108, 168-179.
-
Boakye, C., Patel, K., Patel, A. R., Faria, H., Zucolotto, V., Safe, S., & Singh, M.
(2016).
Lipid-based oral delivery systems for skin deposition of a potential chemopreventive DIM derivative: characterization and evaluation. Drug Delivery and Translational Research.
6(5), 526-539.
-
Pena-Abaurrea, M., Robson, M., Chaudhuri, S., Riddell, N., McCrindle, R., Chittim, B., ... Reiner, E. J.
(2016).
Environmental levels and toxicological potencies of a novel mixed halogenated carbazole. Emerging Contaminants.
2(3), 166-172.
-
Moore, R. W., Fritz, W. A., Schneider, A. J., Lin, T., Branam, A. M., Safe, S., & Peterson, R. E.
(2016).
2,3,7,8-Tetrachlorodibenzo-p-dioxin has both pro-carcinogenic and anti-carcinogenic effects on neuroendocrine prostate carcinoma formation in TRAMP mice. TOXICOLOGY AND APPLIED PHARMACOLOGY.
305, 242-249.
-
Takeuchi, H., Taoka, R., Mmeje, C. O., Jinesh, G. G., Safe, S., & Kamat, A. M.
(2016).
CDODA-Me decreases specificity protein transcription factors and induces apoptosis in bladder cancer cells through induction of reactive oxygen species. Urologic Oncology: seminars and original investigations.
34(8), 337.e11-337.e18.
-
Boakye, C., Patel, K., Doddapaneni, R., Bagde, A., Behl, G., Chowdhury, N., Safe, S., & Singh, M.
(2016).
Ultra-flexible nanocarriers for enhanced topical delivery of a highly lipophilic antioxidative molecule for skin cancer chemoprevention. Colloids and Surfaces B: Biointerfaces.
143, 156-167.
-
Lacey, A., Hedrick, E., Li, X. i., Patel, K., Doddapaneni, R., Singh, M., & Safe, S.
(2016).
Nuclear receptor 4A1 (NR4A1) as a drug target for treating rhabdomyosarcoma (RMS). 7(21), 31257-31269.
-
Delgado, E., Boisen, M. M., Laskey, R., Chen, R., Song, C., Sallit, J., ... Oesterreich, S.
(2016).
High expression of orphan nuclear receptor NR4A1 in a subset of ovarian tumors with worse outcome. Gynecologic Oncology.
141(2), 348-356.
-
Hedrick, E., Lee, S., Doddapaneni, R., Singh, M., & Safe, S.
(2016).
NR4A1 Antagonists Inhibit 1-Integrin-Dependent Breast Cancer Cell Migration. 36(9), 1383-1394.
-
Takeuchi, H., Taoka, R., Jinesh, G. G., Mmeje, C. O., Safe, S., Aoyagi, T., Tachibana, M., & Kamat, A. M.
(2016).
MP45-02 CDODA-ME DECREASES SPECIFICITY PROTEIN TRANSCRIPTION FACTORS AND INDUCES APOPTOSIS IN BLADDER CANCER CELLS THROUGH INDUCTION OF REACTIVE OXYGEN SPECIES. 195(4), e607-e608.
-
Hedrick, E., Cheng, Y., Jin, U., Kim, K., & Safe, S.
(2016).
Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells. Oncotarget.
7(16), 22245-22256.
-
Ying, W., Tseng, A., Chang, R., Wang, H., Lin, Y., Kanameni, S., ... Zhou, B.
(2016).
miR-150 regulates obesity-associated insulin resistance by controlling B cell functions. Scientific Reports.
6(1), 20176.
-
Safe, S., Jin, U., Morpurgo, B., Abudayyeh, A., Singh, M., & Tjalkens, R. B.
(2016).
Nuclear receptor 4A (NR4A) family - orphans no more. The Journal of Steroid Biochemistry and Molecular Biology.
157, 48-60.
-
Goldberg, A. A., Draz, H., Montes-Grajales, D., Olivero-Verbl, J., Safe, S. H., & Sanderson, J. T.
(2016).
Erratum: 3,3'-Diindolylmethane (DIM) and its ring-substituted halogenated analogs (ring-DIMs) induce differential mechanisms of survival and death in androgen-dependent and-independent prostate cancer cells. 7(1-2), 59.
-
Li, X. i., Pathi, S. S., & Safe, S.
(2015).
Sulindac sulfide inhibits colon cancer cell growth and downregulates specificity protein transcription factors. BMC Cancer.
15(1), 974.
-
Ying, W., Tseng, A., Chang, R., Morin, A., Brehm, T., Triff, K., ... Zhou, B.
(2015).
MicroRNA-223 is a crucial mediator of PPAR-regulated alternative macrophage activation. Journal of Clinical Investigation.
125(11), 4149-4159.
-
Hammond, S. L., Safe, S., & Tjalkens, R. B.
(2015).
A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. NEUROSCIENCE LETTERS.
607, 83-89.
-
Cheng, Y., Jin, U., Allred, C. D., Jayaraman, A., Chapkin, R. S., & Safe, S.
(2015).
Aryl Hydrocarbon Receptor Activity of Tryptophan Metabolites in Young Adult Mouse Colonocytes. Drug Metabolism and Disposition.
43(10), 1536-1543.
-
Hedrick, E., Lee, S., Doddapaneni, R., Singh, M., & Safe, S.
(2015).
Nuclear receptor 4A1 as a drug target for breast cancer chemotherapy. Endocrine-Related Cancer.
22(5), 831-840.
-
Riddell, N., Jin, U., Safe, S., Cheng, Y., Chittim, B., Konstantinov, A., ... McCrindle, R.
(2015).
Characterization and Biological Potency of Mono- to Tetra-Halogenated Carbazoles. Environmental Science and Technology.
49(17), 10658-10666.
-
Das Gupta, S., Sae-tan, S., Wahler, J., So, J. Y., Bak, M. J., Cheng, L. C., ... Suh, N.
(2015).
Dietary -Tocopherol-Rich Mixture Inhibits Estrogen-Induced Mammary Tumorigenesis by Modulating Estrogen Metabolism, Antioxidant Response, and PPAR. Cancer Prevention Research.
8(9), 807-816.
-
Patel, A. R., Doddapaneni, R., Andey, T., Wilson, H., Safe, S., & Singh, M.
(2015).
Evaluation of self-emulsified DIM-14 in dogs for oral bioavailability and in Nu/nu mice bearing stem cell lung tumor models for anticancer activity. Journal of Controlled Release.
213, 18-26.
-
Hedrick, E., Crose, L., Linardic, C. M., & Safe, S.
(2015).
Histone Deacetylase Inhibitors Inhibit Rhabdomyosarcoma by Reactive Oxygen Species-Dependent Targeting of Specificity Protein Transcription Factors. MOLECULAR CANCER THERAPEUTICS.
14(9), 2143-2153.
-
Gandhy, S. U., Imanirad, P., Jin, U., Nair, V., Hedrick, E., Cheng, Y., ... Safe, S.
(2015).
Specificity protein (Sp) transcription factors and metformin regulate expression of the long non-coding RNA HULC. Oncotarget.
6(28), 26359-26372.
-
Fan, Y., Davidson, L. A., Callaway, E. S., Wright, G. A., Safe, S., & Chapkin, R. S.
(2015).
A bioassay to measure energy metabolism in mouse colonic crypts, organoids, and sorted stem cells. American Journal of Physiology: Gastrointestinal and Liver Physiology.
309(1), G1-G9.
-
Boakye, C., Shah, P. P., Doddapaneni, R., Patel, A. R., Safe, S., & Singh, M.
(2015).
Enhanced Percutaneous Delivery of 1,1-bis(3'-indolyl)-1-(p-chlorophenyl) Methane for Skin Cancer Chemoprevention. Journal of Biomedical Nanotechnology.
11(7), 1269-1281.
-
Patel, A. R., Godugu, C., Wilson, H., Safe, S., & Singh, M.
(2015).
Evaluation of Spray BIO-Max DIM-P in Dogs for Oral Bioavailability and in Nu/nu Mice Bearing Orthotopic/Metastatic Lung Tumor Models for Anticancer Activity. Pharmaceutical Research.
32(7), 2292-2300.
-
Tjalkens, R. B., & Safe, S.
(2015).
Nurr1 in Glial Cells as a Disease-Modifying Target for Parkinson's Disease. Neurotherapeutics.
12(3), 681-681.
-
Hedrick, E., Lee, S., Kim, G., Abdelrahim, M., Jin, U., Safe, S., & Abudayyeh, A.
(2015).
Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Renal Cell Adenocarcinoma. PLoS ONE.
10(6), e0128308-e0128308.
-
De Miranda, B. R., Popichak, K. A., Hammond, S. L., Jorgensen, B. A., Phillips, A. T., Safe, S., & Tjalkens, R. B.
(2015).
The Nurr1 Activator 1,1-Bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor B. Molecular Pharmacology.
87(6), 1021-1034.
-
Goldberg, A. A., Draz, H., Montes-Grajales, D., Olivero-Verbl, J., Safe, S. H., & Sanderson, J. T.
(2015).
3,3'-Diindolylmethane (DIM) and its ring-substituted halogenated analogs (ring-DIMs) induce differential mechanisms of survival and death in androgen-dependent and -independent prostate cancer cells. Genes and Cancer.
6(5-6), 265-280.
-
Jin, U., Kim, S., & Safe, S.
(2015).
Omeprazole Inhibits Pancreatic Cancer Cell Invasion through a Nongenomic Aryl Hydrocarbon Receptor Pathway. CHEMICAL RESEARCH IN TOXICOLOGY.
28(5), 907-918.
-
Cheng, Y., Jutooru, I., Chadalapaka, G., Corton, J. C., & Safe, S.
(2015).
The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration. Oncotarget.
6(13), 10840-10852.
-
Safe, S.
(2015).
MicroRNA-Specificity Protein (Sp) Transcription Factor Interactions and Significance in Carcinogenesis. Current pharmacology reports.
1(2), 73-78.
-
Safe, S.
(2015).
Targeting apoptosis pathways in cancer--letter. Cancer Prevention Research.
8(4), 338-338.
-
De Miranda, B. R., Popichak, K. A., Hammond, S. L., Miller, J. A., Safe, S., & Tjalkens, R. B.
(2015).
Novel para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and suppress glial activation in a mouse model of Parkinson's disease. TOXICOLOGICAL SCIENCES.
143(2), 360-373.
-
Phillips, T. D., Richardson, M., Cheng, Y., He, L., McDonald, T. J., Cizmas, L. H., ... Zhou, G.
(2015).
Mechanistic relationships between hepatic genotoxicity and carcinogenicity in male B6C3F1 mice treated with polycyclic aromatic hydrocarbon mixtures. Archives of Toxicology.
89(6), 967-977.
-
Yang, W. S., Chadalapaka, G., Cho, S., Lee, S., Jin, U., Jutooru, I., ... Kim, K.
(2014).
The transcriptional repressor ZBTB4 regulates EZH2 through a MicroRNA-ZBTB4-specificity protein signaling axis. Neoplasia.
16(12), 1059-1069.
-
Nair, V., Sreevalsan, S., Basha, R., Abdelrahim, M., Abudayyeh, A., Rodrigues Hoffman, A., & Safe, S.
(2014).
Mechanism of metformin-dependent inhibition of mammalian target of rapamycin (mTOR) and Ras activity in pancreatic cancer: role of specificity protein (Sp) transcription factors. 289(40), 27692-27701.
-
Lee, S., Li, X. i., Hedrick, E., Jin, U., Tjalkens, R. B., Backos, D. S., ... Safe, S.
(2014).
Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells. Molecular Endocrinology.
28(10), 1729-1739.
-
Jutooru, I., Guthrie, A. S., Chadalapaka, G., Pathi, S., Kim, K., Burghardt, R., Jin, U., & Safe, S.
(2014).
Mechanism of action of phenethylisothiocyanate and other reactive oxygen species-inducing anticancer agents. Molecular and Cellular Biology.
34(13), 2382-2395.
-
Zhang, Z., Kim, K., Li, X., Moreno, M., Sharp, T., Goodheart, M. J., ... Amendt, B. A.
(2014).
MicroRNA-26b represses colon cancer cell proliferation by inhibiting lymphoid enhancer factor 1 expression. MOLECULAR CANCER THERAPEUTICS.
13(7), 1942-1951.
-
Jin, U., Lee, S., Pfent, C., & Safe, S.
(2014).
The aryl hydrocarbon receptor ligand omeprazole inhibits breast cancer cell invasion and metastasis. BMC Cancer.
14(1), 498.
-
Patel, A. R., Chougule, M. B., Lim, E. d., Francis, K. P., Safe, S., & Singh, M.
(2014).
Theranostic tumor homing nanocarriers for the treatment of lung cancer. Nanomedicine: Nanotechnology, Biology and Medicine.
10(5), 1053-1063.
-
Safe, S., Imanirad, P., Sreevalsan, S., Nair, V., & Jutooru, I.
(2014).
Transcription factor Sp1, also known as specificity protein 1 as a therapeutic target. Expert Opinion on Therapeutic Targets.
18(7), 759-769.
-
Ying, W., Kanameni, S., Chang, C., Nair, V., Safe, S., Bazer, F. W., & Zhou, B.
(2014).
Interferon tau alleviates obesity-induced adipose tissue inflammation and insulin resistance by regulating macrophage polarization. PLoS ONE.
9(6), e98835-e98835.
-
Jin, U., Lee, S., Sridharan, G., Lee, K., Davidson, L. A., Jayaraman, A., ... Safe, S.
(2014).
Microbiome-derived tryptophan metabolites and their aryl hydrocarbon receptor-dependent agonist and antagonist activities. Molecular Pharmacology.
85(5), 777-788.
-
Lee, S., Jin, U., Kang, J. H., Kim, S. B., Guthrie, A. S., Sreevalsan, S., Lee, J., & Safe, S.
(2014).
The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells. Molecular Cancer Research.
12(4), 527-538.
-
Safe, S., Jin, U., Hedrick, E., Reeder, A., & Lee, S.
(2014).
Minireview: role of orphan nuclear receptors in cancer and potential as drug targets. Molecular Endocrinology.
28(2), 157-172.
-
Goldberg, A. A., Titorenko, V. I., Beach, A., Abdelbaqi, K., Safe, S., & Sanderson, J. T.
(2014).
Ring-substituted analogs of 3,3'-diindolylmethane (DIM) induce apoptosis and necrosis in androgen-dependent and -independent prostate cancer cells. Investigational New Drugs.
32(1), 25-36.
-
Pathi, S., Li, X. i., & Safe, S.
(2014).
Tolfenamic acid inhibits colon cancer cell and tumor growth and induces degradation of specificity protein (Sp) transcription factors. Molecular Carcinogenesis.
53 Suppl 1(S1), E53-E61.
-
Ying, W., Cheruku, P. S., Bazer, F. W., Safe, S. H., & Zhou, B.
(2013).
Investigation of macrophage polarization using bone marrow derived macrophages. Journal of Visualized Experiments.
-
Nair, V., Pathi, S., Jutooru, I., Sreevalsan, S., Basha, R., Abdelrahim, M., Samudio, I., & Safe, S.
(2013).
Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors. Carcinogenesis.
34(12), 2870-2879.
-
Sreevalsan, S., & Safe, S.
(2013).
REACTIVE OXYGEN SPECIES AND COLORECTAL CANCER. Current Colorectal Cancer Reports.
9(4), 350-357.
-
Li, L., Wang, R., Wilcox, D., Sarthy, A., Lin, X., Huang, X., ... Shen, Y. u.
(2013).
Developing Lipid Nanoparticle-Based siRNA Therapeutics for Hepatocellular Carcinoma Using an Integrated Approach. MOLECULAR CANCER THERAPEUTICS.
12(11), 2308-2318.
-
Goldberg, A. A., Montes-Grajales, D., Olivero, J., Beach, A., Titorenko, V., Safe, S., & Sanderson, T.
(2013).
Ring-DIMs induce mitochondrial dysfunction and ER stress in human prostate cancer cells. MOLECULAR CANCER THERAPEUTICS.
12(11), b256-b256.
-
Sreevalsan, S., & Safe, S.
(2013).
The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells. MOLECULAR CANCER THERAPEUTICS.
12(11), 2483-2493.
-
Andey, T., Patel, A., Jackson, T., Safe, S., & Singh, M.
(2013).
1,1-Bis (3'-indolyl)-1-(p-substitutedphenyl)methane compounds inhibit lung cancer cell and tumor growth in a metastasis model. European Journal of Pharmaceutical Sciences.
50(2), 227-241.
-
Safe, S., Lee, S., & Jin, U.
(2013).
Role of the aryl hydrocarbon receptor in carcinogenesis and potential as a drug target. TOXICOLOGICAL SCIENCES.
135(1), 1-16.
-
Noratto, G. D., Jutooru, I., Safe, S., Angel-Morales, G., & Mertens-Talcott, S. U.
(2013).
The drug resistance suppression induced by curcuminoids in colon cancer SW-480 cells is mediated by reactive oxygen species-induced disruption of the microRNA-27a-ZBTB10-Sp axis. Molecular Nutrition and Food Research.
57(9), 1638-1648.
-
Mertens-Talcott, S. U., Noratto, G. D., Li, X., Angel-Morales, G., Bertoldi, M. C., & Safe, S.
(2013).
Betulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: role of Sp transcription factors and microRNA-27a:ZBTB10. Molecular Carcinogenesis.
52(8), 591-602.
-
Boakye, C., Doddapaneni, R., Shah, P. P., Patel, A. R., Godugu, C., Safe, S., Katiyar, S. K., & Singh, M.
(2013).
Chemoprevention of skin cancer with 1,1-Bis (3'-indolyl)-1-(aromatic) methane analog through induction of the orphan nuclear receptor, NR4A2 (Nurr1). PLoS ONE.
8(8), e69519-e69519.
-
Bousquet, M., Zhuang, G., Meng, C., Ying, W., Cheruku, P. S., Shie, A. T., ... Zhou, B.
(2013).
miR-150 blocks MLL-AF9-associated leukemia through oncogene repression. Molecular Cancer Research.
11(8), 912-922.
-
Ying, W., Cheruku, P. S., Bazer, F. W., Safe, S. H., & Zhou, B.
(2013).
Investigation of macrophage polarization using bone marrow derived macrophages. Journal of Visualized Experiments.
-
van den Berg, M., Denison, M. S., Birnbaum, L. S., Devito, M. J., Fiedler, H., Falandysz, J., ... Peterson, R. E.
(2013).
Polybrominated dibenzo-p-dioxins, dibenzofurans, and biphenyls: inclusion in the toxicity equivalency factor concept for dioxin-like compounds. TOXICOLOGICAL SCIENCES.
133(2), 197-208.
-
De Miranda, B. R., Miller, J. A., Hansen, R. J., Lunghofer, P. J., Safe, S., Gustafson, D. L., Colagiovanni, D., & Tjalkens, R. B.
(2013).
Neuroprotective efficacy and pharmacokinetic behavior of novel anti-inflammatory para-phenyl substituted diindolylmethanes in a mouse model of Parkinson's disease. Journal of Pharmacology and Experimental Therapeutics.
345(1), 125-138.
-
Del Follo-Martinez, A., Banerjee, N., Li, X., Safe, S., & Mertens-Talcott, S.
(2013).
Resveratrol and quercetin in combination have anticancer activity in colon cancer cells and repress oncogenic microRNA-27a. Nutrition and Cancer: an international journal.
65(3), 494-504.
-
Safe, S.
(2013).
Endocrine disruptors and falling sperm counts: lessons learned or not!. Asian Journal of Andrology.
15(2), 191-194.
-
Kim, K., Jutooru, I., Chadalapaka, G., Johnson, G., Frank, J., Burghardt, R., Kim, S., & Safe, S.
(2013).
HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene.
32(13), 1616-1625.
-
Chadalapaka, G., Jutooru, I., Sreevalsan, S., Pathi, S., Kim, K., Chen, C., ... Safe, S.
(2013).
Inhibition of rhabdomyosarcoma cell and tumor growth by targeting specificity protein (Sp) transcription factors. International Journal of Cancer.
132(4), 795-806.
-
Ying, W., Cheruku, P. S., Bazer, F. W., Safe, S. H., & Zhou, B.
(2013).
Investigation of macrophage polarization using bone marrow derived macrophages. Journal of Visualized Experiments.
-
Shin, J., Jung, J., Ryu, M. H., Safe, S., & Cho, S.
(2013).
Mithramycin A inhibits myeloid cell leukemia-1 to induce apoptosis in oral squamous cell carcinomas and tumor xenograft through activation of Bax and oligomerization. Molecular Pharmacology.
83(1), 33-41.
-
Safe, S. H., Prather, P. L., Brents, L. K., Chadalapaka, G., & Jutooru, I.
(2012).
Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs. Anti-Cancer Agents in Medicinal Chemistry.
12(10), 1211-1220.
-
Jin, U., Lee, S., & Safe, S.
(2012).
Aryl hydrocarbon receptor (AHR)-active pharmaceuticals are selective AHR modulators in MDA-MB-468 and BT474 breast cancer cells. Journal of Pharmacology and Experimental Therapeutics.
343(2), 333-341.
-
Gandhy, S. U., Kim, K., Larsen, L., Rosengren, R. J., & Safe, S.
(2012).
Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs. BMC Cancer.
12(1), 564.
-
Banerjee, N., Talcott, S., Safe, S., & Mertens-Talcott, S. U.
(2012).
Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo: potential role of miRNA-27a and miRNA-155 in cell survival and inflammation. Breast Cancer Research and Treatment.
136(1), 21-34.
-
Sankpal, U. T., Abdelrahim, M., Connelly, S. F., Lee, C. M., Madero-Visbal, R., Colon, J., ... Basha, R.
(2012).
Small molecule tolfenamic acid inhibits PC-3 cell proliferation and invasion in vitro, and tumor growth in orthotopic mouse model for prostate cancer. The Prostate.
72(15), 1648-1658.
-
Pathi, S., Jutooru, I., Chadalapaka, G., Nair, V., Lee, S., & Safe, S.
(2012).
Aspirin inhibits colon cancer cell and tumor growth and downregulates specificity protein (Sp) transcription factors. PLoS ONE.
7(10), e48208-e48208.
-
Kim, K., Chadalapaka, G., Pathi, S. S., Jin, U., Lee, J., Park, Y., ... Safe, S.
(2012).
Induction of the transcriptional repressor ZBTB4 in prostate cancer cells by drug-induced targeting of microRNA-17-92/106b-25 clusters. MOLECULAR CANCER THERAPEUTICS.
11(9), 1852-1862.
-
Lee, S., Andey, T., Jin, U., Kim, K., Singh, M., & Safe, S.
(2012).
Erratum: The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53. 31(27), 3310-3310.
-
Liu, X., Jutooru, I., Lei, P., Kim, K., Lee, S., Brents, L. K., Prather, P. L., & Safe, S.
(2012).
Betulinic Acid Targets YY1 and ErbB2 through Cannabinoid Receptor-Dependent Disruption of MicroRNA-27a:ZBTB10 in Breast Cancer. MOLECULAR CANCER THERAPEUTICS.
11(7), 1421-1431.
-
Wilson, H., Chadalapaka, G., Jutooru, I., Sheppard, S., Pfent, C., & Safe, S.
(2012).
Effect of tolfenamic acid on canine cancer cell proliferation, specificity protein (sp) transcription factors, and sp-regulated proteins in canine osteosarcoma, mammary carcinoma, and melanoma cells. Journal of Veterinary Internal Medicine (JVIM).
26(4), 977-986.
-
Schulz, V. J., Smit, J. J., Huijgen, V., Bol-Schoenmakers, M., van Roest, M., Kruijssen, L., ... Pieters, R.
(2012).
Non-dioxin-like AhR ligands in a mouse peanut allergy model. TOXICOLOGICAL SCIENCES.
128(1), 92-102.
-
Lee, S., Andey, T., Jin, U., Kim, K., Singh, M., & Safe, S.
(2012).
The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53. Oncogene.
31(27), 3265-3276.
-
Zhuang, G., Meng, C., Guo, X., Cheruku, P. S., Shi, L., Xu, H., ... Zhou, B.
(2012).
A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation. Circulation.
125(23), 2892-2903.
-
Maliakal, P., Abdelrahim, M., Sankpal, U. T., Maliakal, C., Baker, C. H., Safe, S., ... Basha, R.
(2012).
Chemopreventive effects of tolfenamic acid against esophageal tumorigenesis in rats. Investigational New Drugs.
30(3), 853-861.
-
Barchowsky, A., Buckley, L. A., Carlson, G. P., Fitsanakis, V. A., Ford, S. M., Genter, M. B., ... Eidemiller, B. J.
(2012).
The Toxicology Education Summit: building the future of toxicology through education. TOXICOLOGICAL SCIENCES.
127(2), 331-338.
-
Patel, A. R., Spencer, S. D., Chougule, M. B., Safe, S., & Singh, M.
(2012).
Pharmacokinetic evaluation and in vitro-in vivo correlation (IVIVC) of novel methylene-substituted 3,3' diindolylmethane (DIM). European Journal of Pharmaceutical Sciences.
46(1-2), 8-16.
-
Li, X. i., Lee, S., & Safe, S.
(2012).
Structure-dependent activation of NR4A2 (Nurr1) by 1,1-bis(3'-indolyl)-1-(aromatic)methane analogs in pancreatic cancer cells. Biochemical Pharmacology.
83(10), 1445-1455.
-
Chadalapaka, G., Jutooru, I., & Safe, S.
(2012).
Celastrol decreases specificity proteins (Sp) and fibroblast growth factor receptor-3 (FGFR3) in bladder cancer cells. Carcinogenesis.
33(4), 886-894.
-
Kim, K., Chadalapaka, G., Lee, S., Yamada, D., Sastre-Garau, X., Defossez, P., ... Safe, S.
(2012).
Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer. Oncogene.
31(8), 1034-1044.
-
Zhang, S., Kim, K., Jin, U. H., Pfent, C., Cao, H., Amendt, B., ... Safe, S.
(2012).
Aryl hydrocarbon receptor agonists induce microRNA-335 expression and inhibit lung metastasis of estrogen receptor negative breast cancer cells. MOLECULAR CANCER THERAPEUTICS.
11(1), 108-118.
-
Li, Z., Chadalapaka, G., Ramesh, A., Khoshbouei, H., Maguire, M., Safe, S., ... Hood, D. B.
(2012).
PAH particles perturb prenatal processes and phenotypes: protection from deficits in object discrimination afforded by dampening of brain oxidoreductase following in utero exposure to inhaled benzo(a)pyrene. TOXICOLOGICAL SCIENCES.
125(1), 233-247.
-
Park, Y., Kim, K., Kim, S., Hennessy, B. T., Kim, S. M., Park, E. S., ... Lee, J.
(2012).
Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer. EMBO Molecular Medicine.
4(1), 52-67.
-
Sreevalsan, S., Joseph, S., Jutooru, I., Chadalapaka, G., & Safe, S. H.
(2011).
Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent. Anticancer Research: international journal of cancer research and treatment.
31(11), 3799-3807.
-
Pathi, S. S., Lei, P., Sreevalsan, S., Chadalapaka, G., Jutooru, I., & Safe, S.
(2011).
Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells. 63(7), 1133-1142.
-
Abdelbaqi, K., Lack, N., Guns, E. T., Kotha, L., Safe, S., & Sanderson, J. T.
(2011).
Antiandrogenic and growth inhibitory effects of ring-substituted analogs of 3,3'-diindolylmethane (ring-DIMs) in hormone-responsive LNCaP human prostate cancer cells. The Prostate.
71(13), 1401-1412.
-
Shin, J., Shim, J., Choi, E., Leem, D., Kwon, K. H., Lee, S., ... Cho, S.
(2011).
Chemopreventive effects of synthetic C-substituted diindolylmethanes originating from cruciferous vegetables in human oral cancer cells. 20(5), 417-425.
-
Chintharlapalli, S., Papineni, S., Lee, S., Lei, P., Jin, U. H., Sherman, S. I., Santarpia, L., & Safe, S.
(2011).
Inhibition of pituitary tumor-transforming gene-1 in thyroid cancer cells by drugs that decrease specificity proteins. Molecular Carcinogenesis.
50(9), 655-667.
-
Chintharlapalli, S., Papineni, S., Lei, P., Pathi, S., & Safe, S.
(2011).
Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors. BMC Cancer.
11(1), 371.
-
Yoon, K., Lee, S., Cho, S., Kim, K., Khan, S., & Safe, S.
(2011).
Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumors. Carcinogenesis.
32(6), 836-842.
-
Kim, K., Burghardt, R., Barhoumi, R., Lee, S., Liu, X., & Safe, S.
(2011).
MDM2 regulates estrogen receptor α and estrogen responsiveness in breast cancer cells. Journal of Molecular Endocrinology.
46(2), 67-79.
-
Jutooru, I., Chadalapaka, G., Abdelrahim, M., Basha, M. R., Samudio, I., Konopleva, M., Andreeff, M., & Safe, S.
(2011).
Correction to Methyl 2-Cyano-3,12-dioxooleana-1, 9-dien-28-oate Decreases Specificity Protein Transcription Factors and Inhibits Pancreatic Tumor Growth: Role of MicroRNA-27a. Molecular Pharmacology.
79(2), 336-336.
-
Pathi, S. S., Jutooru, I., Chadalapaka, G., Sreevalsan, S., Anand, S., Thatcher, G. R., & Safe, S.
(2011).
GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway. Molecular Cancer Research.
9(2), 195-202.
-
Lee, S., Li, X. i., Khan, S., & Safe, S.
(2011).
Targeting NR4A1 (TR3) in cancer cells and tumors. Expert Opinion on Therapeutic Targets.
15(2), 195-206.
-
Colon, J., Basha, M. R., Madero-Visbal, R., Konduri, S., Baker, C. H., Herrera, L. J., ... Abdelrahim, M.
(2011).
Tolfenamic acid decreases c-Met expression through Sp proteins degradation and inhibits lung cancer cells growth and tumor formation in orthotopic mice. Investigational New Drugs.
29(1), 41-51.
-
Barhoumi, R., Mouneimne, Y., Ramos, E., Morisseau, C., Hammock, B. D., Safe, S., Parrish, A. R., & Burghardt, R. C.
(2011).
Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in a rat liver cell line. TOXICOLOGY AND APPLIED PHARMACOLOGY.
253(1), 45-56.
-
Basha, R., Baker, C. H., Sankpal, U. T., Ahmad, S., Safe, S., Abbruzzese, J. L., & Abdelrahim, M.
(2011).
Therapeutic applications of NSAIDS in cancer: special emphasis on tolfenamic acid. Frontiers in Bioscience-Scholar.
3(2), 797-805.
-
Roberts, R. A., Smith, R. A., Safe, S., Szabo, C., Tjalkens, R. B., & Robertson, F. M.
(2011).
Toxicological and pathophysiological roles of reactive oxygen and nitrogen species (vol 276, pg 85, 2010). Toxicology.
279(1-3), 208-208.
-
Ortholan, C., Durivault, J., Hannoun-Levi, J., Guyot, M., Bourcier, C., Ambrosetti, D., Safe, S., & Pags, G.
(2010).
Bevacizumab/docetaxel association is more efficient than docetaxel alone in reducing breast and prostate cancer cell growth: a new paradigm for understanding the therapeutic effect of combined treatment. European Journal of Cancer.
46(16), 3022-3036.
-
Ichite, N., Chougule, M., Patel, A. R., Jackson, T., Safe, S., & Singh, M.
(2010).
Inhalation delivery of a novel diindolylmethane derivative for the treatment of lung cancer. MOLECULAR CANCER THERAPEUTICS.
9(11), 3003-3014.
-
Pang, X., Zhang, L. i., Wu, Y., Lin, L., Li, J., Qu, W., Safe, S., & Liu, M.
(2010).
Methyl 2-cyano-3,11-dioxo-18-olean-1,12-dien-30-oate (CDODA-Me), a derivative of glycyrrhetinic acid, functions as a potent angiogenesis inhibitor. Journal of Pharmacology and Experimental Therapeutics.
335(1), 172-179.
-
Roberts, R. A., Smith, R. A., Safe, S., Szabo, C., Tjalkens, R. B., & Robertson, F. M.
(2010).
Toxicological and pathophysiological roles of reactive oxygen and nitrogen species. Toxicology.
276(2), 85-94.
-
Safe, S.
(2010).
3-methylcholanthrene induces differential recruitment of aryl hydrocarbon receptor to human promoters. TOXICOLOGICAL SCIENCES.
117(1), 1-3.
-
Lee, S., Abdelrahim, M., Yoon, K., Chintharlapalli, S., Papineni, S., Kim, K., Wang, H., & Safe, S.
(2010).
Inactivation of the orphan nuclear receptor TR3/Nur77 inhibits pancreatic cancer cell and tumor growth. Cancer Research.
70(17), 6824-6836.
-
Jutooru, I., Chadalapaka, G., Lei, P., & Safe, S.
(2010).
Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation. Journal of Biological Chemistry.
285(33), 25332-25344.
-
Jutooru, I., Chadalapaka, G., Abdelrahim, M., Basha, M. R., Samudio, I., Konopleva, M., Andreeff, M., & Safe, S.
(2010).
Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a. Molecular Pharmacology.
78(2), 226-236.
-
Tsao, T., Kornblau, S., Safe, S., Watt, J. C., Ruvolo, V., Chen, W., ... Konopleva, M.
(2010).
Role of peroxisome proliferator-activated receptor-gamma and its coactivator DRIP205 in cellular responses to CDDO (RTA-401) in acute myelogenous leukemia. Cancer Research.
70(12), 4949-4960.
-
Li, X., Mertens-Talcott, S. U., Zhang, S., Kim, K., Ball, J., & Safe, S.
(2010).
MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells. ENDOCRINOLOGY.
151(6), 2462-2473.
-
Reddivari, L., Vanamala, J., Safe, S. H., & Miller, J. C.
(2010).
The bioactive compounds alpha-chaconine and gallic acid in potato extracts decrease survival and induce apoptosis in LNCaP and PC3 prostate cancer cells. Nutrition and Cancer: an international journal.
62(5), 601-610.
-
Chadalapaka, G., Jutooru, I., Burghardt, R., & Safe, S.
(2010).
Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells. Molecular Cancer Research.
8(5), 739-750.
-
Guo, J., Chintharlapalli, S., Lee, S., Cho, S. D., Lei, P., Papineni, S., & Safe, S.
(2010).
Peroxisome proliferator-activated receptor gamma-dependent activity of indole ring-substituted 1,1-bis(3'-indolyl)-1-(p-biphenyl)methanes in cancer cells. Cancer Chemotherapy and Pharmacology.
66(1), 141-150.
-
Bredfeldt, T. G., Greathouse, K. L., Safe, S. H., Hung, M., Bedford, M. T., & Walker, C. L.
(2010).
Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT. Molecular Endocrinology.
24(5), 993-1006.
-
Mahammad, R. B., Madero-Visbal, R., Baker, C. H., Colon, J., Safe, S., Abudayyeh, A., & Abdelrahim, M.
(2010).
Abstract 4075: Tolfenamic Acid Inhibits Prostate Cancer Cells Growth and Tumor Development in Orthotopic Mice. 70(8_Supplement), 4075-4075.
-
Cho, S. D., Lee, S., Chintharlapalli, S., Abdelrahim, M., Khan, S., Yoon, K., Kamat, A. M., & Safe, S.
(2010).
Activation of nerve growth factor-induced B alpha by methylene-substituted diindolylmethanes in bladder cancer cells induces apoptosis and inhibits tumor growth. Molecular Pharmacology.
77(3), 396-404.
-
Choi, K., Kim, H., Kim, J., Choi, E., Shin, J., Lee, S., ... Cho, S.
(2010).
The p38 MAPK pathway is critical for 5,5'-dibromodiindolylmethane-induced apoptosis to prevent oral squamous carcinoma cells. European Journal of Cancer Prevention.
19(2), 153-159.
-
Vanderlaag, K., Su, Y., Frankel, A. E., Burghardt, R. C., Barhoumi, R., Chadalapaka, G., Jutooru, I., & Safe, S.
(2010).
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer. BMC Cancer.
10(1), 669.
-
Jutooru, I., Chadalapaka, G., Sreevalsan, S., Lei, P., Barhoumi, R., Burghardt, R., & Safe, S.
(2010).
Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth. Experimental Cell Research.
316(13), 2174-2188.
-
Sreevalsan, S., Jutooru, I., Chadalapaka, G., Walker, M., & Safe, S.
(2009).
1,1-Bis(3'-indolyl)-1-(p-bromophenyl)methane and related compounds repress survivin and decrease gamma-radiation-induced survivin in colon and pancreatic cancer cells. International Journal of Oncology.
35(5), 1191-1199.
-
Sreevalsan, S., Jutooru, I., Chadalapaka, G., Walker, M., & Safe, S.
(2009).
1,1-Bis(3-indolyl)-1-(p-bromophenyl)methane and related compounds repress survivin and decrease -radiation-induced survivin in colon and pancreatic cancer cells. International Journal of Oncology.
35(5), 1191-1199.
-
da Costa, C. A., Sunyach, C., Giaime, E., West, A., Corti, O., Brice, A., ... Checler, F.
(2009).
Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease. Nature Cell Biology.
11(11), 1370-1375.
-
Chintharlapalli, S., Papineni, S., Abdelrahim, M., Abudayyeh, A., Jutooru, I., Chadalapaka, G., ... Safe, S.
(2009).
Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate in colon cancer cells. International Journal of Cancer.
125(8), 1965-1974.
-
Zhang, S., Lei, P., Liu, X., Li, X., Walker, K., Kotha, L., Rowlands, C., & Safe, S.
(2009).
The aryl hydrocarbon receptor as a target for estrogen receptor-negative breast cancer chemotherapy. Endocrine-Related Cancer.
16(3), 835-844.
-
Jutooru, I., Chadalapaka, G., Chintharlapalli, S., Papineni, S., & Safe, S.
(2009).
Induction of apoptosis and nonsteroidal anti-inflammatory drug-activated gene 1 in pancreatic cancer cells by a glycyrrhetinic acid derivative. Molecular Carcinogenesis.
48(8), 692-702.
-
Papineni, S., Chintharlapalli, S., Abdelrahim, M., Lee, S., Burghardt, R., Abudayyeh, A., ... Safe, S.
(2009).
Tolfenamic acid inhibits esophageal cancer through repression of specificity proteins and c-Met. Carcinogenesis.
30(7), 1193-1201.
-
Lee, S., Chintharlapalli, S., Liu, S., Papineni, S., Cho, S. D., Yoon, K., & Safe, S.
(2009).
p21 Expression Is Induced by Activation of Nuclear Nerve Growth Factor–Induced Bα (Nur77) in Pancreatic Cancer Cells. Molecular Cancer Research.
7(7), 1169-1178.
-
Liu, X., Abdelrahim, M., Abudayyeh, A., Lei, P., & Safe, S.
(2009).
The nonsteroidal anti-inflammatory drug tolfenamic acid inhibits BT474 and SKBR3 breast cancer cell and tumor growth by repressing erbB2 expression. MOLECULAR CANCER THERAPEUTICS.
8(5), 1207-1217.
-
Fritz, W. A., Lin, T., Safe, S., Moore, R. W., & Peterson, R. E.
(2009).
The selective aryl hydrocarbon receptor modulator 6-methyl-1,3,8-trichlorodibenzofuran inhibits prostate tumor metastasis in TRAMP mice. Biochemical Pharmacology.
77(7), 1151-1160.
-
Konduri, S., Colon, J., Baker, C. H., Safe, S., Abbruzzese, J. L., Abudayyeh, A., Basha, M. R., & Abdelrahim, M.
(2009).
Tolfenamic acid enhances pancreatic cancer cell and tumor response to radiation therapy by inhibiting survivin protein expression. MOLECULAR CANCER THERAPEUTICS.
8(3), 533-542.
-
Barhoumi, R., Catania, J. M., Parrish, A. R., Awooda, I., Tiffany-Castiglioni, E., Safe, S., & Burghardt, R. C.
(2009).
Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in breast epithelial cell lines. The Journal of Toxicological Sciences.
34(1), 13-25.
-
Wu, F., Ivanov, I., Xu, R., & Safe, S.
(2009).
Role of SP transcription factors in hormone-dependent modulation of genes in MCF-7 breast cancer cells: microarray and RNA interference studies. Journal of Molecular Endocrinology.
42(1), 19-33.
-
Ichite, N., Chougule, M. B., Jackson, T., Fulzele, S. V., Safe, S., & Singh, M.
(2009).
Enhancement of docetaxel anticancer activity by a novel diindolylmethane compound in human non-small cell lung cancer. CLINICAL CANCER RESEARCH.
15(2), 543-552.
-
Carbone, D. L., Popichak, K. A., Moreno, J. A., Safe, S., & Tjalkens, R. B.
(2009).
Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nitric-oxide synthase 2 expression in astrocytes by a novel diindolylmethane analog protects striatal neurons against apoptosis. Molecular Pharmacology.
75(1), 35-43.
-
Inamoto, T., Papineni, S., Chintharlapalli, S., Cho, S., Safe, S., & Kamat, A. M.
(2008).
1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth. 7(12), 3825-3833.
-
Lee, S., Bahn, J. H., Choi, C. K., Whitlock, N. C., English, A. E., Safe, S., & Baek, S. J.
(2008).
ESE-1/EGR-1 pathway plays a role in tolfenamic acid-induced apoptosis in colorectal cancer cells. MOLECULAR CANCER THERAPEUTICS.
7(12), 3739-3750.
-
Wu, F., Xu, R., Kim, K., Martin, J., & Safe, S.
(2008).
In vivo profiling of estrogen receptor/specificity protein-dependent transactivation. ENDOCRINOLOGY.
149(11), 5696-5705.
-
Safe, S., & Kim, K.
(2008).
Non-classical genomic estrogen receptor (ER)/specificity protein and ER/activating protein-1 signaling pathways. Journal of Molecular Endocrinology.
41(5), 263-275.
-
Lei, P., Abdelrahim, M., Cho, S. D., Liu, X., & Safe, S.
(2008).
Structure-dependent activation of endoplasmic reticulum stress_mediated apoptosis in pancreatic cancer by 1,1-bis(3-indoly)-1-(p_substituted phenyl)methanes (Molecular Cancer Therapeutics (2008) 7, (3363-3372)). MOLECULAR CANCER THERAPEUTICS.
7(11), 3654.
-
Safe, S., Papineni, S., & Chintharlapalli, S.
(2008).
Cancer chemotherapy with indole-3-carbinol, bis(3'-indolyl)methane and synthetic analogs. Cancer Letters.
269(2), 326-338.
-
Lei, P., Abdelrahim, M., Cho, S. D., Liu, X., & Safe, S.
(2008).
Structure-dependent activation of endoplasmic reticulum stress-mediated apoptosis in pancreatic cancer by 1,1-bis(3'-indoly)-1-(p-substituted phenyl)methanes. MOLECULAR CANCER THERAPEUTICS.
7(10), 3363-3372.
-
Hong, J., Samudio, I., Chintharlapalli, S., & Safe, S.
(2008).
1,1-bis(3'-indolyl)-1-(p-substituted phenyl)methanes decrease mitochondrial membrane potential and induce apoptosis in endometrial and other cancer cell lines. Molecular Carcinogenesis.
47(7), 492-507.
-
Cho, S. D., Chintharlapalli, S., Abdelrahim, M., Papineni, S., Liu, S., Guo, J., ... Safe, S.
(2008).
5,5'-Dibromo-bis(3'-indolyl)methane induces Kruppel-like factor 4 and p21 in colon cancer cells. MOLECULAR CANCER THERAPEUTICS.
7(7), 2109-2120.
-
Chadalapaka, G., Jutooru, I., Chintharlapalli, S., Papineni, S., Smith, R., Li, X., & Safe, S.
(2008).
Curcumin decreases specificity protein expression in bladder cancer cells. 68(13), 5345-5354.
-
Lei, P., Abdelrahim, M., Cho, S. D., Liu, S., Chintharlapalli, S., & Safe, S.
(2008).
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through activation of c-jun N-terminal kinase. Carcinogenesis.
29(6), 1139-1147.
-
Pacheco-Palencia, L. A., Talcott, S. T., Safe, S., & Mertens-Talcott, S.
(2008).
Absorption and biological activity of phytochemical-rich extracts from aai (Euterpe oleracea Mart.) pulp and oil in vitro. Journal of Agricultural and Food Chemistry.
56(10), 3593-3600.
-
Cho, S. D., Lei, P., Abdelrahim, M., Yoon, K., Liu, S., Guo, J., ... Safe, S.
(2008).
1,1-bis(3'-indolyl)-1-(p-methoxyphenyl)methane activates Nur77-independent proapoptotic responses in colon cancer cells. Molecular Carcinogenesis.
47(4), 252-263.
-
Chadalapaka, G., Jutooru, I., McAlees, A., Stefanac, T., & Safe, S.
(2008).
Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives. Bioorganic and Medicinal Chemistry Letters.
18(8), 2633-2639.
-
Reddivari, L., Vanamala, J., Safe, S. H., & Miller, J.
(2008).
Colored Potato Bioactive Compounds Suppress Proliferation and Induce Apoptosis in Both Androgen-Dependent and - Independent Prostate Cancer Cell Lines. The FASEB Journal.
22(S1), 158.3-158.3.
-
Zhang, S., Rowlands, C., & Safe, S.
(2008).
Ligand-dependent interactions of the Ah receptor with coactivators in a mammalian two-hybrid assay. TOXICOLOGY AND APPLIED PHARMACOLOGY.
227(2), 196-206.
-
Talcott, S. U., Li, X., Chintharlapalli, S., & Safe, S.
(2008).
The Effects of betulinic acid on microRNA-27a regulated target genes in MDA-MB-231 breast cancer cells. The FASEB Journal.
22(S1), 158.8-158.8.
-
Lee, S., Whitlock, N. C., Choi, C. K., English, A. E., Safe, S. H., & Baek, S. J.
(2008).
Tolfenamic Acid Increases EGR-1 Expression through a PKC/ERK Dependent Pathway in Human Colorectal Cancer Cells. The FASEB Journal.
22(S1), 649.3-649.3.
-
Papineni, S., Chintharlapalli, S., & Safe, S.
(2008).
Methyl 2-cyano-3,11-dioxo-18 beta-olean-1,12-dien-30-oate is a peroxisome proliferator-activated receptor-gamma agonist that induces receptor-independent apoptosis in LNCaP prostate cancer cells. Molecular Pharmacology.
73(2), 553-565.
-
Tjalkens, R. B., Liu, X., Mohl, B., Wright, T., Moreno, J. A., Carbone, D. L., & Safe, S.
(2008).
The peroxisome proliferator-activated receptor-gamma agonist 1,1-bis(3'-indolyl)-1-(p-trifluoromethylphenyl)methane suppresses manganese-induced production of nitric oxide in astrocytes and inhibits apoptosis in cocultured PC12 cells. Journal of Neuroscience Research.
86(3), 618-629.
-
Higgins, K. J., Liu, S., Abdelrahim, M., Vanderlaag, K., Liu, X., Porter, W., Metz, R., & Safe, S.
(2008).
Vascular endothelial growth factor receptor-2 expression is down-regulated by 17beta-estradiol in MCF-7 breast cancer cells by estrogen receptor alpha/Sp proteins. Molecular Endocrinology.
22(2), 388-402.
-
Vanderlaag, K., Su, Y., Frankel, A. E., Grage, H., Smith, R., Khan, S., & Safe, S.
(2008).
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit proliferation of estrogen receptor-negative breast cancer cells by activation of multiple pathways. Breast Cancer Research and Treatment.
109(2), 273-283.
-
Wu, F., Khan, S., Wu, Q., Barhoumi, R., Burghardt, R., & Safe, S.
(2008).
Ligand structure-dependent activation of estrogen receptor alpha/Sp by estrogens and xenoestrogens. The Journal of Steroid Biochemistry and Molecular Biology.
110(1-2), 104-115.
-
York, M., Abdelrahim, M., Chintharlapalli, S., Lucero, S. D., & Safe, S.
(2007).
1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes induce apoptosis and inhibit renal cell carcinoma growth. CLINICAL CANCER RESEARCH.
13(22 Pt 1), 6743-6752.
-
Mertens-Talcott, S. U., Chintharlapalli, S., Li, X., & Safe, S.
(2007).
The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells. Cancer Research.
67(22), 11001-11011.
-
Chintharlapalli, S., Papineni, S., Liu, S., Jutooru, I., Chadalapaka, G., Cho, S., ... Safe, S.
(2007).
2-cyano-lup-1-en-3-oxo-20-oic acid, a cyano derivative of betulinic acid, activates peroxisome proliferator-activated receptor gamma in colon and pancreatic cancer cells. Carcinogenesis.
28(11), 2337-2346.
-
Reddivari, L., Vanamala, J., Chintharlapalli, S., Safe, S. H., & Miller, J. C.
(2007).
Anthocyanin fraction from potato extracts is cytotoxic to prostate cancer cells through activation of caspase-dependent and caspase-independent pathways. Carcinogenesis.
28(10), 2227-2235.
-
Khan, S., Wu, F., Liu, S., Wu, Q., & Safe, S.
(2007).
Role of specificity protein transcription factors in estrogen-induced gene expression in MCF-7 breast cancer cells. Journal of Molecular Endocrinology.
39(4), 289-304.
-
Su, Y., Vanderlaag, K., Ireland, C., Ortiz, J., Grage, H., Safe, S., & Frankel, A. E.
(2007).
1,1-Bis(3'-indolyl)-1-(p-biphenyl)methane inhibits basal-like breast cancer growth in athymic nude mice. Breast Cancer Research.
9(4), R56.
-
Murthy, K., Jayaprakasha, G. K., Safe, S. H., & Patil, B. S.
(2007).
AGFD 243-Potential of citrus limonoids in pancreatic cancer prevention. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
234.
-
Khan, S., Liu, S., Stoner, M., & Safe, S.
(2007).
Cobaltous chloride and hypoxia inhibit aryl hydrocarbon receptor-mediated responses in breast cancer cells. TOXICOLOGY AND APPLIED PHARMACOLOGY.
223(1), 28-38.
-
Lee, J., & Safe, S.
(2007).
Coactivation of estrogen receptor alpha (ER alpha)/Sp1 by vitamin D receptor interacting protein 150 (DRIP150). Archives of Biochemistry and Biophysics.
461(2), 200-210.
-
Chintharlapalli, S., Papineni, S., Jutooru, I., McAlees, A., & Safe, S.
(2007).
Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator-activated receptor {gamma} agonists in colon cancer cells. MOLECULAR CANCER THERAPEUTICS.
6(5), 1588-1598.
-
Abdelrahim, M., Baker, C. H., Abbruzzese, J. L., Sheikh-Hamad, D., Liu, S., Cho, S. D., Yoon, K., & Safe, S.
(2007).
Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells. Cancer Research.
67(7), 3286-3294.
-
Chintharlapalli, S., Papineni, S., Ramaiah, S. K., & Safe, S.
(2007).
Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors. Cancer Research.
67(6), 2816-2823.
-
Chintharlapalli, S., Papineni, S., & Safe, S.
(2007).
1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes inhibit growth, induce apoptosis, and decrease the androgen receptor in LNCaP prostate cancer cells through peroxisome proliferator-activated receptor gamma-independent pathways. Molecular Pharmacology.
71(2), 558-569.
-
Cho, S. D., Yoon, K., Chintharlapalli, S., Abdelrahim, M., Lei, P., Hamilton, S., ... Safe, S.
(2007).
Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathways. Cancer Research.
67(2), 674-683.
-
Wu, F., & Safe, S.
(2007).
Differential activation of wild-type estrogen receptor alpha and C-terminal deletion mutants by estrogens, antiestrogens and xenoestrogens in breast cancer cells. The Journal of Steroid Biochemistry and Molecular Biology.
103(1), 1-9.
-
Khan, S., Konstantinov, A., Chittim, B., McAlees, A., Yeo, B., & Safe, S.
(2006).
Structure-dependent Ah receptor agonist activities of chlorinated biphenylenes. Toxicology in Vitro.
20(7), 1234-1237.
-
Van den Berg, M., Birnbaum, L. S., Denison, M., De Vito, M., Farland, W., Feeley, M., ... Peterson, R. E.
(2006).
The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds. TOXICOLOGICAL SCIENCES.
93(2), 223-241.
-
Lei, P., Abdelrahim, M., & Safe, S.
(2006).
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit ovarian cancer cell growth through peroxisome proliferator-activated receptor-dependent and independent pathways. MOLECULAR CANCER THERAPEUTICS.
5(9), 2324-2336.
-
Ru Lee, W., Chen, C., Liu, S., & Safe, S.
(2006).
17beta-estradiol (E2) induces cdc25A gene expression in breast cancer cells by genomic and non-genomic pathways. Journal of Cellular Biochemistry.
99(1), 209-220.
-
Liu, S., Abdelrahim, M., Khan, S., Ariazi, E., Jordan, V. C., & Safe, S.
(2006).
Aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha in MCF-7 breast cancer cells. Biological Chemistry: official scientific journal of the GBM.
387(9), 1209-1213.
-
Khan, S., Barhoumi, R., Burghardt, R., Liu, S., Kim, K., & Safe, S.
(2006).
Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells. Molecular Endocrinology.
20(9), 2199-2214.
-
Harding, A. K., Daston, G. P., Boyd, G. R., Lucier, G. W., Safe, S. H., Stewart, J., Tillitt, D. E., & Van Der Kraak, G.
(2006).
Endocrine disrupting chemicals research program of the U.S. Environmental Protection Agency: summary of a peer-review report. Environmental Health Perspectives.
114(8), 1276-1282.
-
Safe, S., & Papineni, S.
(2006).
The role of xenoestrogenic compounds in the development of breast cancer. Trends in Pharmacological Sciences.
27(8), 447-454.
-
Higgins, K. J., Liu, S., Abdelrahim, M., Yoon, K., Vanderlaag, K., Porter, W., Metz, R. P., & Safe, S.
(2006).
Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins. ENDOCRINOLOGY.
147(7), 3285-3295.
-
Higgins, K. J., Abdelrahim, M., Liu, S., Yoon, K., & Safe, S.
(2006).
Regulation of vascular endothelial growth factor receptor-2 expression in pancreatic cancer cells by Sp proteins. Biochemical and Biophysical Research Communications.
345(1), 292-301.
-
Abdelrahim, M., Baker, C. H., Abbruzzese, J. L., & Safe, S.
(2006).
Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation. Journal of the National Cancer Institute.
98(12), 855-868.
-
Chintharlapalli, S., Papineni, S., & Safe, S.
(2006).
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through PPARgamma-dependent and PPARgamma-independent pathways. MOLECULAR CANCER THERAPEUTICS.
5(5), 1362-1370.
-
Lee, S., Yamaguchi, K., Kim, J., Eling, T. E., Safe, S., Park, Y., & Baek, S. J.
(2006).
Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner. Carcinogenesis.
27(5), 972-981.
-
Abdelrahim, M., Newman, K., Vanderlaag, K., Samudio, I., & Safe, S.
(2006).
3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5. Carcinogenesis.
27(4), 717-728.
-
Abdelrahim, M., Ariazi, E., Kim, K., Khan, S., Barhoumi, R., Burghardt, R., ... Safe, S.
(2006).
3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha. Cancer Research.
66(4), 2459-2467.
-
Li, X., Zhang, S., & Safe, S.
(2006).
Activation of kinase pathways in MCF-7 cells by 17beta-estradiol and structurally diverse estrogenic compounds. The Journal of Steroid Biochemistry and Molecular Biology.
98(2-3), 122-132.
-
Fleming, J., Spencer, T. E., Safe, S. H., & Bazer, F. W.
(2006).
Estrogen regulates transcription of the ovine oxytocin receptor gene through GC-rich SP1 promoter elements. ENDOCRINOLOGY.
147(2), 899-911.
-
Konopleva, M., Zhang, W., Shi, Y., McQueen, T., Tsao, T., Abdelrahim, M., ... Andreeff, M.
(2006).
Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells. MOLECULAR CANCER THERAPEUTICS.
5(2), 317-328.
-
Mitchell, D. C., Abdelrahim, M., Weng, J., Stafford, L. J., Safe, S., Bar-Eli, M., & Liu, M.
(2006).
Regulation of KiSS-1 metastasis suppressor gene expression in breast cancer cells by direct interaction of transcription factors activator protein-2alpha and specificity protein-1. 281(1), 51-58.
-
Barhoumi, R., Awooda, I., Mouneimne, Y., Safe, S., & Burghardt, R. C.
(2006).
Effects of benzo-a-pyrene on oxytocin-induced Ca2+ oscillations in myometrial cells. Toxicology Letters.
165(2), 133-141.
-
Vanderlaag, K., Samudio, I., Burghardt, R., Barhoumi, R., & Safe, S.
(2006).
Inhibition of breast cancer cell growth and induction of cell death by 1,1-bis(3'-indolyl)methane (DIM) and 5,5'-dibromoDIM. Cancer Letters.
236(2), 198-212.
-
Kassouf, W., Chintharlapalli, S., Abdelrahim, M., Nelkin, G., Safe, S., & Kamat, A. M.
(2006).
Inhibition of bladder tumor growth by 1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes: a new class of peroxisome proliferator-activated receptor gamma agonists. Cancer Research.
66(1), 412-418.
-
Chintharlapalli, S., Papineni, S., Baek, S. J., Liu, S., & Safe, S.
(2005).
1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes are peroxisome proliferator-activated receptor gamma agonists but decrease HCT-116 colon cancer cell survival through receptor-independent activation of early growth response-1 and nonsteroidal anti-inflammatory drug-activated gene-1. Molecular Pharmacology.
68(6), 1782-1792.
-
Samudio, I., Konopleva, M., Safe, S., McQueen, T., & Andreeff, M.
(2005).
Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure. MOLECULAR CANCER THERAPEUTICS.
4(12), 1982-1992.
-
Zhang, S., Li, X., Burghardt, R., Smith, R., & Safe, S. H.
(2005).
Role of estrogen receptor (ER) alpha in insulin-like growth factor (IGF)-I-induced responses in MCF-7 breast cancer cells. Journal of Molecular Endocrinology.
35(3), 433-447.
-
Calabr, P., Samudio, I., Safe, S. H., Willerson, J. T., & Yeh, E.
(2005).
Inhibition of tumor-necrosis-factor-alpha induced endothelial cell activation by a new class of PPAR-gamma agonists. An in vitro study showing receptor-independent effects. Journal of Vascular Research.
42(6), 509-516.
-
Safe, S., & Abdelrahim, M.
(2005).
Sp transcription factor family and its role in cancer. European Journal of Cancer.
41(16), 2438-2448.
-
Samudio, I., Konopleva, M., Hail, N., Shi, Y., McQueen, T., Hsu, T., ... Andreeff, M.
(2005).
2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer. Journal of Biological Chemistry.
280(43), 36273-36282.
-
Abdelrahim, M., & Safe, S.
(2005).
Cyclooxygenase-2 inhibitors decrease vascular endothelial growth factor expression in colon cancer cells by enhanced degradation of Sp1 and Sp4 proteins. Molecular Pharmacology.
68(2), 317-329.
-
Chintharlapalli, S., Papineni, S., Konopleva, M., Andreef, M., Samudio, I., & Safe, S.
(2005).
2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid and related compounds inhibit growth of colon cancer cells through peroxisome proliferator-activated receptor gamma-dependent and -independent pathways. Molecular Pharmacology.
68(1), 119-128.
-
Chintharlapalli, S., Burghardt, R., Papineni, S., Ramaiah, S., Yoon, K., & Safe, S.
(2005).
Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways. Journal of Biological Chemistry.
280(26), 24903-24914.
-
Safe, S.
(2005).
Clinical correlates of environmental endocrine disruptors. Trends in Endocrinology and Metabolism.
16(4), 139-144.
-
Abdelrahim, M., Liu, S., & Safe, S.
(2005).
Induction of endoplasmic reticulum-induced stress genes in Panc-1 pancreatic cancer cells is dependent on Sp proteins. 280(16), 16508-16513.
-
Contractor, R., Samudio, I. J., Estrov, Z., Harris, D., McCubrey, J. A., Safe, S. H., Andreeff, M., & Konopleva, M.
(2005).
A novel ring-substituted diindolylmethane,1,1-bis[3'-(5-methoxyindolyl)]-1-(p-t-butylphenyl) methane, inhibits extracellular signal-regulated kinase activation and induces apoptosis in acute myelogenous leukemia. 65(7), 2890-2898.
-
Kim, K., Barhoumi, R., Burghardt, R., & Safe, S.
(2005).
Analysis of estrogen receptor alpha-Sp1 interactions in breast cancer cells by fluorescence resonance energy transfer. Molecular Endocrinology.
19(4), 843-854.
-
Lee, J. E., Kim, K., Sacchettini, J. C., Smith, C. V., & Safe, S.
(2005).
DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs. 280(10), 8819-8830.
-
Wu, Q., Burghardt, R., & Safe, S.
(2004).
Vitamin D-interacting protein 205 (DRIP205) coactivation of estrogen receptor alpha (ERalpha) involves multiple domains of both proteins. Journal of Biological Chemistry.
279(51), 53602-53612.
-
Purkey, H. E., Palaninathan, S. K., Kent, K. C., Smith, C., Safe, S. H., Sacchettini, J. C., & Kelly, J. W.
(2004).
Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity. Chemistry and Biology.
11(12), 1719-1728.
-
Hong, J., Samudio, I., Liu, S., Abdelrahim, M., & Safe, S.
(2004).
Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins. ENDOCRINOLOGY.
145(12), 5774-5785.
-
Chen, C., Lee, W., & Safe, S.
(2004).
Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1. Journal of Cellular Biochemistry.
93(5), 1063-1074.
-
Fretland, A. J., Safe, S., & Hankinson, O.
(2004).
Lack of antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin's (TCDDs) induction of cytochrome P4501A1 (CYP1A1) by the putative selective aryl hydrocarbon receptor modulator 6-alkyl-1,3,8-trichlorodibenzofuran (6-MCDF) in the mouse hepatoma cell line Hepa-1c1c7. CHEMICO-BIOLOGICAL INTERACTIONS.
150(2), 161-170.
-
Abdelrahim, M., Smith, R., Burghardt, R., & Safe, S.
(2004).
Role of Sp proteins in regulation of vascular endothelial growth factor expression and proliferation of pancreatic cancer cells. Cancer Research.
64(18), 6740-6749.
-
Chintharlapalli, S., Smith, R., Samudio, I., Zhang, W., & Safe, S.
(2004).
1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes induce peroxisome proliferator-activated receptor gamma-mediated growth inhibition, transactivation, and differentiation markers in colon cancer cells. Cancer Research.
64(17), 5994-6001.
-
Qin, C., Samudio, I., Ngwenya, S., & Safe, S.
(2004).
Estrogen-dependent regulation of ornithine decarboxylase in breast cancer cells through activation of nongenomic cAMP-dependent pathways. Molecular Carcinogenesis.
40(3), 160-170.
-
Li, X., Qin, C., Burghardt, R., & Safe, S.
(2004).
Hormonal regulation of lactate dehydrogenase-A through activation of protein kinase C pathways in MCF-7 breast cancer cells. Biochemical and Biophysical Research Communications.
320(3), 625-634.
-
Gross-Steinmeyer, K., Stapleton, P. L., Liu, F., Tracy, J. H., Bammler, T. K., Quigley, S. D., ... Eaton, D. L.
(2004).
Phytochemical-induced changes in gene expression of carcinogen-metabolizing enzymes in cultured human primary hepatocytes. Xenobiotica: the fate of foreign compounds in biological systems.
34(7), 619-632.
-
Cizmas, L., Zhou, G., Safe, S. H., McDonald, T. J., Zhu, L. i., & Donnelly, K. C.
(2004).
Comparative in vitro and in vivo genotoxicities of 7H-benzo[c]fluorene, manufactured gas plant residue (MGP), and MGP fractions. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.
43(3), 159-168.
-
Corbin, C. J., Mapes, S. M., Marcos, J., Shackleton, C. H., Morrow, D., Safe, S., ... Conley, A. J.
(2004).
Paralogues of porcine aromatase cytochrome P450: a novel hydroxylase activity is associated with the survival of a duplicated gene. ENDOCRINOLOGY.
145(5), 2157-2164.
-
Pearce, S. T., Liu, H., Radhakrishnan, I., Abdelrahim, M., Safe, S., & Jordan, V. C.
(2004).
Interaction of the aryl hydrocarbon receptor ligand 6-methyl-1,3,8-trichlorodibenzofuran with estrogen receptor alpha. Cancer Research.
64(8), 2889-2897.
-
Qin, C., Morrow, D., Stewart, J., Spencer, K., Porter, W., Smith, R., ... Safe, S.
(2004).
A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes. MOLECULAR CANCER THERAPEUTICS.
3(3), 247-260.
-
Stoner, M., Wormke, M., Saville, B., Samudio, I., Qin, C., Abdelrahim, M., & Safe, S.
(2004).
Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor alpha and SP proteins. Oncogene.
23(5), 1052-1063.
-
Morrow, D., Qin, C., Smith, R., & Safe, S.
(2004).
Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation. The Journal of Steroid Biochemistry and Molecular Biology.
88(1), 27-36.
-
Safe, S., & Kim, K.
(2004).
Nuclear receptor-mediated transactivation through interaction with Sp proteins. Progress in Molecular Biology and Translational Science.
77, 1-36.
-
Zhang, S., Qin, C., & Safe, S. H.
(2003).
Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context. Environmental Health Perspectives.
111(16), 1877-1882.
-
Zhang, W., Jiang, J., Qin, C. H., Perez, L. M., Parrish, A. R., Safe, S. H., & Simanek, E. E.
(2003).
Triazine dendrimers for drug delivery: Evaluation of solubilization properties, activity in cell culture, and in vivo toxicity of a candidate vehicle. Supramolecular Chemistry.
15(7-8), 607-+.
-
Safe, S.
(2003).
Cadmium's disguise dupes the estrogen receptor. Nature Medicine.
9(8), 1000-1001.
-
Safe, S., & Wormke, M.
(2003).
Inhibitory aryl hydrocarbon receptor-estrogen receptor alpha cross-talk and mechanisms of action. CHEMICAL RESEARCH IN TOXICOLOGY.
16(7), 807-816.
-
Abdelrahim, M., Smith, R., & Safe, S.
(2003).
Aryl hydrocarbon receptor gene silencing with small inhibitory RNA differentially modulates Ah-responsiveness in MCF-7 and HepG2 cancer cells. Molecular Pharmacology.
63(6), 1373-1381.
-
Khan, S., Abdelrahim, M., Samudio, I., & Safe, S.
(2003).
Estrogen receptor/Sp1 complexes are required for induction of cad gene expression by 17beta-estradiol in breast cancer cells. ENDOCRINOLOGY.
144(6), 2325-2335.
-
Ngwenya, S., & Safe, S.
(2003).
Cell context-dependent differences in the induction of E2F-1 gene expression by 17 beta-estradiol in MCF-7 and ZR-75 cells. ENDOCRINOLOGY.
144(5), 1675-1685.
-
Kim, K., Thu, N., Saville, B., & Safe, S.
(2003).
Domains of estrogen receptor alpha (ERalpha) required for ERalpha/Sp1-mediated activation of GC-rich promoters by estrogens and antiestrogens in breast cancer cells. Molecular Endocrinology.
17(5), 804-817.
-
Qin, C., Burghardt, R., Smith, R., Wormke, M., Stewart, J., & Safe, S.
(2003).
Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells. Cancer Research.
63(5), 958-964.
-
Wormke, M., Stoner, M., Saville, B., Walker, K., Abdelrahim, M., Burghardt, R., & Safe, S.
(2003).
The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes. Molecular and Cellular Biology.
23(6), 1843-1855.
-
Castro-Rivera, E., & Safe, S.
(2003).
17 beta-estradiol- and 4-hydroxytamoxifen-induced transactivation in breast, endometrial and liver cancer cells is dependent on ER-subtype, cell and promoter context. The Journal of Steroid Biochemistry and Molecular Biology.
84(1), 23-31.
-
Vyhlidal, C., Li, X., & Safe, S.
(2002).
Estrogen regulation of transferrin gene expression in MCF-7 human breast cancer cells. Journal of Molecular Endocrinology.
29(3), 305-317.
-
Safe, S. H., Pallaroni, L., Yoon, K., Gaido, K., Ross, S., & McDonnell, D.
(2002).
Problems for risk assessment of endocrine-active estrogenic compounds. Environmental Health Perspectives.
110(SUPPL. 6), 925-929.
-
Safe, S. H., Pallaroni, L., Yoon, K., Gaido, K., Ross, S., & McDonnell, D.
(2002).
Problems for risk assessment of endocrine-active estrogenic compounds. Environmental Health Perspectives.
110 Suppl 6(Suppl 6), 925-929.
-
Avakian, M. D., Dellinger, B., Fiedler, H., Gullet, B., Koshland, C., Marklund, S., ... Suk, W. A.
(2002).
The origin, fate, and health effects of combustion by-products: a research framework. Environmental Health Perspectives.
110(11), 1155-1162.
-
Stoner, M., Saville, B., Wormke, M., Dean, D., Burghardt, R., & Safe, S.
(2002).
Hypoxia induces proteasome-dependent degradation of estrogen receptor alpha in ZR-75 breast cancer cells. Molecular Endocrinology.
16(10), 2231-2242.
-
SAFE, S. H.
(2002).
:Endocrine Disruptors and Human Health : Is There a Problem?(21). 33(3), a2.
-
Koliopanos, A., Kleeff, J., Xiao, Y. i., Safe, S., Zimmermann, A., Bchler, M. W., & Friess, H.
(2002).
Increased arylhydrocarbon receptor expression offers a potential therapeutic target for pancreatic cancer. Oncogene.
21(39), 6059-6070.
-
Abdelrahim, M., Samudio, I., Smith, R., Burghardt, R., & Safe, S.
(2002).
Small inhibitory RNA duplexes for Sp1 mRNA block basal and estrogen-induced gene expression and cell cycle progression in MCF-7 breast cancer cells. Journal of Biological Chemistry.
277(32), 28815-28822.
-
Barhoumi, R., Mouneimne, Y., Awooda, I., Safe, S. H., Donnelly, K. C., & Burghardt, R. C.
(2002).
Characterization of calcium oscillations in normal and benzo[a]pyrene-treated clone 9 cells. TOXICOLOGICAL SCIENCES.
68(2), 444-450.
-
Qin, C., Nguyen, T., Stewart, J., Samudio, I., Burghardt, R., & Safe, S.
(2002).
Estrogen up-regulation of p53 gene expression in MCF-7 breast cancer cells is mediated by calmodulin kinase IV-dependent activation of a nuclear factor kappaB/CCAAT-binding transcription factor-1 complex. Molecular Endocrinology.
16(8), 1793-1809.
-
Duan, R., Xie, W., Li, X., McDougal, A., & Safe, S.
(2002).
Estrogen regulation of c-fos gene expression through phosphatidylinositol-3-kinase-dependent activation of serum response factor in MCF-7 breast cancer cells. 294(2), 384-394.
-
Safe, S., & McDougal, A.
(2002).
Mechanism of action and development of selective aryl hydrocarbon receptor modulators for treatment of hormone-dependent cancers (Review). International Journal of Oncology.
20(6), 1123-1128.
-
Mealey, K. L., Barhoumi, R., Burghardt, R. C., Safe, S., & Kochevar, D. T.
(2002).
Doxycycline induces expression of P glycoprotein in MCF-7 breast carcinoma cells. 46(3), 755-761.
-
Saville, B., Poukka, H., Wormke, M., Janne, O. A., Palvimo, J. J., Stoner, M., Samudio, I., & Safe, S.
(2002).
Cooperative coactivation of estrogen receptor alpha in ZR-75 human breast cancer cells by SNURF and TATA-binding protein. Journal of Biological Chemistry.
277(4), 2485-2497.
-
Safe, S.
(2002).
Environmental estrogens: roles in male reproductive tract problems and in breast cancer. Reviews on Environmental Health.
17(4), 253-262.
-
Safe, S. H., Pallaroni, L., Yoon, K., Gaido, K., Ross, S., Saville, B., & McDonnellc, D.
(2001).
Toxicology of environmental estrogens. REPRODUCTION FERTILITY AND DEVELOPMENT.
13(4), 307-315.
-
Wang, F., Samudio, I., & Safe, S.
(2001).
Transcriptional activation of rat creatine kinase B by 17beta-estradiol in MCF-7 cells involves an estrogen responsive element and GC-rich sites. 84(1), 156-172.
-
Safe, S.
(2001).
Transcriptional activation of genes by 17 beta-estradiol through estrogen receptor-Sp1 interactions. Vitamins and Hormones: Advances in Research and Applications.
62, 231-252.
-
Lee, J. E., & Safe, S.
(2001).
Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast cancer cells. Biochemical Pharmacology.
62(8), 1113-1124.
-
Waters, K. M., Safe, S., & Gaido, K. W.
(2001).
Differential gene expression in response to methoxychlor and estradiol through ERalpha, ERbeta, and AR in reproductive tissues of female mice. TOXICOLOGICAL SCIENCES.
63(1), 47-56.
-
Safe, S. H.
(2001).
Endocrine-related carcinogenesis. 12(7), 328-329.
-
Castro-Rivera, E., Samudio, I., & Safe, S.
(2001).
Estrogen regulation of cyclin D1 gene expression in ZR-75 breast cancer cells involves multiple enhancer elements. 276(33), 30853-30861.
-
Yoon, K., Pallaroni, L., Stoner, M., Gaido, K., & Safe, S.
(2001).
Differential activation of wild-type and variant forms of estrogen receptor alpha by synthetic and natural estrogenic compounds using a promoter containing three estrogen-responsive elements. The Journal of Steroid Biochemistry and Molecular Biology.
78(1), 25-32.
-
Xie, W., Duan, R., & Safe, S.
(2001).
Activation of adenosine deaminase in MCF-7 cells through IGF-estrogen receptor alpha crosstalk. Journal of Molecular Endocrinology.
26(3), 217-228.
-
James, W. H.
(2001).
Sex ratios at birth as monitors of endocrine disruption. Environmental Health Perspectives.
109(6), A250-A251.
-
Safe, S.
(2001).
Sex ratios: Safe's response. Environmental Health Perspectives.
109(6), A251-A251.
-
Sanderson, J. T., Slobbe, L., Lansbergen, G. W., Safe, S., & van den Berg, M.
(2001).
2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells. TOXICOLOGICAL SCIENCES.
61(1), 40-48.
-
McDougal, A., Wormke, M., Calvin, J., & Safe, S.
(2001).
Tamoxifen-induced antitumorigenic/antiestrogenic action synergized by a selective aryl hydrocarbon receptor modulator. Cancer Research.
61(10), 3902-3907.
-
Duan, R., Xie, W., Burghardt, R. C., & Safe, S.
(2001).
Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1. Journal of Biological Chemistry.
276(15), 11590-11598.
-
Qin, C., Wilson, C., Blancher, C., Taylor, M., Safe, S., & Harris, A. L.
(2001).
Association of ARNT splice variants with estrogen receptor-negative breast cancer, poor induction of vascular endothelial growth factor under hypoxia, and poor prognosis. CLINICAL CANCER RESEARCH.
7(4), 818-823.
-
McDougal, A., Gupta, M. S., Morrow, D., Ramamoorthy, K., Lee, J. E., & Safe, S. H.
(2001).
Methyl-substituted diindolylmethanes as inhibitors of estrogen-induced growth of T47D cells and mammary tumors in rats. Breast Cancer Research and Treatment.
66(2), 147-157.
-
Samudio, I., Vyhlidal, C., Wang, F., Stoner, M., Chen, I., Kladde, M., ... Safe, S.
(2001).
Transcriptional activation of deoxyribonucleic acid polymerase alpha gene expression in MCF-7 cells by 17 beta-estradiol. ENDOCRINOLOGY.
142(3), 1000-1008.
-
Wang, F., Samudio, I., & Safe, S.
(2001).
Transcriptional activation of cathepsin D gene expression by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition. Molecular and Cellular Endocrinology.
172(1-2), 91-103.
-
Porter, W., Wang, F., Duan, R., Qin, C., Castro-Rivera, E., Kim, K., & Safe, S.
(2001).
Transcriptional activation of heat shock protein 27 gene expression by 17beta-estradiol and modulation by antiestrogens and aryl hydrocarbon receptor agonists. Journal of Molecular Endocrinology.
26(1), 31-42.
-
Chen, I., Hsieh, T., Thomas, T., & Safe, S.
(2001).
Identification of estrogen-induced genes downregulated by AhR agonists in MCF-7 breast cancer cells using suppression subtractive hybridization. Gene.
262(1-2), 207-214.
-
Stewart, M. D., Johnson, G. A., Vyhlidal, C. A., Burghardt, R. C., Safe, S. H., Yu-Lee, L. Y., Bazer, F. W., & Spencer, T. E.
(2001).
Interferon-tau activates multiple signal transducer and activator of transcription proteins and has complex effects on interferon-responsive gene transcription in ovine endometrial epithelial cells. ENDOCRINOLOGY.
142(1), 98-107.
-
Lee, J. E., & Safe, S.
(2000).
3',4'-dimethoxyflavone as an aryl hydrocarbon receptor antagonist in human breast cancer cells. TOXICOLOGICAL SCIENCES.
58(2), 235-242.
-
Xie, W., Barwick, J. L., Simon, C. M., Pierce, A. M., Safe, S., Blumberg, B., Guzelian, P. S., & Evans, R. M.
(2000).
Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. Genes and Development.
14(23), 3014-3023.
-
Gaido, K. W., Maness, S. C., McDonnell, D. P., Dehal, S. S., Kupfer, D., & Safe, S.
(2000).
Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies. Molecular Pharmacology.
58(4), 852-858.
-
Safe, S.
(2000).
Bisphenol A and related endocrine disruptors. TOXICOLOGICAL SCIENCES.
56(2), 251-252.
-
Stoner, M., Wang, F., Wormke, M., Nguyen, T., Samudio, I., Vyhlidal, C., ... Safe, S.
(2000).
Inhibition of vascular endothelial growth factor expression in HEC1A endometrial cancer cells through interactions of estrogen receptor alpha and Sp3 proteins. 275(30), 22769-22779.
-
Wormke, M., Stoner, M., Saville, B., & Safe, S.
(2000).
Crosstalk between estrogen receptor alpha and the aryl hydrocarbon receptor in breast cancer cells involves unidirectional activation of proteasomes. FEBS Letters.
478(1-2), 109-112.
-
Safe, S., Wormke, M., & Samudio, I.
(2000).
Mechanisms of inhibitory aryl hydrocarbon receptor-estrogen receptor crosstalk in human breast cancer cells. Journal of Mammary Gland Biology and Neoplasia.
5(3), 295-306.
-
Xie, W., Duan, R., Chen, I., Samudio, I., & Safe, S.
(2000).
Transcriptional activation of thymidylate synthase by 17beta-estradiol in MCF-7 human breast cancer cells. ENDOCRINOLOGY.
141(7), 2439-2449.
-
Safe, S. H.
(2000).
Endocrine disruptors and human health--is there a problem? An update. Environmental Health Perspectives.
108(6), 487-493.
-
Vyhlidal, C., Samudio, I., Kladde, M. P., & Safe, S.
(2000).
Transcriptional activation of transforming growth factor alpha by estradiol: requirement for both a GC-rich site and an estrogen response element half-site. Journal of Molecular Endocrinology.
24(3), 329-338.
-
Kester, M. H., Bulduk, S., Tibboel, D., Meinl, W., Glatt, H., Falany, C. N., ... Visser, T. J.
(2000).
Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: a novel pathway explaining the estrogenic activity of PCBs. ENDOCRINOLOGY.
141(5), 1897-1900.
-
Wormke, M., Castro-Rivera, E., Chen, I., & Safe, S.
(2000).
Estrogen and aryl hydrocarbon receptor expression and crosstalk in human Ishikawa endometrial cancer cells. The Journal of Steroid Biochemistry and Molecular Biology.
72(5), 197-207.
-
McDougal, A., Sethi Gupta, M., Ramamoorthy, K., Sun, G., & Safe, S. H.
(2000).
Inhibition of carcinogen-induced rat mammary tumor growth and other estrogen-dependent responses by symmetrical dihalo-substituted analogs of diindolylmethane. Cancer Letters.
151(2), 169-179.
-
Yoon, K., Pellaroni, L., Ramamoorthy, K., Gaido, K., & Safe, S.
(2000).
Ligand structure-dependent differences in activation of estrogen receptor alpha in human HepG2 liver and U2 osteogenic cancer cell lines. Molecular and Cellular Endocrinology.
162(1-2), 211-220.
-
Wang, F., Duan, R., Chirgwin, J., & Safe, S. H.
(2000).
Transcriptional activation of cathepsin D gene expression by growth factors. Journal of Molecular Endocrinology.
24(2), 193-202.
-
Barhoumi, R., Mouneimne, Y., Ramos, K. S., Safe, S. H., Phillips, T. D., Centonze, V. E., ... Burghardt, R. C.
(2000).
Analysis of benzo[a]pyrene partitioning and cellular homeostasis in a rat liver cell line. TOXICOLOGICAL SCIENCES.
53(2), 264-270.
-
Saville, B., Wormke, M., Wang, F., Nguyen, T., Enmark, E., Kuiper, G., Gustafsson, J. A., & Safe, S.
(2000).
Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements. Journal of Biological Chemistry.
275(8), 5379-5387.
-
Stewart, M. D., Johnson, G. A., Burghardt, R. C., Vyhlidal, C. A., Safe, S. H., Bazer, F. W., & Spencer, T. E.
(2000).
Effects of interferon tau on short- and long-term activation of STAT proteins in immortalized ovine uterine luminal epithelial cells. Biology of Reproduction.
62, 118-118.
-
Safe, S. H.
(2000).
Toxicology of persistent organic pollutants. EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY.
102(1), 52-53.
-
Gaido, K. W., Leonard, L. S., Maness, S. C., Hall, J. M., McDonnell, D. P., Saville, B., & Safe, S.
(1999).
Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta. ENDOCRINOLOGY.
140(12), 5746-5753.
-
Dong, L., Wang, W., Wang, F., Stoner, M., Reed, J. C., Harigai, M., ... Safe, S.
(1999).
Mechanisms of transcriptional activation of bcl-2 gene expression by 17beta-estradiol in breast cancer cells. Journal of Biological Chemistry.
274(45), 32099-32107.
-
Letcher, R. J., van Holsteijn, I., Drenth, H. J., Norstrom, R. J., Bergman, A., Safe, S., Pieters, R., & van den Berg, M.
(1999).
Cytotoxicity and aromatase (CYP19) activity modulation by organochlorines in human placental JEG-3 and JAR choriocarcinoma cells. TOXICOLOGY AND APPLIED PHARMACOLOGY.
160(1), 10-20.
-
Safe, S., Qin, C., & McDougal, A.
(1999).
Development of selective aryl hydrocarbon receptor modulators for treatment of breast cancer. Expert Opinion on Investigational Drugs.
8(9), 1385-1396.
-
Duan, R., Porter, W., Samudio, I., Vyhlidal, C., Kladde, M., & Safe, S.
(1999).
Transcriptional activation of c-fos protooncogene by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition. Molecular Endocrinology.
13(9), 1511-1521.
-
Wang, F., Wang, W., & Safe, S.
(1999).
Regulation of constitutive gene expression through interactions of Sp1 protein with the nuclear aryl hydrocarbon receptor complex. Biochemistry.
38(35), 11490-11500.
-
Wang, W., Dong, L., Saville, B., & Safe, S.
(1999).
Transcriptional activation of E2F1 gene expression by 17beta-estradiol in MCF-7 cells is regulated by NF-Y-Sp1/estrogen receptor interactions. Molecular Endocrinology.
13(8), 1373-1387.
-
Nguyen, T. A., Hoivik, D., Lee, J. E., & Safe, S.
(1999).
Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex. Archives of Biochemistry and Biophysics.
367(2), 250-257.
-
Qin, C., Singh, P., & Safe, S.
(1999).
Transcriptional activation of insulin-like growth factor-binding protein-4 by 17beta-estradiol in MCF-7 cells: role of estrogen receptor-Sp1 complexes. ENDOCRINOLOGY.
140(6), 2501-2508.
-
Castro-Rivera, E., Wormke, M., & Safe, S.
(1999).
Estrogen and aryl hydrocarbon responsiveness of ECC-1 endometrial cancer cells. Molecular and Cellular Endocrinology.
150(1-2), 11-21.
-
Safe, S.
(1999).
Transcriptional activation of estrogen-induced gene expression through estrogen receptor Sp1 complexes. 77(4), B5-B5.
-
Ramamoorthy, K., Gupta, M. S., Sun, G., McDougal, A., & Safe, S. H.
(1999).
3,3'4,4'-Tetrachlorobiphenyl exhibits antiestrogenic and antitumorigenic activity in the rodent uterus and mammary cells and in human breast cancer cells. Carcinogenesis.
20(1), 115-123.
-
Safe, S. H.
(1999).
Development and application of TEFs. Human and Ecological Risk Assessment.
5(1), 9-12.
-
Xie, W., Duan, R., & Safe, S.
(1999).
Estrogen induces adenosine deaminase gene expression in MCF-7 human breast cancer cells: role of estrogen receptor-Sp1 interactions. ENDOCRINOLOGY.
140(1), 219-227.
-
Safe, S. H., & Ramamoorthy, K.
(1998).
Disruptive behavior. Forum for applied research and public policy.
13(3), 19-23.
-
Gupta, M., McDougal, A., & Safe, S.
(1998).
Estrogenic and antiestrogenic activities of 16alpha- and 2-hydroxy metabolites of 17beta-estradiol in MCF-7 and T47D human breast cancer cells. The Journal of Steroid Biochemistry and Molecular Biology.
67(5-6), 413-419.
-
Connor, K., Howell, J., Safe, S., Chen, I., Liu, H., Berhane, K., Sciarretta, C., & Zacharewski, T.
(1998).
Failure of Chloro-s-triazine-Derived Compounds to Induce Estrogenic Responses in Vivo and in Vitro. ACS Symposium Series.
683, 424-431.
-
Van den Berg, M., Birnbaum, L., Bosveld, A. T., Brunstrm, B., Cook, P., Feeley, M., ... Zacharewski, T.
(1998).
Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environmental Health Perspectives.
106(12), 775-792.
-
Kuiper, G. G., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., van der Saag, P. T., van der Burg, B., & Gustafsson, J. A.
(1998).
Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. ENDOCRINOLOGY.
139(10), 4252-4263.
-
Fernandez, P., Wilson, C., Hoivik, D., & Safe, S. H.
(1998).
Altered phenotypic characteristics of T47d human breast cancer cells after prolonged growth in estrogen-deficient medium. Cell Biology International.
22(9‐10), 623-633.
-
Chen, I., McDougal, A., Wang, F., & Safe, S.
(1998).
Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane. Carcinogenesis.
19(9), 1631-1639.
-
Safe, S. H.
(1998).
Hazard and risk assessment of chemical mixtures using the toxic equivalency factor approach. Environmental Health Perspectives.
106(SUPPL. 4), 1051-1058.
-
Wilson, C. L., & Safe, S.
(1998).
Mechanisms of ligand-induced aryl hydrocarbon receptor-mediated biochemical and toxic responses. Toxicologic Pathology.
26(5), 657-671.
-
Safe, S. H.
(1998).
Hazard and risk assessment of chemical mixtures using the toxic equivalency factor approach. Environmental Health Perspectives.
106 Suppl 4(Suppl 4), 1051-1058.
-
Gould, J. C., Leonard, L. S., Maness, S. C., Wagner, B. L., Conner, K., Zacharewski, T., ... Gaido, K. W.
(1998).
Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol. Molecular and Cellular Endocrinology.
142(1-2), 203-214.
-
Sun, G., Porter, W., & Safe, S.
(1998).
Estrogen-induced retinoic acid receptor alpha 1 gene expression: role of estrogen receptor-Sp1 complex. Molecular Endocrinology.
12(6), 882-890.
-
Wang, F., Hoivik, D., Pollenz, R., & Safe, S.
(1998).
Functional and physical interactions between the estrogen receptor Sp1 and nuclear aryl hydrocarbon receptor complexes. Nucleic Acids Research (NAR).
26(12), 3044-3052.
-
Gupta, M., Miggens, J., Parrish, A., Womack, J., Ramos, K. S., Rodriguez, L. V., ... Safe, S. H.
(1998).
Ah receptor-independent induction of CYP1A2 gene expression in genetically inbred mice. Environmental Toxicology and Pharmacology.
5(3), 205-213.
-
vom Saal, F. S., Welshons, W. V., & Hansen, L. G.
(1998).
Organochlorine residues and breast cancer. NEW ENGLAND JOURNAL OF MEDICINE.
338(14), 988-991.
-
Duan, R., Porter, W., & Safe, S.
(1998).
Estrogen-induced c-fos protooncogene expression in MCF-7 human breast cancer cells: role of estrogen receptor Sp1 complex formation. ENDOCRINOLOGY.
139(4), 1981-1990.
-
McDougal, A., & Safe, S.
(1998).
Induction of 16alpha-/2-hydroxyestrone metabolite ratios in MCF-7 cells by pesticides, carcinogens, and antiestrogens does not predict mammary carcinogens. Environmental Health Perspectives.
106(4), 203-206.
-
Safe, S. H.
(1998).
Interactions between hormones and chemicals in breast cancer. Annual Review of Pharmacology and Toxicology.
38(1), 121-158.
-
Safe, S.
(1998).
Organochlorine residues and breast cancer. NEW ENGLAND JOURNAL OF MEDICINE.
338(14), 991-991.
-
Ramamoorthy, K., Wang, F., Chen, I. C., Safe, S., Norris, J. D., McDonnell, D. P., ... Sumpter, J. P.
(1998).
Potency of combined estrogenic pesticides: Synergy between synthetic oestrogens?. Chemtracts.
11(4), 306-308.
-
Castro-Rivera, E., & Safe, S.
(1998).
Estrogen- and antiestrogen-responsiveness of HEC1A endometrial adenocarcinoma cells in culture. The Journal of Steroid Biochemistry and Molecular Biology.
64(5-6), 287-295.
-
Willett, K. L., Randerath, K., Zhou, G. D., & Safe, S. H.
(1998).
Inhibition of CYP1A1-dependent activity by the polynuclear aromatic hydrocarbon (PAH) fluoranthene. Biochemical Pharmacology.
55(6), 831-839.
-
Wang, W., Smith, R., & Safe, S.
(1998).
Aryl hydrocarbon receptor-mediated antiestrogenicity in MCF-7 cells: modulation of hormone-induced cell cycle enzymes. Archives of Biochemistry and Biophysics.
356(2), 239-248.
-
Safe, S. H.
(1998).
Endocrine disruptors - Effects on human health. Biology of Reproduction.
58, 32-32.
-
Safe, S. H.
(1998).
Development validation and problems with the toxic equivalency factor approach for risk assessment of dioxins and related compounds. Journal of Animal Science.
76(1), 134-141.
-
Hong, S. J., Grover, C. A., Safe, S. H., Tiffany-Castiglioni, E., & Frye, G. D.
(1998).
Halogenated aromatic hydrocarbons suppress CA1 field excitatory postsynaptic potentials in rat hippocampal slices. TOXICOLOGY AND APPLIED PHARMACOLOGY.
148(1), 7-13.
-
Safe, S. H., & Gaido, K.
(1998).
Phytoestrogens and anthropogenic estrogenic compounds. Environmental Toxicology and Chemistry.
17(1), 119-126.
-
Goldstein, L. S., Weyand, E. H., Safe, S., Steinberg, M., Culp, S. J., Gaylor, D. W., Beland, F. A., & Rodriguez, L. V.
(1998).
Tumors and DNA adducts in mice exposed to benzo[a]pyrene and coal tars: Implications for risk assessment. Environmental Health Perspectives.
106(SUPPL. 6), 1325-1330.
-
Safe, S. H.
(1997).
'Environmental factors and breast cancer' - Reply. Endocrine-Related Cancer.
4(4), 477-478.
-
Ramamoorthy, K., Vyhlidal, C., Wang, F., Chen, I., Safe, S., McDonnell, D. P., Leonard, L. S., & Gaido, K. W.
(1997).
Additive estrogenic activities of a binary mixture of 2',4',6'-trichloro- and 2',3',4',5'-tetrachloro-4-biphenylol. TOXICOLOGY AND APPLIED PHARMACOLOGY.
147(1), 93-100.
-
Hoivik, D., Willett, K., Wilson, C., & Safe, S.
(1997).
Estrogen does not inhibit 2,3,7, 8-tetrachlorodibenzo-p-dioxin-mediated effects in MCF-7 and Hepa 1c1c7 cells. Journal of Biological Chemistry.
272(48), 30270-30274.
-
Fielden, M. R., Chen, I., Chittim, B., Safe, S. H., & Zacharewski, T. R.
(1997).
Examination of the estrogenicity of 2,4,6,2',6'-pentachlorobiphenyl (PCB 104), its hydroxylated metabolite 2,4,6,2',6'-pentachloro-4-biphenylol (HO-PCB 104), and a further chlorinated derivative, 2,4,6,2',4',6'-hexachlorobiphenyl (PCB 155). Environmental Health Perspectives.
105(11), 1238-1248.
-
McDougal, A., Wilson, C., & Safe, S.
(1997).
Inhibition of 7,12-dimethylbenz[a]anthracene-induced rat mammary tumor growth by aryl hydrocarbon receptor agonists. Cancer Letters.
120(1), 53-63.
-
Safe, S. H.
(1997).
Xenoestrogens and breast cancer. NEW ENGLAND JOURNAL OF MEDICINE.
337(18), 1303-1304.
-
Wilson, C. L., Thomsen, J., Hoivik, D. J., Wormke, M. T., Stanker, L., Holtzapple, C., & Safe, S. H.
(1997).
Aryl hydrocarbon (Ah) nonresponsiveness in estrogen receptor-negative MDA-MB-231 cells is associated with expression of a variant arnt protein. Archives of Biochemistry and Biophysics.
346(1), 65-73.
-
Porter, W., Saville, B., Hoivik, D., & Safe, S.
(1997).
Functional synergy between the transcription factor Sp1 and the estrogen receptor. Molecular Endocrinology.
11(11), 1569-1580.
-
Gray, L. E., Kelce, W. R., Wiese, T., Tyl, R., Gaido, K., Cook, J., ... Colborn, T.
(1997).
Endocrine Screening Methods Workshop report: detection of estrogenic and androgenic hormonal and antihormonal activity for chemicals that act via receptor or steroidogenic enzyme mechanisms. Reproductive Toxicology.
11(5), 719-750.
-
Willett, K. L., McDonald, S. J., Steinberg, M. A., Beatty, K. B., Kennicutt, M. C., & Safe, S. H.
(1997).
Biomarker sensitivity for polynuclear aromatic hydrocarbon contamination in two marine fish species collected in Galveston Bay, Texas. Environmental Toxicology and Chemistry.
16(7), 1472-1479.
-
Connor, K., Ramamoorthy, K., Moore, M., Mustain, M., Chen, I., Safe, S., ... Balaguer, P.
(1997).
Hydroxylated polychlorinated biphenyls (PCBs) as estrogens and antiestrogens: structure-activity relationships. TOXICOLOGY AND APPLIED PHARMACOLOGY.
145(1), 111-123.
-
McDougal, A., Wilson, C., & Safe, S.
(1997).
Induction of estradiol 2-hydroxylase activity in MCF-7 human breast cancer cells by pesticides and carcinogens. Environmental Toxicology and Pharmacology.
3(3), 195-199.
-
Sun, G., & Safe, S.
(1997).
Antiestrogenic activities of alternate-substituted polychlorinated dibenzofurans in MCF-7 human breast cancer cells. Cancer Chemotherapy and Pharmacology.
40(3), 239-244.
-
Wang, F., Porter, W., Xing, W., Archer, T. K., & Safe, S.
(1997).
Identification of a functional imperfect estrogen-responsive element in the 5'-promoter region of the human cathepsin D gene. Biochemistry.
36(25), 7793-7801.
-
Willett, K. L., Gardinali, P. R., Sericano, J. L., Wade, T. L., & Safe, S. H.
(1997).
Characterization of the H4IIE rat hepatoma cell bioassay for evaluation of environmental samples containing polynuclear aromatic hydrocarbons (PAHs). Archives of Environmental Contamination and Toxicology.
32(4), 442-448.
-
Gillesby, B. E., Stanostefano, M., Porter, W., Safe, S., Wu, Z. F., & Zacharewski, T. R.
(1997).
Identification of a motif within the 5' regulatory region of pS2 which is responsible for AP-1 binding and TCDD-mediated suppression. Biochemistry.
36(20), 6080-6089.
-
Wang, W. L., Porter, W., Burghardt, R., & Safe, S. H.
(1997).
Mechanism of inhibition of MDA-MB-468 breast cancer cell growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Carcinogenesis.
18(5), 925-933.
-
Ramamoorthy, K., Wang, F., Chen, I. C., Norris, J. D., McDonnell, D. P., Leonard, L. S., ... Safe, S.
(1997).
Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism. ENDOCRINOLOGY.
138(4), 1520-1527.
-
Safe, S. H.
(1997).
Is there an association between exposure to environmental estrogens and breast cancer?. Environmental Health Perspectives.
105(SUPPL. 3), 675-678.
-
Safe, S. H.
(1997).
Is there an association between exposure to environmental estrogens and breast cancer?. Environmental Health Perspectives.
105 Suppl 3(Suppl 3), 675-678.
-
Zhao, F., Mayura, K., Harper, N., Safe, S. H., & Phillips, T. D.
(1997).
Inhibition of 3,3',4,4',5-pentachlorobiphenyl-induced fetal cleft palate and immunotoxicity in C57BL/6 mice by 2,2',4,4',5,5'-hexachlorobiphenyl. Chemosphere.
34(5-7), 1605-1613.
-
Nodland, K. I., Wormke, M., & Safe, S.
(1997).
Inhibition of estrogen-induced activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-7 human breast cancer and other cell lines transfected with vitellogenin A2 gene promoter constructs. Archives of Biochemistry and Biophysics.
338(1), 67-72.
-
Wang, W., Smith, R., Burghardt, R., & Safe, S. H.
(1997).
17 beta-Estradiol-mediated growth inhibition of MDA-MB-468 cells stably transfected with the estrogen receptor: cell cycle effects. Molecular and Cellular Endocrinology.
133(1), 49-62.
-
Zhao, F., Mayura, K., Kocurek, N., Edwards, J. F., Kubena, L. F., Safe, S. H., & Phillips, T. D.
(1997).
Inhibition of 3,3',4,4',5-pentachlorobiphenyl-induced chicken embryotoxicity by 2,2',4,4',5,5'-hexachlorobiphenyl. Fundamental and applied toxicology : official journal of the Society of Toxicology.
35(1), 1-8.
-
Hoivik, D., Wilson, C., Wang, W., Willett, K., Barhoumi, R., Burghardt, R., & Safe, S.
(1997).
Studies on the relationship between estrogen receptor content, glutathione S-transferase pi expression, and induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and drug resistance in human breast cancer cells. Archives of Biochemistry and Biophysics.
348(1), 174-182.
-
Moore, M., Mustain, M., Daniel, K., Chen, I., Safe, S., Zacharewski, T., ... Balaguer, P.
(1997).
Antiestrogenic activity of hydroxylated polychlorinated biphenyl congeners identified in human serum. TOXICOLOGY AND APPLIED PHARMACOLOGY.
142(1), 160-168.
-
Rodriguez, L. V., Dunsford, H. A., Steinberg, M., Chaloupka, K. K., Zhu, L., Safe, S., Womack, J. E., & Goldstein, L. S.
(1997).
Carcinogenicity of benzo[a]pyrene and manufactured gas plant residues in infant mice. Carcinogenesis.
18(1), 127-135.
-
Hanneman, W. H., Legare, M. E., TiffanyCastiglioni, E., & Safe, S. H.
(1997).
Comments on ''Developmental neurotoxicity of PCBs in humans: What do we know and where do we go from here?'' Reply. NEUROTOXICOLOGY AND TERATOLOGY.
19(1), 3-3.
-
Randerath, K., Zhou, G. D., Randerath, E., Safe, S. H., & Donnelly, K. C.
(1997).
Comparative 32P-postlabeling analysis of exogenous and endogenous DNA adducts in mouse skin exposed to a wood-preserving waste extract, a complex mixture of polycyclic and polychlorinated chemicals. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.
29(4), 372-378.
-
Randerath, K., Zhou, G., Randerath, E., Safe, S. H., & Donnelly, K. C.
(1997).
Comparative32P-postlabeling analysis of exogenous and endogenous DNA adducts in mouse skin exposed to a wood-preserving waste extract, a complex mixture of polycyclic and polychlorinated chemicals. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.
29(4), 372-378.
-
ZHAO, F., MAYURA, K., KOCUREK, N., EDWARDS, J. F., KUBENA, L. F., SAFE, S. H., & PHILLIPS, T. D.
(1997).
Inhibition of 3,3,4,4,5-Pentachlorobiphenyl-Induced Chicken Embryotoxicity by 2,2,4,4,5,5-Hexachlorobiphenyl. TOXICOLOGICAL SCIENCES.
35(1), 1-8.
-
Zhao, F., Mayura, K., Kocurek, N., Edwards, J. F., Kubena, L. F., Safe, S. H., & Phillips, T. D.
(1997).
Inhibition of 3,3,4,4,5-pentachlorobiphenyl-induced chicken embryotoxicity by 2,2,4,4,5,5-hexachlorobiphenyl. Fundamental and applied toxicology : official journal of the Society of Toxicology.
35(1), 1-8.
-
Safe, S. H., & Zacharewski, T.
(1997).
Organochlorine exposure and risk for breast cancer. Progress in clinical and biological research.
396, 133-145.
-
Ramamoorthy, K., Wang, F., Chen, I. C., Safe, S., Norris, J. D., McDonnell, D. P., ... Korach, K. S.
(1997).
Potency of combined estrogenic pesticides. Science.
275(5298), 405-406.
-
Safe, S. H.
(1996).
Endocrine disruptors and human health. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
212(1-2), 3-TOXI.
-
Wilker, C., Johnson, L., & Safe, S.
(1996).
Effects of developmental exposure to indole-3-carbinol or 2,3,7,8-tetrachlorodibenzo-p-dioxin on reproductive potential of male rat offspring. TOXICOLOGY AND APPLIED PHARMACOLOGY.
141(1), 68-75.
-
Porter, W., Wang, F., Wang, W., Duan, R., & Safe, S.
(1996).
Role of estrogen receptor/Sp1 complexes in estrogen-induced heat shock protein 27 gene expression. Molecular Endocrinology.
10(11), 1371-1378.
-
McDonald, S. J., Willett, K. L., Thomsen, J., Beatty, K. B., Connor, K., Narasimhan, T. R., Erickson, C. M., & Safe, S. H.
(1996).
Sublethal detoxification responses to contaminant exposure associated with offshore production platforms. CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES.
53(11), 2606-2617.
-
Barhoumi, R., Mouneimne, Y., Phillips, T. D., Safe, S. H., & Burghardt, R. C.
(1996).
Alteration of oxytocin-induced calcium oscillations in Clone 9 cells by toxin exposure. Fundamental and applied toxicology : official journal of the Society of Toxicology.
33(2), 220-228.
-
Randerath, E., Zhou, G. D., Donnelly, K. C., Safe, S. H., & Randerath, K.
(1996).
DNA damage induced in mouse tissues by organic wood preserving waste extracts as assayed by 32P-postlabeling. Archives of Toxicology.
70(11), 683-695.
-
Bowes, R. C., Parrish, A. R., Steinberg, M. A., Willett, K. L., Zhao, W., Savas, U., ... Ramos, K. S.
(1996).
Atypical cytochrome P450 induction profiles in glomerular mesangial cells at the mRNA and enzyme level. Evidence for CYP1A1 and CYP1B1 expression and their involvement in benzo[a]pyrene metabolism. Biochemical Pharmacology.
52(4), 587-595.
-
Safe, S. H.
(1996).
Chemospheric evaluation - Toxic equivalency factors do not predict the acute toxicities of dioxins in rats - Comment. Human toxicology.
15(8), 695-696.
-
Safe, S. H.
(1996).
Chemospheric evaluation. Human and Experimental Toxicology.
15(8), 695-696.
-
Lu, Y. F., Sun, G., Wang, X., & Safe, S.
(1996).
Inhibition of prolactin receptor gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 human breast cancer cells. Archives of Biochemistry and Biophysics.
332(1), 35-40.
-
Liu, H., & Safe, S.
(1996).
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on insulin-induced responses in MCF-7 human breast cancer cells. TOXICOLOGY AND APPLIED PHARMACOLOGY.
138(2), 242-250.
-
Santostefano, M., & Safe, S.
(1996).
Characterization of the molecular and structural properties of the transformed and nuclear aryl hydrocarbon (Ah) receptor complexes by proteolytic digestion. CHEMICO-BIOLOGICAL INTERACTIONS.
100(3), 221-240.
-
Harper, N., Steinberg, M., & Safe, S.
(1996).
Immunotoxicity of a reconstituted polynuclear aromatic hydrocarbon mixture in B6C3F1 mice. Toxicology.
109(1), 31-38.
-
Hanneman, W. H., Legare, M. E., Tiffany-Castiglioni, E., & Safe, S. H.
(1996).
The need for cellular, biochemical, and mechanistic studies. NEUROTOXICOLOGY AND TERATOLOGY.
18(3), 247-250.
-
Chen, I., Safe, S., & Bjeldanes, L.
(1996).
Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells. Biochemical Pharmacology.
51(8), 1069-1076.
-
Markiewicz, K. V., Howie, L. E., Safe, S. H., & Donnelly, K. C.
(1996).
Mutagenic potential of binary and complex mixtures using different enzyme induction systems. Journal of Toxicology and Environmental Health.
47(5), 443-451.
-
Lu, Y. F., Santostefano, M., Cunningham, B. D., Threadgill, M. D., & Safe, S.
(1996).
Substituted flavones as aryl hydrocarbon (Ah) receptor agonists and antagonists. Biochemical Pharmacology.
51(8), 1077-1087.
-
Connor, K., Howell, J., Chen, I., Liu, H., Berhane, K., Sciarretta, C., Safe, S., & Zacharewski, T.
(1996).
Failure of chloro-S-triazine-derived compounds to induce estrogen receptor-mediated responses in vivo and in vitro. Fundamental and applied toxicology : official journal of the Society of Toxicology.
30(1), 93-101.
-
Connor, K., Howell, J., Safe, S., Chen, I., Liu, H., Berhane, K., Sciarretta, C., & Zacharewski, T.
(1996).
Failure of chloro-S-triazine-derived compounds to induce estrogenic responses in vivo and in vitro. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
211, 177-AGRO.
-
Moore, M., Ruh, M., Steinberg, M., & Safe, S.
(1996).
Isolation and characterization of variant benzo[a]pyrene-resistant T47D human breast-cancer cells. International Journal of Cancer.
66(1), 117-123.
-
Barhoumi, R., Mouneimne, Y., Phillips, T. D., Safe, S. H., & Burghardt, R. C.
(1996).
Alteration of oxytocin-induced calcium oscillations in clone 9 cells by toxin exposure. Fundamental and applied toxicology : official journal of the Society of Toxicology.
33(2), 220-228.
-
Wang, W. L., Thomsen, J. S., Porter, W., Moore, M., & Safe, S.
(1996).
Effect of transient expression of the oestrogen receptor on constitutive and inducible CYP1A1 in Hs578T human breast cancer cells. British Journal of Cancer.
73(3), 316-322.
-
CONNOR, K., HOWELL, J., CHEN, I., LIU, H., BERHANE, K., SCIARRETTA, C., SAFE, S., & ZACHAREWSKI, T.
(1996).
Failure of Chloro-S-triazine-Derived Compounds to Induce Estrogen Receptor-Mediated Responses in Vivo and in Vitro. TOXICOLOGICAL SCIENCES.
30(1), 93-101.
-
Hanneman, W. H., Legare, M. E., Barhoumi, R., Burghardt, R. C., Safe, S., & Tiffany-Castiglioni, E.
(1996).
Stimulation of calcium uptake in cultured rat hippocampal neurons by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology.
112(1), 19-28.
-
BARHOUMI, R., MOUNEIMNE, Y., PHILLIPS, T. D., SAFE, S. H., & BURGHARDT, R. C.
(1996).
Alteration of Oxytocin-Induced Calcium Oscillations in Clone 9 Cells by Toxin Exposure. TOXICOLOGICAL SCIENCES.
33(2), 220-228.
-
Dickerson, R., Keller, L. H., & Safe, S.
(1995).
Alkyl polychlorinated dibenzofurans and related compounds as antiestrogens in the female rat uterus: structure-activity studies. TOXICOLOGY AND APPLIED PHARMACOLOGY.
135(2), 287-298.
-
Krishnan, V., Porter, W., Santostefano, M., Wang, X., & Safe, S.
(1995).
Molecular mechanism of inhibition of estrogen-induced cathepsin D gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in MCF-7 cells. Molecular and Cellular Biology.
15(12), 6710-6719.
-
Connor, K., Safe, S., Jefcoate, C. R., & Larsen, M.
(1995).
Structure-dependent induction of CYP2B by polychlorinated biphenyl congeners in female Sprague-Dawley rats. Biochemical Pharmacology.
50(11), 1913-1920.
-
Xiaohong Wang, .., Thomsen, J. S., Santostefano, M., Rosengren, R., Safe, S., & Perdew, G. H.
(1995).
Comparative properties of the nuclear aryl hydrocarbon (Ah) receptor complex from several human cell lines. European Journal of Pharmacology - Environmental Toxicology and Pharmacology Section.
293(3), 191-205.
-
Wang, X., Thomsen, J. S., Santostefano, M., Rosengren, R., Safe, S., & Perdew, G. H.
(1995).
Comparative properties of the nuclear aryl hydrocarbon (Ah) receptor complex from several human cell lines. European Journal of Pharmacology.
293(3), 191-205.
-
Ruh, M. F., Zacharewski, T., Connor, K., Howell, J., Chen, I., & Safe, S.
(1995).
Naringenin: a weakly estrogenic bioflavonoid that exhibits antiestrogenic activity. Biochemical Pharmacology.
50(9), 1485-1493.
-
SAFE, S. H.
(1995).
ENVIRONMENTAL ESTROGENS - RESPONSE. Environmental Health Perspectives.
103(9), 784-785.
-
WILLETT, K., STEINBERG, M., THOMSEN, J., NARASIMHAN, T. R., SAFE, S., MCDONALD, S., BEATTY, K., & KENNICUTT, M. C.
(1995).
EXPOSURE OF KILLIFISH TO BENZO[A]PYRENE - COMPARATIVE METABOLISM, DNA ADDUCT FORMATION AND ARYL-HYDROCARBON (AH) RECEPTOR AGONIST ACTIVITIES. Comparative Biochemistry and Physiology - B: Comparative Biochemistry.
112(1), 93-103.
-
MCDONALD, S. J., KENNICUTT, M. C., LIU, H., & SAFE, S. H.
(1995).
ASSESSING AROMATIC HYDROCARBON EXPOSURE IN ANTARCTIC FISH CAPTURED NEAR PALMER AND MCMURDO STATIONS, ANTARCTICA. Archives of Environmental Contamination and Toxicology.
29(2), 232-240.
-
HARPER, N., CONNOR, K., STEINBERG, M., & SAFE, S.
(1995).
Immunosuppressive Activity of Polychiorinated Biphenyl Mixtures and Congeners: Nonadditive (Antagonistic) Interactions. TOXICOLOGICAL SCIENCES.
27(1), 131-139.
-
Harper, N., Connor, K., Steinberg, M., & Safe, S.
(1995).
Immunosuppressive activity of polychlorinated biphenyl mixtures and congeners: nonadditive (antagonistic) interactions. Fundamental and applied toxicology : official journal of the Society of Toxicology.
27(1), 131-139.
-
Merchant, M., & Safe, S.
(1995).
In vitro inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced activity by alpha-naphthoflavone and 6-methyl-1,3,8-trichlorodibenzofuran using an aryl hydrocarbon (Ah)-responsive construct. Biochemical Pharmacology.
50(5), 663-668.
-
Safe, S., Washburn, K., Zacharewski, T., & Phillips, T.
(1995).
Synthesis and characterization of hydroxylated polychlorinated biphenyls (PCBs) identified in human serum. Chemosphere.
31(4), 3017-3023.
-
Safe, S., Rodriguez, L. V., & Goldstein, L. S.
(1995).
Toxic equivalency factor approach for risk assessment of combustion byproducts. Toxicological and Environmental Chemistry.
49(3), 181-191.
-
Suk, W. A., & Safe, S.
(1995).
Toxicity and health effects of combustion byproducts. Toxicological and Environmental Chemistry.
49(3), 129-130.
-
Safe, S. H.
(1995).
Do environmental estrogens play a role in development of breast cancer in women and male reproductive problems?. Human and Ecological Risk Assessment.
1(2), 17-23.
-
Chaloupka, K., Steinberg, M., Santostefano, M., Rodriguez, L. V., Goldstein, L., & Safe, S.
(1995).
Induction of Cyp1a-1 and Cyp1a-2 gene expression by a reconstituted mixture of polynuclear aromatic hydrocarbons in B6C3F1 mice. CHEMICO-BIOLOGICAL INTERACTIONS.
96(3), 207-221.
-
Harper, N., Steinberg, M., Thomsen, J., & Safe, S.
(1995).
Halogenated aromatic hydrocarbon-induced suppression of the plaque-forming cell response in B6C3F1 splenocytes cultured with allogenic mouse serum: Ah receptor structure activity relationships. Toxicology.
99(3), 199-206.
-
Kennicutt Ii, M. C., McDonald, S. J., Sericano, J. L., Boothe, P., Oliver, J., Safe, S., ... Bockus, D.
(1995).
Human Contamination of the Marine Environment-Arthur Harbor and McMurdo Sound, Antarctica. Environmental Science and Technology.
29(5), 1279-1287.
-
Safe, S. H.
(1995).
Environmental and dietary estrogens and human health: is there a problem?. Environmental Health Perspectives.
103(4), 346-351.
-
Safe, S., & Krishnan, V.
(1995).
Cellular and molecular biology of aryl hydrocarbon (Ah) receptor-mediated gene expression. Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.
17(17), 99-115.
-
HARPER, N., STEINBERG, M., & SAFE, S.
(1995).
EFFECTS OF ALLOGENIC SERUM ON THE IN-VITRO IMMUNE-RESPONSE - AH RECEPTOR STRUCTURE-IMMUNOTOXICITY RELATIONSHIPS. Journal of Cellular Biochemistry.
194-194.
-
Wilker, C. E., Welsh, T. H., Safe, S. H., Narasimhan, T. R., & Johnson, L.
(1995).
Human chorionic gonadotropin protects Leydig cell function against 2,3,7,8-tetrachlorodibenzo-p-dioxin in adult rats: role of Leydig cell cytoplasmic volume. Toxicology.
95(1-3), 93-102.
-
SAFE, S.
(1995).
INTERACTIONS BETWEEN THE ARYL-HYDROCARBON AND ESTROGEN RECEPTOR-MEDIATED SIGNAL-TRANSDUCTION PATHWAYS. Journal of Cellular Biochemistry.
188-188.
-
Lu, Y. F., Santostefano, M., Cunningham, B. D., Threadgill, M. D., & Safe, S.
(1995).
Identification of 3'-methoxy-4'-nitroflavone as a pure aryl hydrocarbon (Ah) receptor antagonist and evidence for more than one form of the nuclear Ah receptor in MCF-7 human breast cancer cells. Archives of Biochemistry and Biophysics.
316(1), 470-477.
-
Safe, S. H.
(1995).
Modulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Pharmacology and Therapeutics.
67(2), 247-281.
-
Chaloupka, K., Santostefano, M., Goldfarb, I. S., Liu, G., Myers, M. J., Tsyrolv, I. B., ... Safe, S.
(1994).
Aryl hydrocarbon (Ah) receptor-independent induction of Cyp1a2 gene expression by acenaphthylene and related compounds in B6C3F1 mice. Carcinogenesis.
15(12), 2835-2840.
-
Wang, X., & Safe, S.
(1994).
Development of an in vitro model for investigating the formation of the nuclear Ah receptor complex in mouse Hepa 1c1c7 cells. Archives of Biochemistry and Biophysics.
315(2), 285-292.
-
Liu, H., Wormke, M., Safe, S. H., & Bjeldanes, L. F.
(1994).
Indolo[3,2-b]carbazole: a dietary-derived factor that exhibits both antiestrogenic and estrogenic activity. Journal of the National Cancer Institute.
86(23), 1758-1765.
-
NARASIMHAN, T. R., CRAIG, A., ARELLANO, L., HARPER, N., HOWIE, L., MENACHE, M., BIRNBAUM, L., & SAFE, S.
(1994).
Relative Sensitivities of 2,3,7,8-Tetrachlorodibenzo- p -dioxin-lnduced Cypla-1 and Cypla-2 Gene Expression and Immunotoxicity in Female B6C3F1 Mice. TOXICOLOGICAL SCIENCES.
23(4), 598-607.
-
Narasimhan, T. R., Craig, A., Arellano, L., Harper, N., Howie, L., Menache, M., Birnbaum, L., & Safe, S.
(1994).
Relative sensitivities of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced Cyp1a-1 and Cyp1a-2 gene expression and immunotoxicity in female B6C3F1 mice. Fundamental and applied toxicology : official journal of the Society of Toxicology.
23(4), 598-607.
-
SERICANO, J. L., SAFE, S. H., WADE, T. L., & BROOKS, J. M.
(1994).
TOXICOLOGICAL SIGNIFICANCE OF NON-ORTHO-SUBSTITUTED, MONO-ORTHO-SUBSTITUTED AND DI-ORTHO-SUBSTITUTED POLYCHLORINATED-BIPHENYLS IN OYSTERS FROM GALVESTON AND TAMPA BAYS. Environmental Toxicology and Chemistry.
13(11), 1797-1803.
-
Sericano, J. L., Wade, T. L., Brooks, J. M., & Safe, S. H.
(1994).
Toxicological significance of non-, mono- and di-ortho-substituted polychlorinated biphenyls in oysters from galveston and tampa bays. Environmental Toxicology and Chemistry.
13(11), 1797-1803.
-
Liu, H., Santostefano, M., & Safe, S.
(1994).
2-Phenylphenanthridinone and related compounds: aryl hydrocarbon receptor agonists and suicide inactivators of P4501A1. Archives of Biochemistry and Biophysics.
313(2), 206-214.
-
Harper, N., Connor, K., Steinberg, M., & Safe, S.
(1994).
An enzyme-linked immunosorbent assay (ELISA) specific for antibodies to TNP-LPS detects alterations in serum immunoglobulins and isotype switching in C57BL/6 and DBA/2 mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Toxicology.
92(1-3), 155-167.
-
Nakai, J. S., Winhall, M. J., & Bunce, N. J.
(1994).
Comparative kinetic study of the binding between 2,3,7,8-tetrachlorodibenzo-p-dioxin and related ligands with the hepatic Ah receptors from several rodent species. Journal of biochemical toxicology.
9(4), 199-209.
-
Randerath, K., Zhou, G. D., Donnelly, K. C., Safe, S. H., & Randerath, E.
(1994).
DNA damage induced by wood preserving waste extracts in vitro without metabolic activation, as assayed by 32P-postlabeling. Cancer Letters.
83(1-2), 123-128.
-
Harper, N., Wang, X., Liu, H., & Safe, S.
(1994).
Inhibition of estrogen-induced progesterone receptor in MCF-7 human breast cancer cells by aryl hydrocarbon (Ah) receptor agonists. Molecular and Cellular Endocrinology.
104(1), 47-55.
-
Santosfefano, M., Liu, H., Wang, X., Chaloupka, K., & Safe, S.
(1994).
Effect of ligand structure on formation and DNA binding properties of the transformed rat cytosolic aryl hydrocarbon receptor. CHEMICAL RESEARCH IN TOXICOLOGY.
7(4), 544-550.
-
Holcomb, M., & Safe, S.
(1994).
Inhibition of 7,12-dimethylbenzanthracene-induced rat mammary tumor growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Cancer Letters.
82(1), 43-47.
-
Lu, Y., Wang, X., & Safe, S.
(1994).
Interaction of 2,3,7,8-tetrachlorodibenzo-p-dioxin and retinoic acid in MCF-7 human breast cancer cells. TOXICOLOGY AND APPLIED PHARMACOLOGY.
127(1), 1-8.
-
Weber, T. J., Ou, X., Merchant, M., Wang, X., Safe, S. H., & Ramos, K. S.
(1994).
Biphasic modulation of protein kinase C (PKC) activity by polychlorinated dibenzo-p-dioxins (PCDDs) in serum-deprived rat aortic smooth muscle cells. Journal of biochemical toxicology.
9(3), 113-120.
-
MCDONALD, S. J., KENNICUTT, M. C., SERICANO, J., WADE, T. L., LIU, H., & SAFE, S. H.
(1994).
CORRELATION BETWEEN BIOASSAY-DERIVED P4501A1 INDUCTION ACTIVITY AND CHEMICAL-ANALYSIS OF CLAM (LATERNULA-ELLIPTICA) EXTRACTS FROM MCMURDO SOUND, ANTARCTICA. Chemosphere.
28(12), 2237-2248.
-
Krishnan, V., Wang, X., & Safe, S.
(1994).
Estrogen receptor-Sp1 complexes mediate estrogen-induced cathepsin D gene expression in MCF-7 human breast cancer cells. Journal of Biological Chemistry.
269(22), 15912-15917.
-
Thomsen, J. S., Wang, X., Hines, R. N., & Safe, S.
(1994).
Restoration of aryl hydrocarbon (Ah) responsiveness in MDA-MB-231 human breast cancer cells by transient expression of the estrogen receptor. Carcinogenesis.
15(5), 933-937.
-
Johnson, L., Wilker, C. E., Safe, S. H., Scott, B., Dean, D. D., & White, P. H.
(1994).
2,3,7,8-Tetrachlorodibenzo-p-dioxin reduces the number, size, and organelle content of Leydig cells in adult rat testes. Toxicology.
89(1), 49-65.
-
AHLBORG, U. G., BECKING, G. C., BIRNBAUM, L. S., BROUWER, A., DERKS, H., FEELEY, M., ... YRJANHEIKKI, E.
(1994).
TOXIC EQUIVALENCY FACTORS FOR DIOXIN-LIKE PCBS - REPORT ON A WHO-ECEH AND IPCS CONSULTATION, DECEMBER 1993. Chemosphere.
28(6), 1049-1067.
-
Moore, M., Wang, X., Lu, Y. F., Wormke, M., Craig, A., Gerlach, J. H., ... Safe, S.
(1994).
Benzo[a]pyrene-resistant MCF-7 human breast cancer cells. A unique aryl hydrocarbon-nonresponsive clone. Journal of Biological Chemistry.
269(16), 11751-11759.
-
TIFFANYCASTIGLIONI, E., HANNEMAN, W. H., LEGARE, M. E., HONG, S. J., BARHOUMI, R., BURGHARDT, R. C., & SAFE, S.
(1994).
CONGENER-SPECIFIC EFFECTS OF DIOXINS ON NEURAL CELLS. Journal of Neurochemistry.
62, S28-S28.
-
Fernandez, P., Burghardt, R., Smith, R., Nodland, K., & Safe, S.
(1994).
High passage T47D human breast cancer cells: altered endocrine and 2,3,7,8-tetrachlorodibenzo-p-dioxin responsiveness. European Journal of Pharmacology.
270(1), 53-65.
-
CARVAN, M. J., SANTOSTEFANO, M., SAFE, S., & BUSBEE, D.
(1994).
CHARACTERIZATION OF A BOTTLE-NOSED-DOLPHIN (TURSIOPS-TRUNCATUS) KIDNEY EPITHELIAL-CELL LINE. Marine Mammal Science.
10(1), 52-69.
-
Safe, S. H.
(1994).
Dietary and environmental estrogens and antiestrogens and their possible role in human disease. Environmental Science and Pollution Research.
1(1), 29-33.
-
Safe, S. H.
(1994).
Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. Critical Reviews in Toxicology.
24(2), 87-149.
-
Harper, N., Howie, L., Connor, K., Dickerson, R., & Safe, S.
(1993).
Immunosuppressive effects of highly chlorinated biphenyls and diphenyl ethers on T-cell dependent and independent antigens in mice. Toxicology.
85(2-3), 123-135.
-
Chaloupka, K., Harper, N., Krishnan, V., Santostefano, M., Rodriguez, L. V., & Safe, S.
(1993).
Synergistic activity of polynuclear aromatic hydrocarbon mixtures as aryl hydrocarbon (Ah) receptor agonists. CHEMICO-BIOLOGICAL INTERACTIONS.
89(2-3), 141-158.
-
Liu, H., Santostefano, M., Lu, Y., & Safe, S.
(1993).
6-substituted 3,4-benzocoumarins: a new structural class of inducers and inhibitors of CYP1A1-dependent activity. Archives of Biochemistry and Biophysics.
306(1), 223-231.
-
Safe, S.
(1993).
Development of bioassays and approaches for the risk assessment of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Environmental Health Perspectives.
101 Suppl 3(Suppl 3), 317-325.
-
Randerath, E., Randerath, K., Reddy, R., Narasimhan, T. R., Wang, X., & Safe, S.
(1993).
Effects of polychlorinated dibenzofurans on compounds in hepatic DNA of female Sprague-Dawley rats: structure dependence and mechanistic considerations. CHEMICO-BIOLOGICAL INTERACTIONS.
88(2-3), 175-190.
-
Moore, M., Narasimhan, T. R., Steinberg, M. A., Wang, X., & Safe, S.
(1993).
Potentiation of CYP1A1 gene expression in MCF-7 human breast cancer cells cotreated with 2,3,7,8-tetrachlorodibenzo-p-dioxin and 12-O-tetradecanoylphorbol-13-acetate. Archives of Biochemistry and Biophysics.
305(2), 483-488.
-
Mittwoch, U., Burgess, M. C., & Baker, P. J.
(1993).
Male sexual development in "a sea of oestrogen". The Lancet.
342(8863), 123-124.
-
Safe, S.
(1993).
Male sexual development in "a sea of oestrogen". The Lancet.
342(8863), 125-125.
-
Lans, M. C., Klasson-Wehler, E., Willemsen, M., Meussen, E., Safe, S., & Brouwer, A.
(1993).
Structure-dependent, competitive interaction of hydroxy-polychlorobiphenyls, -dibenzo-p-dioxins and -dibenzofurans with human transthyretin. CHEMICO-BIOLOGICAL INTERACTIONS.
88(1), 7-21.
-
Harper, N., Connor, K., & Safe, S.
(1993).
Immunotoxic potencies of polychlorinated biphenyl (PCB), dibenzofuran (PCDF) and dibenzo-p-dioxin (PCDD) congeners in C57BL/6 and DBA/2 mice. Toxicology.
80(2-3), 217-227.
-
Merchant, M., Krishnan, V., & Safe, S.
(1993).
Mechanism of action of alpha-naphthoflavone as an Ah receptor antagonist in MCF-7 human breast cancer cells. TOXICOLOGY AND APPLIED PHARMACOLOGY.
120(2), 179-185.
-
HARRIS, M., ZACHAREWSKI, T., & SAFE, S.
(1993).
Comparative Potencies of Aroclors 1232, 1242, 1248, 1254, and 1260 in Male Wistar RatsAssessment of the Toxic Equivalency Factor (TEF) Approach for Polychlorinated Biphenyls (PCBs). TOXICOLOGICAL SCIENCES.
20(4), 456-463.
-
Harris, M., Zacharewski, T., & Safe, S.
(1993).
Comparative potencies of Aroclors 1232, 1242, 1248, 1254, and 1260 in male Wistar rats--assessment of the toxic equivalency factor (TEF) approach for polychlorinated biphenyls (PCBs). Fundamental and applied toxicology : official journal of the Society of Toxicology.
20(4), 456-463.
-
HARPER, N., HOWIE, L., CONNOR, K., ARELLANO, L., CRAIG, A., DICKERSON, R., & SAFE, S.
(1993).
Immunosuppressive and Monooxygenase Induction Activities of Highly Chlorinated Diphenyl Ether Congeners in C57BL/6 and DBA/2 Mice. TOXICOLOGICAL SCIENCES.
20(4), 496-502.
-
Harper, N., Howie, L., Connor, K., Arellano, L., Craig, A., Dickerson, R., & Safe, S.
(1993).
Immunosuppressive and monooxygenase induction activities of highly chlorinated diphenyl ether congeners in C57BL/6 and DBA/2 mice. Fundamental and applied toxicology : official journal of the Society of Toxicology.
20(4), 496-502.
-
Krishnan, V., & Safe, S.
(1993).
Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs) as antiestrogens in MCF-7 human breast cancer cells: quantitative structure-activity relationships. TOXICOLOGY AND APPLIED PHARMACOLOGY.
120(1), 55-61.
-
Rowlands, C., Krishnan, V., Wang, X., Santostefano, M., Safe, S., Miller, W. R., & Langdon, S.
(1993).
Characterization of the aryl hydrocarbon receptor and aryl hydrocarbon responsiveness in human ovarian carcinoma cell lines. Cancer Research.
53(8), 1802-1807.
-
Safe, S.
(1993).
Toxicology, structure-function relationship, and human and environmental health impacts of polychlorinated biphenyls: progress and problems. Environmental Health Perspectives.
100, 259-268.
-
Moore, M., Narasimhan, T. R., Wang, X., Krishnan, V., Safe, S., Williams, H. J., & Scott, A. I.
(1993).
Interaction of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 12-O-tetradecanoylphorbol-13-acetate (TPA) and 17 beta-estradiol in MCF-7 human breast cancer cells. The Journal of Steroid Biochemistry and Molecular Biology.
44(3), 251-261.
-
NODLAND, K. I., ARELLANO, L., SAFE, S., RYFFEL, G. U., & KLEINHITPASS, L.
(1993).
2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD)-MEDIATED ANTIESTROGENICITY - INHIBITION OF AN ESTROGEN-INDUCIBLE PLASMID CONSTRUCT. The FASEB Journal.
7(3), A168-A168.
-
Arellano, L. O., Wang, X., & Safe, S.
(1993).
Effects of cycloheximide on the induction of CYP1A1 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in three human breast cancer cell lines. Carcinogenesis.
14(2), 219-222.
-
Santostefano, M., Merchant, M., Arellano, L., Morrison, V., Denison, M. S., & Safe, S.
(1993).
alpha-Naphthoflavone-induced CYP1A1 gene expression and cytosolic aryl hydrocarbon receptor transformation. Molecular Pharmacology.
43(2), 200-206.
-
Wang, X., Porter, W., Krishnan, V., Narasimhan, T. R., & Safe, S.
(1993).
Mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated decrease of the nuclear estrogen receptor in MCF-7 human breast cancer cells. Molecular and Cellular Endocrinology.
96(1-2), 159-166.
-
Santostefano, M., Merchant, M., Arellano, L., Morrison, V., Denison, M. S., & Safe, S.
(1993).
-Naphthoflavone-induced CYP1A1 gene expression and cytosolic aryl hydrocarbon receptor transformation. Molecular Pharmacology.
43(2), 200-206.
-
SANTOSTEFANO, M., MERCHANT, M., ARELLANO, L., MORRISON, V., DENISON, M. S., & SAFE, S.
(1993).
ALPHA-NAPTHOFLAVONE-INDUCED CYP1A1 GENE-EXPRESSION AND CYTOSOLIC ARYL-HYDROCARBON RECEPTOR TRANSFORMATION. Journal of Cellular Biochemistry.
90-90.
-
ROWLANDS, J. C., WANG, X., & SAFE, S. H.
(1993).
INTERACTIVE EFFECTS OF FOS WITH THE AH RECEPTOR IN WILD-TYPE MOUSE HEPATOMA-CELLS. Journal of Cellular Biochemistry.
126-126.
-
THOMSEN, J. S., WANG, X., HINES, R. N., & SAFE, S. H.
(1993).
INTRODUCTION OF A FUNCTIONAL HUMAN ESTROGEN-RECEPTOR RESTORES THE FUNCTION OF THE AH RECEPTOR IN THE HUMAN BREAST-CARCINOMA CELL-LINE MDA-MB-231. Journal of Cellular Biochemistry.
130-130.
-
WANG, X., PORTER, W., & SAFE, S. H.
(1993).
MECHANISM OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) MEDIATED DOWN-REGULATION OF ESTROGEN-RECEPTOR IN HUMAN BREAST-CANCER MCF-7 CELL-LINE. Journal of Cellular Biochemistry.
132-132.
-
Sadhu, D. N., Merchant, M., Safe, S. H., & Ramos, K. S.
(1993).
Modulation of protooncogene expression in rat aortic smooth muscle cells by benzo[a]pyrene. Archives of Biochemistry and Biophysics.
300(1), 124-131.
-
Mayura, K., Spainhour, C. B., Howie, L., Safe, S., & Phillips, T. D.
(1993).
Teratogenicity and immunotoxicity of 3,3',4,4',5-pentachlorobiphenyl in C57BL/6 mice. Toxicology.
77(1-2), 123-131.
-
Ahlborg, U. G., Brouwer, A., Fingerhut, M. A., Jacobson, J. L., Jacobson, S. W., Kennedy, S. W., ... Rappe, C.
(1992).
Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept. European Journal of Pharmacology.
228(4), 179-199.
-
Chaloupka, K., Krishnan, V., & Safe, S.
(1992).
Polynuclear aromatic hydrocarbon carcinogens as antiestrogens in MCF-7 human breast cancer cells: role of the Ah receptor. Carcinogenesis.
13(12), 2233-2239.
-
Wang, X., Santostefano, M., Lu, Y., & Safe, S.
(1992).
A comparison of the mouse versus human aryl hydrocarbon (Ah) receptor complex: effects of proteolysis. CHEMICO-BIOLOGICAL INTERACTIONS.
85(1), 79-93.
-
Merchant, M., Morrison, V., Santostefano, M., & Safe, S.
(1992).
Mechanism of action of aryl hydrocarbon receptor antagonists: inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression. Archives of Biochemistry and Biophysics.
298(2), 389-394.
-
Johnson, L., Dickerson, R., Safe, S. H., Nyberg, C. L., Lewis, R. P., & Welsh, T. H.
(1992).
Reduced Leydig cell volume and function in adult rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin without a significant effect on spermatogenesis. Toxicology.
76(2), 103-118.
-
LIU, H., NARASIMHAN, T. R., & SAFE, S.
(1992).
2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN AS AN ANTIPROLIFERATIVE AGENT IN HUMAN BREAST-CANCER CELLS - EFFECTS ON INSULIN-INDUCED CELL-PROLIFERATION. Chemosphere.
25(7-10), 955-958.
-
MERCHANT, M., MORRISON, V., & SAFE, S.
(1992).
ANTAGONISM OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) - INDUCED CYP1A1 GENE-EXPRESSION BY 6-METHYL-1,3,8-TRICHLORODIBENZOFURAN (MCDF) - MECHANISTIC STUDIES. Chemosphere.
25(7-10), 967-973.
-
WANG, X., ROSENGREN, R., MORRISON, V., & SAFE, S.
(1992).
CHARACTERIZATION OF THE HUMAN AH RECEPTOR. Chemosphere.
25(7-10), 997-1000.
-
KRISHNAN, V., NARISIMHAN, T. R., & SAFE, S.
(1992).
EFFECTS OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) AS AN ANTIESTROGEN IN MCF-7 HUMAN BREAST-CANCER CELLS. Chemosphere.
25(7-10), 947-950.
-
ROWLANDS, C., SAFE, S., LANGDON, S., MILLER, W. R., & LAWRIE, S.
(1992).
HUMAN OVARIAN-CANCER CELLS - INTERACTION WITH TETRACHLORODIBENZO-P-DIOXIN (TCDD). Chemosphere.
25(7-10), 979-983.
-
LIU, H., CHINNAH, A., KEMP, M., & SAFE, S.
(1992).
POSSIBLE INTERRELATIONSHIP BETWEEN TCDD AND INTERLEUKIN-1 AS ANTIPROLIFERATIVE AGENTS IN HUMAN BREAST-CANCER CELLS. Chemosphere.
25(7-10), 951-954.
-
RANDERATH, K., RANDERATH, E., REDDY, R., NARASIMHAN, T. R., WANG, X., & SAFE, S.
(1992).
STRUCTURE-DEPENDENT REDUCTION IN DNA I-COMPOUND ADDUCTS BY POLYCHLORINATED DIBENZOFURANS IN FEMALE SPRAGUE-DAWLEY RAT-LIVER. Chemosphere.
25(7-10), 975-978.
-
Dookwah, H. D., Barhoumi, R., Narasimhan, T. R., Safe, S. H., & Burghardt, R. C.
(1992).
Gap junctions in myometrial cell cultures: evidence for modulation by cyclic adenosine 3':5'-monophosphate. Biology of Reproduction.
47(3), 397-407.
-
Liu, H., Biegel, L., Narasimhan, T. R., Rowlands, C., & Safe, S.
(1992).
Inhibition of insulin-like growth factor-I responses in MCF-7 cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Molecular and Cellular Endocrinology.
87(1-3), 19-28.
-
Santostefano, M., Piskorska-Pliszczynska, J., Morrison, V., & Safe, S.
(1992).
Effects of ligand structure on the in vitro transformation of the rat cytosolic aryl hydrocarbon receptor. Archives of Biochemistry and Biophysics.
297(1), 73-79.
-
SAFE, S.
(1992).
DEVELOPMENT, VALIDATION AND LIMITATIONS OF TOXIC EQUIVALENCY FACTORS. Chemosphere.
25(1-2), 61-64.
-
Krishnan, V., Narasimhan, T., & Safe, S.
(1992).
Development of gel staining techniques for detecting the secretion of procathepsin D (52-kDa protein) in MCF-7 human breast cancer cells. Analytical Biochemistry.
204(1), 137-142.
-
Fernandez, P., & Safe, S.
(1992).
Growth inhibitory and antimitogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in T47D human breast cancer cells. Toxicology Letters.
61(2-3), 185-197.
-
SAFE, S., BIEGEL, L., HARRIS, M., NARASIMHAN, T. R., LUI, H., & FERNANDEZ, P.
(1992).
INHIBITION OF ESTROGEN-INDUCED AND GROWTH FACTOR-INDUCED PROLIFERATION OF HUMAN BREAST-CANCER CELL-LINES BY TCDD - CHARACTERIZATION AND MECHANISTIC STUDIES. Chemosphere.
25(1-2), 83-86.
-
Yao, C., & Safe, S.
(1992).
The interactions of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 6-methyl-1,3,8-trichlorodibenzofuran in chick embryo hepatocytes. Toxicology in Vitro.
6(4), 373-380.
-
NARASIMHAN, T. R., MAYURA, K., CLEMENT, B. A., SAFE, S. H., & PHILLIPS, T. D.
(1992).
EFFECTS OF CHLORINATED PHENOLS ON RAT EMBRYONIC AND HEPATIC MITOCHONDRIAL OXIDATIVE-PHOSPHORYLATION. Environmental Toxicology and Chemistry.
11(6), 805-814.
-
Rosengren, R., Safe, S., & Bunce, N. J.
(1992).
Kinetics of the association of several tritiated polychlorinated dibenzo-p-dioxin and dibenzofuran congeners with hepatic cytosolic Ah receptor from the Wistar rat. CHEMICAL RESEARCH IN TOXICOLOGY.
5(3), 376-382.
-
Zacharewski, T., Harris, M., Biegel, L., Morrison, V., Merchant, M., & Safe, S.
(1992).
6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as an antiestrogen in human and rodent cancer cell lines: evidence for the role of the Ah receptor. TOXICOLOGY AND APPLIED PHARMACOLOGY.
113(2), 311-318.
-
Wang, X., Rosengren, R., Morrison, V., Santostefano, M., & Safe, S.
(1992).
Characterization of the aryl hydrocarbon receptor in the human C-4II cervical squamous carcinoma cell line. Biochemical Pharmacology.
43(7), 1635-1642.
-
DONNELLY, K. C., ANDERSON, C. S., THOMAS, J. C., BROWN, K. W., MANEK, D. J., & SAFE, S. H.
(1992).
BACTERIAL MUTAGENICITY OF SOIL EXTRACTS FROM A BIOREMEDIATION FACILITY TREATING WOOD-PRESERVING WASTE. JOURNAL OF HAZARDOUS MATERIALS.
30(1), 71-81.
-
Dickerson, R., Howie, L., & Safe, S.
(1992).
The effect of 6-nitro-1,3,8-trichlorodibenzofuran as a partial estrogen in the female rat uterus. TOXICOLOGY AND APPLIED PHARMACOLOGY.
113(1), 55-63.
-
BUNCE, N. J., DIDIODATO, G., & SAFE, S. H.
(1992).
PHOTOLYSIS OF NITROPOLYCHLORODIBENZO-P-DIOXINS WITH BASE AS POTENTIAL METHODOLOGY FOR THE DESTRUCTION OF POLYCHLORINATED DIBENZO-P-DIOXINS. Chemosphere.
24(4), 433-438.
-
SAFE, S., BROWN, K. W., DONNELLY, K. C., ANDERSON, C. S., MARKIEWICZ, K. V., MCLACHLAN, M. S., REISCHL, A., & HUTZINGER, O.
(1992).
POLYCHLORINATED DIBENZO-PARA-DIOXINS AND DIBENZOFURANS ASSOCIATED WITH WOOD-PRESERVING CHEMICAL SITES - BIOMONITORING WITH PINE NEEDLES. Environmental Science and Technology.
26(2), 394-396.
-
Merchant, M., Wang, X., Kamps, C., Rosengren, R., Morrison, V., & Safe, S.
(1992).
Mechanism of benzo[a]pyrene-induced Cyp1a-1 gene expression in mouse Hepa 1c1c7 cells: role of the nuclear 6 s and 4 s proteins. Archives of Biochemistry and Biophysics.
292(1), 250-257.
-
Safe, S., Astroff, B., Harris, M., Zacharewski, T., Dickerson, R., Romkes, M., & Biegel, L.
(1991).
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds as antioestrogens: characterization and mechanism of action. Basic and Clinical Pharmacology and Toxicology.
69(6), 400-409.
-
Narasimhan, T. R., Safe, S., Williams, H. J., & Scott, A. I.
(1991).
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on 17 beta-estradiol-induced glucose metabolism in MCF-7 human breast cancer cells: 13C nuclear magnetic resonance spectroscopy studies. Molecular Pharmacology.
40(6), 1029-1035.
-
Safe, S.
(1991).
Polychlorinated dibenzofurans: Environmental impact, toxicology, and risk assessment. Toxic Substances Journal.
11(2), 177-222.
-
Piskorska-Pliszczynska, J., Morrison, V., Zacharewski, T., & Safe, S.
(1991).
DNA binding properties of the Ah receptor in wild-type and variant mouse hepatoma cells. Archives of Biochemistry and Biophysics.
290(2), 362-368.
-
BECKER, M., PHILLIPS, T., & SAFE, S.
(1991).
POLYCHLORINATED DIPHENYL ETHERS - A REVIEW. Toxicological and Environmental Chemistry.
33(3-4), 189-200.
-
Zacharewski, T., Harris, M., & Safe, S.
(1991).
Evidence for the mechanism of action of the 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated decrease of nuclear estrogen receptor levels in wild-type and mutant mouse Hepa 1c1c7 cells. Biochemical Pharmacology.
41(12), 1931-1939.
-
Davis, D., & Safe, S.
(1991).
Halogenated aryl hydrocarbon-induced suppression of the in vitro plaque-forming cell response to sheep red blood cells is not dependent on the Ah receptor. Immunopharmacology.
21(3), 183-190.
-
Wang, X., Narasimhan, T. R., Morrison, V., & Safe, S.
(1991).
In situ and in vitro photoaffinity labeling of the nuclear aryl hydrocarbon receptor from transformed rodent and human cell lines. Archives of Biochemistry and Biophysics.
287(1), 186-194.
-
Astroff, B., Eldridge, B., & Safe, S.
(1991).
Inhibition of the 17 beta-estradiol-induced and constitutive expression of the cellular protooncogene c-fos by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the female rat uterus. Toxicology Letters.
56(3), 305-315.
-
Safe, S. H.
(1991).
Reply. TOXICOLOGY AND APPLIED PHARMACOLOGY.
108(3), 568-569.
-
Haake-McMillan, J. M., & Safe, S. H.
(1991).
Neonatal exposure to Aroclor 1254: effects on adult hepatic testosterone hydroxylase activities. Xenobiotica: the fate of foreign compounds in biological systems.
21(4), 481-489.
-
Astroff, B., & Safe, S.
(1991).
6-Alkyl-1,3,8-trichlorodibenzofurans as antiestrogens in female Sprague-Dawley rats. Toxicology.
69(2), 187-197.
-
Safe, S., Harris, M., & Zacharewski, T.
(1991).
Development and validation of bioassays for polychlorinated dibenzo-p-dioxins and dibenzofurans. IARC scientific publications.
147-159.
-
Narasimhan, T. R., Kim, H. L., & Safe, S. H.
(1991).
Effects of hydroxylated polychlorinated biphenyls on mouse liver mitochondrial oxidative phosphorylation. Journal of biochemical toxicology.
6(3), 229-236.
-
Piskorska-Pliszczynska, J., Astroff, B., Zacharewski, T., Harris, M., Rosengren, R., Morrison, V., Safe, L., & Safe, S.
(1991).
Mechanism of action of 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonists: characterization of 6-[125I]methyl-8-iodo-1,3-dichlorodibenzofuran-Ah receptor complexes. Archives of Biochemistry and Biophysics.
284(1), 193-200.
-
Nair, R. V., Fisher, E. P., Safe, S. H., Cortez, C., Harvey, R. G., & DiGiovanni, J.
(1991).
Novel coumarins as potential anticarcinogenic agents. Carcinogenesis.
12(1), 65-69.
-
SAFE, S.
(1991).
POLYCHLORINATED DIBENZO-PARA-DIOXINS AND RELATED-COMPOUNDS - SOURCES, ENVIRONMENTAL DISTRIBUTION AND RISK ASSESSMENT. Journal of Environmental Science and Health, Part C.
9(2), 261-302.
-
Biegel, L., & Safe, S.
(1990).
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on cell growth and the secretion of the estrogen-induced 34-, 52- and 160-kDa proteins in human breast cancer cells. The Journal of Steroid Biochemistry and Molecular Biology.
37(5), 725-732.
-
Astroff, B., Rowlands, C., Dickerson, R., & Safe, S.
(1990).
2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibition of 17 beta-estradiol-induced increases in rat uterine epidermal growth factor receptor binding activity and gene expression. Molecular and Cellular Endocrinology.
72(3), 247-252.
-
Howie, L., Dickerson, R., Davis, D., & Safe, S.
(1990).
Immunosuppressive and monooxygenase induction activities of polychlorinated diphenyl ether congeners in C57BL/6N mice: quantitative structure-activity relationships. TOXICOLOGY AND APPLIED PHARMACOLOGY.
105(2), 254-263.
-
Harris, M., Zacharewski, T., Piskorska-Pliszczynska, J., Rosengren, R., & Safe, S.
(1990).
Structure-dependent induction of aryl hydrocarbon hydroxylase activity in C57BL/6 mice by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related congeners: mechanistic studies. TOXICOLOGY AND APPLIED PHARMACOLOGY.
105(2), 243-253.
-
DICKERSON, R., HOWIE, L., DAVIS, D., & SAFE, S.
(1990).
The Structure-Dependent Effects of Heptachlorodibenzofuran Isomers in Male C57BL/6 Mice: Immunotoxicity and onooxygenase Enzyme Induction. TOXICOLOGICAL SCIENCES.
15(2), 298-307.
-
BUNCE, N. J., LANDERS, J. P., SCHNEIDER, U. A., SAFE, S. H., & ZACHAREWSKI, T. R.
(1990).
CHLORINATED TRANS STILBENES - COMPETITIVE-BINDING TO THE AH RECEPTOR, INDUCTION OF CYTOCHROME-P-450 MONOOXYGENASE ACTIVITY AND PARTIAL 2,3,7,8-TCDD ANTAGONISM. Toxicological and Environmental Chemistry.
28(4), 217-229.
-
Golas, C. L., Prokipcak, R. D., Okey, A. B., Manchester, D. K., Safe, S., & Fujita, T.
(1990).
Competitive binding of 7-substituted-2,3-dichlorodibenzo-p-dioxins with human placental ah receptor--a QSAR analysis. Biochemical Pharmacology.
40(4), 737-741.
-
Merchant, M., Arellano, L., & Safe, S.
(1990).
The mechanism of action of alpha-naphthoflavone as an inhibitor of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression. Archives of Biochemistry and Biophysics.
281(1), 84-89.
-
Dickerson, R., Howie, L., Davis, D., & Safe, S.
(1990).
The structure-dependent effects of heptachlorodibenzofuran isomers in male C57BL/6 mice: immunotoxicity and monooxygenase enzyme induction. Fundamental and applied toxicology : official journal of the Society of Toxicology.
15(2), 298-307.
-
Davis, D., & Safe, S.
(1990).
Immunosuppressive activities of polychlorinated biphenyls in C57BL/6N mice: structure-activity relationships as Ah receptor agonists and partial antagonists. Toxicology.
63(1), 97-111.
-
Harris, M., Zacharewski, T., & Safe, S.
(1990).
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds on the occupied nuclear estrogen receptor in MCF-7 human breast cancer cells. Cancer Research.
50(12), 3579-3584.
-
Kelley, M., Womack, J., & Safe, S.
(1990).
Effects of cytochrome P-450 monooxygenase inducers on mouse hepatic microsomal metabolism of testosterone and alkoxyresorufins. Biochemical Pharmacology.
39(12), 1991-1998.
-
Randerath, K., Putman, K. L., Randerath, E., Zacharewski, T., Harris, M., & Safe, S.
(1990).
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on I-compounds in hepatic DNA of Sprague-Dawley rats: sex-specific effects and structure-activity relationships. TOXICOLOGY AND APPLIED PHARMACOLOGY.
103(2), 271-280.
-
Astroff, B., & Safe, S.
(1990).
2,3,7,8-Tetrachlorodibenzo-p-dioxin as an antiestrogen: effect on rat uterine peroxidase activity. Biochemical Pharmacology.
39(3), 485-488.
-
BUNCE, N. J., LANDERS, J. P., NAKAI, J. S., WINHALL, M. J., & SAFE, S. H.
(1990).
INVITRO THERMAL INACTIVATION OF HEPATIC AH RECEPTORS FROM SEVERAL MAMMALIAN-SPECIES. Toxicology in Vitro.
4(2), 87-92.
-
PROKIPCAK, R. D., GOLAS, C. L., MANCHESTER, D. K., OKEY, A. B., SAFE, S., & FUJITA, T.
(1990).
7-SUBSTITUTED-2,3-DICHLORODIBENZO-PARA-DIOXINS AS COMPETITIVE LIGANDS FOR THE AH RECEPTOR - QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS (QSARS) AND A COMPARISON OF HUMAN RECEPTOR WITH AH RECEPTOR FROM RODENTS. Chemosphere.
20(7-9), 1221-1228.
-
Bunce, N. J., Landers, J. P., Nakai, J. S., Winhall, M. J., & Safe, S. H.
(1990).
In vitro thermal inactivation of hepatic Ah receptors from several mammalian species. Toxicology in Vitro.
4(2), 87-92.
-
Donnelly, K. C., Brown, K. W., Anderson, C. S., Barbee, G. C., & Safe, S. H.
(1990).
Metabolism and bacterial mutagenicity of binary mixtures of benzo(a)pyrene and polychlorinated aromatic hydrocarbons. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.
16(4), 238-245.
-
Haake-McMillan, J. M., & Safe, S. H.
(1990).
Neonatal modulation of adult rat hepatic microsomal benzo[a]pyrene hydroxylase activities by Aroclor 1254 or phenobarbital. Journal of biochemical toxicology.
5(4), 203-210.
-
Safe, S.
(1990).
Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). Critical Reviews in Toxicology.
21(1), 51-88.
-
YAO, C., PANIGRAHY, B., & SAFE, S.
(1990).
UTILIZATION OF CULTURED CHICK-EMBRYO HEPATOCYTES AS INVITRO BIOASSAYS FOR POLYCHLORINATED-BIPHENYLS (PCBS) - QUANTITATIVE STRUCTURE-INDUCTION RELATIONSHIPS. Chemosphere.
21(8), 1007-1016.
-
Astroff, B., & Safe, S.
(1989).
6-substituted-1,3,8-trichlorodibenzofurans as 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonists in the rat: structure activity relationships. Toxicology.
59(3), 285-296.
-
Landers, J. P., Piskorska-Pliszczynska, J., Zacharewski, T., Bunce, N. J., & Safe, S.
(1989).
Photoaffinity labeling of the nuclear Ah receptor from mouse Hepa 1c1c7 cells using 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin. Journal of Biological Chemistry.
264(31), 18463-18471.
-
Safe, S., Mason, G., Sawyer, T., Zacharewski, T., Harris, M., Yao, C., ... Davis, D.
(1989).
Development and validation of in vitro induction assays for toxic halogenated aromatic mixtures: a review. Toxicology and Industrial Health.
5(5), 757-775.
-
Yao, C., & Safe, S.
(1989).
2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced porphyria in genetically inbred mice: partial antagonism and mechanistic studies. TOXICOLOGY AND APPLIED PHARMACOLOGY.
100(2), 208-216.
-
Zacharewski, T., Harris, M., & Safe, S.
(1989).
Induction of cytochrome P450-dependent monooxygenase activities in rat hepatoma H-4-IIE cells in culture by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds: mechanistic studies using radiolabeled congeners. Archives of Biochemistry and Biophysics.
272(2), 344-355.
-
Harris, M., Piskorska-Pliszczynska, J., Zacharewski, T., Romkes, M., & Safe, S.
(1989).
Structure-dependent induction of aryl hydrocarbon hydroxylase in human breast cancer cell lines and characterization of the Ah receptor. Cancer Research.
49(16), 4531-4535.
-
Davis, D., & Safe, S.
(1989).
Dose-response immunotoxicities of commercial polychlorinated biphenyls (PCBs) and their interaction with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology Letters.
48(1), 35-43.
-
ZACHAREWSKI, T., SAFE, L., SAFE, S., CHITTIM, B., DEVAULT, D., WIBERG, K., BERGQVIST, P. A., & RAPPE, C.
(1989).
COMPARATIVE-ANALYSIS OF POLYCHLORINATED DIBENZO-P-DIOXIN AND DIBENZOFURAN CONGENERS IN GREAT-LAKES FISH EXTRACTS BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY AND INVITRO ENZYME-INDUCTION ACTIVITIES. Environmental Science and Technology.
23(6), 730-735.
-
LI, S., DENOMME, M. A., LEECE, B., TOWNER, R., & SAFE, S.
(1989).
HEXACHLOROBENZENE - BIOCHEMICAL EFFECTS AND SYNERGISTIC TOXIC INTERACTIONS WITH 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN. Toxicological and Environmental Chemistry.
22(1-4), 215-227.
-
Harris, M., Zacharewski, T., Astroff, B., & Safe, S.
(1989).
Partial antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated induction of aryl hydrocarbon hydroxylase by 6-methyl-1,3,8-trichlorodibenzofuran: mechanistic studies. Molecular Pharmacology.
35(5), 729-735.
-
Biegel, L., Harris, M., Davis, D., Rosengren, R., Safe, L., & Safe, S.
(1989).
2,2',4,4',5,5'-hexachlorobiphenyl as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6J mice. TOXICOLOGY AND APPLIED PHARMACOLOGY.
97(3), 561-571.
-
Bannister, R., Biegel, L., Davis, D., Astroff, B., & Safe, S.
(1989).
6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6 mice. Toxicology.
54(2), 139-150.
-
JONES, D., SAFE, S., MORCOM, E., HOLCOMB, M., COPPOCK, C., & IVIE, W.
(1989).
BIOAVAILABILITY OF GRAIN AND SOIL-BORNE TRITIATED 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN (TCDD) ADMINISTERED TO LACTATING HOLSTEIN COWS. Chemosphere.
18(1-6), 1257-1263.
-
BANNISTER, R., DAVIS, D., BIEGEL, L., ASTROFF, B., & SAFE, S.
(1989).
6-METHYL-1,3,8-TRICHLORODIBENZOFURAN (MCDF) AS A 2,3,7,8-TCDD ANTAGONIST IN C57BL/6 MICE. Chemosphere.
19(1-6), 949-953.
-
ZACHAREWSKI, T., HARRIS, M., SAFE, S., THOMA, H., HAUSCHULZ, G., KNORR, E., & HUTZINGER, O.
(1989).
APPLICATIONS OF THE INVITRO AHH INDUCTION BIOASSAY FOR DETERMINING 2,3,7,8-TCDD EQUIVALENTS - PYROLYZED FLAME-RETARDANT MIXTURES. Chemosphere.
18(1-6), 383-387.
-
SAFE, S., BANNISTER, R., DAVIS, D., HAAKE, J. M., ZACHAREWSKI, T., MAYURA, K., & PHILLIPS, T. D.
(1989).
AROCLOR 1254 AS A 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN ANTAGONIST IN MICE. Chemosphere.
18(1-6), 709-714.
-
HARRIS, M., ZACHAREWSKI, T., ASTROFF, B., KAMPS, C., & SAFE, S.
(1989).
CHARACTERIZATION OF 6-METHYL-1,3,8-TRICHLORODIBENZOFURAN (MCDF) AS A 2,3,7,8-TCDD ANTAGONIST IN MALE-RATS - INDUCTION OF MONOOXYGENASES. Chemosphere.
19(1-6), 769-772.
-
ROMKES, M., & SAFE, S.
(1989).
COMPARATIVE EFFECTS OF 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN (TCDD) AND PROGESTERONE ON ESTROGENIC RESPONSES IN RATS. Chemosphere.
18(1-6), 745-751.
-
SAFE, S., DAVIS, D., ROMKES, M., YAO, C., KEYES, B., PISKORSKAPLISZCZYNSKA, J., ... HOLCOMB, M.
(1989).
DEVELOPMENT AND VALIDATION OF INVITRO BIOASSAYS FOR 2,3,7,8-TCDD EQUIVALENTS. Chemosphere.
19(1-6), 853-860.
-
Narasimham, T. R., Kim, H. L., & Safe, S. H.
(1989).
Effects of sesquiterpene lactones on mitochondrial oxidative phosphorylation. General pharmacology.
20(5), 681-687.
-
WAERN, F., HANBERG, A., MANZOOR, E., SAFE, S., & AHLBORG, U. G.
(1989).
INTERACTION OF 6-METHYL-1,3,8-TRICHLORODIBENZOFURAN WITH TCDD-INDUCED VITAMIN A REDUCTION. Chemosphere.
19(1-6), 1005-1008.
-
LANDERS, J. P., BUNCE, N. J., NAKAI, J. S., WINHALL, M. J., & SAFE, S. H.
(1989).
INTERSPECIES DIFFERENCES IN INVITRO THERMAL INACTIVATION OF UNLIGANDED HEPATIC AH-RECEPTOR. Chemosphere.
19(1-6), 959-962.
-
Makary, M., Kim, H. L., Safe, S., Womack, J., & Ivie, G. W.
(1989).
Induction of glutathione S-transferases in genetically inbred male mice by dietary ethoxyquin hydrochloride. Comparative Biochemistry and Physiology - Part C: Comparative Pharmacology and Toxicology.
92(2), 171-174.
-
BUNCE, N. J., LANDERS, J. P., & SAFE, S. H.
(1989).
KINETICS OF THE INTERACTION BETWEEN 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN AND THE AH RECEPTOR PROTEIN. Chemosphere.
18(1-6), 731-736.
-
RANDERATH, K., PUTMAN, K. L., RANDERATH, E., MASON, G., KELLEY, M., & SAFE, S.
(1989).
LIVER DNA ALTERATIONS BY 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN AND 1,2,3,7,8-PENTACHLORODIBENZO-PARA-DIOXIN IN THE FEMALE RAT. Chemosphere.
18(1-6), 681-685.
-
ASTROFF, B., ROMKES, M., & SAFE, S.
(1989).
MECHANISM OF ACTION OF 2,3,7,8-TCDD AND 6-METHYL-1,3,8-TRICHLORODIBENZOFURAN (MCDF) AS ANTIESTROGENS IN THE FEMALE RAT. Chemosphere.
19(1-6), 785-788.
-
BIEGEL, L., HOWIE, L., & SAFE, S.
(1989).
POLYCHLORINATED BIPHENYL (PCB) CONGENERS AS 2,3,7,8-TCDD ANTAGONISTS - TERATOGENICITY STUDIES. Chemosphere.
19(1-6), 955-958.
-
Safe, S.
(1989).
Polychlorinated biphenyls (PCBs): mutagenicity and carcinogenicity. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS.
220(1), 31-47.
-
PISKORSKAPLISZCZYNSKA, J., & SAFE, S.
(1989).
RADIOLIGAND-DEPENDENT PROPERTIES OF THE AH-RECEPTOR FROM RAT AND MOUSE HEPATIC CYTOSOL. Chemosphere.
19(1-6), 963-968.
-
FARRELL, K., SAFE, L., & SAFE, S.
(1989).
RECEPTOR-BINDING CHARACTERISTICS OF 2,3,7,8-SUBSTITUTED POLYCHLORINATED DIBENZOFURAN RADIOLIGANDS. Chemosphere.
18(1-6), 1089-1092.
-
SAFE, S.
(1989).
RISK ASSESSMENT OF PCDDS AND PCDFS BASED ON INVITRO AND INVIVO BIOASSAYS. Chemosphere.
19(1-6), 609-613.
-
SAFE, S., ZACHAREWSKI, T., SAFE, L., HARRIS, M., YAO, C., & HOLCOMB, M.
(1989).
VALIDATION OF THE AHH INDUCTION BIOASSAY FOR THE DETERMINATION OF 2,3,7,8-TCDD TOXIC EQUIVALENTS. Chemosphere.
18(1-6), 941-946.
-
Parkinson, A., Thomas, P. E., Ryan, D. E., Levin, W., Fujita, T., & Safe, S.
(1988).
Induction of rat liver microsomal cytochrome P-450 isozymes and epoxide hydrolase by a series of 4'-substituted-2,3,4,5-tetrachlorobiphenyls. Toxicology.
53(2-3), 289-300.
-
Randerath, K., Putman, K. L., Randerath, E., Mason, G., Kelley, M., & Safe, S.
(1988).
Organ-specific effects of long term feeding of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 1,2,3,7,8-pentachlorodibenzo-p-dioxin on I-compounds in hepatic and renal DNA of female Sprague-Dawley rats. Carcinogenesis.
9(12), 2285-2289.
-
Halvorson, M. R., Safe, S. H., Parkinson, A., & Phillips, T. D.
(1988).
Aflatoxin B1 hydroxylation by the pregnenolone-16 alpha-carbonitrile-inducible form of rat liver microsomal cytochrome P-450. Carcinogenesis.
9(11), 2103-2108.
-
Bunce, N. J., Landers, J. P., & Safe, S. H.
(1988).
Kinetic models for association of 2,3,7,8-tetrachlorodibenzo-p-dioxin with the Ah receptor. Archives of Biochemistry and Biophysics.
267(1), 384-397.
-
Piskorska-Pliszczynska, J., & Safe, S.
(1988).
Radioligand-dependent differences in the molecular properties of the mouse and rat hepatic aryl hydrocarbon receptor complexes. Archives of Biochemistry and Biophysics.
267(1), 372-383.
-
Zacharewski, T., Harris, M., Safe, S., Thoma, H., & Hutzinger, O.
(1988).
Applications of the in vitro aryl hydrocarbon hydroxylase induction assay for determining "2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents": pyrolyzed brominated flame retardants. Toxicology.
51(2-3), 177-189.
-
Astroff, B., & Safe, S.
(1988).
Comparative antiestrogenic activities of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 6-methyl-1,3,8-trichlorodibenzofuran in the female rat. TOXICOLOGY AND APPLIED PHARMACOLOGY.
95(3), 435-443.
-
Harris, M., Kamps, C., & Safe, S.
(1988).
Role of the 4-5S binding protein in the induction of aryl hydrocarbon hydroxylase in the rat. Carcinogenesis.
9(8), 1475-1479.
-
Davis, D., & Safe, S.
(1988).
Immunosuppressive activities of polychlorinated dibenzofuran congeners: quantitative structure-activity relationships and interactive effects. TOXICOLOGY AND APPLIED PHARMACOLOGY.
94(1), 141-149.
-
Holcomb, M., Yao, C., & Safe, S.
(1988).
Biologic and toxic effects of polychlorinated dibenzo-p-dioxin and dibenzofuran congeners in the guinea pig. Quantitative structure-activity relationships. Biochemical Pharmacology.
37(8), 1535-1539.
-
Crocker, J. F., Safe, S. H., & Acott, P.
(1988).
Effects of chronic phthalate exposure on the kidney. Journal of Toxicology and Environmental Health.
23(4), 433-444.
-
Romkes, M., & Safe, S.
(1988).
Comparative activities of 2,3,7,8-tetrachlorodibenzo-p-dioxin and progesterone as antiestrogens in the female rat uterus. TOXICOLOGY AND APPLIED PHARMACOLOGY.
92(3), 368-380.
-
Astroff, B., Zacharewski, T., Safe, S., Arlotto, M. P., Parkinson, A., Thomas, P., & Levin, W.
(1988).
6-Methyl-1,3,8-trichlorodibenzofuran as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: inhibition of the induction of rat cytochrome P-450 isozymes and related monooxygenase activities. Molecular Pharmacology.
33(2), 231-236.
-
Merrill, J. C., Kim, H. L., Safe, S., Murray, C. A., & Hayes, M. A.
(1988).
Role of glutathione in the toxicity of the sesquiterpene lactones hymenoxon and helenalin. Journal of Toxicology and Environmental Health.
23(2), 159-169.
-
Donnelly, K. C., Brown, K. W., Estiri, M., Jones, D. H., & Safe, S.
(1988).
Mutagenic potential of binary mixtures of nitro-polychlorinated dibenzo-p-dioxins and related compounds. Journal of Toxicology and Environmental Health.
24(3), 345-356.
-
Makary, M., Kim, H. L., Safe, S., Womack, J., & Ivie, G. W.
(1988).
Constitutive and Aroclor 1254-induced hepatic glutathione S-transferase, peroxidase and reductase activities in genetically inbred mice. Comparative Biochemistry and Physiology - Part C: Comparative Pharmacology and Toxicology.
91(2), 425-429.
-
Haake, J. M., & Safe, S. H.
(1988).
Neonatal phenobarbital imprinting of rat hepatic microsomal testosterone hydroxylations. Journal of biochemical toxicology.
3(4), 309-319.
-
SAFE, S. H.
(1988).
THE ARYL-HYDROCARBON (AH) RECEPTOR. ISI ATLAS OF SCIENCE-PHARMACOLOGY.
2(1), 78-83.
-
Kelley, M., Hantelle, P., Safe, S., Levin, W., & Thomas, P. E.
(1987).
Co-induction of cytochrome P-450 isozymes in rat liver by 2,4,5,2',4',5'-hexachlorobiphenyl or 3-methoxy-4-aminoazobenzene. Molecular Pharmacology.
32(2), 206-211.
-
KIM, H. L., SAFE, S. H., & CALHOUN, M. C.
(1987).
QUANTITATION OF HYMENOXON AND RELATED SESQUITERPENE LACTONES. Journal of Agricultural and Food Chemistry.
35(6), 891-895.
-
Farrell, K., Safe, L., & Safe, S.
(1987).
Synthesis and aryl hydrocarbon receptor binding properties of radiolabeled polychlorinated dibenzofuran congeners. Archives of Biochemistry and Biophysics.
259(1), 185-195.
-
Bannister, R., Davis, D., Zacharewski, T., Tizard, I., & Safe, S.
(1987).
Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: effects on enzyme induction and immunotoxicity. Toxicology.
46(1), 29-42.
-
Haake, J. M., Safe, S., Mayura, K., & Phillips, T. D.
(1987).
Aroclor 1254 as an antagonist of the teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology Letters.
38(3), 299-306.
-
Romkes, M., Piskorska-Pliszczynska, J., Keys, B., Safe, S., & Fujita, T.
(1987).
Quantitative structure-activity relationships: analysis of interactions of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2-substituted analogues with rat, mouse, guinea pig, and hamster cytosolic receptor. Cancer Research.
47(19), 5108-5111.
-
Leece, B., Denomme, M. A., Towner, R., Li, A., Landers, J., & Safe, S.
(1987).
Nonadditive interactive effects of polychlorinated biphenyl congeners in rats: role of the 2,3,7,8-tetrachlorodibenzo-p-dioxin receptor. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY.
65(9), 1908-1912.
-
Kelley, M., Hantelle, P., Safe, S., Levin, W., & Thomas, P. E.
(1987).
Co-induction of cytochrome P-450 isozymes in rat liver by 2,4,5,2',4',5'-hexachlorobiphenyl or 3-methoxy-4-aminoazobenzene. Molecular Pharmacology.
32(1), 206-211.
-
WADDELL, D. S., MCKINNON, H. S., CHITTIM, B. G., SAFE, S., & BOYD, R. K.
(1987).
GAS-CHROMATOGRAPHIC MASS-SPECTROMETRIC CHARACTERISTICS OF PURIFIED SYNTHETIC ISOMERS OF TETRACHLORODIBENZOFURAN. Biomedical & environmental mass spectrometry.
14(8), 457-464.
-
Farrell, K., & Safe, S.
(1987).
Absence of positive co-operativity in the binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to its cytosolic receptor protein. Biochemical Journal.
244(3), 539-546.
-
Mason, G., Zacharewski, T., Denomme, M. A., Safe, L., & Safe, S.
(1987).
Polybrominated dibenzo-p-dioxins and related compounds: quantitative in vivo and in vitro structure-activity relationships. Toxicology.
44(3), 245-255.
-
LEECE, B. D., DENOMMI, M. A., TOWNER, R., LI, S., & SAFE, S.
(1987).
POLYCHLORINATED-BIPHENYLS (PCBS) - INVIVO QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS (QSARS) AND INTERACTIVE EFFECTS. FEDERATION PROCEEDINGS.
46(6), 2255-2255.
-
Bannister, R., & Safe, S.
(1987).
Synergistic interactions of 2,3,7,8-TCDD and 2,2',4,4',5,5'-hexachlorobiphenyl in C57BL/6J and DBA/2J mice: role of the Ah receptor. Toxicology.
44(2), 159-169.
-
BUNCE, N. J., LANDERS, J. P., SAFE, S. H., & ZACHAREWSKI, T. R.
(1987).
COMPETITIVE-BINDING OF CHLORINATED AZOBENZENES AND AZOXYBENZENES TO THE AH RECEPTOR PROTEIN. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
193, 30-ENVR.
-
Kamps, C., & Safe, S.
(1987).
Binding of polynuclear aromatic hydrocarbons to the rat 4S cytosolic binding protein: structure-activity relationships. Cancer Letters.
34(2), 129-137.
-
Romkes, M., Piskorska-Pliszczynska, J., & Safe, S.
(1987).
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic and uterine estrogen receptor levels in rats. TOXICOLOGY AND APPLIED PHARMACOLOGY.
87(2), 306-314.
-
JONES, D., SAFE, S., MORCOM, E., HOLCOMB, M., COPPOCK, C., & IVIE, W.
(1987).
BIOAVAILABILITY OF TRITIATED 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN (TCDD) ADMINISTERED TO HOLSTEIN DAIRY-COWS. Chemosphere.
16(8-9), 1743-1748.
-
ROMKES, M., SAFE, S., MASON, G., PISKORSKAPLISZCZYNSKA, J., & FUJITA, T.
(1987).
BINDING OF SUBSTITUTED ARYL HYDROCARBONS TO THE AH RECEPTOR - A QSAR ANALYSIS. Chemosphere.
16(8-9), 1719-1722.
-
SAFE, S.
(1987).
DETERMINATION OF 2,3,7,8-TCDD TOXIC EQUIVALENT FACTORS (TEFS) - SUPPORT FOR THE USE OF THE INVITRO AHH INDUCTION ASSAY. Chemosphere.
16(4), 791-802.
-
MASON, G., DENOMME, M. A., SAFE, L., & SAFE, S.
(1987).
POLYBROMINATED AND CHLORINATED DIBENZO-PARA-DIOXINS - SYNTHESIS BIOLOGIC AND TOXIC EFFECTS AND STRUCTURE-ACTIVITY-RELATIONSHIPS. Chemosphere.
16(8-9), 1729-1731.
-
Romkes, M., Piskorska-Pliszczynska, J., Keys, B., Safe, S., & Fujita, T.
(1987).
Quantitative Structure-Activity Relationships: Analysis of Interactions of 2,3,7,8-Tetrachlorodibenzo-p-dioxin and 2-Substituted Analogues with Rat, Mouse, Guinea Pig, and Hamster Cytosolic Receptor1. Cancer Research.
47(19), 5092-5140.
-
ROMKES, M., PISKORSKAPLISZCZYNSKA, J., & SAFE, S.
(1987).
ROLE OF THE AH RECEPTOR IN MEDIATING THE DOWN REGULATION OF UTERINE AND HEPATIC ESTROGEN-RECEPTOR LEVELS IN RATS. Chemosphere.
16(8-9), 1691-1694.
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WADDELL, D. S., BOYD, R. K., MCKINNON, H. S., SAFE, L., SAFE, S., & CHITTIM, B. G.
(1987).
TETRACHLORODIBENZOFURANS - GAS-CHROMATOGRAPHIC AND MASS-SPECTROMETRIC CHARACTERISTICS. Chemosphere.
16(8-9), 1655-1660.
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BANNISTER, R., & SAFE, S.
(1987).
THE EFFECTS OF RECEPTOR ANTAGONISTS ON THE AHH INDUCTION ACTIVITY OF 2,3,7,8-TCDD IN C57BL/6 AND DBA/2 MICE - 1,3,6,8-TETRACHLORODIBENZOFURAN. Chemosphere.
16(8-9), 1739-1742.
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BANNISTER, R., KELLEY, M., & SAFE, S.
(1987).
THE EFFECTS OF RECEPTOR MODULATORS ON THE AHH INDUCTION ACTIVITY OF 2,3,7,8-TCDD IN C57BL/6 AND DBA/2 MICE. Chemosphere.
16(8-9), 1687-1689.
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Haake, J., Kelley, M., Keys, B., & Safe, S.
(1987).
The effects of organochlorine pesticides as inducers of testosterone and benzo[a]pyrene hydroxylases. General pharmacology.
18(2), 165-169.
-
SAFE, S., MASON, G., FARRELL, K., KEYS, B., PISKORSKAPLISZCZYNSKA, J., MADGE, J. A., & CHITTIM, B.
(1987).
VALIDATION OF IN VITRO BIOASSAYS FOR 2,3,7,8-TCDD EQUIVALENTS. Chemosphere.
16(8-9), 1723-1728.
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FARRELL, K., SAFE, L., & SAFE, S.
(1987).
[H-3] 2,3,7,8-TETRACHLORODIBENZOFURAN (TCDF)-SYNTHESIS AND CHARACTERIZATION AS A RADIOLIGAND FOR THE AH RECEPTOR. Chemosphere.
16(8-9), 1733-1737.
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Li, S. M., Denomme, M. A., Leece, B., Safe, S., Dutton, D., Parkinson, A., ... Reik, L. M.
(1986).
Hexachlorobenzene and substituted pentachlorobenzenes (X-C6Cl5) as inducers of hepatic cytochrome P-450-dependent mono-oxygenases. IARC scientific publications.
527-534.
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Piskorska-Pliszczynska, J., Keys, B., Safe, S., & Newman, M. S.
(1986).
The cytosolic receptor binding affinities and AHH induction potencies of 29 polynuclear aromatic hydrocarbons. Toxicology Letters.
34(1), 67-74.
-
Safe, S. H.
(1986).
Book review. 19(2), 299-300.
-
Leece, B. D., Denomme, M. A., Li, S. M., Towner, R. A., Gyorkos, J. W., Chittim, B. G., & Safe, S.
(1986).
Effects of individual terphenyls and polychlorinated terphenyls on rat hepatic microsomal cytochrome P-450-dependent monooxygenases: structure-activity relationships. 59(3), 186-189.
-
Mason, G., Farrell, K., Keys, B., Piskorska-Pliszczynska, J., Safe, L., & Safe, S.
(1986).
Polychlorinated dibenzo-p-dioxins: quantitative in vitro and in vivo structure-activity relationships. Toxicology.
41(1), 21-31.
-
Mason, G., & Safe, S.
(1986).
Synthesis, biologic and toxic effects of the major 2,3,7,8-tetrachlorodibenzo-p-dioxin metabolites in the rat. Toxicology.
41(2), 153-159.
-
Keys, B., Piskorska-Pliszczynska, J., & Safe, S.
(1986).
Polychlorinated dibenzofurans as 2,3,7,8-TCDD antagonists: in vitro inhibition of monooxygenase enzyme induction. Toxicology Letters.
31(2), 151-158.
-
Safe, S. H.
(1986).
Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans. Annual Review of Pharmacology and Toxicology.
26(1), 371-399.
-
Hayes, M. A., Roberts, E., Safe, S. H., Farber, E., & Cameron, R. G.
(1986).
Influences of different polychlorinated biphenyls on cytocidal, mitoinhibitory, and nodule-selecting activities of N-2-fluorenylacetamide in rat liver. Journal of the National Cancer Institute.
76(4), 683-691.
-
Schuetz, E. G., Wrighton, S. A., Safe, S. H., & Guzelian, P. S.
(1986).
Regulation of cytochrome P-450p by phenobarbital and phenobarbital-like inducers in adult rat hepatocytes in primary monolayer culture and in vivo. Biochemistry.
25(5), 1124-1133.
-
Kennel, S. J., Jason, C., Albro, P. W., Mason, G., & Safe, S. H.
(1986).
Monoclonal antibodies to chlorinated dibenzo-p-dioxins. TOXICOLOGY AND APPLIED PHARMACOLOGY.
82(2), 256-263.
-
Denomme, M. A., Homonko, K., Fujita, T., Sawyer, T., & Safe, S.
(1986).
Substituted polychlorinated dibenzofuran receptor binding affinities and aryl hydrocarbon hydroxylase induction potencies--a QSAR analysis. CHEMICO-BIOLOGICAL INTERACTIONS.
57(2), 175-187.
-
DONNELLY, K. C., JONES, D. H., & SAFE, S.
(1986).
THE BACTERIAL MUTAGENICITY OF NITROPOLYCHLORINATED DIBENZO-PARA-DIOXINS AND RELATED-COMPOUNDS. Chemosphere.
15(9-12), 1961-1964.
-
DONNELLY, K. C., BROWN, K. W., JONES, D. H., & SAFE, S. H.
(1986).
THE MUTAGENIC POTENTIAL OF BINARY-MIXTURES NITRO-POLYCHLORINATED DIBENZO-P-DIOXINS AND RELATED-COMPOUNDS. 8, 25-26.
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Donnelly, K. C., Jones, D. H., & Safe, S.
(1986).
The bacterial mutagenicity of nitropolychlorinated dibenzo-p-dioxins. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS.
169(1-2), 17-22.
-
Sawyer, T., Jones, D., Rosanoff, K., Mason, G., Piskorska-Pliszczynska, J., & Safe, S.
(1986).
The biologic and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in chickens. Toxicology.
39(2), 197-206.
-
FARRELL, K., & SAFE, S.
(1986).
2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN - RELATIONSHIP BETWEEN TOXICITY AND THE INDUCTION OF ARYL-HYDROCARBON HYDROXYLASE AND ORNITHINE DECARBOXYLASE. Chemosphere.
15(9-12), 1971-1976.
-
Denomme, M. A., Leece, B., Li, A., Towner, R., & Safe, S.
(1986).
Elevation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) polychlorinated biphenyls. Structure-activity relationships. Biochemical Pharmacology.
35(2), 277-282.
-
Merrill, J., Kim, H. L., & Safe, S.
(1986).
Helenalin: mechanism of toxic action. Advances in Experimental Medicine and Biology.
197, 891-896.
-
SUNDSTROM, G., SAWYER, T., HUTZINGER, O., & SAFE, S.
(1986).
INVITRO BIOASSAYS FOR TOXIC POLYCHLORINATED AZOBENZENES. Chemosphere.
15(9-12), 2105-2107.
-
SAFE, S. H., PISKORSKAPLISZCZYNSKA, J., DENOMME, M. A., LEECE, B. D., TOWNER, R. A., & LI, S.
(1986).
MODULATION OF HEPATIC 2,3,7,8-TCDD CYTOSOLIC RECEPTOR LEVELS BY PCBS AND ORGANOCHLORINE POLLUTANTS. Chemosphere.
15(9-12), 2085-2088.
-
KENNEL, S. J., MASON, G., & SAFE, S.
(1986).
MONOCLONAL-ANTIBODIES TO CHLORINATED DIBENZO-PARA-DIOXINS. Chemosphere.
15(9-12), 2007-2010.
-
CHITTIM, B. G., MADGE, J. A., & SAFE, S. H.
(1986).
PENTACHLORODIBENZOFURANS - SYNTHESIS, CAPILLARY GAS-CHROMATOGRAPHY AND GAS-CHROMATOGRAPHIC MASS-SPECTROMETRIC CHARACTERISTICS. Chemosphere.
15(9-12), 1931-1934.
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SAFE, S., MASON, G., KEYS, B., FARRELL, K., ZMUDZKA, B., SAWYER, T., ... BANDIERA, S.
(1986).
POLYCHLORINATED DIBENZO-PARA-DIOXINS AND DIBENZOFURANS - CORRELATION BETWEEN INVITRO AND INVIVO STRUCTURE-ACTIVITY-RELATIONSHIPS (SARS). Chemosphere.
15(9-12), 1725-1731.
-
SAFE, S., FUJITA, T., ROMKES, M., PISKORSKAPLISZCZYNSKA, J., HOMONKO, K., & DENOMME, M. A.
(1986).
PROPERTIES OF THE 2,3,7,8-TCDD RECEPTOR - A QSAR APPROACH. Chemosphere.
15(9-12), 1657-1663.
-
MASON, G., & SAFE, S.
(1986).
SYNTHESIS, BIOLOGIC AND TOXIC PROPERTIES OF 2,3,7,8-TCDD METABOLITES. Chemosphere.
15(9-12), 2081-2083.
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BANNISTER, R., MASON, G., KELLEY, M., & SAFE, S.
(1986).
THE EFFECTS OF CYTOSOLIC RECEPTOR MODULATION ON THE AHH-INDUCING ACTIVITY OF 2,3,7,8-TCDD. Chemosphere.
15(9-12), 1909-1911.
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Keys, B., Hlavinka, M., Mason, G., & Safe, S.
(1985).
Modulation of rat hepatic microsomal testosterone hydroxylases by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related toxic isostereomers. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY.
63(12), 1537-1542.
-
Kelley, M., Lambert, I., Merrill, J., & Safe, S.
(1985).
1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) and related compounds as inducers of hepatic monooxygenases. Structure-activity effects. Biochemical Pharmacology.
34(19), 3489-3494.
-
Mason, G., Sawyer, T., Keys, B., Bandiera, S., Romkes, M., Piskorska-Pliszczynska, J., Zmudzka, B., & Safe, S.
(1985).
Polychlorinated dibenzofurans (PCDFs): correlation between in vivo and in vitro structure-activity relationships. Toxicology.
37(1-2), 1-12.
-
Safe, S., Bandiera, S., Sawyer, T., Zmudzka, B., Mason, G., Romkes, M., ... Fujita, T.
(1985).
Effects of structure on binding to the 2,3,7,8-TCDD receptor protein and AHH induction--halogenated biphenyls. Environmental Health Perspectives.
61(SEP), 21-33.
-
Merrill, J., Kim, H., & Safe, S.
(1985).
Hymenoxon: biologic and toxic effects. Biochemical Pharmacology.
34(18), 3383-3386.
-
Haake, J. M., Merrill, J. C., & Safe, S.
(1985).
The in vitro metabolism of benzo[a]pyrene by polychlorinated and polybrominated biphenyl induced rat hepatic microsomal monooxygenases. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY.
63(9), 1096-1100.
-
Denomme, M. A., Homonoko, K., Fujita, T., Sawyer, T., & Safe, S.
(1985).
Effects of substituents on the cytosolic receptor-binding avidities and aryl hydrocarbon hydroxylase induction potencies of 7-substituted 2,3-dichlorodibenzo-p-dioxins. A quantitative structure-activity relationship analysis. Molecular Pharmacology.
27(6), 656-661.
-
Fung, D., Boyd, R. K., Safe, S., & Chittim, B. G.
(1985).
Gas chromatographic/mass spectrometric analysis of specific isomers of polychlorodibenzofurans. Biomedical mass spectrometry.
12(6), 247-253.
-
Hayes, M. A., Safe, S. H., Armstrong, D., & Cameron, R. G.
(1985).
Influence of cell proliferation on initiating activity of pure polychlorinated biphenyls and complex mixtures in resistant hepatocyte in vivo assays for carcinogenicity. Journal of the National Cancer Institute.
74(5), 1037-1041.
-
Safe, S., Bandiera, S., Sawyer, T., Robertson, L., Safe, L., Parkinson, A., ... Levin, W.
(1985).
PCBs: structure-function relationships and mechanism of action. Environmental Health Perspectives.
60(MAY), 47-56.
-
Halvorson, M. R., Phillips, T. D., Safe, S. H., & Robertson, L. W.
(1985).
Metabolism of aflatoxin B1 by rat hepatic microsomes induced by polyhalogenated biphenyl congeners. Applied and Environmental Microbiology.
49(4), 882-886.
-
CROCKER, J., & SAFE, S. H.
(1985).
AN ANIMAL-MODEL OF HEMODIALYSIS-INDUCED POLYCYSTIC KIDNEY-DISEASE (PKD). Kidney International.
27(3), 601-601.
-
DENOMME, M. A., HOMONOKO, K., SAWYER, T., SAFE, S., & FUJITA, T.
(1985).
EFFECTS OF SUBSTITUENT STRUCTURE ON BINDING TO THE TCDD RECEPTOR - A QSAR ANALYSIS. Proceedings / Annual Meeting of the American Association for Cancer Research [and] Annual Meeting of the American Society of Clinical Oncology. American Association for Cancer Research. Meeting.
26(MAR), 7-7.
-
HAAKE, J. M., MERRILL, J. C., & SAFE, S.
(1985).
THE INVITRO METABOLISM OF BENZO[A]PYRENE BY POLYCHLORINATED AND POLYBROMINATED BIPHENYL INDUCED RAT HEPATIC-MICROSOMAL MONOOXYGENASES. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY.
63(9), 1096-1100.
-
SAWYER, T. W., & SAFE, S.
(1985).
INVITRO AHH INDUCTION BY POLYCHLORINATED BIPHENYL AND DIBENZOFURAN MIXTURES - ADDITIVE EFFECTS. Chemosphere.
14(1), 79-84.
-
SAFE, S., SAWYER, T., MASON, G., BANDIERA, S., KEYS, B., ROMKES, M., ... SAFE, L.
(1985).
POLYCHLORINATED DIBENZOFURANS - QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIPS. Chemosphere.
14(6-7), 675-683.
-
SAFE, S., SAFE, L., & MULLIN, M.
(1985).
POLYCHLORINATED-BIPHENYLS - CONGENER-SPECIFIC ANALYSIS OF A COMMERCIAL MIXTURE AND A HUMAN-MILK EXTRACT. Journal of Agricultural and Food Chemistry.
33(1), 24-29.
-
Leece, B., Denomme, M. A., Towner, R., Li, S. M., & Safe, S.
(1985).
Polychlorinated biphenyls: correlation between in vivo and in vitro quantitative structure-activity relationships (QSARs). Journal of Toxicology and Environmental Health.
16(3-4), 379-388.
-
Gyorkos, J., Denomme, M. A., Leece, B., Homonko, K., Valli, V. E., & Safe, S.
(1985).
Reconstituted halogenated hydrocarbon pesticide and pollutant mixtures found in human tissues: effects on the immature male Wistar rat after short-term exposure. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY.
63(1), 36-43.
-
Hayes, M. A., Roberts, E., Roomi, M. W., Safe, S. H., Farber, E., & Cameron, R. G.
(1984).
Comparative influences of different PB-type and 3-MC-type polychlorinated biphenyl-induced phenotypes on cytocidal hepatotoxicity of bromobenzene and acetaminophen. TOXICOLOGY AND APPLIED PHARMACOLOGY.
76(1), 118-127.
-
Shepherd, E. C., Phillips, T. D., Irvin, T. R., Safe, S. H., & Robertson, L. W.
(1984).
Aflatoxin B1 metabolism in the rat: polyhalogenated biphenyl enhanced conversion to aflatoxin M1. Xenobiotica: the fate of foreign compounds in biological systems.
14(9), 741-750.
-
ROBERTSON, L. W., SAFE, S. H., PARKINSON, A., PELLIZZARI, E., POCHINI, C., & MULLIN, M. D.
(1984).
SYNTHESIS AND IDENTIFICATION OF HIGHLY TOXIC POLYBROMINATED BIPHENYLS IN THE FIRE RETARDANT FIREMASTER BP-6. Journal of Agricultural and Food Chemistry.
32(5), 1107-1111.
-
Bandiera, S., Sawyer, T., Romkes, M., Zmudzka, B., Safe, L., Mason, G., Keys, B., & Safe, S.
(1984).
Polychlorinated dibenzofurans (PCDFs): effects of structure on binding to the 2,3,7,8-TCDD cytosolic receptor protein, AHH induction and toxicity. Toxicology.
32(2), 131-144.
-
FUNG, D., SAFE, S., & CROCKER, J.
(1984).
DETECTION OR TRACE LEVELS OF POLYETHYLENE-GLYCOL ETHER SURFACTANTS IN BIOLOGICAL TISSUES. Toxicological and Environmental Chemistry.
8(2-3), 109-118.
-
Mullins, M. D., Pochini, C. M., McCrindle, S., Romkes, M., Safe, S. H., & Safe, L. M.
(1984).
High-resolution PCB analysis: synthesis and chromatographic properties of all 209 PCB congeners. Environmental Science and Technology.
18(6), 468-476.
-
Robertson, L. W., Parkinson, A., Bandiera, S., Lambert, I., Merrill, J., & Safe, S. H.
(1984).
PCBs and PBBs: biologic and toxic effects on C57BL/6J and DBA/2J inbred mice. Toxicology.
31(3-4), 191-206.
-
Safe, S. H.
(1984).
Reviews in biochemical toxicology Vol. V. E. Hodgson, J. R. Bend, and R. M. Philpot, Editors, Elsevier Biomedical, New York, 1983.415 pp, $60.00 (U.S.). 21(3), 417-417.
-
CROCKER, J., & SAFE, S. H.
(1984).
AN ANIMAL-MODEL OF HEMODIALYSIS INDUCED POLYCYSTIC KIDNEY-DISEASE (PKD). Kidney International.
25(1), 183-183.
-
SAFE, S., & MULLIN, M.
(1984).
HIGH-RESOLUTION ISOMER-SPECIFIC PCB ANALYSIS. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
187(APR), 16-ENVR.
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GYORKOS, J., & SAFE, S.
(1984).
INDUCTION OF NUCLEAR BENZO[A]PYRENE HYDROXYLASE-ACTIVITY BY ORGANOCHLORINE POLLUTANTS. Proceedings / Annual Meeting of the American Association for Cancer Research [and] Annual Meeting of the American Society of Clinical Oncology. American Association for Cancer Research. Meeting.
25(MAR), 106-106.
-
HAYES, M. A., CAMERON, R. G., ROBERTS, E., SAFE, S., & FARBER, E.
(1984).
MODULATION OF CYTOCIDAL AND MITOINHIBITORY TOXICITY OF HEPATOCARCINOGENS IN RATS PRETREATED WITH DIFFERENT PURE PCBS AND OTHER INDUCERS. Proceedings / Annual Meeting of the American Association for Cancer Research [and] Annual Meeting of the American Society of Clinical Oncology. American Association for Cancer Research. Meeting.
25(MAR), 128-128.
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SAWYER, T. W., VATCHER, A. D., & SAFE, S.
(1984).
COMPARATIVE ARYL-HYDROCARBON HYDROXYLASE INDUCTION ACTIVITIES OF COMMERCIAL PCBS IN WISTAR RATS AND RAT HEPATOMA H-4-II-E-CELLS IN CULTURE. Chemosphere.
13(7), 695-701.
-
BANDIERA, S., FARRELL, K., MASON, G., KELLEY, M., ROMKES, M., BANNISTER, R., & SAFE, S.
(1984).
COMPARATIVE TOXICITIES OF THE POLYCHLORINATED DIBENZOFURAN (PCDF) AND BIPHENYL (PCB) MIXTURES WHICH PERSIST IN YUSHO VICTIMS. Chemosphere.
13(4), 507-512.
-
Hayes, M. A., Roberts, E., Jago, M. V., Safe, S. H., Farber, E., & Cameron, R. C.
(1984).
Influences of various xenobiotic inducers on cytocidal toxicity of lasiocarpine and senecionine in primary cultures of rat hepatocytes. Journal of Toxicology and Environmental Health.
14(5-6), 683-694.
-
Safe, S.
(1984).
Polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs): biochemistry, toxicology, and mechanism of action. Critical Reviews in Toxicology.
13(4), 319-395.
-
SAFE, S. H., & SAFE, L. M.
(1984).
SYNTHESIS AND CHARACTERIZATION OF 22 PURIFIED POLYCHLORINATED DIBENZOFURAN CONGENERS. Journal of Agricultural and Food Chemistry.
32(1), 68-71.
-
Crocker, J. F., Blecher, S. R., & Safe, S. H.
(1983).
Chemically induced polycystic kidney disease. Progress in clinical and biological research.
140, 281-296.
-
Bandiera, S., Sawyer, T. W., Campbell, M. A., Fujita, T., & Safe, S.
(1983).
Competitive binding to the cytosolic 2,3,7,8-tetrachlorodibenzo-p-dioxin receptor. Effects of structure on the affinities of substituted halogenated biphenyls--a QSAR analysis. Biochemical Pharmacology.
32(24), 3803-3813.
-
Denomme, M. A., Bandiera, S., Lambert, I., Copp, L., Safe, L., & Safe, S.
(1983).
Polychlorinated biphenyls as phenobarbitone-type inducers of microsomal enzymes. Structure-activity relationships for a series of 2,4-dichloro-substituted congeners. Biochemical Pharmacology.
32(19), 2955-2963.
-
Denomme, M. A., Leece, B., Gyorkos, J., Homonko, K., & Safe, S.
(1983).
Polychlorinated benzene and phenol congeners as inducers of rat hepatic drug-metabolizing enzymes in immature male Wistar rats. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY.
61(9), 1063-1070.
-
Andres, J., Lambert, I., Robertson, L., Bandiera, S., Sawyer, T., Lovering, S., & Safe, S.
(1983).
The comparative biologic and toxic potencies of polychlorinated biphenyls and polybrominated biphenyls. TOXICOLOGY AND APPLIED PHARMACOLOGY.
70(2), 204-215.
-
Clark, D. A., Sweeney, G., Safe, S., Hancock, E., Kilburn, D. G., & Gauldie, J.
(1983).
Cellular and genetic basis for suppression of cytotoxic T cell generation by haloaromatic hydrocarbons. Immunopharmacology.
6(2), 143-153.
-
Parkinson, A., Thomas, P. E., Ryan, D. E., Reik, L. M., Safe, S. H., Robertson, L. W., & Levin, W.
(1983).
Differential time course of induction of rat liver microsomal cytochrome P-450 isozymes and epoxide hydrolase by Aroclor 1254. Archives of Biochemistry and Biophysics.
225(1), 203-215.
-
Parkinson, A., Robertson, L. W., & Safe, S. H.
(1983).
Induction of rat hepatic microsomal cytochrome P-450 by 2,3',4,4',5,5'-hexachlorobiphenyl. Biochemical Pharmacology.
32(14), 2269-2279.
-
Parkinson, A., Safe, S. H., Robertson, L. W., Thomas, P. E., Ryan, D. E., Reik, L. M., & Levin, W.
(1983).
Immunochemical quantitation of cytochrome P-450 isozymes and epoxide hydrolase in liver microsomes from polychlorinated or polybrominated biphenyl-treated rats. A study of structure-activity relationships. Journal of Biological Chemistry.
258(9), 5967-5976.
-
Campbell, M. A., Bandiera, S., Robertson, L., Parkinson, A., & Safe, S.
(1983).
Hepta-, hexa-, tetra- and dichloronaphthalene congeners as inducers of hepatic microsomal drug-metabolizing enzymes. Toxicology.
26(3-4), 193-205.
-
ROBERTSON, L. W., CHITTIM, B., SAFE, S. H., MULLIN, M. D., & POCHINI, C. M.
(1983).
PHOTO-DECOMPOSITION OF A COMMERCIAL POLYBROMINATED BIPHENYL FIRE RETARDANT - HIGH-RESOLUTION GAS-CHROMATOGRAPHIC ANALYSIS. Journal of Agricultural and Food Chemistry.
31(2), 454-457.
-
ROBERTSON, L. W., MULLIN, M. D., PARKINSON, A., & SAFE, S.
(1983).
IDENTIFICATION AND ASSESSMENT OF POLYBROMINATED BIPHENYL (PBB) CONGENERS PRESENT IN THE COMMERCIAL FIRE RETARDANT, FIREMASTER BP-6. JOURNAL OF THE AMERICAN COLLEGE OF TOXICOLOGY.
2(2), 240-240.
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BANDIERA, S., SAFE, S., & FUJITA, T.
(1983).
LIGAND-BINDING TO THE TCDD RECEPTOR - QUANTITATIVE STRUCTURE-ACTIVITY CORRELATIONS. Proceedings / Annual Meeting of the American Association for Cancer Research [and] Annual Meeting of the American Society of Clinical Oncology. American Association for Cancer Research. Meeting.
24(MAR), 75-75.
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SAFE, S. H.
(1983).
THE HANDBOOK OF ENVIRONMENTAL CHEMISTRY, VOL 1, PT A, VOL 2, PT A, VOL 3, PT A - HUTZINGER,O. Journal of the American Chemical Society.
105(15), 5172-5172.
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SAFE, S.
(1983).
2,3,7,8-TCDD - BIOCHEMICAL EFFECTS. Chemosphere.
12(4-5), 447-451.
-
SAWYER, T., BANDIERA, S., SAFE, S., HUTZINGER, O., & OLIE, K.
(1983).
BIOANALYSIS OF POLYCHLORINATED DIBENZOFURAN AND DIBENZO-P-DIOXIN MIXTURES IN FLY-ASH. Chemosphere.
12(4-5), 529-535.
-
Campbell, M. A., Gyorkos, J., Leece, B., Homonko, K., & Safe, S.
(1983).
The effects of twenty-two organochlorine pesticides as inducers of the hepatic drug-metabolizing enzymes. General pharmacology.
14(4), 445-454.
-
Robertson, L. W., Andres, J. L., Safe, S. H., & Lovering, S. L.
(1983).
Toxicity of 3,3',4,4'- and 2,2',5,5'-tetrabromobiphenyl: correlation of activity with aryl hydrocarbon hydroxylase induction and lack of protection by antioxidants. Journal of Toxicology and Environmental Health.
11(1), 81-91.
-
Parkinson, A., Robertson, L. W., & Safe, S.
(1982).
Binding of metyrapone to dithionite-reduced cytochrome P-450 from rats treated with xenobiotics. Biochemical Pharmacology.
31(21), 3489-3494.
-
Robertson, L. W., Parkinson, A., Campbell, M. A., & Safe, S.
(1982).
Polybrominated biphenyls as aryl hydrocarbon hydroxylase inducers: structure-activity correlations. CHEMICO-BIOLOGICAL INTERACTIONS.
42(1), 53-66.
-
Parkinson, A., Robertson, L., Uhlig, L., Campbell, M. A., & Safe, S.
(1982).
2,3,4,4'-Pentachlorobiphenyl: differential effects on C57BL/6J and DBA/2J inbred mice. Biochemical Pharmacology.
31(17), 2830-2833.
-
Sawyer, T., & Safe, S.
(1982).
PCB isomers and congeners: induction of aryl hydrocarbon hydroxylase and ethoxyresorufin O-deethylase enzyme activities in rat hepatoma cells. Toxicology Letters.
13(1-2), 87-93.
-
Bandiera, S., Sawyer, T., Campbell, M. A., Robertson, L., & Safe, S.
(1982).
Halogenated biphenyls as AHH inducers: effects of different halogen substituents. LIFE SCIENCES.
31(6), 517-525.
-
Safe, S., Robertson, L. W., Safe, L., Parkinson, A., Bandiera, S., Sawyer, T., & Campbell, M. A.
(1982).
Halogenated biphenyls: molecular toxicology. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY.
60(7), 1057-1064.
-
Parkinson, A., & Safe, S.
(1982).
Cytochrome P-450-mediated metabolism of biphenyl and the 4-halobiphenyls. Biochemical Pharmacology.
31(10), 1849-1856.
-
Safe, S.
(1982).
Halogenated hydrocarbons and aryl hydrocarbons identified in human tissues. Toxicological and Environmental Chemistry.
5(2), 153-165.
-
Bandiera, S., Safe, S., & Okey, A. B.
(1982).
Binding of polychlorinated biphenyls classified as either phenobarbitone-, 3-methylcholanthrene- or mixed-type inducers to cytosolic Ah receptor. CHEMICO-BIOLOGICAL INTERACTIONS.
39(3), 259-277.
-
ROBERTSON, L. W., PARKINSON, A., & SAFE, S.
(1982).
EFFECTS OF STRUCTURE ON THE ACTIVITY OF POLYBROMINATED BIPHENYLS (PBB) AS MICROSOMAL-ENZYME INDUCERS. JAOCS.
59(4), A286-A286.
-
SAFE, S., SAFE, L., ROBERTSON, L., PARKINSON, A., GYORKOS, J., CAMPBELL, M. A., & BANDIERA, S.
(1982).
HALOGENATED HYDROCARBONS IN HUMAN-TISSUE - BIOLOGIC AND TOXIC EFFECTS. JAOCS.
59(4), A286-A286.
-
PARKINSON, A., THOMAS, P. E., RYAN, D. E., REIK, L. M., SAFE, S., ROBERTSON, L. W., SPARLING, J., & LEVIN, W.
(1982).
TIME COURSE OF INDUCTION BY AROCLOR 1254 OF THREE FORMS OF CYTOCHROME-P-450 AND EPOXIDE HYDROLASE (EH) IN RAT-LIVER MICROSOMES. FEDERATION PROCEEDINGS.
41(4), 1299-1299.
-
Parkinson, A., Robertson, L. W., & Safe, S.
(1981).
Further characterization and applications of the 4-chlorobiphenyl hydroxylase assay. Advances in Experimental Medicine and Biology.
136 Pt A, 753-759.
-
Parkinson, A., & Safe, S.
(1981).
The cytochrome P-450-mediated metabolism of biphenyl and the 4-halobiphenyls. Advances in Experimental Medicine and Biology.
136 Pt A, 745-752.
-
Wong, A. K., & Safe, S.
(1981).
Effects of Aroclor 1254-induced rat liver S-9 fraction on benzo[a]pyrene-mediated DNA damage and benzo[a]pyrene metabolism in cultured human skin fibroblasts. Research communications in chemical pathology and pharmacology.
33(1), 129-143.
-
Parkinson, A., & Safe, S.
(1981).
Aryl hydrocarbon hydroxylase induction and its relationship to the toxicity of halogenated aryl hydrocarbons. Toxicological and Environmental Chemistry.
4(1-2), 1-46.
-
Mullin, M., Sawka, G., Safe, L., McCrindle, S., & Safe, S.
(1981).
Synthesis of the Octa- and nonachlorobiphenyl isomers and congeners and their quantitation in commercial polychlorinated biphenyls and identification in human breast milk. Journal of Analytical Toxicology.
5(3), 138-142.
-
Parkinson, A., Robertson, L. W., Safe, L., & Safe, S.
(1981).
Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: effects of di-ortho substitution. CHEMICO-BIOLOGICAL INTERACTIONS.
35(1), 1-12.
-
Robertson, L. W., Parkinson, A., Bandiera, S., & Safe, S.
(1981).
Potent induction of rat liver microsomal, drug-metabolizing enzymes by 2,3,3',4,4',5-hexabromobiphenyl, a component of fireMaster. CHEMICO-BIOLOGICAL INTERACTIONS.
35(1), 13-24.
-
Robertson, L., Parkinson, A., & Safe, S.
(1981).
Induction of drug-metabolizing enzymes by fractionated commercial polybrominated biphenyls (PBBs). TOXICOLOGY AND APPLIED PHARMACOLOGY.
57(2), 254-262.
-
Safe, S., Robertson, L., Safe, L., Parkinson, A., Campbell, M. A., Sawyer, T., & Bandiera, S.
(1981).
POLYCHLORINATED BIPHENYLS (PCBs) AS INDUCERS OF THE HEPATIC MICROSOMAL DRUG-METABOLIZING ENZYMES - EFFECTS OF STRUCTURE ON ACTIVITY. Drug Metabolism and Drug Interactions.
3(4), 255-270.
-
Robertson, L. W., Parkinson, A., Chittim, B., Bandiera, S., Sawyer, T. W., & Safe, S.
(1981).
Aryl hydrocarbon hydroxylase (AHH) induction by polybrominated biphenyls (PBBs): enchancement by photolysis. Toxicology.
22(2), 103-114.
-
Clegg, S., Safe, S., & Crocker, J. F.
(1981).
Identification of a toxic impurity in commercial diphenylamine. Journal of Environmental Science and Health Part B: Pesticides, Food Contaminants, and Agricultural Wastes.
16(2), 125-130.
-
Campbell, M. A., Bandiera, S., Robertson, L., Parkinson, A., & Safe, S.
(1981).
Octachloronaphthalene induction of hepatic microsomal aryl hydrocarbon hydroxylase activity in the immature male rat. Toxicology.
22(2), 123-132.
-
HUTZINGER, O., OLIE, K., LUSTENHOUWER, J., OKEY, A. B., BANDIERA, S., & SAFE, S.
(1981).
POLYCHLORINATED DIBENZO-P-DIOXINS AND DIBENZOFURANS - A BIOANALYTICAL APPROACH. Chemosphere.
10(1), 19-25.
-
Cockerline, R., Shilling, M., & Safe, S.
(1981).
Polychlorinated naphthalenes as hepatic microsomal enzyme inducers in the immature male rat. General pharmacology.
12(2), 83-87.
-
Parkinson, A., Robertson, L. W., & Safe, S.
(1980).
Hepatic microsomal enzyme induction by 2,2', 3,3', 4,4'- and 2,2', 3', 4,4', 5-hexachlorobiphenyl. LIFE SCIENCES.
27(24), 2333-2337.
-
Sparling, J., & Safe, S.
(1980).
The effects of ortho chloro substituents on the retention of PCB isomers in rat, rabbit, Japanese quail, guinea pig and trout. Toxicology Letters.
7(1), 23-28.
-
Parkinson, A., Robertson, L. W., & Safe, S.
(1980).
Reconstituted human breast milk PCBs as potent inducers of aryl hydrocarbon hydroxylase. Biochemical and Biophysical Research Communications.
96(2), 882-889.
-
Purdy, R., & Safe, S.
(1980).
The in vitro metabolism of 2,2',4,4',5,5'-hexabromobiphenyl. Journal of environmental pathology and toxicology.
4(1), 277-284.
-
Parkinson, A., Robertson, L., Safe, L., & Safe, S.
(1980).
Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: structure-activity rules. CHEMICO-BIOLOGICAL INTERACTIONS.
30(3), 271-285.
-
Parkinson, A., Copp, L., & Safe, S.
(1980).
The utility of the microsomal 4-chlorobiphenyl hydroxylase enzyme assay in distinguishing between phenobarbitone- and 3-methylcholanthrene-induced microsomal monooxygenases. Analytical Biochemistry.
105(1), 65-73.
-
Tulp, M. T., Safe, S. H., & Boyd, R. K.
(1980).
Fragmentation pathways in electron impact mass spectra of methoxyhalobiphenyls. Biomedical mass spectrometry.
7(3), 109-114.
-
Parkinson, A., Cockerline, R., & Safe, S.
(1980).
Polychlorinated biphenyl isomers and congeners as inducers of both 3-methylcholanthrene- and phenobarbitone-type microsomal enzyme activity. CHEMICO-BIOLOGICAL INTERACTIONS.
29(3), 277-289.
-
Parkinson, A., Cockerline, R., & Safe, S.
(1980).
Induction of both 3-methylcholanthrene- and phenobarbitone-type microsomal enzyme activity by a single polychlorinated biphenyl isomer. Biochemical Pharmacology.
29(2), 259-262.
-
SAFE, S., PARKINSON, A., ROBERTSON, L., COCKERLINE, R., & SAFE, L.
(1980).
PCBS AS MICROSOMAL-ENZYME INDUCERS - STRUCTURE-ACTIVITY RULES. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
180(AUG), 150-ENVR.
-
SAFE, S., COCKERLINE, R., PARKINSON, A., & ROBERTSON, L.
(1980).
POLYBROMINATED BIPHENYLS, POLYCHLORINATED NAPHTHALENES AND POLYCHLORINATED TERPHENYLS AS MICROSOMAL-ENZYME INDUCERS. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
180(AUG), 154-ENVR.
-
Sparling, J., Fung, D., & Safe, S.
(1980).
Bromo and chlorobiphenyl metabolism: gas chromatography mass spectrometric identification of urinary metabolites and the effects of structure on their rates of excretion. Biomedical mass spectrometry.
7(1), 13-19.
-
Robertson, L. W., Parkinson, A., & Safe, S.
(1980).
Induction of both cytochromes P-450 and P-448 by 2,3',4,4',5-pentabromobiphenyl, a component of fireMaster. Biochemical and Biophysical Research Communications.
92(1), 175-182.
-
SPARLING, J., & SAFE, S.
(1980).
THE EFFECTS OF THE DEGREE OF ORTHO CHLORO SUBSTITUTION ON THE PHARMACOKINETICS OF 5 HEXACHLOROBIPHENYLS IN THE RAT. Chemosphere.
9(3), 129-137.
-
Parkinson, A., & Safe, S.
(1979).
The detection of enzyme induction by rat liver microsomes prepared by isoelectric precipitation. Journal of Pharmacy and Pharmacology.
31(7), 444-447.
-
Wong, A., Basrur, P., & Safe, S.
(1979).
The metabolically mediated DNA damage and subsequent DNA repair by 4-chlorobiphenyl in Chinese hamster ovary cells. Research communications in chemical pathology and pharmacology.
24(3), 543-550.
-
Ecobichon, D. J., Hansell, M. M., & Safe, S.
(1979).
Isomerically pure bromobiphenyl congeners and hepatic mono-oxygenase activities in the rat: influence of position and degree of bromination. TOXICOLOGY AND APPLIED PHARMACOLOGY.
47(2), 341-352.
-
Jones, D. H., Kohli, J., & Safe, S.
(1979).
Avian metabolism of halogenated biphenyls. Xenobiotica: the fate of foreign compounds in biological systems.
9(12), 733-736.
-
SAFE, S., & WYNDHAM, C.
(1979).
COMPARATIVE METABOLISM OF HALOGENATED BIPHENYLS. TOXICOLOGY AND APPLIED PHARMACOLOGY.
48(1), A181-A181.
-
PARKINSON, A., & SAFE, S.
(1979).
DETECTION OF ENZYME-INDUCTION BY RAT-LIVER MICROSOMES PREPARED BY ISOELECTRIC PRECIPITATION. Journal of Pharmacy and Pharmacology.
31(7), 444-447.
-
Crawford, A., & Safe, S.
(1979).
4-chlorobiphenyl metabolism: the effects of chemical inducers. General pharmacology.
10(3), 227-231.
-
SHUSHAN, B., SAFE, S. H., & BOYD, R. K.
(1979).
MASS-SPECTROMETRY OF POLYCYCLIC AROMATIC-HYDROCARBONS BY LINKED-SCAN STUDIES OF METASTABLE IONS. Analytical Chemistry.
51(1), 156-158.
-
Crocker, J., Lee, S., & Safe, S. H.
(1979).
Pesticide emulsifier actions on the cell to change viral replication. Annals (Royal College of Physicians and Surgeons of Canada).
12(1), No.-134.
-
Safe, S., & Wyndham, C.
(1979).
The comparative metabolism of halogenated biphenyls. TOXICOLOGY AND APPLIED PHARMACOLOGY.
48(1 II),
-
BUNCE, N. J., KUMAR, Y., RAVANAL, L., & SAFE, S.
(1978).
PHOTOCHEMISTRY OF CHLORINATED BIPHENYLS IN ISO-OCTANE SOLUTION. 0(9), 880-884.
-
Wyndham, C., & Safe, S.
(1978).
A comparison of the in vitro metabolism of biphenyl and 4-chlorobiphenyl by rat liver microsomes. Canadian journal of biochemistry.
56(10), 993-997.
-
CHITTIM, B., SAFE, S., BUNCE, N. J., RUZO, L. O., OLIE, K., & HUTZINGER, O.
(1978).
PHOTOLYSIS OF CHLORINATED PARA-TERPHENYLS. Canadian Journal of Chemistry.
56(9), 1253-1260.
-
Safe, S., Kohli, J., & Crawford, A.
(1978).
FireMaster BP-6: fractionation, metabolic and enzyme induction studies. Environmental Health Perspectives.
23(APR), 147-152.
-
Rozee, K. R., Lee, S. H., Crocker, J. F., & Safe, S. H.
(1978).
Enhanced virus replication in mammalian cells exposed to commercial emulsifiers. Applied and Environmental Microbiology.
35(2), 297-300.
-
Wyndham, C., & Safe, S.
(1978).
In vitro metabolism of 4-chlorobiphenyl by control and induced rat liver microsomes. Biochemistry.
17(2), 208-215.
-
Kohli, J., Wyndham, C., Smylie, M., & Safe, S.
(1978).
Metabolism of bromobiphenyls. Biochemical Pharmacology.
27(8), 1245-1249.
-
LEE, S., ROZEE, K. R., SAFE, S. H., & CROCKER, J.
(1978).
PROPERTIES OF EMULSIFIERS THAT ENHANCE REPLICATION OF VIRUSES IN CELL-CULTURES. Chemosphere.
7(7), 573-589.
-
RAHMAN, R., SAFE, S., & TAYLOR, A.
(1978).
SPORIDESMINS .17. ISOLATION OF SPORIDESMIN-H AND SPORIDESMIN-J. Journal of the Chemical Society. Perkin transactions 1.
0(12), 1476-1479.
-
SPARLING, J., CHITTIM, B., CLEGG, B. S., SAFE, S., & CROCKER, J.
(1978).
TISSUE DISTRIBUTION AND CLEARANCE OF AEROTEX 3470, AN AROMATIC HYDROCARBON SOLVENT. Chemosphere.
7(7), 607-614.
-
CROCKER, J., DIGOUT, S., BAGNELL, P., LEE, S., ROZEE, K., & SAFE, S.
(1978).
VIRAL INTERACTION WITH PESTICIDE EMULSIFIERS INVIVO. Chemosphere.
7(7), 597-606.
-
Ecobichon, D. J., Hansell, M. M., & Safe, S.
(1977).
Halogen substituents at the 4- and 4'-positions of biphenyl: influence on hepatic function in the rat. TOXICOLOGY AND APPLIED PHARMACOLOGY.
42(2), 359-366.
-
Crawford, A., & Safe, S.
(1977).
An assessment of the effects of enzyme inducers on aryl hydrocarbon hydroxylase activity. Research communications in chemical pathology and pharmacology.
18(1), 59-66.
-
Subden, R. E., Safe, L., Morris, D. C., Brown, R. G., & Safe, S.
(1977).
Eburicol, lichesterol, ergosterol, and obtusifoliol from polyene antibiotic-resistant mutants of Candida albicans. Canadian Journal of Microbiology.
23(6), 751-754.
-
CROCKER, J. F., OZERE, R. L., LEE, S. H., DIGOUT, S. C., ROZEE, K. R., HUTZINGER, O., & SAFE, S. H.
(1977).
LETHAL VIRUS-EMULSIFIER-SOLVENT INTERACTION - INVIVO AND INVITRO STUDIES. Pediatric Research.
11(4), 498-498.
-
Safe, L. M., Safe, S. H., Subden, R. E., & Morris, D. C.
(1977).
Sterol content and polyene antibiotic resistance in isolates of Candida krusei, Candida parakrusei, and Candida tropicalis. Canadian Journal of Microbiology.
23(4), 398-401.
-
Chittim, B., Safe, S., Ruzo, L. O., Hutzinger, O., & Zitko, V.
(1977).
Synthesis and spectroscopic and gas chromatographic behavior of isomeric chlorinated terphenyls. Journal of Agricultural and Food Chemistry.
25(2), 323-326.
-
Safe, S., Hutzinger, O., Crocker, J. F., & Digout, S. C.
(1977).
Identification of toxic impurities in commercial diphenylamine. BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY.
17(2), 204-207.
-
SAFE, S., PLUGGE, H., & CROCKER, J.
(1977).
ANALYSIS OF AN AROMATIC SOLVENT USED IN A FOREST SPRAY PROGRAM. Chemosphere.
6(10), 641-651.
-
Sundstrm, G., Olie, K., Hutzinger, O., Safe, S., & Chittim, B.
(1977).
Composition and photochemistry of Iralec. Chemosphere.
6(2-3), 103-107.
-
ECOBICHON, D. J., HANSELL, M. M., & SAFE, S.
(1977).
HALOGEN SUBSTITUENTS AT 4-POSITION AND 4'-POSITION OF BIPHENYL - INFLUENCE ON HEPATIC FUNCTION IN RAT. TOXICOLOGY AND APPLIED PHARMACOLOGY.
41(1), 220-220.
-
RUZO, L. O., SUNDSTROM, G., HUTZINGER, O., & SAFE, S.
(1977).
HEAVY-ATOM EFFECTS IN PHOTOREACTIONS OF HALOGENATED AROMATIC-COMPOUNDS. Recueil des Travaux Chimiques des Pays-Bas.
96(10), 249-251.
-
CHITTIM, B., & SAFE, S.
(1977).
PHOTODECOMPOSITION OF 2,5-DICHLORO-P-TERPHENYL, 2,4,6-TRICHLORO-P-TERPHENYL AND 2,5-DICHLORO-O-TERPHENYL IN SOLUTION. Chemosphere.
6(5), 269-277.
-
PLUGGE, H., & SAFE, S.
(1977).
VINYLCHLORIDE METABOLISM - REVIEW. Chemosphere.
6(6), 309-325.
-
BEDFORD, C. T., BHATTACHARJEE, D., FAIRBROTHER, J., JONES, E., SAFE, S., & THALLER, V.
(1976).
NATURAL ACETYLENES .49. POLYACETYLENES FROM DAHLIA-SCAPIGERA (A DIETR) LINK AND OTTO VAR SCAPIGERA-F-SCAPIGERA AND SOME DAHLIA HYBRIDS. 0(7), 735-741.
-
Wyndham, C., Devenish, J., & Safe, S.
(1976).
The in vitro metabolism, macromolecular binding and bacterial mutagenicity of 4-chloribiphenyl, a model PCB substrate. Research communications in chemical pathology and pharmacology.
15(3), 563-570.
-
Safe, S., Jones, D., Kohli, J., Ruzo, L. O., Hutzinger, O., & Sundstrom, G.
(1976).
The metabolism of chlorinated aromatic pollutants by the frog. Canadian Journal of Zoology.
54(11), 1818-1823.
-
Safe, S., & Caldwell, J.
(1976).
In vitro binding of sterols by extracts from Mucor rouxii cells grown under different environmental conditions. Canadian Journal of Microbiology.
22(8), 1163-1168.
-
Ruzo, L. O., Jones, D., & Platonow, N.
(1976).
Uptake and distribution of chloronaphthalenes and their metabolites in pigs. 16(2), 233-239.
-
Sundstrm, G., Hutzinger, O., Safe, S., & Zitko, V.
(1976).
The synthesis and gas chromatographic properties of bromobiphenyls. Science of the Total Environment.
6(1), 15-29.
-
BEDFORD, C. T., BHATTACHARJEE, D., FAIRBROTHER, J., JONES, E., SAFE, S., & THALLER, V.
(1976).
ChemInform Abstract: NATURAL ACETYLENES. PART XLIX. POLYACETYLENES FROM DAHLIA SCAPIGERA (A. DIETR.) LINK AND OTTO VAR. SCAPIGERA F. SCAPIGERA AND SOME DAHLIA HYBRIDS. 7(25), no-no.
-
Crocker, J. F., Ozere, R. L., Safe, S. H., Digout, S. C., Rozee, K. R., & Hutzinger, O.
(1976).
Lethal interaction of ubiquitous insecticide carriers with virus. Science.
192(4246), 1351-1353.
-
Ruzo, L., Jones, D., Safe, S., & Hutzinger, O.
(1976).
Metabolism of chlorinated naphthalenes. Journal of Agricultural and Food Chemistry.
24(3), 581-583.
-
Ruzo, L. O., Sundstrm, G., Hutzinger, O., & Safe, S.
(1976).
Photodegradation of polybromobiphenyls (PBB). Journal of Agricultural and Food Chemistry.
24(5), 1062-1065.
-
SAFE, S., & SAFE, L. M.
(1976).
ChemInform Abstract: ISOLATION AND SYNTHESIS OF E24ETHYLIDENE5LANOST8EN3YL ACETATE. 7(10), no-no.
-
Ruzo, L. O., Safe, S., & Hutzinger, O.
(1976).
Metabolism of bromobenzenes in the rabbit. Journal of Agricultural and Food Chemistry.
24(2), 291-293.
-
Kohli, J., Jones, D., & Safe, S.
(1976).
The metabolism of higher chlorinated benzene isomers. Canadian journal of biochemistry.
54(3), 203-208.
-
Rogers, A., Mellors, A., & Safe, S.
(1976).
Lysosomal membrane labilization by DDT, DDE and polychlorinated biphenyls (PCB). Research communications in chemical pathology and pharmacology.
13(2), 341-343.
-
SUNDSTROM, G., HUTZINGER, O., SAFE, S., & PLATONOW, N. S.
(1976).
METABOLISM OF P,P'-ISOMERS OF DDT COMPOUNDS IN PIG. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
172(SEP3), 86-86.
-
CROCKER, J. F., SAFE, S., & HUTZINGER, O.
(1976).
ORIGIN OF CYSTS IN RENAL TUBULE. Pediatric Research.
10(4), 438-438.
-
Ruzo, L. O., Sundstrm, G., Hutzinger, O., & Safe, S.
(1976).
Environmental chemistry of PCB - replacement compounds II. Photochemical properties of alkylchlorobiphenyls. Chemosphere.
5(2), 71-76.
-
Hutzinger, O., Sundstrm, G., & Safe, S.
(1976).
Environmental chemistry of flame retardants part I. Introduction and principles. Chemosphere.
5(1), 3-10.
-
RENAUD, R., SAFE, S., & SUBDEN, R.
(1976).
FREE AND BOUND LIPIDS OF NEUROSPORA-CRASSA. Phytochemistry: the international journal of plant chemistry, plant biochemistry and molecular biology.
15(6), 977-979.
-
Sundstrm, G., Hutzinger, O., & Safe, S.
(1976).
Identification of 2,2,4,4,5,5-hexabromobiphenyl as the major component of flame retardant fireMaster BP-6. Chemosphere.
5(1), 11-14.
-
Safe, S., Jones, D., & Hutzinger, O.
(1976).
Metabolism of 4,4'-dihalogenobiphenyls. Journal of the Chemical Society. Perkin transactions 1.
0(4), 357-359.
-
Ruzo, L. O., Sundstrom, G., Safe, S., & Hutzinger, O.
(1976).
Photochemical reactions of environmentally toxic substances (Dutch). Chemisch Weekblad.
72(Aug.), 420-423.
-
Safe, S., Ellis, B. E., & Hutzinger, O.
(1976).
The in vitro hydroxylation of 4'-chloro-4-biphenylol by a mushroom tyrosinase preparation. Canadian Journal of Microbiology.
22(1), 104-106.
-
Sundstrm, G., Hutzinger, O., & Safe, S.
(1976).
The metabolism of 2,2,4,45,5-hexachlorobiphenyl by rabbits, rats and mice. Chemosphere.
5(4), 249-253.
-
Kohli, J., & Safe, S.
(1976).
The metabolism of brominated aromatic compounds. Chemosphere.
5(6), 433-437.
-
Sundstrm, G., Hutzinger, O., & Safe, S.
(1976).
The metabolism of chlorobiphenyls A review. Chemosphere.
5(5), 267-298.
-
MacNeil, J. D., Safe, S., & Hutzinger, O.
(1976).
The ultraviolet absorption spectra of some chlorinated biphenyls. BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY.
15(1), 66-77.
-
Jones, D. H., Platonow, N. S., & Safe, S.
(1975).
Contamination of agricultural products by halogenated biphenyls. Canadian Veterinary Journal.
16(12), 349-356.
-
Maass, W. S., & Hutzinger, O.
(1975).
Metabolism of 4-chlorobiphenyl by lichens. Archives of Environmental Contamination and Toxicology.
3(4), 470-478.
-
BUNCE, N. J., SAFE, S., & OCTAVIORUZO, L.
(1975).
PHOTOCHEMISTRY OF BROMOBIPHENYLS - STERIC EFFECTS AND ELECTRON-TRANSFER. Journal of the Chemical Society. Perkin transactions 1.
0(16), 1607-1610.
-
BUNCE, N. J., SAFE, S., & RUZO, L. O.
(1975).
ChemInform Abstract: PHOTOCHEMISTRY OF BROMOBIPHENYLS, STERIC EFFECTS AND ELECTRON TRANSFER. 6(47), no-no.
-
SAFE, S., & SAFE, L. M.
(1975).
ISOLATION AND SYNTHESIS OF E-24-ETHYLIDENE-5ALPHA-LANOST-8-EN-3BETA-YL ACETATE. Canadian Journal of Chemistry.
53(21), 3247-3249.
-
Ruzo, L. O., Bunce, N. J., & Safe, S.
(1975).
Photodegradation of polychloronaphthalenes in methanol solution. BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY.
14(3), 341-345.
-
SAFE, S., PLATONOW, N., HUTZINGER, O., & JAMIESON, W. D.
(1975).
ANALYSIS OF ORGANOCHLORINE METABOLITES IN CRUDE EXTRACTS BY HIGH-RESOLUTION PHOTOPLATE MASS-SPECTROMETRY. Biomedical mass spectrometry.
2(4), 201-203.
-
SAFE, S., SAFE, L. M., & MAASS, W.
(1975).
STEROLS OF THREE LICHEN SPECIES - LOBARIA-PULMONARIA, LOBARIA-SCROBICULATA AND USNEA-LONGISSIMA. Phytochemistry: the international journal of plant chemistry, plant biochemistry and molecular biology.
14(8), 1821-1823.
-
Safe, S., & Ruzo, L. O.
(1975).
The metabolism of 4-chlorobiphenyl in the pig. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY.
53(3), 392-396.
-
Ruzo, L. O., Safe, S., & Zabik, M. J.
(1975).
Photodecomposition of unsymmetrical polychlorobisphenyls. Journal of Agricultural and Food Chemistry.
23(3), 594-595.
-
Safe, S., Hutzinger, O., Ecobichon, D. J., & Grey, A. A.
(1975).
The metabolism of 4'chloro-4-biphenylol in the rat. Canadian journal of biochemistry.
53(4), 415-420.
-
Safe, S., Platonow, N., & Hutzinger, O.
(1975).
Metabolism of chlorobiphenyls in the goat and cow. Journal of Agricultural and Food Chemistry.
23(2), 259-261.
-
RUZO, L. O., BUNCE, N. J., & SAFE, S.
(1975).
PHOTOREACTIONS OF SIMPLE HALONAPHTHALENES IN SOLUTION. Canadian Journal of Chemistry.
53(5), 688-693.
-
SAFE, S., JAMIESON, W. D., HUTZINGER, O., & POHLAND, A. E.
(1975).
MASS AND ION KINETIC-ENERGY SPECTRA OF SOME CHLORINATED DIBENZO-PARA-DIOXINS. Analytical Chemistry.
47(2), 327-329.
-
Ruzo, L. O., Safe, S., Hutzinger, O., Platonow, N., & Jones, D.
(1975).
Hydroxylated metabolites of chloronaphthalenes (Halowax 1031) in pig urine. Chemosphere.
4(3), 121-123.
-
Safe, S., Hutzinger, O., & Jones, D.
(1975).
The mechanism of chlorobiphenyl metabolism. Journal of Agricultural and Food Chemistry.
23(5), 851-853.
-
CROCKER, J. F., OZERE, R. L., SAFE, S. H., DIGOUT, S. C., ROZEE, K. R., & HUTZINGER, O.
(1975).
LETHAL INTERACTION OF INSECTICIDE CARRIERS WITH VIRUS. Clinical research.
23(5), A633-A633.
-
Sundstrom, G., Safe, S., & Hutzinger, O.
(1975).
Polychlorinated biphenyls as a classic case of environmental pollution (Dutch). Chemisch Weekblad.
71(27), 9-11.
-
Safe, S., & Caldwell, J.
(1975).
The effect of growth environment on the chloroform-methanol and alkali-extractable cell wall and cytoplasm lipid levels of Mucor rouxii. Canadian Journal of Microbiology.
21(1), 79-84.
-
Morris, D. C., Safe, S., & Subden, R. E.
(1974).
Detection of the ergosterol and episterol isomers lichesterol and fecosterol in nystatin-resistant mutants of Neurospora crassa. Biochemical Genetics.
12(6), 459-466.
-
Przybylska, M., Gopalakrishna, E. M., Taylor, A., & Safe, S.
(1974).
Erratum: X-Ray crystallographic determination of the stereochemistry of the tetrathio-bridge in sporidesmin G (J.C.S. Chem. Comm. (1973), (554)). Journal of the Chemical Society, Chemical Communications.
-
Hutzinger, O., Jamieson, W. D., Safe, S., Paulmann, L., & Ammon, R.
(1974).
Identification of metabolic dechlorination of highly chlorinated biphenyl in rabbit. Nature.
252(5485), 698-699.
-
Safe, S.
(1974).
Lipid and alkali extractable fatty acids from Mucor rouxii: effect of thermal changes in growth environment and age of cells. Lipids.
9(12), 952-956.
-
Hutzinger, O., Heacock, R. A., & Safe, S.
(1974).
Chlorobiphenylols. Thin-layer chromatography and colour reactions of some hydroxylated chlorobiphenyls. Journal of Chromatography A.
97(2), 233-247.
-
Hutzinger, O., Safe, S., & Zitko, V.
(1974).
Preparation, gas chromatographic behavior, and spectroscopic properties of hydroxylated chlorobiphenyls. Journal - Association of Official Analytical Chemists.
57(5), 1061-1067.
-
Safe, S., Hutzinger, O., & Ecobichon, D.
(1974).
Identification of 4-chloro-4'-hydroxybiphenyl and 4,4'-dichloro-3-hydroxybiphenyl as metabolites of 4-chloro- and 4,4'-dichlorobiphenyl fed to rats. 30(7), 720-721.
-
Safe, S., & Duncan, J.
(1974).
Effect of oxygen levels on the fatty acids and lipids of Mucor rouxii. 9(4), 285-289.
-
Safe, S., Hutzinger, O., Jamieson, W. D., & Cook, M.
(1974).
MASS AND ION KINETIC ENERGY SPECTRA OF THE CHLORINATED ANILINES. 85-91.
-
Hutzinger, O., Safe, S., & Zitko, V.
(1974).
The Chemistry of PCBs. 269 p..
-
Safe, S.
(1973).
Substituent and H/D randomization in the mass spectra of substituted diphenylacetylenic compounds. Organic Mass Spectrometry.
7(12), 1329-1336.
-
Safe, S.
(1973).
The effect of environment on the free and hydrosoluble sterols of Mucor rouxii. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
326(3), 471-475.
-
Wallnfer, P. R., Safe, S., & Hutzinger, O.
(1973).
Microbial demethylation and debutynylation of four phenylurea herbicides. Pesticide Biochemistry and Physiology.
3(3), 253-258.
-
Hutzinger, O., Safe, S., Wentzell, B. R., & Zitko, V.
(1973).
Photochemical degradation of di- and octachlorodibenzofuran. Environmental Health Perspectives.
5, 267-271.
-
Hutzinger, O., Jamieson, W., Safe, S. S., & Zitko, V. Z.
(1973).
Exhaustive Chlorination as a Technique in the Analysis of Aromatic Hydrocarbons. Journal - Association of Official Analytical Chemists.
56(4), 982-986.
-
Safe, S., & Brewer, D.
(1973).
Lipid composition of Chaetomium cochliodes: effect of media. 8(5), 311-314.
-
Wallnfer, P. R., Safe, S., & Hutzinger, O.
(1973).
Microbial hydroxylation of the herbicide N-(3,4-dichlorophenyl)methacrylamide (dicryl). Journal of Agricultural and Food Chemistry.
21(3), 502-504.
-
HUTZINGER, O., NASH, D. M., SAFE, S., DEFREITAS, A., NORSTROM, R. J., WILDISH, D. J., & ZITKO, V.
(1973).
ChemInform Abstract: POLYCHLORIERTE BIPHENYLE, DAS METABOLISCHE VERH. DER REINEN ISOMEREN IN TAUBEN, RATTEN UND BACHFORELLEN. 4(10), no-no.
-
Wallnfer, P. R., Engelhardt, G., Safe, S., & Hutzinger, O.
(1973).
Microbial hydroxylation of 4-chlorobiphenyl and 4,4-dichlorobiphenyl. Chemosphere.
2(2), 69-72.
-
Safe, S., Hutzinger, O., & Jamieson, W. D.
(1973).
The ion kinetic energy spectra of isomeric chlorobenzenes and polychlorinated biphenyls (PCB'S). Organic Mass Spectrometry.
7(2), 169-176.
-
Safe, S., Hutzinger, O., Jamieson, W. D., & Cook, M.
(1973).
The ion kinetic energy spectra of some chlorinated insecticides. Organic Mass Spectrometry.
7(2), 217-224.
-
Ackman, R. G., Safe, L., Hooper, S. N., Paradis, M., & Safe, S.
(1973).
7-Methyl-7-hexadecenoic acid: isolation from lipids of the ocean sunfish Mola mola (Linnaeus) 1758. Lipids.
8(1), 21-24.
-
Prazybylska, M., Gopalakrishna, E. M., Taylor, A., & Safe, S.
(1973).
X -Ray crystallographic determination of the stereochemistry of the tetrathio-bridge in sporidesmin G. Chemical Communications.
0(15), 554-555.
-
Safe, S., & Taylor, A.
(1972).
Sporidesmins. 8. Ovine ill-thrift in Nova Scotia. 3. The characterisation of chetomin a toxic metabolite of Chaetomium cochliodes and Chaetomium globosum. Journal of the Chemical Society. Perkin transactions 1.
4(0), 472-479.
-
Francis, E., Rahman, R., Safe, S., & Taylor, A.
(1972).
Sporidesmins. XII. Isolation and structure of sporidesmin G, a naturally-occuring 3,6-epitetrahiopiperazine-2,5-dione. Journal of the Chemical Society. Perkin transactions 1.
4(0), 470-472.
-
Safe, S., Hutzinger, O., & Cook, M.
(1972).
The ion kinetic energy and mass spectra of the isomeric mono- and di-chloronaphthalenes. Chemical Communications.
0(5), 260-262.
-
Safe, S., & Hutzinger, O.
(1972).
The mass spectra of polychlorinated biphenyls. Journal of the Chemical Society. Perkin transactions 1.
5(0), 686-691.
-
Hutzinger, O., & Zitko, V.
(1972).
Analysis of chlorinated aromatic hydrocarbons by exhaustive chlorination: qualitative and structural aspects of the perchloro-derivatives of biphenyl, naphthalene, terphenyl, dibenzofuran, dibenzodioxin and DDE. International Journal of Environmental Analytical Chemistry.
2(2), 95-106.
-
MacNeil, J. D., Frei, R. W., Safe, S., & Hutzinger, O.
(1972).
Electron-donor-acceptor complexing reagents in the analysis of pesticides. V. The analysis of pesticide decomposition products via electron-donor-acceptor complexes; photolysis of methoxychlor. Journal - Association of Official Analytical Chemists.
55(6), 1270-1275.
-
Hutzinger, O., Nash, D. M., Safe, S., DeFreitas, A. S., Norstrom, R. J., Wildish, D. J., & Zitko, V.
(1972).
Polychlorinated biphenyls: metabolic behavior of pure isomers in pigeons, rats, and brook trout. Science.
178(4058), 312-314.
-
Wallnfer, P. R., Kniger, M., Safe, S., & Hutzinger, O.
(1972).
The Metabolism of the Systemic Fungicide Carboxin (Vitavax) by Rhizopus japonicus. International Journal of Environmental Analytical Chemistry.
2(1), 37-43.
-
Wallnfer, P. R., Safe, S., & Hutzinger, O.
(1972).
Die hydroxylation des herbizids karsil (N-(3,4-Dichlorophenyl)-2-methylpentanamid) durch Rhizopusjaponicus. Chemosphere.
1(4), 155-158.
-
Brewer, D., Duncan, J. M., Safe, S., & Taylor, A.
(1972).
Ovine ill-thrift in Nova Scotia. 4. The survival at low oxygen partial pressure of fungi isolated from the contents of the ovine rumen. Canadian Journal of Microbiology.
18(7), 1119-1128.
-
Brewer, D., Duncan, J. M., Jerram, W. A., Leach, C. K., Safe, S., Taylor, A., ... Christensen, C. M.
(1972).
Ovine ill-thrift in Nova Scotia. 5. The production and toxicology of chetomin, a metabolite of chaetomium spp. Canadian Journal of Microbiology.
18(7), 1129-1137.
-
Hutzinger, O., & Safe, S.
(1972).
A general method for the preparation of tritiated polychlorobiphenyls of high specific activity: 2,2',5,5'-tetrachlorobiphenyl-(3H) and 2,2',4,4',5,5'-hexachlorobiphenyl-(3H). BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY.
7(6), 374-375.
-
Hutzinger, O., Safe, S., & Zitko, V.
(1972).
Photochemical Degradation of Chloro-biphenyls (PCBs). 1, 15-20.
-
Hutzinger, O., Safe, S., & Zitko, V.
(1972).
Photochemical Degradation of Chlorobiphenyls (PCBs). 1, 15-15.
-
Atherton, L., Duncan, J. M., & Safe, S.
(1972).
Isolation and biosynthesis of ergosta-5,7,9(11),22-tetraen-3-ol from Mucor rouxii. Chemical Communications.
0(15), 882-883.
-
Wallnfer, P. R., Kniger, M., Safe, S., & Hutzinger, O.
(1972).
Metabolism of the systemic fungicide 2,5-dimethyl-3-furancarboxylic acid anilide (BAS 3191) by Rhizopus japonicus and related fungi. Journal of Agricultural and Food Chemistry.
20(1), 20-22.
-
Safe, S., Jamieson, W. D., & Hutzinger, O.
(1972).
The ion kinetic energy and mass spectra of isomeric methyl indoles. Organic Mass Spectrometry.
6(1), 33-37.
-
Safe, S.
(1971).
Mass spectra of aromatic and acetylenic compounds. Part VI. The electron impact-induced rearrangements of substituted phenylacetylenes. Journal of the Chemical Society B: Physical Organic.
962-965.
-
Wallnfer, P. R., Safe, S., & Hutzinger, O.
(1971).
Metabolism of the systemic fungicides 2-methylbenzanilide and 2-chlorobenzanilide by Rhizopus japonicus. Pesticide Biochemistry and Physiology.
1(3-4), 458-463.
-
Rahman, R., Safe, S., & Taylor, A.
(1971).
Separation of polythiadioxopiperazine antibiotics by thin-layer chromatography. Journal of Chromatography A.
53(3), 592-594.
-
Hutzinger, O., Jamieson, W. D., & Safe, S.
(1971).
Mass spectra of some fungicidal organomercury compounds. International Journal of Environmental Analytical Chemistry.
1(2), 85-97.
-
Wallnfer, P. R., Kniger, M., Safe, S., & Hutzinger, O.
(1971).
The Metabolism of the Systemic Fungicide Carboxin (Vitavax) by Rhizopus japonicus. International Journal of Environmental Analytical Chemistry.
1(2), 37-43.
-
Safe, S.
(1971).
Electronimpact induced rearrangements of substituted biphenyls. Organic Mass Spectrometry.
5(10), 1221-1226.
-
Safe, S., & Hutzinger, O.
(1971).
Polychlorinated biphenyls: photolysis of 2,4,6,2',4',6'-hexachlorobiphenyl. Nature.
232(5313), 641-642.
-
Safe, S., & Penney, C.
(1971).
Preparation of cis and transd3alkenoic acids. Journal of Labelled Compounds and Radiopharmaceuticals.
7(3), 341-343.
-
Hutzinger, O., Safe, S., & Zitko, V.
(1971).
Polychlorinated biphenyls: synthesis of some individual chlorobiphenyls. BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY.
6(3), 209-219.
-
Zitko, V., Hutzinger, O., & Safe, S.
(1971).
Retention times and electron-capture detector responses of some individual chlorobiphenyls. BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY.
6(2), 160-163.
-
Marchelli, R., Jamieson, W. D., Safe, S. H., Hutzinger, O., & Heacock, R. A.
(1971).
Mass Spectra of the Hydroxyindole-3-carboxylic Acids and the Hydroxyskatoles. Canadian Journal of Chemistry.
49(8), 1296-1300.
-
Safe, S., & Hutzinger, O.
(1971).
Chlorine randomization between phenyl groups in the electron impact-induced fragmentation of polychlorinated biphenyls. Journal of the Chemical Society D: Chemical Communications.
0(9), 446-448.
-
Hutzinger, O., Jamieson, W. D., & Safe, S.
(1971).
Mass spectra of fifteen chlorinated aromatic fungicides. Journal - Association of Official Analytical Chemists.
54(1), 178-186.
-
Safe, S., & Taylor, A.
(1971).
Sporidesmins. Part XI. The reaction of triphenylphosphine with epipolythiodioxopiperazines. 0(0), 1189-1192.
-
Idler, D. R., Safe, L. M., & Safe, S. H.
(1970).
Mass spectrometric studies on methyl ether derivatives of sterols. Steroids.
16(3), 251-262.
-
CHIN, C., CUTLER, M. C., JONES, E., LEE, J., SAFE, S., & THALLER, V.
(1970).
ChemInform Abstract: NATUERLICHE ACETYLENE 31. MITT. C(14)TETRAHYDROPYRANYL UND ANDERE POLYACETYLENE AUS DAHLIA COCCINEA CAV. VAR. COCCINEA. 1(17), no-no.
-
Safe, S.
(1970).
Preparation of iodobenzened5 and diphenylacetylened5. Journal of Labelled Compounds and Radiopharmaceuticals.
6(2), 197-198.
-
Safe, S.
(1970).
Timing of hydrogen randomization in substituted diphenyl acetylenes. Organic Mass Spectrometry.
3(2), 239-240.
-
Chin, C., Cutler, M. C., Jones, E., Lee, J., Safe, S., & Thaller, V.
(1970).
Natural acetylenes. Part XXXI. C 14 -tetrahydropyranyl and other polyacetylenes from the compositae Dahlia coccinea Cav. var. coccinea. 0(2), 314-322.
-
Safe, S., & Taylor, A.
(1970).
Sporidesmins. Part X. Synthesis of polysulphides by reaction of dihydrogen disulphide with disulphides and thiols. 0(3), 432-435.
-
Rahman, R., Safe, S., & Taylor, A.
(1970).
The stereochemistry of polysulphides. Quarterly Reviews Chemical Society.
24(2), 208-237.
-
Safe, S.
(1969).
Hydrogen randomization between phenyl groups in the electron impact-induced fragmentation of substituted diphenylacetylenes. Journal of the Chemical Society D: Chemical Communications.
0(10), 534-535.
-
Safe, S., & Taylor, A.
(1969).
Stereochemistry of the reaction of epipolythiadioxopiperazines with triphenylphosphine. Journal of the Chemical Society D: Chemical Communications.
0(24), 1466b-11467.
-
Rahman, R., Safe, S., & Taylor, A.
(1969).
Sporidesmins. Part IX. Isolation and structure of sporidesmin E. 0(12), 1665-1668.
-
Brewer, D., Rahman, R., Safe, S., & Taylor, A.
(1968).
A new toxic metabolite of Pithomyces chartarum related to the sporidesmins. Chemical Communications.
0(24), 1571-1571.
-
Aplin, R. T., & Safe, S.
(1967).
Electron impact-induced rearrangements of natural polyacetylenes. Chemical Communications.
0(3), 140-142.
-
Jones, E., Safe, S., & Thaller, V.
(1967).
Natural acetylenes. Part XXVI. Transformations of phenyl-polyacetylenes in the tubers of Dahlia hybrids. 0(0), 1038-1041.
-
Aplin, R. T., Durham, L. J., Kanazawa, Y., & Safe, S.
(1967).
2- O -- D -galactopyranosylglycerol from Laurencia pinnatifida. 0(0), 1346-1347.
-
Jones, E., Safe, S., & Thaller, V.
(1966).
Natural acetylenes. Part XXIII. A C 18 polyacetylenic keto-aldehyde related to falcarinone from an Umbellifer ( Pastinaca sativa L.). 0(0), 1220-1221.
-
Safe, S.
Environmental estrogens and cancer. Toxicologic Pathology.
34(7), 981-982.
-
Baek, S. J., Hammock, B. D., Hwang, I., Li, Q., Moustaid-Moussa, N., Park, Y., ... Han, H.
Natural Products in the Prevention of Metabolic Diseases: Lessons Learned from the 20th KAST Frontier Scientists Workshop. Nutrients.
13(6), 1881-1881.
-
Upadhyay, S., Hailemariam, A. E., Mariyam, F., Hafiz, Z., Martin, G., Kothari, J., ... Safe, S.
(2024).
Bis-Indole Derivatives as Dual Nuclear Receptor 4A1 (NR4A1) and NR4A2 Ligands. Biomolecules.
14(3), 284-284.
-
chapter
-
Safe, S.
(2021).
Aryl Hydrocarbon Receptor. Encyclopedia of Molecular Pharmacology.
(pp. 248-254).
Springer Nature.
-
Safe, S., Jin, U. H., & Li, X. i.
(2018).
Chemical-Induced Estrogenicity. VETERINARY TOXICOLOGY: BASIC AND CLINICAL PRINCIPLES, 3RD EDITION.
(pp. 805-816).
Elsevier.
-
Safe, S., Jutooru, I., Jin, U., & Chadalapaka, G.
(2018).
8.22 Estrogenic Endocrine Disruptors: Molecular Characteristics and Human Impacts. Comprehensive Toxicology.
(pp. 450-462).
Elsevier.
-
Safe, S., Jin, U. H., & Li, X. i.
(2018).
Chapter 59 Chemical-Induced Estrogenicity. Veterinary Toxicology.
(pp. 805-816).
Elsevier.
-
Safe, S., Papineni, S., & Chintharlapalli, S.
(2017).
Betulinic Acid. Encyclopedia of Cancer.
(pp. 484-486).
Springer Nature.
-
Safe, S., Lee, S., Meng, C., & Zhou, B.
(2015).
NR4A Orphan Receptors as Drug Targets. Targeted Therapy of Acute Myeloid Leukemia.
(pp. 509-528).
Springer Nature.
-
Safe, S.
(2013).
RNA Interference. Brenner's Encyclopedia of Genetics.
(pp. 288-289).
Elsevier.
-
Safe, S. H., Khan, S., Wu, F., Li, X., & Sreevalsan, S.
(2012).
Chemical-induced estrogenicity. VETERINARY TOXICOLOGY: BASIC AND CLINICAL PRINCIPLES, 2ND EDITION.
(pp. 999-1011).
Elsevier.
-
Safe, S. H., Khan, S., Wu, F., Li, X., & Sreevalsan, S.
(2012).
Chapter 75 Chemical-induced estrogenicity. Veterinary Toxicology.
(pp. 999-1011).
Elsevier.
-
Safe, S., Chadalapaka, G., & Jutooru, I.
(2011).
AHRActive Compounds in the Human Diet. The AH Receptor in Biology and Toxicology.
(pp. 331-342).
Wiley.
-
Safe, S., Walker, K., & Zhang, S.
(2011).
Dioxin as an Environmental Pollutant and Its Role in Breast Cancer. ENVIRONMENT AND BREAST CANCER.
(pp. 127-146).
Springer Nature.
-
Safe, S., Chintharlapalli, S., & Papineni, S.
(2011).
Betulinic Acid. Encyclopedia of Cancer.
(pp. 386-388).
Springer Nature.
-
Safe, S., Jutooru, I., & Chadalapaka, G.
(2010).
Estrogenic Endocrine Disruptors: Molecular Characteristics and Human Impacts. COMPREHENSIVE TOXICOLOGY, VOL 2: CELLULAR AND MOLECULAR TOXICOLOGY, 2ND EDITION.
(pp. 609-621).
Elsevier.
-
Safe, S., Chadalapaka, G., Jutooru, I., Chintharlapalli, S., & Papineni, S.
(2010).
HIGHLIGHTS OF PENTACYCLIC TRITERPENES IN THE CANCER SETTING. PENTACYCLIC TRITERPENES AS PROMISING AGENTS IN CANCER.
(pp. 277-306).
-
Safe, S. H., Khan, S., Wu, F., & Li, X.
(2007).
Chemical-induced estrogenicity. VETERINARY TOXICOLOGY: BASIC AND CLINICAL PRINCIPLES.
(pp. 811-822).
Elsevier.
-
Safe, S. H.
(2004).
2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and related environmental antiestrogens: Characterization and mechanism of action. Endocrine Disruptors: Effects on Male and Female Reproductive Systems, Second Edition.
(pp. 249-287).
-
Safe, S.
(2003).
Estrogen Receptor (ER) Actions through Other Transcription Factor Sites. Encyclopedia of Hormones.
(pp. 591-594).
Elsevier.
-
Safe, S.
(2003).
Toxicology and Risk Assessment of POPs. Handbook of Environmental Chemistry.
Persistent Organic Pollutants.
(pp. 223-235).
Springer Nature.
-
Safe, S. H.
(2002).
Chlorocarbons and Chlorohydrocarbons, Toxic Aromatics. Encyclopedia of Agrochemicals.
Wiley.
-
Safe, S. H., Saville, B., & Stoner, M.
(2002).
SP1 and SP3 Transcription Factors. Wiley Encyclopedia of Molecular Medicine.
Wiley.
-
Kleeff, J., Friess, H., Koliopanos, A., Safe, S., Zimmermann, A., & Bchler, M. W.
(2002).
Der Arylhydrocarbon Rezeptor als neue Zielscheibe zur Behandlung des Pankreaskarzinoms. Chirurgisches Forum 2002.
(pp. 129-131).
Springer Nature.
-
Safe, S.
(2001).
Hydroxylated polychlorinated Biphenyls (PCBs) and Organochlorine Pesticides as Potential Endocrine Disruptors. Handbook of Environmental Chemistry.
Endocrine Disruptors Part I.
(pp. 155-167).
Springer Nature.
-
Gaido, K. W., McDonnell, D. P., & Safe, S.
(2001).
In Vitro Methods for Characterizing Chemical Interactions with Steroid Hormone Receptors. Handbook of Environmental Chemistry.
Endocrine Disruptors Part I.
(pp. 27-38).
Springer Nature.
-
Safe, S.
(1999).
Chapter 52 Toxicity Equivalents and Their Use in Hazard and Risk Assessment. Toxicology.
(pp. 1191-1197).
Elsevier.
-
Safe, S.
(1988).
Polychlorinated Biphenyls Human Health Effects. Hazards, Decontamination, and Replacement of PCB.
(pp. 51-69).
Springer Nature.
-
Parkinson, A., & Safe, S.
(1987).
Mammalian Biologic and Toxic Effects of PCBs. Polychlorinated Biphenyls (PCBs): Mammalian and Environmental Toxicology.
(pp. 49-75).
Springer Nature.
-
Safe, S.
(1987).
PCBs and Human Health. Polychlorinated Biphenyls (PCBs): Mammalian and Environmental Toxicology.
(pp. 133-145).
Springer Nature.
-
Safe, S., Safe, L., & Mullin, M.
(1987).
Polychlorinated Biphenyls: Environmental Occurrence and Analysis. Polychlorinated Biphenyls (PCBs): Mammalian and Environmental Toxicology.
(pp. 1-13).
Springer Nature.
-
Safe, S., & Sparling, J.
(1985).
Other Industrial Pollutants and Natural Toxins. Mass Spectrometry in Environmental Sciences.
(pp. 551-558).
Springer Nature.
-
Safe, S., Robertson, L., Sawyer, T., Parkinson, A., Bandiera, S., Safe, L., & Campbell, M.
(1983).
PCDDs and Related Compounds: Metabolism and Biochemistry. Human and Environmental Risks of Chlorinated Dioxins and Related Compounds.
(pp. 393-403).
Springer Nature.
-
Safe, S., Parkinson, A., Robertson, L., Cockerline, R., Safe, L., Bandiera, S., & Okey, A.
(1982).
PCBs AS AHH INDUCERS. Chlorinated Dioxins & Related Compounds.
(pp. 383-392).
Elsevier.
-
Sundstrom, G., Hutzinger, O., Safe, S., Ruzo, L., & Jones, D. H.
(1975).
Methods for the study of metabolism of toxic and persistent chemicals in aquatic organisms as exemplified by chloronaphthalene. Koeman, J. H., & Strik, J. (Eds.),
Sublethal effects of toxic chemicals on aquatic animals.
(pp. 177-178).
Elsevier Science & Technology.
-
Safe, S.
(2021).
Aryl Hydrocarbon Receptor. Encyclopedia of Molecular Pharmacology.
(pp. 248-254).
Springer Nature.
-
conference paper
-
Mohankumar, K., Karki, K., Safe, S., & Abdelrahim, M.
(2021).
Nuclear receptor 4A1 (NR4A1) antagonists target PD-L1 in colon cancer. Cancer Research.
-
Shrestha, R., Mohankumar, K., Martin, G., & Safe, S.
(2021).
Flavonoids are NR4A1 antagonists and target PAX3-FOXO1 and G9a in alveolar rhabdomyosarcoma cells. Cancer Research.
-
Mohankumar, K., Shrestha, R., & Safe, S.
(2021).
NR4A1 ligands inhibits PSPC1 regulated EMT and stemness markers in breast, lung and liver cancer cells. Cancer Research.
-
Safe, S.
(2019).
Bis-Indoles as receptor ligands and novel anticancer agents. Toxicology Letters.
S14-S15.
-
Choudhary, M., Safe, S. H., & Malek, G.
(2017).
Aryl hydrocarbon receptor (AhR) activation decreases severity of laser-induced choroidal neovascular lesions (CNV). Investigative Ophthalmology and Visual Science.
-
Carcia-Villatoro, E. L., Davidson, L., Callaway, E., Allred, K., Hensel, M., Jayaraman, A., ... Allred, C. D.
(2017).
The Aryl Hydrocarbon Receptor is a repressor of colorectal cancer development induced by high-fat diet in mice. The FASEB Journal.
-
Patel, A. R., Godugu, C., Heather, W. R., Safe, S., & Sachdeva, M. S.
(2013).
Pharmacokinetic and pharmacodynamic evaluation of novel dual channel spray dried enteric coated self-emulsifying capsules for anti-cancer agents in dogs. Cancer Research.
3361-3361.
-
Abdelrahim, M., Safe, S., & Abudayyeh, A.
(2013).
Inactivation of the nuclear receptor TR3 as an important new drug target for treating RCC. Journal of Clinical Oncology.
-
Singh, M., Patel, A., Lim, E., Zhang, N., Francis, K., Singh, R., & Safe, S.
(2012).
Nanotechnology systems for drug delivery, multi-modal targeting and imaging of tumors. 346-349.
-
Lee, S., Kang, J. H., Jin, U., Guthrie, A. S., Sreevalsan, S., & Safe, S. H.
(2012).
Abstract B101: Inactivation of the orphan nuclear receptor TR3 induces ER stress-mediated apoptosis by increasing ROS production in pancreatic cancer cells. b101-b101.
-
Bell, D. R., & Safe, S.
(2012).
Comparative hazards: Chemicals in the environment are the largest risk to human health. Toxicology Letters.
S3-S3.
-
Safe, S.
(2004).
Endocrine disruptors and human health: is there a problem. Toxicology.
3-10.
-
Gaido, K., You, L., & Safe, S.
(2003).
Modification of endocrine active potential by mixtures. Pure and Applied Chemistry.
2069-2079.
-
Safe, S.
(2001).
Molecular biology of the Ah receptor and its role in carcinogenesis. Toxicology Letters.
1-7.
-
Safe, S., Wargovich, M. J., Lamartiniere, C. A., & Mukhtar, H.
(1999).
Symposium on mechanisms of action of naturally occurring anticarcinogens. TOXICOLOGICAL SCIENCES.
1-8.
-
Safe, S., Wang, F., Porter, W., Duan, R., & McDougal, A.
(1998).
Ah receptor agonists as endocrine disruptors: antiestrogenic activity and mechanisms. Toxicology Letters.
343-347.
-
Safe, S., Connor, K., & Gaido, K.
(1998).
Methods for xenoestrogen testing. Toxicology Letters.
665-670.
-
Fiedler, H., Cooper, K., Bergek, S., Hjelt, M., Rappe, C., Bonner, M., ... Safe, S.
(1998).
PCDD, PCDF, and PCB in farm-raised catfish from southeast United States--concentrations, sources, and CYP1A induction. Chemosphere.
1645-1656.
-
Safe, S., & Wilson, C. L.
(1998).
Health effects and risk assessment of halogenated aromatic hydrocarbons. Central European Journal of Public Health.
113-116.
-
Gaido, K., Dohme, L., Wang, F., Chen, I., Blankvoort, B., Ramamoorthy, K., & Safe, S.
(1998).
Comparative estrogenic activity of wine extracts and organochlorine pesticide residues in food. Environmental Health Perspectives.
1347-1351.
-
Safe, S.
(1997).
Limitations of the toxic equivalency factor approach for risk assessment of TCDD and related compounds. Birth Defects Research Part B: Developmental and Reproductive Toxicology.
285-304.
-
Safe, S., Connor, K., Ramamoorthy, K., Gaido, K., & Maness, S.
(1997).
Human exposure to endocrine-active chemicals: hazard assessment problems. Regulatory Toxicology and Pharmacology.
52-58.
-
Safe, S. H., & McDougal, A.
(1997).
Environmental factors and breast cancer. Endocrine-Related Cancer.
113-123.
-
McDonald, S. J., Willett, K. L., Safe, S. H., Beatty, K. B., Steinberg, M., Mayor, P., & Kennicutt, M. C.
(1996).
Validation of bioassays for assessing the contamination of marine environments. Polycyclic Aromatic Compounds.
57-65.
-
Moore, M., Ruh, M., Steinberg, M., & Safe, S.
(1996).
Isolation and characterization of variant benzo[a]pyrene-resistant T47D human breast-cancer cells. International Journal of Cancer.
117-123.
-
Safe, S., & Krishnan, V.
(1995).
Chlorinated hydrocarbons: estrogens and antiestrogens. Toxicology Letters.
731-736.
-
DONNELLY, K. C., SAFE, S. H., RANDERATH, K., & RANDERATH, E.
(1995).
BIOASSAY-BASED RISK ASSESSMENT OF COMPLEX-MIXTURES. JOURNAL OF HAZARDOUS MATERIALS.
341-350.
-
CHALOUPKA, K., HARPER, N., KRISHNAN, V., KSTEINBERG, M., SANTOSTEFANO, M., SAFE, S. H., ... GOLDSTEIN, L. S.
(1994).
ENHANCED ACTIVITY OF POLYNUCLEAR AROMATIC HYDROCARBON MIXTURES AS ARYL-HYDROCARBON (AH) RECEPTOR AGONISTS. Polycyclic Aromatic Compounds.
191-198.
-
DUNSFORD, H. A., ZHU, L. J., CHALOUPKA, K. K., STEINBERG, M., SAFE, S., WOMACK, J. E., GOLDSTEIN, L. S., & RODRIGUEZ, L. V.
(1994).
INDUCTION OF TRANSIENT CELL-PROLIFERATION BY MANUFACTURED-GAS PLANT RESIDUE IN B6C3F1 MALE-MICE. Polycyclic Aromatic Compounds.
183-189.
-
Safe, S.
(1993).
Development of bioassays and approaches for the risk assessment of 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related compounds. Environmental Health Perspectives.
317-325.
-
JOHNSON, L., SAFE, S. H., & DICKERSON, R.
(1992).
EFFECT OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) ON SPERMATOGENESIS AND LEYDIG-CELL VOLUME IN ADULT-RATS. Chemosphere.
1175-1181.
-
RANDERATH, K., PUTMAN, K. L., RANDERATH, E., HARRIS, M., ZACHAREWSKI, T., & SAFE, S.
(1990).
EFFECTS OF 2,3,7,8-TCDD AND RELATED-COMPOUNDS ON THE LEVELS OF AGE-DEPENDENT I-SPOT DNA ADDUCTS IN THE LIVER OF FEMALE AND MALE SPRAGUE-DAWLEY RATS. Chemosphere.
1049-1052.
-
HARRIS, M., PISKORSKAPLISZCZYNSKA, J., ZACHAREWSKI, T., & SAFE, S.
(1990).
HUMAN BREAST-CANCER CELL-LINES AS MODELS FOR INVESTIGATING THE EFFECTS OF 2,3,7,8-TCDD AND RELATED-COMPOUNDS. Chemosphere.
1135-1140.
-
DAVIS, D., & SAFE, S.
(1990).
INTERACTIONS OF 2,3,7,8-TCDD AND PCB MIXTURES CONGENERS - IMMUNOTOXICITY STUDIES. Chemosphere.
1141-1146.
-
WADDELL, D., SPARLING, J., CHITTIM, B., & SAFE, S.
(1990).
INVESTIGATION OF THE UTILITY OF VARIOUS MIXED AND HALOGENATED DIBENZO-PARA-DIOXINS, DIBENZOFURANS AND BIPHENYLS AS SURROGATE INTERNAL AND INJECTION STANDARDS. Chemosphere.
1299-1306.
-
ROSENGREN, R., SAFE, L. M., BUNCE, N. J., & SAFE, S. H.
(1990).
KINETICS OF THE ASSOCIATION OF SEVERAL TRITIATED PCDD AND PCDF CONGENERS WITH THE CYTOSOLIC AH RECEPTOR FROM THE SPRAGUE-DAWLEY RAT. Chemosphere.
1249-1252.
-
PISKORSKAPLISZCZYNSKA, J., ZACHAREWSKI, T., & SAFE, S.
(1990).
MOLECULAR-PROPERTIES OF CYTOSOLIC AND NUCLEAR TCDD RECEPTOR COMPLEXES FROM MOUSE HEPATOMA-CELL LINES. Chemosphere.
1253-1256.
-
HANBERG, A., WAERN, F., ASPLUND, L., HAGLUND, E., & SAFE, S.
(1990).
SWEDISH DIOXIN SURVEY - DETERMINATION OF 2,3,7,8-TCDD TOXIC EQUIVALENT FACTORS FOR SOME POLYCHLORINATED-BIPHENYLS AND NAPHTHALENES USING BIOLOGICAL TESTS. Chemosphere.
1161-1164.
-
RORDORF, B. F., SARNA, L. P., WEBSTER, G., SAFE, S. H., SAFE, L. M., LENOIR, D., SCHWIND, K. H., & HUTZINGER, O.
(1990).
VAPOR-PRESSURE MEASUREMENTS ON HALOGENATED DIBENZO-PARA-DIOXINS AND DIBENZOFURANS - AN EXTENDED DATA SET FOR A CORRELATION METHOD. Chemosphere.
1603-1609.
-
LANDERS, J. P., SAFE, S. H., & BUNCE, N. J.
(1990).
[H-3] TETRACHLORODIBENZO-PARA-DIOXIN - AN EFFICIENT PHOTOAFFINITY LABEL FOR THE AH RECEPTOR. Chemosphere.
1241-1248.
-
Hutzinger, O., Berg, M., Olie, K., Opperhuizen, A., & Safe, S.
(1985).
DIOXINS AND FURANS IN THE ENVIRONMENT: EVALUATING TOXICOLOGICAL RISK FROM DIFFERENT SOURCES BY MULTI-CRITERIA ANALYSIS. 9-32.
-
Jamieson, W. D., Gershey, R. M., Guevremont, R., Fung, D., Boyd, R. K., Safe, S., & Chittim, B. G.
(1984).
COMPARATIVE CAPILLARY GC/MS OF STANDARD SOLUTIONS OF CHLORINATED BIPHENLYS. Annual Conference on Mass Spectrometry and Allied Topics.
685-686.
-
Fung, D., Boyd, R. K., Chittim, B., & Safe, S.
(1984).
GC/MS STUDIES OF SPECIFIC CONGENERS OF POLYCHLORODIBENZOFURANS. Annual Conference on Mass Spectrometry and Allied Topics.
291-292.
-
Safe, S., & Mullin, M.
(1984).
HIGH RESOLUTION ISOMER-SPECIFIC PCB ANALYSIS. National Meeting - American Chemical Society, Division of Environmental Chemistry.
39-40.
-
Mullin, M. D., Pochini, C. M., Safe, S. H., & Safe, L. M.
(1983).
ANALYSIS OF PCBs USING SPECIFIC ISOMER HIGH RESOLUTION CAPILLARY GAS CHROMATOGRAPHY. 165-176.
-
Safe, S., Mullin, M., Safe, L., Pochini, C., McGrindle, S., & Romkes, M.
(1983).
HIGH RESOLUTION PCB ANALYSIS. 1-13.
-
Mohankumar, K., Karki, K., Safe, S., & Abdelrahim, M.
(2021).
Nuclear receptor 4A1 (NR4A1) antagonists target PD-L1 in colon cancer. Cancer Research.
-
institutional repository document
-
Glan, E. E., Nowshad, F., Leigh, M. D., Crott, J. W., Safe, S., Jayaraman, A., & Lee, K.
(2022).
A Chalcone Synthase-Like Bacterial Protein Catalyzes Heterocyclic C-Ring Cleavage of Naringenin to Alter Bioactivity Against Nuclear Receptors in Colonic Epithelial Cells
-
Glan, E. E., Nowshad, F., Leigh, M. D., Crott, J. W., Park, H., Martin, G., ... Lee, K.
(2022).
A Chalcone Synthase-Like Bacterial Protein Catalyzes Heterocyclic C-Ring Cleavage of Naringenin to Alter Bioactivity Against Nuclear Receptors in Colonic Epithelial Cells
-
Shrestha, R., Mohankumar, K., Martin, G., Hailemariam, A., Lee, S., Jin, U., Burghardt, R., & Safe, S.
(2021).
Flavonoids Kaempferol and Quercetin are Nuclear Receptor 4A1 (NR4A1, Nur77) Ligands and inhibit Rhabdomyosarcoma Cell and Tumor Growth
-
Glan, E. E., Nowshad, F., Leigh, M. D., Crott, J. W., Safe, S., Jayaraman, A., & Lee, K.
(2022).
A Chalcone Synthase-Like Bacterial Protein Catalyzes Heterocyclic C-Ring Cleavage of Naringenin to Alter Bioactivity Against Nuclear Receptors in Colonic Epithelial Cells
Research
principal investigator on
- Dietary Flavonoids-Microbiota-Ah Receptor Interactions in the Gut awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2018 - 2022
- A Novel Approach for Targeting Pediatric Sarcoma 2017 - 2020
- Cytosolic Ah Receptor: Mechanism of Action awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2015 - 2018
- Molecular Mechanisms and Application of Ah Receptor - Microrna Interactions awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2010 - 2017
- Micrornas As Targets for Colon Cancer Chemotherapy awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2009 - 2015
co-principal investigator on
- Innovation Grant 2020 - 2022
- Diet induced modifications of microbiota metabolites in colon tumorigenesis awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2016 - 2021
- Role of Aryl Hydrocarbon Receptor in Microbiota-Colon Stem Cell Interactions awarded by National Institute of Environmental Health Sciences - (Durham, North Carolina, United States) 2016 - 2021
- Aryl Hydrocarbon Receptor Mediated Modulation of Colorectal Cancer by Microbiota Metabolites awarded by Cancer Prevention and Research Institute of Texas - (Austin, Texas, United States) 2016 - 2019
investigator on
- Texas A&M Center for Environmental Health Research awarded by National Institute of Environmental Health Sciences - (Durham, North Carolina, United States) 2019 - 2024
- Nutrition, Biostatistics and Bioinformatics Training Grant awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2013 - 2021
Teaching
teaching activities
- BICH491 Hnr-research Instructor
- BICH691 Research Instructor
- BIOT684 Directed Pro Internship: In-ab Instructor
- BIOT684 Directed Prof Internship Instructor
- BIOT684 Directed Prof Internshp Instructor
- BIOT685 Directed Studies Instructor
- GENE491 Hnr-research Instructor
- MSCI691 Research Credit: Medical Sci Instructor
- VTPP285 Directed Studies Instructor
- VTPP485 Directed Studies Instructor
- VTPP491 Hnr-research Instructor
- VTPP673 Metabolic & Detox Mech Instructor
- VTPP681 Seminar Instructor
- VTPP691 Research Instructor
Works By Students
chaired theses and dissertations
-
Chadalapaka, Gayathri (2013-03). Mechanism Based Anticancer Drugs that Degrade Sp Transcription Factors.
-
Chen, Chien-Cheng (2009-06). Mechanisms of transcriptional activation of estrogen responsive genes in breast cancer cells.
-
Cheng, Yating (2016-12). The Role of Long Noncoding RNAs in Cancer and Microbiota-derived Aryl Hydrocarbon Receptor Ligands.
-
Chintharlapalli, Sudhakar Reddy (2007-09). New mechanism-based anticancer drugs that act as orphan nuclear receptor agonists.
-
Guthrie, Aaron S 1987- (2012-12). Phenethyl Isothiocyanate (PEITC) Decreases Specficity Protein (SP) Tanscription Factors through an ROS-dependent Mechanism.
-
Hedrick, Erik Duane (2016-12). Diindolylmethane Analogs as Novel NR4A1 Antagonists and as a Novel Class of Anticancer Agents and Sp Transcription Factors as Nononcogene Addiction Genes That Are Targets of ROS Inducing Agents.
-
Higgins, Kelly Jean (2007-09). Regulation of vascular endothelial growth factor receptor-2 in pancreatic and breast cancer cells by Sp proteins.
-
Hosako, Hiromi (2009-05). The role of p53 in normal development and teratogen-induced apoptosis and birth defects in mouse embryos.
-
Hou, Tim Yu-Tien (2014-12). n-3 Polyunsaturated Fatty Acids Alter Mouse CD4+ T Cell Activation by Modifying the Lipid Bilayer Properties.
-
Jutooru, Indira Devi (2011-08). New Mechanism Based Anticancer Drugs for Treatment of Pancreatic and Bladder Cancers.
-
Khan, Shaheen Munawar Ali (2007-04). Mechanisms of hormonal regulation of CAD gene expression and inhibition by Aryl hydrocarbon receptor agonist in human breast cancer cells.
-
Kim, KyoungHyun (2004-08). Domain analysis for estrogen receptor/Sp1-mediated transactivation and detection of estrogen receptor/Sp1 protein interactions in living cells.
-
Kotha, Leela (2009-05). Inhibition of breast and prostate cancer cell growth by 3,3'-diindolylmethane and related compounds.
-
Lacey, Alexandra Dianne (2017-08). NR4A1 Antagonists Target the Oncogenic PAX3-FOXO1A Gene and Induce Interleukin -24 in Rhabdomyosarcoma (RMS).
-
Lee, Jeong Eun (2004-12). Mechanisms of aryl hydrocarbon receptor and estrogen receptor action in breast cancer cells.
-
Lee, Wan-Ru (2009-05). Mechanisms of hormonal activation of Cdc25A and coactivation of estrogen receptor alpha by protein inhibitor of activated STAT3 (PIAS3).
-
Li, Xi (2014-05). Mechanism of Action of Sulindac and Diindolylmethane Analogs as Anticancer Agents.
-
Li, Xiangrong (2006-08). Hormonal activation of genes through nongenomic pathways by estrogen and structurally diverse estrogenic compounds.
-
Liu, Xinyi (2012-10). Mechanistic Investigation of Tolfenamic Acid, Betulinic Acid, and Aspirin in Anti-Cancer Therapy.
-
Nemec, Matthew James (2016-08). Polyphenolics from Mango (Mangifera Indica L.) Suppress Breast Cancer Ductal Carcinoma In Situ Proliferation Both In Vitro And In Vivo: Potential Role of the IGFR-1-AKT-AMPK-mTOR-Signaling Axis.
-
Papineni, Sabitha (2009-05). New synthetic derivatives of triterpenoids in the treatment of cancer.
-
Partridge, Charles Randal (2007-04). Identification and molecular characterization of novel genomic targets in oxidant-induced vascular injury.
-
Pathi, Satya (2012-10). Mechanisms of Action of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in Colon Cancer.
-
Ramachandran Nair Vasanthakum, Vijayalekshmi (2014-08). Mechanisms of Action of Metformin as an Anti-cancer Agent.
-
Scott, Maya Millicent (2005-05). Canine hepatic slices as a model for studying drug toxicity and metabolism.
-
Sreevalsan, Sandeep (2013-05). Molecular Mechanisms of Cannabinoids as Anti-cancer Agents.
-
Vanderlaag, Kathryn Elisabeth (2009-05). Mechanisms of growth inhibition induced by methylene-substituted and ring-substituted dims in breast cancer cells.
-
Wu, Fei (2009-05). Comparative activation of estrogen receptor alpha (er alpha) by endocrine disruptors.
-
Wu, Qian (2009-05). Mechanisms of coactivation of estrogen receptor alpha (ER alpha)- and ER alpha/Sp-mediated gene transactivation by vitamin D receptor interacting protein 205 (DRIP205) in breast cancer cells.
-
York, Melissa Dawn (2009-06). 1,1-bis(3-indolyl)-1-(p-substitutedphenyl) methanes induce apoptosis and inhibit renal cell carcinoma growth.
-
Zhang, Shu (2009-05). Role of estrogen receptor alpha (ER alpha) insulin-like growth factor (IGF)-I-induced responses in MCF-7 breast cancer cells.
Background
education and training
- D.Phil., University of Oxford - (Oxford, Oxfordshire, United Kingdom) 1966
- B.S., Queens University - (Dhaka, Bangladesh) 1962
awards and honors
- AAAS Fellow, conferred by American Association For The Advancement of Science - (Washington D.C., District of Columbia, United States), 2021
- Association of Former Students University-Level Distinguished Achievement Award, The, conferred by Texas A&M University - (College Station, Texas, United States), 2021
- Association of Former Students University-Level Distinguished Achievement Award, The, conferred by Texas A&M University - (College Station, Texas, United States), 2020
- Distinguished Toxicology Scholar Award, conferred by Society of Toxicology - (Reston, Virginia, United States), 2007
- Distinguished Toxicology Scholar Award, conferred by Society of Toxicology - (Reston, Virginia, United States), 2007
- Association of Former Students University-Level Distinguished Achievement Award, The, conferred by Texas A&M University - (College Station, Texas, United States), 2006
- JoAnn Treat Research Excellence Award, conferred by Texas A&M University - (College Station, Texas, United States), 2004
- Highly Cited Researcher, conferred by Thomson Reuters - (New York, New York, United States), 2002
- Highly Cited Researcher, conferred by Thomson Reuters - (New York, New York, United States), 2001
- Distinguished Research Award of the Sigma Xi, conferred by Texas A&M University - (College Station, Texas, United States), 1977
Contact
first name
- Stephen
has last name
- Safe
mailing address
-
Texas A&M University
Vet Med - Physiology & Pharmacology
4466 TAMU
College Station, TX 77843-4466
USA
Other
In the News
- s-safe@tamu.edu