Template-Free Fabrication of Vertically-Aligned Polymer Nanowire Array on the Flat-end Tip for Quantifying the Single Living Cancer Cells and Nanosurface Interaction Academic Article uri icon


  • © 2018 We fabricated vertically aligned polyaniline (PANI) nanowire arrays on flat-end AFM tips via template-free methods. 4-Aminothiophenol was used for tailoring the nucleation size, chain propagation and orientation of the PANI nanowires. The microscopy characterization indicated that diameter was centered at a mean of 33.7 nm with a standard deviation of 6.5 nm, and length was centered at a mean of 50.3 nm with a standard deviation of 7.6 nm. PANI nanowire arrays are non-toxic, low-cost, and tunable, and thus PANI nanowire-grown tips could perfectly simulate different nanosurfaces. Via the force spectroscopy, we demonstrate the feasibility in real-time quantifying the nanostructure-cell interactions at the single cell level with high reliability and accuracy. This work will enable a new tool in precisely quantifying the interactions of single living cells and nanosurface, and thus opens a new door to understand how single living cells sense and respond to the specific nanostructures.

author list (cited authors)

  • Wang, B., Wang, L., Li, X. i., Liu, Y., Zhang, Z., Hedric, E., ... Wang, S.

citation count

  • 1

publication date

  • April 2018