Inhibition of 3,3,4,4,5-Pentachlorobiphenyl-Induced Chicken Embryotoxicity by 2,2,4,4,5,5-Hexachlorobiphenyl Academic Article uri icon

abstract

  • 3,3',4,4',5-Pentachlorobiphenyl (pentaCB) caused a dose dependent induction of chicken embryolethality, malformations, edema, and liver lesions at doses ranging from 0.5 to 12.0 g/kg. In contrast, no embryotoxicity was observed after treatment with 10, 25, or 50 mg/kg 2,2',4,4',5,5'-hexaCB. In eggs cotreated with 2.0 g/kg, 3,3',4,4',5-pentaCB plus 10, 25, or 50 mg/kg 2,2',4,4',5,5'-hexaCB, there was significant protection from 3,3',4,4',5-pentaCB-induced embryo malformations, edema, and liver lesions, whereas no inhibition of embryolethality was observed. These results further extend the response-specific nonadditive interactions of binary mixtures of polychlorinated biphenyls (PCBs) and should be considered in the development of approaches for hazard assessment of PCB mixtures and related compounds.

published proceedings

  • Toxicological Sciences

altmetric score

  • 3

author list (cited authors)

  • ZHAO, F., MAYURA, K., KOCUREK, N., EDWARDS, J. F., KUBENA, L. F., SAFE, S. H., & PHILLIPS, T. D.

citation count

  • 4

complete list of authors

  • ZHAO, FENG||MAYURA, KITTANE||KOCUREK, NATHAN||EDWARDS, JOHN F||KUBENA, LEON F||SAFE, STEPHEN H||PHILLIPS, TIMOTHY D

publication date

  • January 1997