Inhibition of 3,3,4,4,5-Pentachlorobiphenyl-Induced Chicken Embryotoxicity by 2,2,4,4,5,5-Hexachlorobiphenyl
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3,3',4,4',5-Pentachlorobiphenyl (pentaCB) caused a dose dependent induction of chicken embryolethality, malformations, edema, and liver lesions at doses ranging from 0.5 to 12.0 g/kg. In contrast, no embryotoxicity was observed after treatment with 10, 25, or 50 mg/kg 2,2',4,4',5,5'-hexaCB. In eggs cotreated with 2.0 g/kg, 3,3',4,4',5-pentaCB plus 10, 25, or 50 mg/kg 2,2',4,4',5,5'-hexaCB, there was significant protection from 3,3',4,4',5-pentaCB-induced embryo malformations, edema, and liver lesions, whereas no inhibition of embryolethality was observed. These results further extend the response-specific nonadditive interactions of binary mixtures of polychlorinated biphenyls (PCBs) and should be considered in the development of approaches for hazard assessment of PCB mixtures and related compounds.
author list (cited authors)
ZHAO, F., MAYURA, K., KOCUREK, N., EDWARDS, J. F., KUBENA, L. F., SAFE, S. H., & PHILLIPS, T. D.
complete list of authors
ZHAO, FENG||MAYURA, KITTANE||KOCUREK, NATHAN||EDWARDS, JOHN F||KUBENA, LEON F||SAFE, STEPHEN H||PHILLIPS, TIMOTHY D