Toxicological Sciences Journal

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Overview

publication venue for

• Analysis of reproducibility and robustness of a renal proximal tubule microphysiological system OrganoPlate 3-lane 40 for in vitro studies of drug transport and toxicity..  196:52-70. 2023
• Refining risk estimates for lead in drinking water based on the impact of genetics and diet on blood lead levels using the Collaborative Cross mouse population..  194:226-234. 2023
• A tiered testing strategy based on in vitro phenotypic and transcriptomic data for selecting representative petroleum UVCBs for toxicity evaluation in vivo..  193:219-233. 2023
• Single-cell transcriptomics shows dose-dependent disruption of hepatic zonation by TCDD in mice..  191:135-148. 2023
• Decision-Making with New Approach Methodologies: Time to Replace Default Uncertainty Factors with Data..  189:148-149. 2022
• Microphysiological Systems Evaluation: Experience of TEX-VAL Tissue Chip Testing Consortium..  188:143-152. 2022
• Quantitative Characterization of Population-Wide Tissue- and Metabolite-Specific Variability in Perchloroethylene Toxicokinetics in Male Mice..  182:168-182. 2021
• Quantitative In Vitro-to-In Vivo Extrapolation for Mixtures: A Case Study of Superfund Priority List Pesticides..  183:60-69. 2021
• Genetics-Based Approach to Identify Novel Genes Regulated by the Aryl Hydrocarbon Receptor inMouse Liver..  181:285-294. 2021
• Hydroxylated Chalcones as Aryl Hydrocarbon Receptor Agonists: Structure-Activity Effects..  180:148-159. 2021
• Gestational Exposure to Ultrafine Particles Reveals Sex- and Dose-Specific Changes in Offspring Birth Outcomes, Placental Morphology, and Gene Networks..  184:204-213. 2021
• Skeletal Toxicity of Coplanar Polychlorinated Biphenyl Congener 126 in the Rat Is Aryl Hydrocarbon Receptor Dependent..  175:113-125. 2020
• Tissue-Engineered Bone Tumor as a Reproducible Human in Vitro Model for Studies of Anticancer Drugs..  173:65-76. 2020
• Gene Expression and DNA Methylation Alterations in the Glycine N-Methyltransferase Gene in Diet-Induced Nonalcoholic Fatty Liver Disease-Associated Carcinogenesis..  170:273-282. 2019
• Histopathological and Molecular Signatures of a Mouse Model of Acute-on-Chronic Alcoholic Liver Injury Demonstrate Concordance With Human Alcoholic Hepatitis..  170:427-437. 2019
• Refining In Vitro Toxicity Models: Comparing Baseline Characteristics of Lung Cell Types..  168:302-314. 2019
• Oy Vey! A Comment on "Machine Learning of Toxicological Big Data Enables Read-Across Structure Activity Relationships Outperforming Animal Test Reproducibility"..  167:3-4. 2019
• Chromium Burden in Human Placenta: Author(s) Responses to Thompson et al..  165:270-271. 2018
• Metabolism and Toxicity of Trichloroethylene and Tetrachloroethylene in Cytochrome P450 2E1 Knockout and Humanized Transgenic Mice..  164:489-500. 2018
• Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids..  164:205-217. 2018
• Sexually Dimorphic Impact of Chromium Accumulation on Human Placental Oxidative Stress and Apoptosis..  161:375-387. 2018
• The Impact of Novel Assessment Methodologies in Toxicology on Green Chemistry and Chemical Alternatives..  161:276-284. 2018
• Editor's Highlight: Comparative Dose-Response Analysis of Liver and Kidney Transcriptomic Effects of Trichloroethylene and Tetrachloroethylene in B6C3F1 Mouse..  160:95-110. 2017
• Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice..  159:481-481. 2017
• Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice..  159:102-113. 2017
• Editor's Highlight: Microbial-Derived 1,4-Dihydroxy-2-naphthoic Acid and Related Compounds as Aryl Hydrocarbon Receptor Agonists/Antagonists: Structure-Activity Relationships and Receptor Modeling..  155:458-473. 2017
• PBPK-Based Probabilistic Risk Assessment for Total Chlorotriazines in Drinking Water..  150:269-282. 2016
• The Contribution of Peroxisome Proliferator-Activated Receptor Alpha to the Relationship Between Toxicokinetics and Toxicodynamics of Trichloroethylene..  147:339-349. 2015
• Novel para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and suppress glial activation in a mouse model of Parkinson's disease..  143:360-373. 2015
• Epigenetic events determine tissue-specific toxicity of inhalational exposure to the genotoxic chemical 1,3-butadiene in male C57BL/6J mice..  142:375-384. 2014
• Genetic or pharmacologic activation of Nrf2 signaling fails to protect against aflatoxin genotoxicity in hypersensitive GSTA3 knockout mice..  139:293-300. 2014
• EADB: an estrogenic activity database for assessing potential endocrine activity..  135:277-291. 2013
• Role of the aryl hydrocarbon receptor in carcinogenesis and potential as a drug target..  135:1-16. 2013
• Consideration of Rat Chronic Progressive Nephropathy in Regulatory Evaluations for Carcinogenicity (vol 132, pg 268, 2013).  133:344-344. 2013
• Polybrominated dibenzo-p-dioxins, dibenzofurans, and biphenyls: inclusion in the toxicity equivalency factor concept for dioxin-like compounds..  133:197-208. 2013
• Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis..  132:53-63. 2013
• Consideration of rat chronic progressive nephropathy in regulatory evaluations for carcinogenicity..  132:268-275. 2013
• Non-dioxin-like AhR ligands in a mouse peanut allergy model..  128:92-102. 2012
• The Toxicology Education Summit: building the future of toxicology through education..  127:331-338. 2012
• Predictive modeling of chemical hazard by integrating numerical descriptors of chemical structures and short-term toxicity assay data..  127:1-9. 2012
• Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model..  126:578-588. 2012
• PAH particles perturb prenatal processes and phenotypes: protection from deficits in object discrimination afforded by dampening of brain oxidoreductase following in utero exposure to inhaled benzo(a)pyrene..  125:233-247. 2012
• Epigenetic mechanisms of mouse interstrain variability in genotoxicity of the environmental toxicant 1,3-butadiene..  122:448-456. 2011
• Manganese induces IGF-1 and cyclooxygenase-2 gene expressions in the basal hypothalamus during prepubertal female development..  121:389-396. 2011
• Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice..  120:206-217. 2011
• In vitro screening for population variability in chemical toxicity..  119:398-407. 2011
• 3-methylcholanthrene induces differential recruitment of aryl hydrocarbon receptor to human promoters..  117:1-3. 2010
• Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors..  115:131-139. 2010
• Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel..  110:235-243. 2009
• Age-dependent susceptibility to manganese-induced neurological dysfunction..  112:394-404. 2009
• Acute effect of manganese on hypothalamic luteinizing hormone releasing hormone secretion in adult male rats: involvement of specific neurotransmitter systems..  105:295-302. 2008
• Pregnane X receptor protects HepG2 cells from BaP-induced DNA damage..  104:67-73. 2008
• Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor..  99:315-325. 2007
• Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses..  99:326-337. 2007
• WY-14,643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase..  98:366-374. 2007
• Effect of manganese on luteinizing hormone-releasing hormone secretion in adult male rats..  97:75-80. 2007
• Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis..  96:2-15. 2007
• The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds..  93:223-241. 2006
• Phenotypic anchoring of acetaminophen-induced oxidative stress with gene expression profiles in rat liver..  93:213-222. 2006
• Azoxymethane is a genetic background-dependent colorectal tumor initiator and promoter in mice: effects of dose, route, and diet..  88:340-345. 2005
• Toxicogenomic profile of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the murine fetal heart: modulation of cell cycle and extracellular matrix genes..  88:231-241. 2005
• Manganese acts centrally to stimulate luteinizing hormone secretion: a potential influence on female pubertal development..  85:880-885. 2005
• The effects of low-level Pb on steroidogenic acute regulatory protein (StAR) in the prepubertal rat ovary..  77:35-40. 2004
• Differential gene expression in response to methoxychlor and estradiol through ERalpha, ERbeta, and AR in reproductive tissues of female mice..  63:47-56. 2001
• 2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells..  61:40-48. 2001
• 3',4'-dimethoxyflavone as an aryl hydrocarbon receptor antagonist in human breast cancer cells..  58:235-242. 2000
• Bisphenol A and related endocrine disruptors..  56:251-252. 2000
• A rapid and sensitive reporter gene that uses green fluorescent protein expression to detect chemicals with estrogenic activity..  55:69-77. 2000
• Dietary clay in the chemoprevention of aflatoxin-induced disease.  52:118-126. 1999
• Effects of dietary 17 beta-estradiol exposure on serum hormone concentrations and testicular parameters in male Crl:CD BR rats..  44:155-168. 1998
• Prevention of maternal and developmental toxicity in rats via dietary inclusion of common aflatoxin sorbents: potential for hidden risks..  41:175-182. 1998
• Inhibition of 3,3,4,4,5-Pentachlorobiphenyl-Induced Chicken Embryotoxicity by 2,2,4,4,5,5-Hexachlorobiphenyl.  35:1-8. 1997
• Retinoid-Induced Epiphyseal Plate Closure in Guinea Pigs.  34:91-98. 1996
• Failure of Chloro-S-triazine-Derived Compounds to Induce Estrogen Receptor-Mediated Responses in Vivo and in Vitro.  30:93-101. 1996
• Protection of Organophosphate-Inactivated Esterases with Phosphotriesterase.  31:210-217. 1996
• Immunosuppressive Activity of Polychiorinated Biphenyl Mixtures and Congeners: Nonadditive (Antagonistic) Interactions.  27:131-139. 1995
• PhosphotriesteraseA Promising Candidate for Use in Detoxification of Organophosphates.  23:578-584. 1994
• Relative Sensitivities of 2,3,7,8-Tetrachlorodibenzo- p -dioxin-lnduced Cypla-1 and Cypla-2 Gene Expression and Immunotoxicity in Female B6C3F1 Mice.  23:598-607. 1994
• Comparative Potencies of Aroclors 1232, 1242, 1248, 1254, and 1260 in Male Wistar RatsAssessment of the Toxic Equivalency Factor (TEF) Approach for Polychlorinated Biphenyls (PCBs).  20:456-463. 1993
• Immunosuppressive and Monooxygenase Induction Activities of Highly Chlorinated Diphenyl Ether Congeners in C57BL/6 and DBA/2 Mice.  20:496-502. 1993
• The Structure-Dependent Effects of Heptachlorodibenzofuran Isomers in Male C57BL/6 Mice: Immunotoxicity and onooxygenase Enzyme Induction.  15:298-307. 1990
• A Bayesian Method for Population-wide Cardiotoxicity Hazard and Risk Characterization Using an In Vitro Human Model..  178:391-403.
• Alteration of Oxytocin-Induced Calcium Oscillations in Clone 9 Cells by Toxin Exposure.  33:220-228.
• Analysis of Pb2+ entry into cultured astroglia..  46:90-100.
• Analysis of benzo[a]pyrene partitioning and cellular homeostasis in a rat liver cell line..  53:264-270.
• Characterization of calcium oscillations in normal and benzo[a]pyrene-treated clone 9 cells..  68:444-450.
• Characterizing uncertainty and variability in physiologically based pharmacokinetic models: state of the science and needs for research and implementation..  99:395-402.
• Disruption of cadherin/catenin expression, localization, and interactions during HgCl2-induced nephrotoxicity..  80:170-182.
• Editor's Highlight: Collaborative Cross Mouse Population Enables Refinements to Characterization of the Variability in Toxicokinetics of Trichloroethylene and Provides Genetic Evidence for the Role of PPAR Pathway in Its Oxidative Metabolism..  158:48-62.
• Editor's Highlight: Exposure to CrVI during Early Pregnancy Increases Oxidative Stress and Disrupts the Expression of Antioxidant Proteins in Placental Compartments..  155:497-511.
• Editor's Highlight: Exposure to CrVI during Early Pregnancy Increases Oxidative Stress and Disrupts the Expression of Antioxidant Proteins in Placental Compartments..  155:497-511.
• Enhancement of Melphalan Toxicity by Octanol in Ovarian Adenocarcinoma Cell Lines: Effects of Altered Cell-Cell Communication, Glutathione Levels, and Plasma Membrane Fluidity.  25:70-79.
• In Vitro Bioavailability of the Hydrocarbon Fractions of Dimethyl Sulfoxide Extracts of Petroleum Substances..  174:168-177.
• Kinetic Analysis of the Chronology of Patulin- and Gossypol-Induced Cytotoxicity in Vitro.  30:290-297.
• Modulation of Tetrachloroethylene-Associated Kidney Effects by Nonalcoholic Fatty Liver or Steatohepatitis in Male C57BL/6J Mice..  167:126-137.
• Questioning Existing Cancer Hazard Evaluation Standards in the Name of Statistics..  177:521-522.
• Risk Characterization of Environmental Samples Using In Vitro Bioactivity and Polycyclic Aromatic Hydrocarbon Concentrations Data..  179:108-120.
• Toxicokinetics of inhaled trichloroethylene and tetrachloroethylene in humans at 1 ppm: empirical results and comparisons with previous studies..  95:23-36.
• Aryl hydrocarbon receptor gene silencing with small inhibitory RNA differentlally modulates Ah-responsiveness in MCF-7 and HepG2 cancer cells. 2003
• Expression and localization of P70 albumin precursor protein and phi AP3 in oxidatively stressed vascular smooth muscle cells. 2003
• A cell-based assay for screening inducers of cytochrome P450 3A4 and analyzing transcriptional regulation by pregane X receptor (PXR). 2003
• Ah receptor-mediated transcriptional suppression of interleukin-6. 2003
• Application of clustering methodologies to the analysis of altered cellular phenotypes induced by oxidative stress. 2003
• Beyond genomics: Image analysis and computational biology. 2003
• Chemical disruption of global gene expression during nephrogenesis: Role of aryl hydrocarbon receptor. 2003
• Decreased N- and Ksp-cadherin expression associated with HGCL2-induced acute renal failure is related to the spatial expression pattern of cadherins along the nephron. 2003
• Dioxin induces growth arrest and reduces cell cycle gene expression in the fetal murine heart. 2003
• From "omics" to insight: The use of a novel computational approach to study genegene interactions. 2003
• Genomic and immunofluorescence analysis of interactive gene networks in oxidant induced atherogenesis. 2003
• Maternal and developmental assessment of montmorillonite clays commonly added to animal feeds: Toxicity evaluation and metal bioavailability in the pregnant rat. 2003
• Regulation of CYF1A1 transcription elongation by aft receptor through interaction with P-TEF B. 2003
• Urinary metabolites of aflatoxin in dogs and dietary protection by clay against canine aflatoxicosis. 2003
• Effects of complex PAH mixtures and 7H-benzo(c)fluorene on DNA adduct formation in mice. 2003
• Enhanced clay-based enterosorbent for the prevention of aflatoxicosis:: In vitro and in vivo characterization. 2003
• Regulation of cyclin D1 gene expression in the mouse uterus by estrogen and 2,3,7,8-tetrachlorodibenzo-p-dioxin. 2003
• Symposium on mechanisms of action of naturally occurring anticarcinogens. 1999

Identity

International Standard Serial Number (ISSN)

• 1096-6080