TOXICOLOGICAL SCIENCES
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Overview
publication venue for
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Analysis of reproducibility and robustness of a renal proximal tubule microphysiological system OrganoPlate 3-lane 40 for in vitro studies of drug transport and toxicity..
196:52-70.
2023
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Refining risk estimates for lead in drinking water based on the impact of genetics and diet on blood lead levels using the Collaborative Cross mouse population..
194:226-234.
2023
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A tiered testing strategy based on in vitro phenotypic and transcriptomic data for selecting representative petroleum UVCBs for toxicity evaluation in vivo..
193:219-233.
2023
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Single-cell transcriptomics shows dose-dependent disruption of hepatic zonation by TCDD in mice..
191:135-148.
2023
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Decision-Making with New Approach Methodologies: Time to Replace Default Uncertainty Factors with Data..
189:148-149.
2022
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Microphysiological Systems Evaluation: Experience of TEX-VAL Tissue Chip Testing Consortium..
188:143-152.
2022
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Quantitative Characterization of Population-Wide Tissue- and Metabolite-Specific Variability in Perchloroethylene Toxicokinetics in Male Mice..
182:168-182.
2021
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Quantitative In Vitro-to-In Vivo Extrapolation for Mixtures: A Case Study of Superfund Priority List Pesticides..
183:60-69.
2021
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Genetics-Based Approach to Identify Novel Genes Regulated by the Aryl Hydrocarbon Receptor inMouse Liver..
181:285-294.
2021
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Hydroxylated Chalcones as Aryl Hydrocarbon Receptor Agonists: Structure-Activity Effects..
180:148-159.
2021
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Gestational Exposure to Ultrafine Particles Reveals Sex- and Dose-Specific Changes in Offspring Birth Outcomes, Placental Morphology, and Gene Networks..
184:204-213.
2021
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Skeletal Toxicity of Coplanar Polychlorinated Biphenyl Congener 126 in the Rat Is Aryl Hydrocarbon Receptor Dependent..
175:113-125.
2020
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Tissue-Engineered Bone Tumor as a Reproducible Human in Vitro Model for Studies of Anticancer Drugs..
173:65-76.
2020
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Gene Expression and DNA Methylation Alterations in the Glycine N-Methyltransferase Gene in Diet-Induced Nonalcoholic Fatty Liver Disease-Associated Carcinogenesis..
170:273-282.
2019
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Histopathological and Molecular Signatures of a Mouse Model of Acute-on-Chronic Alcoholic Liver Injury Demonstrate Concordance With Human Alcoholic Hepatitis..
170:427-437.
2019
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Refining In Vitro Toxicity Models: Comparing Baseline Characteristics of Lung Cell Types..
168:302-314.
2019
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Oy Vey! A Comment on "Machine Learning of Toxicological Big Data Enables Read-Across Structure Activity Relationships Outperforming Animal Test Reproducibility"..
167:3-4.
2019
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Chromium Burden in Human Placenta: Author(s) Responses to Thompson et al..
165:270-271.
2018
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Metabolism and Toxicity of Trichloroethylene and Tetrachloroethylene in Cytochrome P450 2E1 Knockout and Humanized Transgenic Mice..
164:489-500.
2018
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Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids..
164:205-217.
2018
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Sexually Dimorphic Impact of Chromium Accumulation on Human Placental Oxidative Stress and Apoptosis..
161:375-387.
2018
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The Impact of Novel Assessment Methodologies in Toxicology on Green Chemistry and Chemical Alternatives..
161:276-284.
2018
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Editor's Highlight: Comparative Dose-Response Analysis of Liver and Kidney Transcriptomic Effects of Trichloroethylene and Tetrachloroethylene in B6C3F1 Mouse..
160:95-110.
2017
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Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice..
159:481-481.
2017
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Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice..
159:102-113.
2017
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Editor's Highlight: Exposure to CrVI during Early Pregnancy Increases Oxidative Stress and Disrupts the Expression of Antioxidant Proteins in Placental Compartments..
155:497-511.
2017
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Editor's Highlight: Exposure to CrVI during Early Pregnancy Increases Oxidative Stress and Disrupts the Expression of Antioxidant Proteins in Placental Compartments..
155:497-511.
2017
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Editor's Highlight: Microbial-Derived 1,4-Dihydroxy-2-naphthoic Acid and Related Compounds as Aryl Hydrocarbon Receptor Agonists/Antagonists: Structure-Activity Relationships and Receptor Modeling..
155:458-473.
2017
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PBPK-Based Probabilistic Risk Assessment for Total Chlorotriazines in Drinking Water..
150:269-282.
2016
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The Contribution of Peroxisome Proliferator-Activated Receptor Alpha to the Relationship Between Toxicokinetics and Toxicodynamics of Trichloroethylene..
147:339-349.
2015
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Novel para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and suppress glial activation in a mouse model of Parkinson's disease..
143:360-373.
2015
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Epigenetic events determine tissue-specific toxicity of inhalational exposure to the genotoxic chemical 1,3-butadiene in male C57BL/6J mice..
142:375-384.
2014
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Genetic or pharmacologic activation of Nrf2 signaling fails to protect against aflatoxin genotoxicity in hypersensitive GSTA3 knockout mice..
139:293-300.
2014
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EADB: an estrogenic activity database for assessing potential endocrine activity..
135:277-291.
2013
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Role of the aryl hydrocarbon receptor in carcinogenesis and potential as a drug target..
135:1-16.
2013
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Consideration of Rat Chronic Progressive Nephropathy in Regulatory Evaluations for Carcinogenicity (vol 132, pg 268, 2013).
133:344-344.
2013
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Polybrominated dibenzo-p-dioxins, dibenzofurans, and biphenyls: inclusion in the toxicity equivalency factor concept for dioxin-like compounds..
133:197-208.
2013
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Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis..
132:53-63.
2013
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Consideration of rat chronic progressive nephropathy in regulatory evaluations for carcinogenicity..
132:268-275.
2013
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Non-dioxin-like AhR ligands in a mouse peanut allergy model..
128:92-102.
2012
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The Toxicology Education Summit: building the future of toxicology through education..
127:331-338.
2012
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Predictive modeling of chemical hazard by integrating numerical descriptors of chemical structures and short-term toxicity assay data..
127:1-9.
2012
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Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model..
126:578-588.
2012
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PAH particles perturb prenatal processes and phenotypes: protection from deficits in object discrimination afforded by dampening of brain oxidoreductase following in utero exposure to inhaled benzo(a)pyrene..
125:233-247.
2012
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Epigenetic mechanisms of mouse interstrain variability in genotoxicity of the environmental toxicant 1,3-butadiene..
122:448-456.
2011
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Manganese induces IGF-1 and cyclooxygenase-2 gene expressions in the basal hypothalamus during prepubertal female development..
121:389-396.
2011
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Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice..
120:206-217.
2011
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In vitro screening for population variability in chemical toxicity..
119:398-407.
2011
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3-methylcholanthrene induces differential recruitment of aryl hydrocarbon receptor to human promoters..
117:1-3.
2010
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Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors..
115:131-139.
2010
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Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel..
110:235-243.
2009
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Age-dependent susceptibility to manganese-induced neurological dysfunction..
112:394-404.
2009
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Acute effect of manganese on hypothalamic luteinizing hormone releasing hormone secretion in adult male rats: involvement of specific neurotransmitter systems..
105:295-302.
2008
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Pregnane X receptor protects HepG2 cells from BaP-induced DNA damage..
104:67-73.
2008
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Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor..
99:315-325.
2007
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Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses..
99:326-337.
2007
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WY-14,643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase..
98:366-374.
2007
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Effect of manganese on luteinizing hormone-releasing hormone secretion in adult male rats..
97:75-80.
2007
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Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis..
96:2-15.
2007
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The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds..
93:223-241.
2006
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Phenotypic anchoring of acetaminophen-induced oxidative stress with gene expression profiles in rat liver..
93:213-222.
2006
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Azoxymethane is a genetic background-dependent colorectal tumor initiator and promoter in mice: effects of dose, route, and diet..
88:340-345.
2005
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Toxicogenomic profile of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the murine fetal heart: modulation of cell cycle and extracellular matrix genes..
88:231-241.
2005
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Manganese acts centrally to stimulate luteinizing hormone secretion: a potential influence on female pubertal development..
85:880-885.
2005
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Disruption of cadherin/catenin expression, localization, and interactions during HgCl2-induced nephrotoxicity..
80:170-182.
2004
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The effects of low-level Pb on steroidogenic acute regulatory protein (StAR) in the prepubertal rat ovary..
77:35-40.
2004
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Characterization of calcium oscillations in normal and benzo[a]pyrene-treated clone 9 cells..
68:444-450.
2002
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Differential gene expression in response to methoxychlor and estradiol through ERalpha, ERbeta, and AR in reproductive tissues of female mice..
63:47-56.
2001
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2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells..
61:40-48.
2001
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3',4'-dimethoxyflavone as an aryl hydrocarbon receptor antagonist in human breast cancer cells..
58:235-242.
2000
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Bisphenol A and related endocrine disruptors..
56:251-252.
2000
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A rapid and sensitive reporter gene that uses green fluorescent protein expression to detect chemicals with estrogenic activity..
55:69-77.
2000
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Analysis of benzo[a]pyrene partitioning and cellular homeostasis in a rat liver cell line..
53:264-270.
2000
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Dietary clay in the chemoprevention of aflatoxin-induced disease.
52:118-126.
1999
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Effects of dietary 17 beta-estradiol exposure on serum hormone concentrations and testicular parameters in male Crl:CD BR rats..
44:155-168.
1998
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Prevention of maternal and developmental toxicity in rats via dietary inclusion of common aflatoxin sorbents: potential for hidden risks..
41:175-182.
1998
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Analysis of Pb2+ entry into cultured astroglia..
46:90-100.
1998
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Inhibition of 3,3,4,4,5-Pentachlorobiphenyl-Induced Chicken Embryotoxicity by 2,2,4,4,5,5-Hexachlorobiphenyl.
35:1-8.
1997
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Retinoid-Induced Epiphyseal Plate Closure in Guinea Pigs.
34:91-98.
1996
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Failure of Chloro-S-triazine-Derived Compounds to Induce Estrogen Receptor-Mediated Responses in Vivo and in Vitro.
30:93-101.
1996
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Kinetic Analysis of the Chronology of Patulin- and Gossypol-Induced Cytotoxicity in Vitro.
30:290-297.
1996
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Alteration of Oxytocin-Induced Calcium Oscillations in Clone 9 Cells by Toxin Exposure.
33:220-228.
1996
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Protection of Organophosphate-Inactivated Esterases with Phosphotriesterase.
31:210-217.
1996
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Immunosuppressive Activity of Polychiorinated Biphenyl Mixtures and Congeners: Nonadditive (Antagonistic) Interactions.
27:131-139.
1995
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Enhancement of Melphalan Toxicity by Octanol in Ovarian Adenocarcinoma Cell Lines: Effects of Altered Cell-Cell Communication, Glutathione Levels, and Plasma Membrane Fluidity.
25:70-79.
1995
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PhosphotriesteraseA Promising Candidate for Use in Detoxification of Organophosphates.
23:578-584.
1994
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Relative Sensitivities of 2,3,7,8-Tetrachlorodibenzo- p -dioxin-lnduced Cypla-1 and Cypla-2 Gene Expression and Immunotoxicity in Female B6C3F1 Mice.
23:598-607.
1994
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Comparative Potencies of Aroclors 1232, 1242, 1248, 1254, and 1260 in Male Wistar RatsAssessment of the Toxic Equivalency Factor (TEF) Approach for Polychlorinated Biphenyls (PCBs).
20:456-463.
1993
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Immunosuppressive and Monooxygenase Induction Activities of Highly Chlorinated Diphenyl Ether Congeners in C57BL/6 and DBA/2 Mice.
20:496-502.
1993
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The Structure-Dependent Effects of Heptachlorodibenzofuran Isomers in Male C57BL/6 Mice: Immunotoxicity and onooxygenase Enzyme Induction.
15:298-307.
1990
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A Bayesian Method for Population-wide Cardiotoxicity Hazard and Risk Characterization Using an In Vitro Human Model..
178:391-403.
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Characterizing uncertainty and variability in physiologically based pharmacokinetic models: state of the science and needs for research and implementation..
99:395-402.
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Editor's Highlight: Collaborative Cross Mouse Population Enables Refinements to Characterization of the Variability in Toxicokinetics of Trichloroethylene and Provides Genetic Evidence for the Role of PPAR Pathway in Its Oxidative Metabolism..
158:48-62.
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In Vitro Bioavailability of the Hydrocarbon Fractions of Dimethyl Sulfoxide Extracts of Petroleum Substances..
174:168-177.
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Modulation of Tetrachloroethylene-Associated Kidney Effects by Nonalcoholic Fatty Liver or Steatohepatitis in Male C57BL/6J Mice..
167:126-137.
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Questioning Existing Cancer Hazard Evaluation Standards in the Name of Statistics..
177:521-522.
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Risk Characterization of Environmental Samples Using In Vitro Bioactivity and Polycyclic Aromatic Hydrocarbon Concentrations Data..
179:108-120.
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Toxicokinetics of inhaled trichloroethylene and tetrachloroethylene in humans at 1 ppm: empirical results and comparisons with previous studies..
95:23-36.
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Aryl hydrocarbon receptor gene silencing with small inhibitory RNA differentlally modulates Ah-responsiveness in MCF-7 and HepG2 cancer cells.
2003
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Expression and localization of P70 albumin precursor protein and phi AP3 in oxidatively stressed vascular smooth muscle cells.
2003
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A cell-based assay for screening inducers of cytochrome P450 3A4 and analyzing transcriptional regulation by pregane X receptor (PXR).
2003
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Ah receptor-mediated transcriptional suppression of interleukin-6.
2003
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Application of clustering methodologies to the analysis of altered cellular phenotypes induced by oxidative stress.
2003
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Beyond genomics: Image analysis and computational biology.
2003
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Chemical disruption of global gene expression during nephrogenesis: Role of aryl hydrocarbon receptor.
2003
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Decreased N- and Ksp-cadherin expression associated with HGCL2-induced acute renal failure is related to the spatial expression pattern of cadherins along the nephron.
2003
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Dioxin induces growth arrest and reduces cell cycle gene expression in the fetal murine heart.
2003
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From "omics" to insight: The use of a novel computational approach to study genegene interactions.
2003
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Genomic and immunofluorescence analysis of interactive gene networks in oxidant induced atherogenesis.
2003
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Maternal and developmental assessment of montmorillonite clays commonly added to animal feeds: Toxicity evaluation and metal bioavailability in the pregnant rat.
2003
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Regulation of CYF1A1 transcription elongation by aft receptor through interaction with P-TEF B.
2003
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Urinary metabolites of aflatoxin in dogs and dietary protection by clay against canine aflatoxicosis.
2003
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Effects of complex PAH mixtures and 7H-benzo(c)fluorene on DNA adduct formation in mice.
2003
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Enhanced clay-based enterosorbent for the prevention of aflatoxicosis:: In vitro and in vivo characterization.
2003
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Regulation of cyclin D1 gene expression in the mouse uterus by estrogen and 2,3,7,8-tetrachlorodibenzo-p-dioxin.
2003
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Symposium on mechanisms of action of naturally occurring anticarcinogens.
1999
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