Induction of glutathione S-transferases in genetically inbred male mice by dietary ethoxyquin hydrochloride. Academic Article

abstract

• 1. Constitutive and ethoxyquin hydrochloride (EQ-HCl)-induced hepatic glutathione (GSH) S-transferase, GSH reductase, and GSH peroxidase activities were determined in 5 strains of 8-10 week old inbred male mice. 2. The constitutive GSH S-transferase (GST) activity varied from 2.9 (SJL/JCR) to 8.9 (C57BL/6NCR) mumol product formed/min/mg protein and the corresponding values for the EQ-HCl-treated mice were in the range of 15.3-25.3 mumol product formed/min/mg protein. 3. EQ-HCl induced GST activity in all the strains examined and this contrasted to the induction activity of Aroclor 1254 which was strain-dependent. GST activity was induced 2.9-fold in Aroclor 1254-responsive (C57BL/6) and 2.8-fold in non-responsive (DBA/2) mice, respectively.

authors

• Safe, Stephen
• Womack, James

published proceedings

• Comp Biochem Physiol C Comp Pharmacol Toxicol

author list (cited authors)

• Makary, M., Kim, H. L., Safe, S., Womack, J., & Ivie, G. W.

citation count

• 9

complete list of authors

• Makary, M||Kim, HL||Safe, S||Womack, J||Ivie, GW

publication date

• January 1989

publisher

• Elsevier  Publisher

published in

• Comparative Biochemistry and Physiology - Part C: Comparative Pharmacology and Toxicology  Journal

keywords

• Animals
• Enzyme Induction
• Ethoxyquin
• Glutathione Transferase
• Liver
• Male
• Mice
• Quinolines

PubMed Central ID

• 2565179

Digital Object Identifier (DOI)

• 10.1016/0742-8413(89)90035-2

start page

• 171

end page

• 174

volume

• 92

issue

• 2

URL

• http://dx.doi.org/10.1016/0742-8413(89)90035-2