REACTIVE OXYGEN SPECIES AND COLORECTAL CANCER. Academic Article

abstract

• Several agents used for treatment of colon and other cancers induce reactive oxygen species (ROS) and this plays an important role in their anticancer activities. In addition to the well-known proapoptotic effects of ROS inducers, these compounds also decrease expression of specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and several pro-oncogenic Spregulated genes important for cancer cell proliferation, survival and metastasis. The mechanism of these responses involve ROS-dependent downregulation of microRNA-27a (miR-27a) or miR-20a (and paralogs) and induction of two Sp-repressors, ZBTB10 and ZBTB4 respectively. This pathway significantly contributes to the anticancer activity of ROS inducers and should be considered in development of drug combinations for cancer chemotherapy.

authors

• Safe, Stephen

published proceedings

• Curr Colorectal Cancer Rep

altmetric score

• 0.75

author list (cited authors)

• Sreevalsan, S., & Safe, S.

citation count

• 80

complete list of authors

• Sreevalsan, Sandeep||Safe, Stephen

publication date

• December 2013

publisher

• Springer Nature  Publisher

published in

• Current Colorectal Cancer Reports  Journal

keywords

• Antioxidants
• Colon Cancer
• Mechanism Based Drugs
• MicroRNA
• Reactive Oxygen Species
• Specificity Transcription Factors
• Targeted Therapy
• Zinc Finger Dna Binding Proteins

PubMed Central ID

• 25584043

Digital Object Identifier (DOI)

• 10.1007/s11888-013-0190-5

start page

• 350

end page

• 357

volume

• 9

issue

• 4

URL

• http%3A%2F%2Fdx.doi.org%2F10.1007%2Fs11888-013-0190-5