Inhibition of 3,3',4,4',5-pentachlorobiphenyl-induced chicken embryotoxicity by 2,2',4,4',5,5'-hexachlorobiphenyl. Academic Article uri icon


  • 3,3',4,4',5-Pentachlorobiphenyl (pentaCB) caused a dose-dependent induction of chicken embryolethality, malformations, edema, and liver lesions at doses ranging from 0.5 to 12.0 microg/kg. In contrast, no embryotoxicity was observed after treatment with 10, 25, or 50 mg/kg 2,2',4,4',5,5'-hexaCB. In eggs cotreated with 2.0 microg/kg, 3,3',4,4',5-pentaCB plus 10, 25, or 50 mg/kg 2,2',4,4',5,5'-hexaCB, there was significant protection from 3,3',4,4',5-pentaCB-induced embryo malformations, edema, and liver lesions, whereas no inhibition of embryolethality was observed. These results further extend the response-specific nonadditive interactions of binary mixtures of polychlorinated biphenyls (PCBs) and should be considered in the development of approaches for hazard assessment of PCB mixtures and related compounds.

published proceedings

  • Fundam Appl Toxicol

author list (cited authors)

  • Zhao, F., Mayura, K., Kocurek, N., Edwards, J. F., Kubena, L. F., Safe, S. H., & Phillips, T. D.

citation count

  • 17

complete list of authors

  • Zhao, F||Mayura, K||Kocurek, N||Edwards, JF||Kubena, LF||Safe, SH||Phillips, TD

publication date

  • January 1997