Induction of both cytochromes P-450 and P-448 by 2,3',4,4',5-pentabromobiphenyl, a component of fireMaster.

abstract

• The synthesis and purification of a component of fireMaster BP-6 and fireMaster FF-1, 2,3,4,4,5-pentabromobiphenyl, is described. The compound was found to be a potent inducer of liver microsomal drug-metabolizing enzymes in the rat, enhancing those enzymic activities induced by both phenobarbitone and 3-methylcholanthrene (i.e. cytochromes P-450 and P-448). The pentabromobiphenyl enhanced the activities of benzo[a]pyrene hydroxylase, dimethylamino-antipyrine N-demethylase and NADPH-cytochrome c reductase. The hepatic cytochromes b5 and P-450 were increased and the Soret peak maximum of the latter was shifted to 448.5 nm. The relative peak intensities and spectral shifts for the ethylisocyanide-binding difference spectra confirmed the mixed induction characteristics of 2,3,4,4,5-pentabromobiphenyl. 1980.

authors

• Safe, Stephen

published proceedings

• Biochem Biophys Res Commun

altmetric score

• 3

author list (cited authors)

• Robertson, L. W., Parkinson, A., & Safe, S.

citation count

• 53

complete list of authors

• Robertson, LW||Parkinson, A||Safe, S

publication date

• January 1980

publisher

• Elsevier  Publisher

published in

• Biochemical and Biophysical Research Communications  Journal

keywords

• Animals
• Benzopyrene Hydroxylase
• Biphenyl Compounds
• Cytochrome P-450 Enzyme System
• Flame Retardants
• Male
• Methylcholanthrene
• Microsomes, Liver
• Nadph-ferrihemoprotein Reductase
• Phenobarbital
• Polybrominated Biphenyls
• Rats
• Spectrophotometry

PubMed Central ID

• 6243934

Digital Object Identifier (DOI)

• 10.1016/0006-291x(80)91536-3

start page

• 175

end page

• 182

volume

• 92

issue

• 1

URL

• http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1980JC32500027&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=dd60ee4408902e709853f976e23bc0ff