6-METHYL-1,3,8-TRICHLORODIBENZOFURAN (MCDF) AS A 2,3,7,8-TCDD ANTAGONIST IN C57BL/6 MICE Academic Article uri icon

abstract

  • MCDF exhibits moderate affinity for the Ah receptor in both mice and rats; however, it is only a weak Ah receptor agonist in both species. In contrast, to previous studies in rats, MCDF was a relatively poor antagonist of TCDD-induced monooxygenase activities in mice, and over a dose range of 10-500 mol/kg, significant inhibition was observed only at a dose of 50 ol/kg. These dose-response interactive studies in C57BL/6 mice showed that MCDF significantly antagonized the TCDD-mediated induction of hepatic microsomal aryl hydrocarbon hydroxylase (AHH), 14% inhibition, and ethoxyresorufin-O-deethylase (EROD), 17% inhibition. MCDF was also a weak agonist for teratogenicity (cleft palate) and immunotoxicity (inhibition of the plaque-forming cell response to sheep erythrocytes) in C57BL/6 mice. Cotreatment of mice with an effective dose of 2,3,7,8-TCDD (ED70-100) and a subeffective dose of MCDF demonstrated that MCDF significantly antagonized 2,3,7,8-TCDD-induced teratogenicity and immunotoxicity in the mice. 1989.

published proceedings

  • CHEMOSPHERE

author list (cited authors)

  • BANNISTER, R., DAVIS, D., BIEGEL, L., ASTROFF, B., & SAFE, S.

citation count

  • 1

complete list of authors

  • BANNISTER, R||DAVIS, D||BIEGEL, L||ASTROFF, B||SAFE, S

publication date

  • January 1989