The effects of twenty-two organochlorine pesticides as inducers of the hepatic drug-metabolizing enzymes. Academic Article

abstract

• The effects of 22 organohalogen pesticides as inducers of hepatic drug-metabolizing enzymes in the immature male Wistar rat have been determined, this group includes four isomeric hexachlorocyclohexanes, technical chlordane, alpha-chlordane, gamma-chlordane, oxychlordane, trans-nonachlor, heptachlor, heptachlor epoxide, aldrin, dieldrin, kepone, toxaphene, mirex, hexachlorobenzene (HCB) and several DDT analogs. With the exception of HCB, all of the pesticides induced microsomal dimethylaminoantipyrine, N-demethylase and aldrin epoxidase activities and the cytochrome P-450 content of microsomes from animals pretreated with most of the compounds was also increased compared to control rats. These pesticides all resembled phenobarbitone in their mode of induction. The effects of HCB as a microsomal enzyme inducer resembled those observed after coadministration of phenobarbitone plus 3-methylcholanthrene.

authors

• nb20fdbd9_77490SE 

published proceedings

• Gen Pharmacol

altmetric score

• 3

author list (cited authors)

• Campbell, M. A., Gyorkos, J., Leece, B., Homonko, K., & Safe, S.

citation count

• 57

complete list of authors

• Campbell, MA||Gyorkos, J||Leece, B||Homonko, K||Safe, S

publication date

• January 1983

publisher

• Elsevier  Publisher

published in

• General pharmacology  Journal

keywords

• Animals
• Cyclohexanes
• DDT
• Enzyme Induction
• Hexachlorobenzene
• Insecticides
• Liver
• Male
• Methylcholanthrene
• Pharmaceutical Preparations
• Phenobarbital
• Rats
• Toxaphene

PubMed Central ID

• 6618147

Digital Object Identifier (DOI)

• 10.1016/0306-3623(83)90028-9

start page

• 445

end page

• 454

volume

• 14

issue

• 4

URL

• http://dx.doi.org/10.1016/0306-3623(83)90028-9