EFFECTS OF 2,3,7,8-TCDD AND RELATED-COMPOUNDS ON THE LEVELS OF AGE-DEPENDENT I-SPOT DNA ADDUCTS IN THE LIVER OF FEMALE AND MALE SPRAGUE-DAWLEY RATS
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Treatment of adult female rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, 1 g and 5 g/kg/week) over a period of 4 weeks resulted in a dose-dependent decrease in the levels of hepatic I-compounds (DNA adducts) as determined by the 32P-postlabeling procedure. In adult male Sprague Dawley rats TCDD did not change the levels of total hepatic I-spots. The significance of these sex-specific effects and other data will be discussed. 1990.
author list (cited authors)
RANDERATH, K., PUTMAN, K. L., RANDERATH, E., HARRIS, M., ZACHAREWSKI, T., & SAFE, S.
complete list of authors
RANDERATH, K||PUTMAN, KL||RANDERATH, E||HARRIS, M||ZACHAREWSKI, T||SAFE, S