Metabolism of bromobenzenes in the rabbit. Academic Article

abstract

• A series of brominated (Br1-Br5) benzenes was administered to rabbits by intraperitoneal injection and mass spectrometric analysis revealed the presence of oxygenated bromobenzene metabolites in the urine and feces. The metabolites were isolated and their structures determined. At least two major metabolites were identified from each bromobenzene (Br1-Br5) fed. Tetrabromo- and pentabromobenzene yielded only trace amounts of metabolite in the urine and none was detected in the feces. The compounds obtained from 1,4-dibromo- and 1,3,5-tribromobenzene showed migration of bromine atoms, suggesting the possibility of arene oxide intermediates. 1976, American Chemical Society. All rights reserved.

authors

• Safe, Stephen

published proceedings

• J Agric Food Chem

altmetric score

• 3

author list (cited authors)

• Ruzo, L. O., Safe, S., & Hutzinger, O.

citation count

• 12

complete list of authors

• Ruzo, LO||Safe, S||Hutzinger, O

publication date

• March 1976

publisher

• American Chemical Society (ACS)  Publisher

published in

• Journal of Agricultural and Food Chemistry  Journal

keywords

• Animals
• Bromobenzenes
• Feces
• Isomerism
• Oxidation-Reduction
• Rabbits
• Structure-Activity Relationship

PubMed Central ID

• 1254808

Digital Object Identifier (DOI)

• 10.1021/jf60204a001

start page

• 291

end page

• 293

volume

• 24

issue

• 2

URL

• http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1976BJ87800019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=dd60ee4408902e709853f976e23bc0ff