Reconstituted human breast milk PCBs as potent inducers of aryl hydrocarbon hydroxylase. Academic Article

abstract

• The major polychlorinated biphenyl (PCB) components identified in human breast milk have been synthesized and a reconstituted breast milk PCB mixture representing the average levels determined in the Osaka Prefecture in Japan has been prepared. The dose effecting the half-maximal (ED50) induction of rat hepatic microsomal aryl hydrocarbon hydroxylase (AHH) for the reconstituted breast milk PCBs (ED50 12 molkg1) was approximately seven times less than the ED50 for the commercial PCB mixture, Kanechlor 500. The increased biological potency of the former mixture reflects the preferential bioconcentration of the toxic PCB congeners, 2,3,3,4,4-penta-, 2,3,4,4,5-penta- and 2,3,3,4,4,5-hexachlorobiphenyl. 1980, All rights reserved.

authors

• Safe, Stephen

published proceedings

• Biochem Biophys Res Commun

altmetric score

• 6

author list (cited authors)

• Parkinson, A., Robertson, L. W., & Safe, S.

citation count

• 36

complete list of authors

• Parkinson, A||Robertson, LW||Safe, S

publication date

• September 1980

publisher

• Elsevier  Publisher

published in

• Biochemical and Biophysical Research Communications  Journal

keywords

• Animals
• Aryl Hydrocarbon Hydroxylases
• Enzyme Induction
• Female
• Humans
• Male
• Microsomes, Liver
• Milk, Human
• Polychlorinated Biphenyls
• Rats

PubMed Central ID

• 6775632

Digital Object Identifier (DOI)

• 10.1016/0006-291x(80)91438-2

start page

• 882

end page

• 889

volume

• 96

issue

• 2

URL

• http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1980KK77400051&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=dd60ee4408902e709853f976e23bc0ff