Polychlorinated biphenyls: metabolic behavior of pure isomers in pigeons, rats, and brook trout.

abstract

• The metabolic behavior of pure mono-, di-, tetra-, and hexachlorobiphenyl isomers in pigeons, rats, and brook trout was investigated. Excreta from these animals were extracted and examined by chromatographic and mass spectrometric techniques. The results showed conversion of the 4-chloro-, 4,4'-dichloro-, and 2,2',5,5'-tetrachlorobiphenyl isomers into monohydroxylated derivatives by the rat and pigeon whereas no hydroxymetabolites were detected in the excreta of the brook trout. No hydroxylated products of 2,2',4,4',5,5'-hexachlorobiphenyl were detected in the excreta of pigeons, rats, or brook trout.

authors

• Safe, Stephen

published proceedings

• Science

altmetric score

• 9

author list (cited authors)

• Hutzinger, O., Nash, D. M., Safe, S., DeFreitas, A. S., Norstrom, R. J., Wildish, D. J., & Zitko, V.

citation count

• 177

complete list of authors

• Hutzinger, O||Nash, DM||Safe, S||DeFreitas, AS||Norstrom, RJ||Wildish, DJ||Zitko, V

publication date

• October 1972

publisher

• American Association for the Advancement of Science (AAAS)  Publisher

published in

• Science  Journal

keywords

• Animals
• Chromatography, Gas
• Chromatography, Thin Layer
• Columbidae
• Feces
• Injections, Intraperitoneal
• Isomerism
• Mass Spectrometry
• Polychlorinated Biphenyls
• Rats
• Salmonidae

PubMed Central ID

• 4627870

Digital Object Identifier (DOI)

• 10.1126/science.178.4058.312

start page

• 312

end page

• 314

volume

• 178

issue

• 4058

URL

• http://dx.doi.org/10.1126/science.178.4058.312