Metabolism of the systemic fungicide 2,5-dimethyl-3-furancarboxylic acid anilide (BAS 3191) by Rhizopus japonicus and related fungi.
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Rhizopus japonicus and related fungi convert the systemic fungicide 2,3-dimethyl-3-furancarboxylic acid anilide (BAS 3191) into two metabolites, 2-hydroxymethyl-5-methyl-3-furancarboxylic acid anilide (M-2) and 2-methyl-5-hydroxymethyl-3-furan-carboxylic acid anilide (M-l). These metabolites, which were identified by nuclear magnetic resonance and mass spectrometric analysis, accumulate after a 1 week growth period. BAS 3191 (60 mol/1.) was transformed into 23 mol/1. of M-l and 12 mol/1. of M-2, respectively. 1972, American Chemical Society. All rights reserved.