Effects of sesquiterpene lactones on mitochondrial oxidative phosphorylation. Academic Article

abstract

• 1. The toxic plant sesquiterpene lactones, helenalin, hymenoxon, mexicanin-E, tenulin, dihydrogriesenin, and psilotropin which were isolated from Helenium, Hymenoxys, and Geigeria spp markedly inhibited "state 3" respiration in mouse hepatic mitochondria. With the exception of dihydrogriesenin and psilotropin, all the other sesquiterpene lactones stimulated "state 4" respiration. 2. The sesquiterpene lactones also stimulated ATPase activity in the presence of Mg2+ ions and caused mitochondrial swelling in buffer solutions containing magnesium, sodium, ammonium and potassium chloride salts. 3. The number of alkylating sites present in a sesquiterpene lactone appears to be related to the inhibitory activity on mitochondrial oxidative phosphorylation, however, the structure-activity relationship of these lactones is not clear at present. 4. Mitochondria prepared from the liver of ethoxyquin hydrochloride-fed mice were less susceptible to sesquiterpene lactone-mediated inhibition of mitochondrial oxidative phosphorylation.

authors

• Safe, Stephen

published proceedings

• Gen Pharmacol

author list (cited authors)

• Narasimham, T. R., Kim, H. L., & Safe, S. H.

citation count

• 13

complete list of authors

• Narasimham, TR||Kim, HL||Safe, SH

publication date

• January 1989

publisher

• Elsevier  Publisher

published in

• General pharmacology  Journal

keywords

• Adenosine Triphosphatases
• Animals
• Cytosol
• Female
• In Vitro Techniques
• Lactones
• Mice
• Mice, Inbred ICR
• Mitochondria, Liver
• Mitochondrial Swelling
• Oligomycins
• Oxidative Phosphorylation
• Oxygen Consumption
• Sesquiterpenes
• Sulfhydryl Compounds

PubMed Central ID

• 2532610

Digital Object Identifier (DOI)

• 10.1016/0306-3623(89)90107-9

start page

• 681

end page

• 687

volume

• 20

issue

• 5

URL

• http://dx.doi.org/10.1016/0306-3623(89)90107-9