ENHANCED ACTIVITY OF POLYNUCLEAR AROMATIC HYDROCARBON MIXTURES AS ARYL-HYDROCARBON (AH) RECEPTOR AGONISTS Conference Paper uri icon

abstract

  • The relative potencies of benzor[a]pyrene and a complex mixture of polycyclic aromatic hydrocarbons (PAH) produced as by-products of manufactured gas plant (MGP) residues as inducers of hepatic microsomal ethoxyresorufin O-deethylase (EROD) were determined in the B6C3F1mouse. The ED50 values for the induction response were 78 and 65 mg/kg for benzo[a]pyrene and the MGP-PAH mixture, respectively, although benzo[a]pyrene and other compounds containing four or more rings were only trace components of this mixture. A comparison of the EROD induction potencies of benzo[a]pyrene and the MGP-PAH mixture showed that the mixture was approximately 706 times more active than expected based on its benzo[a]pyrene content (0.17%). The enhanced activity of the MGP-PAH mixture was also observed for several other aryl hydrocarbon (Ah) receptor-mediated responses, including inhibition of the splenic plaque-forming cell (PFC) response to both T-cell-dependent and independent antigens in B6C3F1mice. The nature of these PAH interactions will be discussed. 1994, Taylor & Francis Group, LLC. All rights reserved.

published proceedings

  • POLYCYCLIC AROMATIC COMPOUNDS

author list (cited authors)

  • CHALOUPKA, K., HARPER, N., KRISHNAN, V., KSTEINBERG, M., SANTOSTEFANO, M., SAFE, S. H., ... GOLDSTEIN, L. S.

citation count

  • 1

complete list of authors

  • CHALOUPKA, K||HARPER, N||KRISHNAN, V||KSTEINBERG, M||SANTOSTEFANO, M||SAFE, SH||WOMACK, J||RODRIGUEZ, LV||DUNSFORD, HA||GOLDSTEIN, LS

publication date

  • August 1994