Sp transcription factor family and its role in cancer. Academic Article

abstract

• Specificity protein 1 (Sp1) and other Sp and Krppel-like factor (KLF) proteins are members of a family of transcription factors which bind GC/GT-rich promoter elements through three C(2)H(2)-type zinc fingers that are present at their C-terminal domains. Sp1-Sp4 proteins regulate expression of multiple genes in normal tissues and tumours. There is growing evidence that some Sp proteins play a critical role in the growth and metastasis of many tumour types by regulating expression of cell cycle genes and vascular endothelial growth factor. Sp/KLF proteins are also potential targets for cancer chemotherapy.

authors

• Safe, Stephen

published proceedings

• Eur J Cancer

author list (cited authors)

• Safe, S., & Abdelrahim, M.

citation count

• 412

complete list of authors

• Safe, Stephen||Abdelrahim, Maen

publication date

• November 2005

publisher

• Elsevier  Publisher

published in

• European Journal of Cancer  Journal

keywords

• Cell Survival
• Gene Expression
• Humans
• Neoplasms
• Sp Transcription Factors
• Vascular Endothelial Growth Factor A

PubMed Central ID

• 16209919

Digital Object Identifier (DOI)

• 10.1016/j.ejca.2005.08.006

start page

• 2438

end page

• 2448

volume

• 41

issue

• 16

URL

• http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000233522700006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=dd60ee4408902e709853f976e23bc0ff