INTERACTION OF 6-METHYL-1,3,8-TRICHLORODIBENZOFURAN WITH TCDD-INDUCED VITAMIN A REDUCTION uri icon

abstract

  • 6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) have been shown to inhibit TCDD-induced enzymeinduction both in rat and in cell culture. MCDF, alone or together with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), was administered to rats in order to investigate the ability of MCDF to reduce TCDD-induced vitamin A depletion. High doses of MCDF induced vitamin A-depletion, but no inhibitory effect on TCDD-induced depletion was seen in this experiment. 1989.

published proceedings

  • CHEMOSPHERE

author list (cited authors)

  • WAERN, F., HANBERG, A., MANZOOR, E., SAFE, S., & AHLBORG, U. G.

citation count

  • 2

complete list of authors

  • Wærn, F||Hanberg, A||Manzoor, E||Safe, S||Ahlborg, UG

publication date

  • January 1989