Interaction of 6-methyl-1,3,8-trichlorodibenzofuran with tcdd-induced vitamin A reduction
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6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) have been shown to inhibit TCDD-induced enzymeinduction both in rat and in cell culture. MCDF, alone or together with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), was administered to rats in order to investigate the ability of MCDF to reduce TCDD-induced vitamin A depletion. High doses of MCDF induced vitamin A-depletion, but no inhibitory effect on TCDD-induced depletion was seen in this experiment. © 1989.
author list (cited authors)
Wærn, F., Hanberg, A., Manzoor, E., Safe, S., & Ahlborg, U. G.