The in vitro metabolism, macromolecular binding and bacterial mutagenicity of 4-chloribiphenyl, a model PCB substrate. Academic Article

abstract

• The in vitro metabolism of 4-chlorobiphenyl, a model polychlorinated biphenyl (PCB) substrate, proceeds via an arene oxide intermediate to give the observed in vivo hydroxylated metabolites. The rabbit liver microsomal fraction mediates binding between the PCB and the endogenous microsomal protein and RNA and the major part of the PCB was bound to the light 3S-10S RNA fraction. The lower chlorinated 4-chlorobiphenyl isomer was highly mutagenic to the Salmonella typhimurium strain TA1538 (sensitive to frameshift mutagens) whereas higher chlorinated PCB were only weakly mutagenic.

authors

• Safe, Stephen

published proceedings

• Res Commun Chem Pathol Pharmacol

author list (cited authors)

• Wyndham, C., Devenish, J., & Safe, S.

citation count

• 62

complete list of authors

• Wyndham, C||Devenish, J||Safe, S

publication date

• November 1976

published in

• Research communications in chemical pathology and pharmacology  Journal

keywords

• Animals
• Aroclors
• Biphenyl Compounds
• Centrifugation, Density Gradient
• In Vitro Techniques
• Macromolecular Substances
• Male
• Microsomes, Liver
• Mutagens
• Polychlorinated Biphenyls
• Protein Binding
• RNA
• Rabbits
• Salmonella Typhimurium
• Structure-Activity Relationship
• Time Factors

PubMed Central ID

• 825937

start page

• 563

end page

• 570

volume

• 15

issue

• 3

URL

• http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1976CM36000013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=dd60ee4408902e709853f976e23bc0ff