Aroclor 1254 as an antagonist of the teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Academic Article uri icon


  • Administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, 20 micrograms/kg) to pregnant C57BL/6J mice (on day 10) resulted in 62% fetuses with cleft palate per litter without any observable maternal toxicity. In contrast, Aroclor 1254 administered at a dose of 750 mumol/kg was not teratogenic. Cotreatment of the pregnant mice with both Aroclor 1254 (244 mg/kg) and 2,3,7,8-TCDD (20 micrograms/kg) resulted in an 8.2% incidence of cleft palate per litter. In contrast, Aroclor 1254 did not afford any protection from the teratogenicity of dexamethasone in C57BL/6J mice. Previous studies have shown that Aroclor 1254 can act as a partial antagonist of the microsomal enzyme induction and immunotoxic effects of 2,3,7,8-TCDD in C57BL/6J mice and this paper demonstrates that the commercial polychlorinated biphenyl mixture also antagonizes 2,3,7,8-TCDD-mediated teratogenicity in this strain of mice.

published proceedings

  • Toxicol Lett

altmetric score

  • 9

author list (cited authors)

  • Haake, J. M., Safe, S., Mayura, K., & Phillips, T. D.

citation count

  • 87

complete list of authors

  • Haake, JM||Safe, S||Mayura, K||Phillips, TD

publication date

  • October 1987