Metabolism of chlorinated naphthalenes. Academic Article uri icon

abstract

  • 1-Chloro-4-[2H]naphthalene was administered to a pig and the 4-chloronaphthol metabolite retained 18% of the deuterium. 1,4-Dichloro- and 1,4-dibromonaphthalene gave 2,4-dihalonaphthols as the major products and the results are consistent with the intermediacy of arene oxides; decomposition of these intermediates is accompanied by a 1,2 migration of deuterium and halogen, respectively. 1,2-Dichloronaphthalene and 1,2,3,4-tetrachloronaphthalene also give phenolic metabolites; however, the higher chlorinated isomer, 1,2,3,4,5,6-hexachloronaphthalene, was not metabolized. 1976, American Chemical Society. All rights reserved.

published proceedings

  • J Agric Food Chem

author list (cited authors)

  • Ruzo, L., Jones, D., Safe, S., & Hutzinger, O.

complete list of authors

  • Ruzo, L||Jones, D||Safe, S||Hutzinger, O

publication date

  • January 1, 1976 11:11 AM