The in vitro hydroxylation of 4'-chloro-4-biphenylol by a mushroom tyrosinase preparation. Academic Article uri icon


  • Incubation of 4'-chloro-4-biphenylol with a mushroom tyrosinase preparation gave the catechol, 4'-chloro-3,4-biphenyldiol as the sole in vitro metabolite. This compound was identical with the major rat urinary metabolite of 4'-chloro-4-biphenylol and thus confirms the structure assigned to the metabolite. This result also demonstrates a possible degradation pathway of hydroxylated chlorobiphenyls which are themselves the major metabolic degradation products of polychlorinated biphenyls.

published proceedings

  • Can J Microbiol

author list (cited authors)

  • Safe, S., Ellis, B. E., & Hutzinger, O.

citation count

  • 6

complete list of authors

  • Safe, S||Ellis, BE||Hutzinger, O

publication date

  • January 1976