Inhibition of 3,3,4,4,5-pentachlorobiphenyl-induced chicken embryotoxicity by 2,2,4,4,5,5-hexachlorobiphenyl
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abstract
3,3,4,4,5-Pentachlorobiphenyl (pentaCB) caused a dose dependent induction of chicken embryolethality, malformations, edema, and liver lesions at doses ranging from 0.5 to 12.0 g/kg. In contrast, no embryotoxicity was observed after treatment with 10, 25, or 50 mg/kg 2,2,4,4,5,5-hexaCB. In eggs cotreated with 2.0 g/kg, 3,3,4,4,5-pentaCB plus 10, 25, or 50 mg/kg 2,2,4,4,5,5-hexaCB, there was significant protection from 3,3,4,4,5-pentaCB-induced embryo malformations, edema, and liver lesions, whereas no inhibition of embryolethality was observed. These results further extend the response-specific nonadditive interactions of binary mixtures of polychlorinated biphenyls (PCBs) and should be considered in the development of approaches for hazard assessment of PCB mixtures and related compounds.
