Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: a novel pathway explaining the estrogenic activity of PCBs. uri icon

abstract

  • Polychlorinated biphenyls (PCBs) are persistent environmental pollutants which exert a variety of toxic effects in animals, including disturbances of sexual development and reproductive function. The estrogenic effects of PCBs may be mediated in part by hydroxylated PCB metabolites (PCB-OHs), but the mechanisms by which they are brought about are not understood. PCBs as well as PCB-Hs show low affinities for both alpha and beta estrogen receptor isoforms. In the present study we demonstrate that various environmentally relevant PCB-OHs are extremely potent inhibitors of human estrogen sulfotransferase, strongly suggesting that they indirectly induce estrogenic activity by increasing estradiol bioavailability in target tissues.

published proceedings

  • Endocrinology

altmetric score

  • 13.25

author list (cited authors)

  • Kester, M. H., Bulduk, S., Tibboel, D., Meinl, W., Glatt, H., Falany, C. N., ... Visser, T. J.

citation count

  • 292

complete list of authors

  • Kester, MH||Bulduk, S||Tibboel, D||Meinl, W||Glatt, H||Falany, CN||Coughtrie, MW||Bergman, A||Safe, SH||Kuiper, GG||Schuur, AG||Brouwer, A||Visser, TJ

publication date

  • May 2000