Identification of a toxic impurity in commercial diphenylamine. Academic Article

abstract

• The impurity in commercial diphenylamine which induces polycystic kidney disease in rats has been identified as N,N,N'-triphenyl-p-phenylenediamine. The structure of the compound was confirmed by mass and proton magnetic resonance spectrometry and by comparison with a synthetic standard prepared by the Ullman coupling of iodobenzene and p-phenylenediamine or N,N-diphenyl-p-phenylenediamine. Laboratory studies with highly purified diphenylamine indicated that N,N,N'-triphenyl-p-phenylenediamine can be formed by heating diphenylamine.

authors

• Safe, Stephen

published proceedings

• J Environ Sci Health B

altmetric score

• 3

author list (cited authors)

• Clegg, S., Safe, S., & Crocker, J. F.

citation count

• 3

complete list of authors

• Clegg, S||Safe, S||Crocker, JF

publication date

• January 1981

publisher

• Taylor & Francis  Publisher

published in

• Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes  Journal

keywords

• Aniline Compounds
• Animals
• Diphenylamine
• Drug Contamination
• Phenylenediamines
• Rats

PubMed Central ID

• 7252059

Digital Object Identifier (DOI)

• 10.1080/03601238109372245

start page

• 125

end page

• 130

volume

• 16

issue

• 2

URL

• http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1981LH06600002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=dd60ee4408902e709853f976e23bc0ff