Lysosomal membrane labilization by DDT, DDE and polychlorinated biphenyls (PCB). Academic Article

abstract

• Incubation of the ubiquitous pollutants, polychlorinated biphenyls (PCB), DDT and DDE with rat liver lysosomes shows that these lipophillic substrates are highly active labilizers of lysosomal membranes. The release of acid phosphatase was used as a marker enzyme and at high PCB, DDT and DDE concentrations (2X10(-3)M) the lytic activity was similar to that of the detergent Triton X-100; at lower concentrations most of the commercial PCB samples, DDT and DDE still retain considerably lytic activity.

authors

• Safe, Stephen

published proceedings

• Res Commun Chem Pathol Pharmacol

author list (cited authors)

• Rogers, A., Mellors, A., & Safe, S.

citation count

• 12

complete list of authors

• Rogers, A||Mellors, A||Safe, S

publication date

• February 1976

published in

• Research communications in chemical pathology and pharmacology  Journal

keywords

• Animals
• DDT
• Dichlorodiphenyl Dichloroethylene
• In Vitro Techniques
• Lysosomes
• Membranes
• Polychlorinated Biphenyls
• Rats

PubMed Central ID

• 815975

start page

• 341

end page

• 343

volume

• 13

issue

• 2

URL

• http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1976BG75700016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=dd60ee4408902e709853f976e23bc0ff