Sporidesmins. XII. Isolation and structure of sporidesmin G, a naturally-occuring 3,6-epitetrahiopiperazine-2,5-dione. Academic Article

abstract

• When the tail fractions from chromatograms of sporidesmin E(I; n = 3) were rechromatographed, a new crystalline metabolite of Pithomyces chartarum was isolated with molecular formula C18H20ClN 3O6S4. The new compound, named, sporidesmin G (I; n = 4), gave sporidesmin (I; n = 2) on irradiation or treatment with triphenylphosphine, and sporidesmin D (V) after reduction and methylation. It was shown that the model compound, 1,4-dimethyl-3,6-epidithiopiperazine-2,5- dione, gave the cyclic tetrasulphide on treatment with dihydrogen disulphide. Similarly, sporidesmin and sporidesmin E when treated with dihydrogen disulphide gave the new metabolite.

authors

• Safe, Stephen

published proceedings

• J Chem Soc Perkin 1

altmetric score

• 3

author list (cited authors)

• Francis, E., Rahman, R., Safe, S., & Taylor, A.

citation count

• 30

complete list of authors

• Francis, E||Rahman, R||Safe, S||Taylor, A

publication date

• December 1972

publisher

• Royal Society of Chemistry (RSC)  Publisher

published in

• Journal of the Chemical Society. Perkin transactions 1  Journal

keywords

• Ketones
• Mitosporic Fungi
• Mycotoxins
• Piperazines
• Sulfides

Digital Object Identifier (DOI)

• 10.1039/p19720000470

start page

• 470

end page

• 472

volume

• 4

issue

• 0

URL

• http://dx.doi.org/10.1039/p19720000470