The effects of organochlorine pesticides as inducers of testosterone and benzo[a]pyrene hydroxylases. Academic Article uri icon

abstract

  • p,p'-DDE, phenobarbital, dieldrin heptachlor, chlordane and toxaphene induced rat liver microsomes exhibited increased formation of the 4,5-dihydrodiol, 3,6-quinone, 9- and 3-hydroxymetabolites of benzo[a]pyrene and the latter three compounds also induced an increase in the rate of formation of the 9,10-dihydrodiol metabolite. Lindane was inactive as an inducer of benzo[a]pyrene hydroxylase. With the exception of lindane, all the organochlorine pesticides and PB induced testosterone 16 alpha- and 16 beta-hydroxylases; in contrast lindane induced testosterone 6 alpha-, 7 alpha- and 6 beta-hydroxylases and PB also induced testosterone 15 beta-hydroxylase and androstenedione formation. Using a battery of monooxygenase enzyme assays it was evident that there were significant differences between PB and several organochlorine pesticides as inducers of rat hepatic cytochrome P-450-dependent monooxygenases.

published proceedings

  • Gen Pharmacol

altmetric score

  • 6

author list (cited authors)

  • Haake, J., Kelley, M., Keys, B., & Safe, S.

citation count

  • 41

complete list of authors

  • Haake, J||Kelley, M||Keys, B||Safe, S

publication date

  • January 1987