Unsolved problems of random noise; Unconditionally secure communications over the wire; KLJN key exchanger; Noise-based logic and computation; Fluctuation-enhanced sensing; SEPTIC bacterium detection method; 1/f noise; Noise in high-Tc superconductors; Conductance noise at percolation; Noise spectrum in self-organized criticality; Stochastic resonance; Nanomaterials and structures; Lognormal distribution; Neuronal firing dynamics; Originality in scientific research; Physical informatics; Energy dissipation in computing and communications; Non-validity of the Landauer theorem; Information versus thermal entropy; etc.