A CMOS Sensor Array IC of Nanowell Devices for Molecular Sensing
Conference Paper
Overview
Research
Identity
Additional Document Info
Other
View All
Overview
abstract
This paper demonstrates a CMOS integrated sensor IC for an array of novel nanowell devices used for molecular sensing. The size of the nanowell (10-100nm) enables high-fidelity detection and analysis through broadband dielectric spectroscopy (BDS) of the parallel-plate capacitor formed by the nanowell and the trapped molecule. The signal transduction is done by a novel, continuous-time detector circuit followed by a low-noise lock-in architecture which measures the admittance of the sensor as a function of frequency for BDS. The CMOS IC has a capacitance resolution of 14 aF (frequency 1Hz - 1GHz) and power consumption of only 30W/channel. The CMOS front-end are implemented in TSMC 0.18 technology. 2004 IEEE.