My lab uses X-ray crystallography to better understand the relationship between proteins and ligands. Tiny differences in the structure of a molecule can radically change the interaction between a protein and ligand and we are only begining to understand how many factors play a role in this interaction. By manipulating the individual components of a compound it is possible to create a chemical that binds to the protein better than the natural substrate, and prevent the natural reaction from occurring. This is the basis for rational drug design. Our efforts have lead us to collaborations with other labs and scientists in many disciplines as our approach to directed compound design has applications not only in basic research but also in pesticide development, health research and clinical research.
Works By Students
principal investigator on
Works By Students
chaired theses and dissertations
Dey, Sanghamitra (2008-08).
Structural insights into the enzymes of the serine and biotin biosynthetic pathways in mycobacterium tuberculosis.
Harshbarger, Wayne (2011-08).
Crystal Structures of Binary and Ternary Complexes of Thymidylate Synthase (ThyA) from Mycobacterium tuberculosis: Insights into Selectivity and Inhibition.
Harshbarger, Wayne (2015-05).
X-Ray Crystal Structure of Human 20s Proteasome in Complex with Carfilzomib.
Hughes, Ryan C (2016-12).
Identification of Whole Cell Active Molecules of Mycobacterium Tuberculosis, Elucidation of Molecular Mechanisms Responsible for Resistance, and Characterization of Rv0272: A potential Therapeutic Target.
Joseph, Sonia (2014-08).
The Biochemical Investigation and Isolation of Small Molecule Inhibitors for Two Essential Proteins of Mycobacterium tuberculosis H37Rv: IspD and Wag31.
Jung, Hunmin (2014-12).
Development of Potent and Selective Inhibitors of Mycobacterium Tuberculosis, Plasmodium Falciparum and Staphylococcus Aureus Dihydrofolate Reductase.
Kuo, Mack Ryan (2006-12).
Structure, function, and inhibition of enoyl reductases.
Kuznetsov, Vladimir 1973- (2011-08).
Structural Studies of Phage Lysis Proteins and Their Targets.
LaiHing, Steven 1983- (2011-08).
Using High Throughput Screening to Acquire Promising Drug Candidates Against Mycobacterium tuberculosis.
Lalgondar, Mallikarjun (2014-05).
Structural Studies and Evaluation of Inhibitors of Mycobacterium tuberculosis H37Rv Shikimate Dehydrogenase (MtSDH).
Liu, Zhen (2013-12).
Understanding and Targeting Lipid Metabolism of Mycobacterium tuberculosis.
Lucumi Moreno, Edinson (2005-12).
Structural determination of triclosan derivatives as inhibitors of Plasmodium falciparum enoyl reductase (PfENR).
Mire, Joseph Andrew (2013-08).
Application of Structure Activity Relationships of the Mycobacterium Tuberculosis Beta-Lactamase (BlaC) and the New Delhi Metallo-Beta-Lactamase (NDM-1) to Combating Beta-Lactamase Mediated Drug Resistance.
Ramesh, Arati (2007-08).
Structural studies of the Ro ribonucleoprotein and the metalloregulator CsoR.
Reyes Caballero, Hermes (2011-08).
Biochemical Characterization of the Mycobacterium tuberculosis Ni(II) Sensor NmtR and Streptococcus pneumoniae Zn(II) Sensor AdcR.
Sun, Qingan (2011-05).
Structural Studies of Bacteriophage Lysins and their Implication in Human Diseases.
Tsai, Han-Chun (2013-08).
Structural Study of Lipid-binding Proteins.
Wang, Feng (2007-08).
Structure-based drug mechanism study and inhibitor design targeting tuberculosis.
Yang, Dong (2006-08).
Structural studies of terpenoid biosynthesis and bacterial cell division.
Yu, Hong (2007-05).
Structural studies of Mycobacterium tuberculosis KatG, an INH drug activator, and Brucella abortus VirB11, an ATPase of type IV translocation system.
Zhu, Wan Wen (2011-08).
Structural and Functional Studies of Mycothiol Biosynthesis Precursor Enzyme in Mycobacterium tuberculosis.