Amino acid sequence of porcine heart fumarase. Academic Article uri icon


  • The complete amino acid sequence of porcine heart fumarase (EC has been determined from peptides produced by cyanogen bromide, endoproteinase Arg-C, S. aureus V8 protease, and trypsin. The enzyme is a tetramer of identical subunits with Mr = 50,015 and composed of 466 amino acid residues. Porcine heart fumarase displays 96% identity to human liver fumarase. Prediction of the secondary structural elements of porcine fumarase indicate that the enzyme contains a large amount of alpha helix with very little beta structure.

published proceedings

  • Biochem Biophys Res Commun

author list (cited authors)

  • Sacchettini, J. C., Frazier, M. W., Chiara, D. C., Banaszak, L. J., & Grant, G. A.

citation count

  • 18

complete list of authors

  • Sacchettini, JC||Frazier, MW||Chiara, DC||Banaszak, LJ||Grant, GA

publication date

  • May 1988