Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes. Academic Article uri icon


  • The Anopheles mosquito that harbors the Plasmodium parasite contains a microbiota that can influence both the vector and the parasite. In recent years, insect-associated microbes have highlighted the untapped potential of exploiting interspecies interactions to discover bioactive compounds. In this study, we report the discovery of nonribosomal lipodepsipeptides that are produced by a Serratia sp. within the midgut and salivary glands of Anopheles stephensi mosquitoes. The lipodepsipeptides, stephensiolidesA-K, have antibiotic activity and facilitate bacterial surface motility. Bioinformatic analyses indicate that the stephensiolides are ubiquitous in nature and are likely important for Serratia spp. colonization within mosquitoes, humans, and other ecological niches. Our results demonstrate the usefulness of probing insect-microbiome interactions, enhance our understanding of the chemical ecology within Anopheles mosquitoes, and provide a secondary-metabolite scaffold for further investigate of this complex relationship.

published proceedings

  • Chembiochem

altmetric score

  • 20.88

author list (cited authors)

  • Ganley, J. G., Carr, G., Ioerger, T. R., Sacchettini, J. C., Clardy, J., & Derbyshire, E. R.

citation count

  • 17

complete list of authors

  • Ganley, Jack G||Carr, Gavin||Ioerger, Thomas R||Sacchettini, James C||Clardy, Jon||Derbyshire, Emily R

publication date

  • August 2018