A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis In Vitro.
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We identified a novel 6-benzyl ether benzoxaborole with potent activity against Mycobacterium tuberculosis The compound had an MIC of 2 M in liquid medium. The compound was also able to prevent growth on solid medium at 0.8 M and was active against intracellular bacteria (50% inhibitory concentration [IC50] = 3.6 M) without cytotoxicity against eukaryotic cells (IC50 > 100 M). We isolated resistant mutants (MIC 100 M), which had mutations in Rv1683, Rv3068c, and Rv0047c.
Antimicrob Agents Chemother
author list (cited authors)
Patel, N., O'Malley, T., Zhang, Y., Xia, Y. i., Sunde, B., Flint, L., ... Parish, T.
complete list of authors
Patel, Nipul||O'Malley, Theresa||Zhang, Yong-Kang||Xia, Yi||Sunde, Bjorn||Flint, Lindsay||Korkegian, Aaron||Ioerger, Thomas R||Sacchettini, Jim||Alley, MRK||Parish, Tanya