A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis In Vitro Academic Article uri icon

abstract

  • We identified a novel 6-benzyl ether benzoxaborole with potent activity against Mycobacterium tuberculosis The compound had an MIC of 2 μM in liquid medium. The compound was also able to prevent growth on solid medium at 0.8 μM and was active against intracellular bacteria (50% inhibitory concentration [IC50] = 3.6 μM) without cytotoxicity against eukaryotic cells (IC50 > 100 μM). We isolated resistant mutants (MIC ≥ 100 μM), which had mutations in Rv1683, Rv3068c, and Rv0047c.

altmetric score

  • 10.25

author list (cited authors)

  • Patel, N., O'Malley, T., Zhang, Y., Xia, Y. i., Sunde, B., Flint, L., ... Parish, T.

citation count

  • 2

publication date

  • August 2017