A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis In Vitro. uri icon

abstract

  • We identified a novel 6-benzyl ether benzoxaborole with potent activity against Mycobacterium tuberculosis The compound had an MIC of 2 M in liquid medium. The compound was also able to prevent growth on solid medium at 0.8 M and was active against intracellular bacteria (50% inhibitory concentration [IC50] = 3.6 M) without cytotoxicity against eukaryotic cells (IC50 > 100 M). We isolated resistant mutants (MIC 100 M), which had mutations in Rv1683, Rv3068c, and Rv0047c.

published proceedings

  • Antimicrob Agents Chemother

altmetric score

  • 11

author list (cited authors)

  • Patel, N., O'Malley, T., Zhang, Y., Xia, Y. i., Sunde, B., Flint, L., ... Parish, T.

citation count

  • 9

complete list of authors

  • Patel, Nipul||O'Malley, Theresa||Zhang, Yong-Kang||Xia, Yi||Sunde, Bjorn||Flint, Lindsay||Korkegian, Aaron||Ioerger, Thomas R||Sacchettini, Jim||Alley, MRK||Parish, Tanya

publication date

  • September 2017