Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis Institutional Repository Document uri icon


  • AbstractA set of 500 purified natural product compounds was screened for inhibition against the human pathogen Mycobacterium tuberculosis. A series of cyclic hexapeptides with anti-tubercular activity was identified. Five analogs from a set of sixteen closely related compounds were active, with minimum inhibitory concentrations ranging from 2.3-8.9 M. Eleven structural analogs had no significant activity (MIC > 20 M) demonstrating structure activity relationship. Sequencing of resistant mutant isolates failed to identify changes accounting for the resistance phenotype.

altmetric score

  • 3.6

author list (cited authors)

  • Singh, S. B., Odingo, J., Bailey, M. A., Sunde, B., Korkegian, A., OMalley, T., ... Parish, T.

citation count

  • 0

complete list of authors

  • Singh, Sheo B||Odingo, Joshua||Bailey, Mai A||Sunde, Bjorn||Korkegian, Aaron||O’Malley, Theresa||Ovechkina, Yulia||Ioerger, Thomas R||Sacchettini, James C||Young, Katherine||Olsen, David B||Parish, Tanya

Book Title

  • bioRxiv

publication date

  • March 2018