Therapeutic strategies for human amyloid diseases. Academic Article

abstract

• Amyloid diseases are a large group of a much larger family of misfolding diseases. This group includes pathologies as diverse as Alzheimer's disease, immunoglobulin-light-chain disease, reactive amyloid disease and the familial amyloid polyneuropathies. These diseases are generally incurable at present, although some drugs are known to transiently slow the progression of Alzheimer's disease. As we increase our understanding of the causative mechanisms of these disorders, the likelihood of success for a given therapeutic strategy will become clearer. This review will look at small-molecule and macromolecular approaches for intervention in amyloid diseases other than Alzheimer's disease, although select examples from Alzheimer's disease will be discussed.

authors

• Sacchettini, James

published proceedings

• Nat Rev Drug Discov

altmetric score

• 9

author list (cited authors)

• Sacchettini, J. C., & Kelly, J. W.

citation count

• 226

complete list of authors

• Sacchettini, James C||Kelly, Jeffery W

publication date

• April 2002

publisher

• Springer Nature  Publisher

published in

• Nature Reviews Drug Discovery  Journal

keywords

• Alzheimer Disease
• Amyloid
• Amyloid Neuropathies, Familial
• Amyloidosis
• Humans
• Immunization
• Risk Factors

PubMed Central ID

• 12120278

Digital Object Identifier (DOI)

• 10.1038/nrd769

start page

• 267

end page

• 275

volume

• 1

issue

• 4