Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis Academic Article uri icon

abstract

  • OBJECTIVE: Our aim was to identify natural products with anti-tubercular activity. RESULTS: A set of ~ 500 purified natural product compounds was screened for inhibition against the human pathogen Mycobacterium tuberculosis. A series of cyclic hexapeptides with anti-tubercular activity was identified. Five analogs from a set of sixteen closely related compounds were active, with minimum inhibitory concentrations ranging from 2.3 to 8.9 μM. Eleven structural analogs had no significant activity (MIC > 20 μM) demonstrating structure activity relationship. Sequencing of resistant mutant isolates failed to identify changes accounting for the resistance phenotype.

altmetric score

  • 4.8

author list (cited authors)

  • Singh, S. B., Odingo, J., Bailey, M. A., Sunde, B., Korkegian, A., O’Malley, T., ... Parish, T.

citation count

  • 0

publication date

  • June 2018