Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis. Academic Article uri icon

abstract

  • OBJECTIVE: Our aim was to identify natural products with anti-tubercular activity. RESULTS: A set of ~500 purified natural product compounds was screened for inhibition against the human pathogen Mycobacterium tuberculosis. A series of cyclic hexapeptides with anti-tubercular activity was identified. Five analogs from a set of sixteen closely related compounds were active, with minimum inhibitory concentrations ranging from 2.3 to 8.9M. Eleven structural analogs had no significant activity (MIC>20M) demonstrating structure activity relationship. Sequencing of resistant mutant isolates failed to identify changes accounting for the resistance phenotype.

published proceedings

  • BMC Res Notes

author list (cited authors)

  • Singh, S. B., Odingo, J., Bailey, M. A., Sunde, B., Korkegian, A., O'Malley, T., ... Parish, T.

complete list of authors

  • Singh, Sheo B||Odingo, Joshua||Bailey, Mai A||Sunde, Bjorn||Korkegian, Aaron||O'Malley, Theresa||Ovechkina, Yulia||Ioerger, Thomas R||Sacchettini, James C||Young, Katherine||Olsen, David B||Parish, Tanya

publication date

  • January 1, 2018 11:11 AM