Mycobacterium tuberculosis: a model system for structural genomics. Academic Article

abstract

• Over the past five years, genomics has had a major impact on Mycobacterium tuberculosis research. With the publication of the sequences of two virulent strains (H37Rv and CDC1551) and three closely related sequences, M. tuberculosis is becoming a model system for proteomics and structural genomics initiatives. Together with the promise of structures of proteins with novel folds, high-resolution structures of drug targets are providing the basis for rational inhibitor design, with the goal of the development of novel anti-tuberculars. In addition, this work is aiding scientists in the quest for an effective vaccine against this persistent pathogen.

authors

• Sacchettini, James

published proceedings

• Curr Opin Struct Biol

author list (cited authors)

• Smith, C. V., & Sacchettini, J. C.

citation count

• 25

complete list of authors

• Smith, Clare V||Sacchettini, James C

publication date

• December 2003

publisher

• Elsevier  Publisher

published in

• Current Opinion in Structural Biology  Journal

keywords

• Animals
• Antitubercular Agents
• Bacterial Proteins
• Drug Delivery Systems
• Drug Design
• Gene Expression Regulation, Bacterial
• Genomics
• Humans
• Mycobacterium Tuberculosis
• Protein Conformation
• Protein Folding
• Protein Structure, Secondary
• Protein Structure, Tertiary
• Structure-Activity Relationship

PubMed Central ID

• 14675542

Digital Object Identifier (DOI)

• 10.1016/j.sbi.2003.10.004

start page

• 658

end page

• 664

volume

• 13

issue

• 6

URL

• http://dx.doi.org/10.1016/j.sbi.2003.10.004

user-defined tag

• 3 Good Health and Well-Being