Mycobacterium tuberculosis: a model system for structural genomics. Academic Article uri icon


  • Over the past five years, genomics has had a major impact on Mycobacterium tuberculosis research. With the publication of the sequences of two virulent strains (H37Rv and CDC1551) and three closely related sequences, M. tuberculosis is becoming a model system for proteomics and structural genomics initiatives. Together with the promise of structures of proteins with novel folds, high-resolution structures of drug targets are providing the basis for rational inhibitor design, with the goal of the development of novel anti-tuberculars. In addition, this work is aiding scientists in the quest for an effective vaccine against this persistent pathogen.

published proceedings

  • Curr Opin Struct Biol

author list (cited authors)

  • Smith, C. V., & Sacchettini, J. C.

citation count

  • 25

complete list of authors

  • Smith, Clare V||Sacchettini, James C

publication date

  • December 2003