The 7-phenyl benzoxaborole series is active against Mycobacterium tuberculosis. Academic Article uri icon

abstract

  • We identified a series of novel 7-phenyl benzoxaborole compounds with activity against Mycobacterium tuberculosis. Compounds had a range of activity with inhibitory concentrations (IC90) as low as 5.1 μM and no cytotoxicity against eukaryotic cells (IC50 > 50 μM). Compounds were active against intracellular mycobacteria cultured in THP-1 macrophages. We isolated and characterized resistant mutants with mutations in NADH dehydrogenase (Ndh) or the regulatory protein Mce3R. Mutations suggest that Ndh may be the target of this series.

published proceedings

  • Tuberculosis (Edinb)

altmetric score

  • 1.75

author list (cited authors)

  • Korkegian, A., O'Malley, T., Xia, Y. i., Zhou, Y., Carter, D. S., Sunde, B., ... Parish, T

citation count

  • 14

complete list of authors

  • Korkegian, Aaron||O'Malley, Theresa||Xia, Yi||Zhou, Yasheen||Carter, David S||Sunde, Bjorn||Flint, Lindsay||Thompson, Dean||Ioerger, Thomas R||Sacchettini, Jim||Alley, MRK||Parish, Tanya

publication date

  • November 2017