The abyssomicin C family as in vitro inhibitors of Mycobacterium tuberculosis.
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The antimycobacterial efficacy of the abyssomicin C family of natural products, in addition to a key synthetic intermediate, has been investigated given their reported inhibition of Bacillus subtilis p-aminobenzoate biosynthesis. The naturally occurring (-)-abyssomicin C and its atropisomer were found to exhibit low micromolar growth inhibition against the relatively fast-growing and non-virulent Mycobacterium smegmatis and the vaccine strain Mycobacterium bovis BCG, while their antipodes were slightly less active. (-)-abyssomicin C and its atropisomer were particularly efficacious against Mycobacterium tuberculosis H37Rv, exhibiting MIC values of 3.6 and 7.2 M, respectively. More specifically, (-)-abyssomicin C was bactericidal. This complex natural product and its analogs, thus, hold promise as chemical tools in the study of M. tuberculosis metabolism.
author list (cited authors)
Freundlich, J. S., Lalgondar, M., Wei, J., Swanson, S., Sorensen, E. J., Rubin, E. J., & Sacchettini, J. C.
complete list of authors
Freundlich, Joel S||Lalgondar, Mallikarjun||Wei, Jun-Rong||Swanson, Stephanie||Sorensen, Erik J||Rubin, Eric J||Sacchettini, James C