The Abyssomicin C family as in vitro inhibitors of Mycobacterium tuberculosis Academic Article uri icon

abstract

  • The antimycobacterial efficacy of the abyssomicin C family of natural products, in addition to a key synthetic intermediate, has been investigated given their reported inhibition of Bacillus subtilis p-aminobenzoate biosynthesis. The naturally occurring (-)-abyssomicin C and its atropisomer were found to exhibit low micromolar growth inhibition against the relatively fast-growing and non-virulent Mycobacterium smegmatis and the vaccine strain Mycobacterium bovis BCG, while their antipodes were slightly less active. (-)-abyssomicin C and its atropisomer were particularly efficacious against Mycobacterium tuberculosis H37Rv, exhibiting MIC values of 3.6 and 7.2 μM, respectively. More specifically, (-)-abyssomicin C was bactericidal. This complex natural product and its analogs, thus, hold promise as chemical tools in the study of M. tuberculosis metabolism.

author list (cited authors)

  • Freundlich, J. S., Lalgondar, M., Wei, J., Swanson, S., Sorensen, E. J., Rubin, E. J., & Sacchettini, J. C.

citation count

  • 34

complete list of authors

  • Freundlich, Joel S||Lalgondar, Mallikarjun||Wei, Jun-Rong||Swanson, Stephanie||Sorensen, Erik J||Rubin, Eric J||Sacchettini, James C

publication date

  • September 2010