Crystal structure of calcium dodecin (Rv0379), from Mycobacterium tuberculosis with a unique calcium‐binding site Academic Article uri icon

abstract

  • In eukaryotes, calcium-binding proteins play a pivotal role in diverse cellular processes, and recent findings suggest similar roles for bacterial proteins at different stages in their life cycle. Here, we report the crystal structure of calcium dodecin, Rv0379, from Mycobacterium tuberculosis with a dodecameric oligomeric assembly and a unique calcium-binding motif. Structure and sequence analysis were used to identify orthologs of Rv0379 with different ligand-binding specificity.

author list (cited authors)

  • Arockiasamy, A., Aggarwal, A., Savva, C. G., Holzenburg, A., & Sacchettini, J. C.

citation count

  • 6

publication date

  • March 2011

publisher