Characterization of Phosphopantetheinyl Hydrolase from Mycobacterium tuberculosis Academic Article uri icon

abstract

  • Tuberculosis (TB), caused by Mycobacterium tuberculosis , was the leading cause of death from an infectious disease before COVID, yet the in vivo essentiality and function of many of the protein-encoding genes expressed by M. tuberculosis are not known. We biochemically characterize M. tuberculosis s phosphopantetheinyl hydrolase, PptH, a protein unique to mycobacteria that removes an essential posttranslational modification on proteins involved in synthesis of lipids important for the bacteriums cell wall and virulence.

published proceedings

  • Microbiology Spectrum

author list (cited authors)

  • Pandey, S., Singh, A., Yang, G., dAndrea, F. B., Jiang, X., Hartman, T. E., ... Burns-Huang, K.

editor list (cited editors)

  • Singh, A.

publication date

  • January 1, 2021 11:11 AM