Crystallographic protein model-building on the web. Academic Article

abstract

• UNLABELLED: X-ray crystallography is the most widely used method to determine the 3D structure of protein molecules. One of the most difficult steps in protein crystallography is model-building, which consists of constructing a backbone and then amino acid side chains into an electron density map. Interpretation of electron density maps represents a major bottleneck in protein structure determination pipelines, and thus, automated techniques to interpret maps can greatly improve the throughput. We have developed WebTex, a simple and yet powerful web interface to TEXTAL, a program that automates this process of fitting atoms into electron density maps. TEXTAL can also be downloaded for local installation. AVAILABILITY: Web interface, downloadable binaries and documentation at http://textal.tamu.edu

authors

• Ioerger, Thomas
• Sacchettini, James

published proceedings

• Bioinformatics

author list (cited authors)

• Gopal, K., McKee, E., Romo, T., Pai, R., Smith, J., Sacchettini, J., & Ioerger, T.

citation count

• 3

complete list of authors

• Gopal, Kreshna||McKee, Erik||Romo, Tod||Pai, Reetal||Smith, Jacob||Sacchettini, James||Ioerger, Thomas

publication date

• February 2007

publisher

• Oxford University Press (OUP)  Publisher

published in

• Bioinformatics  Journal

keywords

• Algorithms
• Computer Simulation
• Crystallography
• Internet
• Models, Chemical
• Models, Molecular
• Protein Conformation
• Proteins
• Sequence Analysis, Protein
• Software

PubMed Central ID

• 17138588

Digital Object Identifier (DOI)

• 10.1093/bioinformatics/btl584

start page

• 375

end page

• 377

volume

• 23

issue

• 3

URL

• http://dx.doi.org/10.1093/bioinformatics/btl584