Threadgill, David Professor

Positions

Director, Institute of Genome Sciences and Society
Professor, Biochemistry and Biophysics, College of Agriculture and Life Sciences
Professor, Nutrition, College of Agriculture and Life Sciences
Professor, Cell Biology and Genetics, College of Medicine

Our laboratory uses the mouse as an experimental genetic model to investigate factors that contribute to inter-individual differences in health and disease. Ourcurrent research activities include the identification and functional characterization of alleles contributing to cancer susceptibility, the function of theErbbgenefamily in development and disease, and the role of genetic variation in response to environmental stimuli. To support these investigations, we also aredeveloping new genetic tools to support mammalian systems genetic approaches to phenotypes with complex genetic and environmental etiologies.

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selected publications

academic article
- McGill, M. P., & Threadgill, D. W. (2023). Adding robustness to rigor and reproducibility for the three Rs of improving translational medical research. Journal of Clinical Investigation. 133(18), e173750.
- Kim, Y. S., Yuan, J., Dewar, A., Borg, J., Threadgill, D. W., Sun, X., & Dey, S. K. (2023). An unanticipated discourse of HB-EGF with VANGL2 signaling during embryo implantation. Proceedings of the National Academy of Sciences of the United States of America. 120(20), e2302937120.
- Zhang, X., Xiao, G., Johnson, C., Cai, Y., Horowitz, Z. K., Mennicke, C., ... Ghashghaei, H. T. (2023). Bulk and mosaic deletions of Egfr reveal regionally defined gliogenesis in the developing mouse forebrain. iScience. 26(3), 106242-106242.
- Karmakar, M., Prez Gmez, A. A., Carroll, R. J., Lawley, K. S., Amstalden, K., Welsh, C. J., Threadgill, D. W., & Brinkmeyer-Langford, C. (2023). Baseline Gait and Motor Function Predict Long-Term Severity of Neurological Outcomes of Viral Infection. International Journal of Molecular Sciences. 24(3), 2843-2843.
- Gaber, A. M., Mandric, I., Nitirahardjo, C., Piontkivska, H., Hillhouse, A. E., Threadgill, D. W., Zelikovsky, A., & Rogovskyy, A. S. (2023). Comparative transcriptome analysis of Peromyscus leucopus and C3H mice infected with the Lyme disease pathogen. Frontiers in Cellular and Infection Microbiology. 13, 1115350.
- Gierus, L., Birand, A., Bunting, M. D., Godahewa, G. I., Piltz, S. G., Oh, K. P., ... Thomas, P. Q. (2022). Leveraging a natural murine meiotic drive to suppress invasive populations. Proceedings of the National Academy of Sciences of the United States of America. 119(46), e2213308119.
- Morgan, A. P., Hughes, J. J., Didion, J. P., Jolley, W. J., Campbell, K. J., Threadgill, D. W., ... de Villena, F. (2022). Population structure and inbreeding in wild house mice (Mus musculus) at different geographic scales. Heredity. 129(3), 183-194.
- Scoggin, K., Gupta, J., Lynch, R., Nagarajan, A., Aminian, M., Peterson, A., ... Andrews-Polymenis, H. L. (2022). Elucidating Mechanisms of Tolerance to Salmonella Typhimurium across Long-Term Infections Using the Collaborative Cross. mBio. 13(4), e0112022-e01122.
- Salvador, A., & Threadgill, D. (2022). Fat Mass Gained Prior to Dietary Intervention Predicts Efficacy of Personalized Dietary Guidance in Mice. 6(Suppl 1), 1125-1125.
- Maxwell, S. A., Wallis, D., Zhou, N., Baker, D., Mousavi-Fard, S. H., Loesch, K., ... Sacchettini, J. C. (2022). Abstract 410: Development of novel, non-toxic rifamycins that reverse drug resistance. Cancer Research. 82(12_Supplement), 410-410.
- McGill, M. P., Rojas, C. M., & Threadgill, D. W. (2022). Abstract 819: ERBB4 mediates IL10-induced growth of EGFR-independent colon tumors. Cancer Research. 82(12_Supplement), 819-819.
- Yan, H., Yang, W., Zhou, F., Pan, Q., Allred, K., Allred, C., ... Guo, S. (2022). Estrogen Protects Cardiac Function and Energy Metabolism in Dilated Cardiomyopathy Induced by Loss of Cardiac IRS1 and IRS2. Circulation: Heart Failure. 15(6), e008758.
- Yang, W., Yan, H., Zhou, F., Pan, Q., Allred, K., Allred, C., ... Guo, S. (2022). Sexual Dimorphism in Control of Heart Failure in Insulin Resistance. The FASEB Journal. 36(S1),
- Scoggin, K., Lynch, R., Gupta, J., Nagarajan, A., Sheffield, M., Elsaadi, A., ... Andrews-Polymenis, H. L. (2022). Genetic background influences survival of infections with Salmonella enterica serovar Typhimurium in the Collaborative Cross. 18(4), e1010075-e1010075.
- Wells, A. E., Barrington, W. T., Dearth, S., Milind, N., Carter, G. W., Threadgill, D. W., Campagna, S. R., & Voy, B. H. (2022). Independent and Interactive Effects of Genetic Background and Sex on Tissue Metabolomes of Adipose, Skeletal Muscle, and Liver in Mice. Metabolites. 12(4), 337-337.
- Luo, L., Santos, A., Konganti, K., Hillhouse, A., Lambertz, I. U., Zheng, Y., ... Fuchs-Young, R. S. (2022). Overexpression of IGF-1 During Early Development Expands the Number of Mammary Stem Cells and Primes them for Transformation. Stem Cells. 40(3), 273-289.
- Orzabal, M. R., Naik, V. D., Lee, J., Hillhouse, A. E., Brashear, W. A., Threadgill, D. W., & Ramadoss, J. (2022). Impact of E-cig aerosol vaping on fetal and neonatal respiratory development and function. 246, 102-114.
- Prez Gmez, A. A., Karmakar, M., Carroll, R. J., Lawley, K. S., Amstalden, K., Young, C. R., ... Brinkmeyer-Langford, C. (2022). Serum Cytokines Predict Neurological Damage in Genetically Diverse Mouse Models. Cells. 11(13), 2044-2044.
- Cuomo, D., Foster, M. J., & Threadgill, D. (2022). Systemic review of genetic and epigenetic factors underlying differential toxicity to environmental lead (Pb) exposure. Environmental Science and Pollution Research. 29(24), 35583-35598.
- Lawley, K. S., Rech, R. R., Perez Gomez, A. A., Hopkins, L., Han, G., Amstalden, K., ... Brinkmeyer-Langford, C. L. (2022). Viral Clearance and Neuroinflammation in Acute TMEV Infection Vary by Host Genetic Background. International Journal of Molecular Sciences. 23(18), 10482-10482.
- Lees-Shepard, J. B., Flint, K., Fisher, M., Omi, M., Richard, K., Antony, M., ... Dealy, C. N. (2022). Cross-talk between EGFR and BMP signals regulates chondrocyte maturation during endochondral ossification. Developmental Dynamics. 251(1), 75-94.
- Huda, M. N., Salvador, A. C., Barrington, W. T., Gacasan, C. A., D'Souza, E. M., Deus Ramirez, L., Threadgill, D. W., & Bennett, B. J. (2022). Gut microbiota and host genetics modulate the effect of diverse diet patterns on metabolic health. 9, 896348.
- Mantilla Rojas, C., McGill, M. P., Salvador, A. C., Bautz, D., & Threadgill, D. W. (2021). Epithelial-specific ERBB3 deletion results in a genetic background-dependent increase in intestinal and colon polyps that is mediated by EGFR. 17(11), e1009931-e1009931.
- Neuman, B. W., Brashear, W. A., Brun, M., Chaki, S. P., Fischer, R., Guidry, S. J., ... Zuelke, K. (2021). Case Report: Paucisymptomatic College-Age Population as a Reservoir for Potentially Neutralization-Resistant Severe Acute Respiratory Syndrome Coronavirus 2 Variants. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 105(5), 1227-1229.
- Rogovskyy, A. S., Rogovska, Y. V., Taylor, B. M., Wiener, D. J., & Threadgill, D. W. (2021). The First Immunocompetent Mouse Model of Strictly Human Pathogen, Borrelia recurrentis. Infection and Immunity. 89(7), e0004821-e00021.
- Vaes, N., Schonkeren, S. L., Rademakers, G., Holland, A. M., Koch, A., Gijbels, M. J., ... Melotte, V. (2021). Loss of enteric neuronal Ndrg4 promotes colorectal cancer via increased release of Nid1 and Fbln2. EMBO Reports. 22(6), e51913.
- Salvador, A. C., Arends, D., Barrington, W. T., Elsaadi, A. M., Brockmann, G. A., & Threadgill, D. W. (2021). Sex-specific genetic architecture in response to American and ketogenic diets. INTERNATIONAL JOURNAL OF OBESITY. 45(6), 1284-1297.
- Jurgelewicz, A., Dornbos, P., Warren, M., Nault, R., Arkatkar, A., Lin, H., ... LaPres, J. J. (2021). Genetics-Based Approach to Identify Novel Genes Regulated by the Aryl Hydrocarbon Receptor inMouse Liver. TOXICOLOGICAL SCIENCES. 181(2), 285-294.
- Mantilla-Rojas, C., Yu, M., Rinella, E. S., Lynch, R. M., Perry, A., Jaimes-Alvarado, J., ... Threadgill, D. W. (2021). A molecular subtype of colorectal cancers initiates independently of epidermal growth factor receptor and has an accelerated growth rate mediated by IL10-dependent anergy. Oncogene. 40(17), 3047-3059.
- Zhong, C., He, L. i., Lee, S., Chang, H., Zhang, Y., Threadgill, D. W., ... Mao, J. (2021). Host genetics and gut microbiota cooperatively contribute to azoxymethane-induced acute toxicity in Collaborative Cross mice. Archives of Toxicology. 95(3), 949-958.
- Elias, L., Blazier, J. C., Rogovska, Y. V., Konganti, K., Wang, J., Liu, S., ... Rogovskyy, A. S. (2021). Extensive sex-specific and regional variations observed in the microbiome of Dermacentor reticulatus. TICKS AND TICK-BORNE DISEASES. 12(5), 101767-101767.
- Perez Gomez, A. A., Karmakar, M., Carroll, R. J., Lawley, K. S., Amstalden, K., Young, C. R., ... Brinkmeyer-Langford, C. (2021). Genetic and immunological contributors to virus-induced paralysis. Brain, Behavior, and Immunity - Health. 18, 100395-100395.
- Brinkmeyer-Langford, C., Amstalden, K., Konganti, K., Hillhouse, A., Lawley, K., Perez-Gomez, A., ... Threadgill, D. W. (2021). Resilience in Long-Term Viral Infection: Genetic Determinants and Interactions. International Journal of Molecular Sciences. 22(21), 11379-11379.
- Lawley, K. S., Rech, R. R., Elenwa, F., Han, G., Perez Gomez, A. A., Amstalden, K., ... Brinkmeyer-Langford, C. L. (2021). Host genetic diversity drives variable central nervous system lesion distribution in chronic phase of Theiler's Murine Encephalomyelitis Virus (TMEV) infection. PLoS ONE. 16(8), e0256370-e0256370.
- Warren, M. R., Radulescu, A., Dornbos, P., Cuomo, D., Zumwalt, S., Bueso-Mendoza, D., ... Threadgill, D. W. (2021). Peanut butter as an alternative dose delivery method to prevent strain-dependent orogastric gavage-induced stress in mouse teratogenicity studies. 107, 106948-106948.
- Sigmon, J. S., Blanchard, M. W., Baric, R. S., Bell, T. A., Brennan, J., Brockmann, G. A., ... Manuel de Villena, F. P. (2020). Content and Performance of the MiniMUGA Genotyping Array: A New Tool To Improve Rigor and Reproducibility in Mouse Research. Genetics. 216(4), 905-930.
- Ma, L., Li, H., Hu, J., Zheng, J., Zhou, J., Botchlett, R., ... Wu, C. (2020). Indole Alleviates Diet-Induced Hepatic Steatosis and Inflammation in a Manner Involving Myeloid Cell 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3. HEPATOLOGY. 72(4), 1191-1203.
- Cross, K., Granados, J., Barrington, W., Thaden, J., Have, G. T., Threadgill, D., Lightfoot, J. T., & Deutz, N. (2020). A Ketogenic Diet In Mice Reduces Cardiac Protein Synthesis Compared to a Western Diet. Current Developments in Nutrition. 4(Suppl 2), nzaa046_015-nzaa046_015.
- Salvador, A., Arends, D., Brockmann, G., & Threadgill, D. (2020). Strain, Sex, and Diet Dependent Responses to American and Ketogenic Diets in Mice. Current Developments in Nutrition. 4(Suppl 2), nzaa058_031-nzaa058_031.
- Mao, J., Kim, Y., Zhou, Y., Hu, D., Zhong, C., Chang, H., ... Snijders, A. M. (2020). Correction to: Genetic and metabolic links between the murine microbiome and memory. Microbiome. 8(1), 73.
- Mao, J., Kim, Y., Zhou, Y., Hu, D., Zhong, C., Chang, H., ... Snijders, A. M. (2020). Genetic and metabolic links between the murine microbiome and memory. Microbiome. 8(1), 53.
- Bissahoyo, A. C., Xie, Y., Yang, L., Pearsall, R. S., Lee, D., Elliott, R. W., ... Threadgill, D. W. (2020). A New Polygenic Model for Nonfamilial Colorectal Cancer Inheritance Based on the Genetic Architecture of the Azoxymethane-Induced Mouse Model. Genetics. 214(3), 691-702.
- Arora, S., Li, X., Hillhouse, A., Konganti, K., Little, S. V., Lawhon, S. D., ... Hook, M. (2020). Staphylococcus epidermidis MSCRAMM SesJ Is Encoded in Composite Islands. mBio. 11(1), e02911-e02919.
- Aminian, M., Andrews-Polymenis, H., Gupta, J., Kirby, M., Kvinge, H., Ma, X., ... Threadgill, D. (2020). Mathematical methods for visualization and anomaly detection in telemetry datasets. Interface Focus. 10(1), 20190086-20190086.
- Price, A., Okumura, A., Haddock, E., Feldmann, F., Meade-White, K., Sharma, P., ... Rasmussen, A. L. (2020). Transcriptional Correlates of Tolerance and Lethality in Mice Predict Ebola Virus Disease Patient Outcomes. Cell Reports. 30(6), 1702-1713.e6.
- Eldridge, R., Osorio, D., Amstalden, K., Edwards, C., Young, C. R., Cai, J. J., ... Brinkmeyer-Langford, C. (2020). Antecedent presentation of neurological phenotypes in the Collaborative Cross reveals four classes with complex sex-dependencies. Scientific Reports. 10(1), 7918.
- Garbutt, T. A., Konganti, K., Konneker, T., Hillhouse, A., Phelps, D., Jones, A., Aylor, D., & Threadgill, D. W. (2020). Derivation of stable embryonic stem cell-like, but transcriptionally heterogenous, induced pluripotent stem cells from non-permissive mouse strains. MAMMALIAN GENOME. 31(9-12), 263-286.
- Wang, P., Wang, Y., Langley, S. A., Zhou, Y., Jen, K., Sun, Q. i., ... Mao, J. (2019). Diverse tumour susceptibility in Collaborative Cross mice: identification of a new mouse model for human gastric tumourigenesis. GUT. 68(11), 1942-1952.
- Sudweeks, J., Hollingsworth, B., Blondel, D. V., Campbell, K. J., Dhole, S., Eisemann, J. D., ... Lloyd, A. L. (2019). Locally Fixed Alleles: A method to localize gene drive to island populations. Scientific Reports. 9(1), 15821.
- Lunde-Young, R., Ramirez, J., Naik, V., Orzabal, M., Lee, J., Konganti, K., ... Ramadoss, J. (2019). Hippocampal transcriptome reveals novel targets of FASD pathogenesis. Brain and Behavior. 9(7), e01334.
- Batool, M., Hillhouse, A. E., Ionov, Y., Kochan, K. J., Mohebbi, F., Stoica, G., ... Rogovskyy, A. S. (2019). New Zealand White Rabbits Effectively Clear Borrelia burgdorferi B31 despite the Bacterium's Functional vlsE Antigenic Variation System. 87(7), e00164-e00119.
- Luo, Y., Cichocki, J. A., Hsieh, N., Lewis, L., Wright, F. A., Threadgill, D. W., Chiu, W. A., & Rusyn, I. (2019). Using Collaborative Cross Mouse Population to Fill Data Gaps in Risk Assessment: A Case Study of Population-Based Analysis of Toxicokinetics and Kidney Toxicodynamics of Tetrachloroethylene. Environmental Health Perspectives. 127(6), 67011.
- Perry, A., Lynch, R. M., Rusyn, I., & Threadgill, D. W. (2019). Long-Term Combinatorial Exposure to Trichloroethylene and Inorganic Arsenic in Genetically Heterogeneous Mice Results in Renal Tubular Damage and Cancer-Associated Molecular Changes. G3: Genes, Genomes, Genetics. 9(5), 1729-1737.
- Orzabal, M. R., Lunde-Young, E. R., Ramirez, J. I., Howe, S., Naik, V. D., Lee, J., ... Ramadoss, J. (2019). Chronic exposure to e-cig aerosols during early development causes vascular dysfunction and offspring growth deficits. 207, 70-82.
- Zhang, K., Guo, X., Yan, H., Wu, Y., Pan, Q., Shen, J. Z., ... Guo, S. (2019). Phosphorylation of Forkhead Protein FoxO1 at S253 Regulates Glucose Homeostasis in Mice. ENDOCRINOLOGY. 160(5), 1333-1347.
- Lewis, L., Borowa-Mazgaj, B., de Conti, A., Chappell, G. A., Luo, Y., Bodnar, W., ... Rusyn, I. (2019). Population-Based Analysis of DNA Damage and Epigenetic Effects of 1,3-Butadiene in the Mouse. CHEMICAL RESEARCH IN TOXICOLOGY. 32(5), 887-898.
- Rogovskyy, A. S., Threadgill, D. W., Akimov, I. A., Nebogatkin, I. V., Rogovska, Y. V., Melnyk, M. V., & Rogovskyy, S. P. (2019). Borrelia and Other Zoonotic Pathogens in Ixodes ricinus and Dermacentor reticulatus Ticks Collected from the Chernobyl Exclusion Zone on the 30th Anniversary of the Nuclear Disaster. Vector-Borne and Zoonotic Diseases. 19(7), 466-473.
- Orzabal, M. R., Lunde-Young, E. R., Ramirez, J. I., Naik, V. D., Hillhouse, A., Konganti, K., Threadgill, D. W., & Ramadoss, J. (2019). Gestational binge alcohol-induced alterations in maternal uterine artery transcriptome. Reproductive Toxicology. 87, 42-49.
- Cichocki, J. A., Luo, Y., Furuya, S., Venkatratnam, A., Konganti, K., Chiu, W. A., ... Rusyn, I. (2019). Modulation of Tetrachloroethylene-Associated Kidney Effects by Nonalcoholic Fatty Liver or Steatohepatitis in Male C57BL/6J Mice. TOXICOLOGICAL SCIENCES. 167(1), 126-137.
- Cuomo, D., Porreca, I., Ceccarelli, M., Threadgill, D. W., Barrington, W. T., Petriella, A., ... Ambrosino, C. (2018). Transcriptional landscape of mouse-aged ovaries reveals a unique set of non-coding RNAs associated with physiological and environmental ovarian dysfunctions. Cell Death Discovery. 4(1), 112.
- Dornbos, P., Warren, M., Crawford, R. B., Kaminski, N. E., Threadgill, D. W., & LaPres, J. J. (2018). Characterizing Serpinb2 as a Modulator of TCDD-Induced Suppression of the B Cell. CHEMICAL RESEARCH IN TOXICOLOGY. 31(11), 1248-1259.
- Konganti, K., Ehrlich, A., Rusyn, I., & Threadgill, D. W. (2018). gQTL: A Web Application for QTL Analysis Using the Collaborative Cross Mouse Genetic Reference Population. G3: Genes, Genomes, Genetics. 8(8), 2559-2562.
- Konganti, K., Guerrero, F. D., Schilkey, F., Ngam, P., Jacobi, J. L., Umale, P. E., Perez de Leon, A. A., & Threadgill, D. W. (2018). A Whole Genome Assembly of the Horn Fly, Haematobia irritans, and Prediction of Genes with Roles in Metabolism and Sex Determination. G3: Genes, Genomes, Genetics. 8(5), 1675-1686.
- Morgan, A. P., Didion, J. P., Hughes, J. J., Searle, J. B., Jolley, W. J., Campbell, K. J., Threadgill, D. W., & de Villena, F. (2018). Genetic characterization of invasive house mouse populations on small islands. 332064.
- Wells, A., Barrington, W. T., Dearth, S., May, A., Threadgill, D. W., Campagna, S. R., & Voy, B. H. (2018). Tissue Level Diet and Sex-by-Diet Interactions Reveal Unique Metabolite and Clustering Profiles Using Untargeted Liquid Chromatography-Mass Spectrometry on Adipose, Skeletal Muscle, and Liver Tissue in C57BL6/J Mice. Journal of Proteome Research. 17(3), 1077-1090.
- Maurizio, P. L., Ferris, M. T., Keele, G. R., Miller, D. R., Shaw, G. D., Whitmore, A. C., ... Valdar, W. (2018). Bayesian Diallel Analysis Reveals Mx1-Dependent and Mx1-Independent Effects on Response to Influenza A Virus in Mice. G3: Genes, Genomes, Genetics. 8(2), 427-445.
- Venkatratnam, A., House, J. S., Konganti, K., McKenney, C., Threadgill, D. W., Chiu, W. A., ... Rusyn, I. (2018). Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse. MAMMALIAN GENOME. 29(1-2), 168-181.
- Leitschuh, C. M., Kanavy, D., Backus, G. A., Valdez, R. X., Serr, M., Pitts, E. A., Threadgill, D., & Godwin, J. (2018). Developing gene drive technologies to eradicate invasive rodents from islands. Journal of Responsible Innovation. 5(sup1), S121-S138.
- Garbutt, T. A., Konneker, T. I., Konganti, K., Hillhouse, A. E., Swift-Haire, F., Jones, A., ... Threadgill, D. W. (2018). Permissiveness to form pluripotent stem cells may be an evolutionarily derived characteristic in Mus musculus. Scientific Reports. 8(1), 14706.
- Barrington, W. T., Wulfridge, P., Wells, A. E., Rojas, C. M., Howe, S., Perry, A., ... Threadgill, D. W. (2018). Improving Metabolic Health Through Precision Dietetics in Mice. Genetics. 208(1), 399-417.
- Gao, Y., Fang, X., Vincent, D. F., Threadgill, D. W., Bartholin, L., & Li, Q. (2017). Disruption of postnatal folliculogenesis and development of ovarian tumor in a mouse model with aberrant transforming growth factor beta signaling. Reproductive Biology and Endocrinology. 15(1), 94.
- Maurizio, P. L., Ferris, M. T., Keele, G. R., Miller, D. R., Shaw, G. D., Whitmore, A. C., ... Valdar, W. (2017). Diallel analysis reveals Mx1-dependent and Mx1-independent effects on response to influenza A virus in mice. 214205.
- Cichocki, J. A., Furuya, S., Luo, Y., Iwata, Y., Konganti, K., Chiu, W. A., ... Rusyn, I. (2017). Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice. TOXICOLOGICAL SCIENCES. 159(2), 481-481.
- Cichocki, J. A., Furuya, S., Luo, Y., Iwata, Y., Konganti, K., Chiu, W. A., ... Rusyn, I. (2017). Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice. TOXICOLOGICAL SCIENCES. 159(1), 102-113.
- Venkatratnam, A., Furuya, S., Kosyk, O., Gold, A., Bodnar, W., Konganti, K., ... Rusyn, I. (2017). Editor's Highlight: Collaborative Cross Mouse Population Enables Refinements to Characterization of the Variability in Toxicokinetics of Trichloroethylene and Provides Genetic Evidence for the Role of PPAR Pathway in Its Oxidative Metabolism. TOXICOLOGICAL SCIENCES. 158(1), 48-62.
- Cichocki, J. A., Furuya, S., Venkatratnam, A., McDonald, T. J., Knap, A. H., Wade, T., ... Rusyn, I. (2017). Characterization of Variability in Toxicokinetics and Toxicodynamics of Tetrachloroethylene Using the Collaborative Cross Mouse Population. Environmental Health Perspectives. 125(5), 057006.
- Feng, Y., Demehri, F. R., Xiao, W., Tsai, Y., Jones, J. C., Brindley, C. D., ... Dempsey, P. J. (2017). Interdependency of EGF and GLP-2 Signaling in Attenuating Mucosal Atrophy in a Mouse Model of Parenteral Nutrition. CMGH Cellular and Molecular Gastroenterology and Hepatology. 3(3), 447-468.
- Cichocki, J. A., Furuya, S., Konganti, K., Luo, Y., McDonald, T. J., Iwata, Y., ... Rusyn, I. (2017). Impact of Nonalcoholic Fatty Liver Disease on Toxicokinetics of Tetrachloroethylene in Mice. Journal of Pharmacology and Experimental Therapeutics. 361(1), 17-28.
- Kelly, S. A., Zhao, L., Jung, K., Hua, K., Threadgill, D. W., Kim, Y., de Villena, F., & Pomp, D. (2017). Prevention of tumorigenesis in mice by exercise is dependent on strain background and timing relative to carcinogen exposure. Scientific Reports. 7(1), 43086-11.
- Bautz, D. J., Sherpa, A. T., & Threadgill, D. W. (2017). Prophylactic vaccination targeting ERBB3 decreases polyp burden in a mouse model of human colorectal cancer. OncoImmunology. 6(1), e1255395-e1255395.
- Brinkmeyer-Langford, C. L., Rech, R., Amstalden, K., Kochan, K. J., Hillhouse, A. E., Young, C., Welsh, C. J., & Threadgill, D. W. (2017). Host genetic background influences diverse neurological responses to viral infection in mice. Scientific Reports. 7(1), 12194.
- Scheving, L. A., Zhang, X., Threadgill, D. W., & Russell, W. E. (2016). Hepatocyte ERBB3 and EGFR are required for maximal CCl4-induced liver fibrosis. American Journal of Physiology - Gastrointestinal and Liver Physiology. 311(5), G807-G816.
- Didion, J. P., Morgan, A. P., Yadgary, L., Bell, T. A., McMullan, R. C., Ortiz de Solorzano, L., ... Pardo-Manuel de Villena, F. (2016). R2d2 Drives Selfish Sweeps in the House Mouse. Molecular Biology and Evolution (MBE). 33(6), 1381-1395.
- Ceddia, R. P., Lee, D., Maulis, M. F., Carboneau, B. A., Threadgill, D. W., Poffenberger, G., ... Breyer, R. M. (2016). The PGE2 EP3 Receptor Regulates Diet-Induced Adiposity in Male Mice. ENDOCRINOLOGY. 157(1), 220-232.
- Scheving, L. A., Zhang, X., Stevenson, M. C., Weintraub, M. A., Abbasi, A., Clarke, A. M., Threadgill, D. W., & Russell, W. E. (2015). Loss of hepatocyte ERBB3 but not EGFR impairs hepatocarcinogenesis. American Journal of Physiology - Gastrointestinal and Liver Physiology. 309(12), G942-G954.
- Gralinski, L. E., Ferris, M. T., Aylor, D. L., Whitmore, A. C., Green, R., Frieman, M. B., ... Baric, R. S. (2015). Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross. 11(10), e1005504-e1005504.
- Crowley, J. J., Zhabotynsky, V., Sun, W., Huang, S., Pakatci, I. K., Kim, Y., ... de Villena, F. (2015). Corrigendum: analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance. Nature Genetics. 47(6), 690-690.
- Chen, J., Nagai, K., Chen, J., Plieth, D., Hino, M., Xu, J., ... Harris, R. C. (2015). Phosphatidylinositol 3-kinase signaling determines kidney size. Journal of Clinical Investigation. 125(6), 2429-2444.
- Campbell, K. J., Beek, J., Eason, C. T., Glen, A. S., Godwin, J., Gould, F., ... Baxter, G. S. (2015). The next generation of rodent eradications: Innovative technologies and tools to improve species specificity and increase their feasibility on islands. Biological Conservation. 185, 47-58.
- Crowley, J. J., Zhabotynsky, V., Sun, W., Huang, S., Pakatci, I. K., Kim, Y., ... Pardo-Manuel de Villena, F. (2015). Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance. Nature Genetics. 47(4), 353-360.
- Song, X., Fan, P., Bantikassegn, A., Guha, U., Threadgill, D. W., Varmus, H., & Politi, K. (2015). ERBB3-independent activation of the PI3K pathway in EGFR-mutant lung adenocarcinomas. Cancer Research. 75(6), 1035-1045.
- Scheving, L. A., Zhang, X., Stevenson, M. C., Threadgill, D. W., & Russell, W. E. (2015). Loss of hepatocyte EGFR has no effect alone but exacerbates carbon tetrachloride-induced liver injury and impairs regeneration in hepatocyte Met-deficient mice. American Journal of Physiology - Gastrointestinal and Liver Physiology. 308(5), G364-G377.
- Didion, J. P., Morgan, A. P., Clayshulte, A., Mcmullan, R. C., Yadgary, L., Petkov, P. M., ... Pardo-Manuel de Villena, F. (2015). A multi-megabase copy number gain causes maternal transmission ratio distortion on mouse chromosome 2. 11(2), e1004850-e1004850.
- Church, R. J., Gatti, D. M., Urban, T. J., Long, N., Yang, X. i., Shi, Q., ... Harrill, A. H. (2015). Sensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred mice. Food and Chemical Toxicology. 76, 19-26.
- Donohoe, D. R., Holley, D., Collins, L. B., Montgomery, S. A., Whitmore, A. C., Hillhouse, A., ... Bultman, S. J. (2014). A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner. Cancer Discovery. 4(12), 1387-1397.
- Didion, J. P., Buus, R. J., Naghashfar, Z., Threadgill, D. W., Morse, H. C., & de Villena, F. (2014). SNP array profiling of mouse cell lines identifies their strains of origin and reveals cross-contamination and widespread aneuploidy. BMC GENOMICS. 15(1), 847.
- Large, M. J., Wetendorf, M., Lanz, R. B., Hartig, S. M., Creighton, C. J., Mancini, M. A., ... DeMayo, F. J. (2014). The epidermal growth factor receptor critically regulates endometrial function during early pregnancy. 10(6), e1004451-e1004451.
- Welsh, C. E., Miller, D. R., Manly, K. F., Wang, J., McMillan, L., Morahan, G., ... de Villena, F. (2014). Status and access to the Collaborative Cross population (vol 23, pg 706, 2012). MAMMALIAN GENOME. 25(3-4), 192-192.
- Scheving, L. A., Zhang, X., Garcia, O. A., Wang, R. F., Stevenson, M. C., Threadgill, D. W., & Russell, W. E. (2014). Epidermal growth factor receptor plays a role in the regulation of liver and plasma lipid levels in adult male mice. American Journal of Physiology - Gastrointestinal and Liver Physiology. 306(5), G370-G381.
- Phillippi, J., Xie, Y., Miller, D. R., Bell, T. A., Zhang, Z., Lenarcic, A. B., ... Frelinger, J. A. (2014). Using the emerging Collaborative Cross to probe the immune system. Genes and Immunity. 15(1), 38-46.
- Bautz, D. J., Broman, K. W., & Threadgill, D. W. (2013). Identification of a novel polymorphism in X-linked sterol-4-alpha-carboxylate 3-dehydrogenase (Nsdhl) associated with reduced high-density lipoprotein cholesterol levels in I/LnJ mice. G3: Genes, Genomes, Genetics. 3(10), 1819-1825.
- Desimone, M. C., Rathmell, W. K., & Threadgill, D. W. (2013). Pleiotropic effects of the trichloroethylene-associated P81S VHL mutation on metabolism, apoptosis, and ATM-mediated DNA damage response. Journal of the National Cancer Institute. 105(18), 1355-1364.
- Neufert, C., Becker, C., Treci, ., Waldner, M. J., Backert, I., Floh, K., ... Neurath, M. F. (2013). Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK. 123(4), 1428-1443.
- Ferris, M. T., Aylor, D. L., Bottomly, D., Whitmore, A. C., Aicher, L. D., Bell, T. A., ... Heise, M. T. (2013). Modeling host genetic regulation of influenza pathogenesis in the collaborative cross. PLOS Pathogens. 9(2), e1003196-e1003196.
- Saito, K., Horiuchi, K., Kimura, T., Mizuno, S., Yoda, M., Morioka, H., ... Sato, K. (2013). Conditional inactivation of TNF-converting enzyme in chondrocytes results in an elongated growth plate and shorter long bones. PLoS ONE. 8(1), e54853-e54853.
- Franzke, C., Cobzaru, C., Triantafyllopoulou, A., Loeffek, S., Horiuchi, K., Threadgill, D. W., ... Blobel, C. P. (2012). Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation (vol 209, pg 1105, 2012). 209(13), 2517-2517.
- Eversley, C. D., Yuying, X., Pearsall, R. S., & Threadgill, D. W. (2012). Mapping six new susceptibility to colon cancer (Scc) loci using a mouse interspecific backcross. G3: Genes, Genomes, Genetics. 2(12), 1577-1584.
- Eversley, C. D., Yuying, X., Pearsall, R. S., & Threadgill, D. W. (2012). Mapping six new susceptibility to colon cancer (Scc) loci using a mouse interspecific backcross. G3: Genes, Genomes, Genetics. 2(12), 1577-1584.
- Mustafi, R., Dougherty, U., Shah, H., Dehghan, H., Gliksberg, A., Wu, J., ... Bissonnette, M. (2012). Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts. Carcinogenesis. 33(10), 1930-1939.
- Welsh, C. E., Miller, D. R., Manly, K. F., Wang, J., McMillan, L., Morahan, G., ... de Villena, F. (2012). Status and access to the Collaborative Cross population. MAMMALIAN GENOME. 23(9-10), 706-712.
- Ardito, C. M., Grner, B. M., Takeuchi, K. K., Lubeseder-Martellato, C., Teichmann, N., Mazur, P. K., ... Siveke, J. T. (2012). EGF receptor is required for KRAS-induced pancreatic tumorigenesis. Cancer Cell. 22(3), 304-317.
- Rinella, E. S., & Threadgill, D. W. (2012). Efficacy of EGFR inhibition is modulated by model, sex, genetic background and diet: implications for preclinical cancer prevention and therapy trials. PLoS ONE. 7(6), e39552-e39552.
- Franzke, C., Cobzaru, C., Triantafyllopoulou, A., Lffek, S., Horiuchi, K., Threadgill, D. W., ... Blobel, C. P. (2012). Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation. 209(6), 1105-1119.
- Crowley, J. J., Kim, Y., Szatkiewicz, J. P., Pratt, A. L., Quackenbush, C. R., Adkins, D. E., ... Sullivan, P. F. (2012). Genome-wide association mapping of loci for antipsychotic-induced extrapyramidal symptoms in mice. MAMMALIAN GENOME. 23(5-6), 322-335.
- Franzke, C., Cobzaru, C., Triantafyllopoulou, A., Lffek, S., Horiuchi, K., Threadgill, D. W., ... Blobel, C. P. (2012). Epidermal ADAM17 maintains the skin barrier by regulating EGFR liganddependent terminal keratinocyte differentiation. Journal of Cell Biology. 197(4), i7-i7.
- Rinella, E. S., Bankaitis, E. D., & Threadgill, D. W. (2012). Dietary calcium supplementation enhances efficacy but also toxicity of EGFR inhibitor therapy for colon cancer. Cancer Biology and Therapy. 13(3), 130-137.
- Chen, J., Chen, J., Nagai, K., Plieth, D., Tan, M., Lee, T., ... Harris, R. C. (2012). EGFR signaling promotes TGF-dependent renal fibrosis. Journal of the American Society of Nephrology. 23(2), 215-224.
- Bottomly, D., Ferris, M. T., Aicher, L. D., Rosenzweig, E., Whitmore, A., Aylor, D. L., ... McWeeney, S. K. (2012). Expression quantitative trait Loci for extreme host response to influenza a in pre-collaborative cross mice. G3: Genes, Genomes, Genetics. 2(2), 213-221.
- Kelada, S., Aylor, D. L., Peck, B., Ryan, J. F., Tavarez, U., Buus, R. J., ... Collins, F. S. (2012). Genetic analysis of hematological parameters in incipient lines of the collaborative cross. G3: Genes, Genomes, Genetics. 2(2), 157-165.
- Threadgill, D. W., & Churchill, G. A. (2012). Ten years of the Collaborative Cross. Genetics. 190(2), 291-294.
- Threadgill, D. W., & Churchill, G. A. (2012). Ten years of the collaborative cross. G3: Genes, Genomes, Genetics. 2(2), 153-156.
- Collaborative Cross Consortium. (2012). The genome architecture of the Collaborative Cross mouse genetic reference population. Genetics. 190(2), 389-401.
- Bollee, G., Flamant, M., Schordan, S., Fligny, C., Rumpel, E., Milon, M., ... Tharaux, P. (2011). Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis (vol 17, pg 1242, 2011). Nature Medicine. 17(11), 1521-1521.
- Bolle, G., Flamant, M., Schordan, S., Fligny, C., Rumpel, E., Milon, M., ... Tharaux, P. (2011). Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis. Nature Medicine. 17(10), 1242-1250.
- Gatti, D. M., Lu, L. u., Williams, R. W., Sun, W., Wright, F. A., Threadgill, D. W., & Rusyn, I. (2011). MicroRNA expression in the livers of inbred mice. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 714(1-2), 126-133.
- Aylor, D. L., Valdar, W., Foulds-Mathes, W., Buus, R. J., Verdugo, R. A., Baric, R. S., ... Churchill, G. A. (2011). Genetic analysis of complex traits in the emerging Collaborative Cross. Genome Research. 21(8), 1213-1222.
- Mathes, W. F., Aylor, D. L., Miller, D. R., Churchill, G. A., Chesler, E. J., de Villena, F., Threadgill, D. W., & Pomp, D. (2011). Architecture of energy balance traits in emerging lines of the Collaborative Cross. American Journal of Physiology: Endocrinology and Metabolism. 300(6), E1124-E1134.
- Zhang, X., Tamasi, J., Lu, X., Zhu, J. i., Chen, H., Tian, X., ... Qin, L. (2011). Epidermal growth factor receptor plays an anabolic role in bone metabolism in vivo. Journal of Bone and Mineral Research. 26(5), 1022-1034.
- Dougherty, U., Mustafi, R., Wu, J., Zhu, H., Joseph, L. J., Hart, J., ... Bissonnette, M. (2011). Stromal Cell and Colonocyte EGFR Are Required for Efficient Tumor Xenograft Growth of Colon Cancer Cells. Gastroenterology. 140(5), s-825.
- Bradford, B. U., Lock, E. F., Kosyk, O., Kim, S., Uehara, T., Harbourt, D., ... Rusyn, I. (2011). Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice. TOXICOLOGICAL SCIENCES. 120(1), 206-217.
- Kim, K., Lee, H., Threadgill, D. W., & Lee, D. (2011). Epiregulin-dependent amphiregulin expression and ERBB2 signaling are involved in luteinizing hormone-induced paracrine signaling pathways in mouse ovary. Biochemical and Biophysical Research Communications. 405(2), 319-324.
- Threadgill, D. W., Miller, D. R., Churchill, G. A., & de Villena, F. (2011). The collaborative cross: a recombinant inbred mouse population for the systems genetic era. Institute for Laboratory Animal Research (ILAR) Journal. 52(1), 24-31.
- Large, M. J., Hartig, S. M., Franco, H. L., Kovanci, E., Mancini, M. A., Threadgill, D. W., ... DeMayo, F. J. (2010). Demonstrating the Critical Role of Uterine Erbb Signaling in Fertility. Biology of Reproduction. 83(Suppl_1), 17-17.
- Eversley, C. D., Clark, T., Xie, Y., Steigerwalt, J., Bell, T. A., de Villena, F., & Threadgill, D. W. (2010). Genetic mapping and developmental timing of transmission ratio distortion in a mouse interspecific backcross. BMC Genetics. 11(1), 98.
- Rusyn, I., Gatti, D. M., Wiltshire, T., Kleeberger, S. R., & Threadgill, D. W. (2010). Corrigendum. Pharmacogenomics. 11(9), 1344-1344.
- Reiter, J. L., Threadgill, D. W., Eley, G. D., Strunk, K. E., Danielsen, A. J., Sinclair, C. S., ... Maihle, N. J. (2010). Comparative genomic sequence analysis and isolation of human and mouse alternative EGFR transcripts encoding truncated receptor isoforms (vol 71, pg 1, 2001). Genomics. 96(2), 128-128.
- Schughart, K., & SYSGENET consortium. (2010). SYSGENET: a meeting report from a new European network for systems genetics. MAMMALIAN GENOME. 21(7-8), 331-336.
- Rusyn, I., Gatti, D. M., Wiltshire, T., Kleeberger, S. R., & Threadgill, D. W. (2010). Toxicogenetics: population-based testing of drug and chemical safety in mouse models. Pharmacogenomics. 11(8), 1127-1136.
- Gordon, R. R., La Merrill, M., Hunter, K. W., Srensen, P., Threadgill, D. W., & Pomp, D. (2010). Dietary fat-dependent transcriptional architecture and copy number alterations associated with modifiers of mammary cancer metastasis. Clinical and Experimental Metastasis. 27(5), 279-293.
- La Merrill, M., Harper, R., Birnbaum, L. S., Cardiff, R. D., & Threadgill, D. W. (2010). Maternal dioxin exposure combined with a diet high in fat increases mammary cancer incidence in mice. Environmental Health Perspectives. 118(5), 596-601.
- Powell, C. L., Bradford, B. U., Craig, C. P., Tsuchiya, M., Uehara, T., O'Connell, T. M., ... Rusyn, I. (2010). Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors. TOXICOLOGICAL SCIENCES. 115(1), 131-139.
- Zhang, Z., Pascuet, E., Hueber, P., Chu, L., Bichet, D. G., Lee, T., Threadgill, D. W., & Goodyer, P. (2010). Targeted inactivation of EGF receptor inhibits renal collecting duct development and function. Journal of the American Society of Nephrology. 21(4), 573-578.
- Arce, R. M., Diaz, P. I., Barros, S. P., Galloway, P., Bobetsis, Y., Threadgill, D., & Offenbacher, S. (2010). Characterization of the invasive and inflammatory traits of oral Campylobacter rectus in a murine model of fetoplacental growth restriction and in trophoblast cultures. Journal of Reproductive Immunology. 84(2), 145-153.
- Mascia, F., Cataisson, C., Lee, T., Threadgill, D., Mariani, V., Amerio, P., ... Pastore, S. (2010). EGFR regulates the expression of keratinocyte-derived granulocyte/macrophage colony-stimulating factor in vitro and in vivo. Journal of Investigative Dermatology. 130(3), 682-693.
- La Merrill, M., Gordon, R. R., Hunter, K. W., Threadgill, D. W., & Pomp, D. (2010). Dietary fat alters pulmonary metastasis of mammary cancers through cancer autonomous and non-autonomous changes in gene expression. Clinical and Experimental Metastasis. 27(2), 107-116.
- Moy, S. S., Ghashghaei, H. T., Nonneman, R. J., Weimer, J. M., Yokota, Y., Lee, D., ... Anton, E. S. (2009). Deficient NRG1-ERBB signaling alters social approach: relevance to genetic mouse models of schizophrenia. Journal of Neurodevelopmental Disorders. 1(4), 302-312.
- Dougherty, U., Cerasi, D., Taylor, I., Kocherginsky, M., Tekin, U., Badal, S., ... Bissonnette, M. (2009). Epidermal growth factor receptor is required for colonic tumor promotion by dietary fat in the azoxymethane/dextran sulfate sodium model: roles of transforming growth factor-{alpha} and PTGS2. CLINICAL CANCER RESEARCH. 15(22), 6780-6789.
- Munger, S. C., Aylor, D. L., Syed, H. A., Magwene, P. M., Threadgill, D. W., & Capel, B. (2009). Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal. Genes and Development. 23(21), 2521-2536.
- Halladay, A. K., Amaral, D., Aschner, M., Bolivar, V. J., Bowman, A., DiCicco-Bloom, E., ... Threadgill, D. W. (2009). Animal models of autism spectrum disorders: information for neurotoxicologists. NeuroToxicology. 30(5), 811-821.
- La Merrill, M., Kuruvilla, B. S., Pomp, D., Birnbaum, L. S., & Threadgill, D. W. (2009). Dietary fat alters body composition, mammary development, and cytochrome p450 induction after maternal TCDD exposure in DBA/2J mice with low-responsive aryl hydrocarbon receptors. Environmental Health Perspectives. 117(9), 1414-1419.
- Harrill, A. H., Watkins, P. B., Su, S., Ross, P. K., Harbourt, D. E., Stylianou, I. M., ... Threadgill, D. W. (2009). Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans. Genome Research. 19(9), 1507-1515.
- Barrick, C. J., Dong, A., Waikel, R., Corn, D., Yang, F., Threadgill, D. W., & Smyth, S. S. (2009). Parent-of-origin effects on cardiac response to pressure overload in mice. American Journal of Physiology. Heart and Circulatory Physiology. 297(3), H1003-H1009.
- Dackor, J., Caron, K. M., & Threadgill, D. W. (2009). Placental and embryonic growth restriction in mice with reduced function epidermal growth factor receptor alleles. Genetics. 183(1), 207-218.
- Lee, D., Yu, M., Lee, E., Kim, H., Yang, Y., Kim, K., ... Threadgill, D. W. (2009). Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium. Journal of Clinical Investigation. 119(9), 2702-2713.
- Harrill, A. H., Ross, P. K., Gatti, D. M., Threadgill, D. W., & Rusyn, I. (2009). Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel. TOXICOLOGICAL SCIENCES. 110(1), 235-243.
- Barrick, C. J., Roberts, R. B., Rojas, M., Rajamannan, N. M., Suitt, C. B., O'Brien, K. D., Smyth, S. S., & Threadgill, D. W. (2009). Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice. American Journal of Physiology. Heart and Circulatory Physiology. 297(1), H65-H75.
- Gatti, D. M., Harrill, A. H., Wright, F. A., Threadgill, D. W., & Rusyn, I. (2009). Replication and narrowing of gene expression quantitative trait loci using inbred mice. MAMMALIAN GENOME. 20(7), 437-446.
- Dackor, J., Li, M., & Threadgill, D. W. (2009). Placental overgrowth and fertility defects in mice with a hypermorphic allele of epidermal growth factor receptor. MAMMALIAN GENOME. 20(6), 339-349.
- Uronis, J. M., & Threadgill, D. W. (2009). Murine models of colorectal cancer. MAMMALIAN GENOME. 20(5), 261-268.
- Pysz, M. A., Leontieva, O. V., Bateman, N. W., Uronis, J. M., Curry, K. J., Threadgill, D. W., ... Black, J. D. (2009). PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1. Experimental Cell Research. 315(8), 1415-1428.
- Dougherty, U., Cerasi, D., Taylor, I., Mustafi, R., Zhu, H., Hart, J., ... Bissonnette, M. (2009). S2051 Stromal Cell EGFR Enhances Colon Cancer Cell Growth in Tumor Xenografts. Gastroenterology. 136(5), a-320.
- Maklad, A., Nicolai, J. R., Bichsel, K. J., Evenson, J. E., Lee, T., Threadgill, D. W., & Hansen, L. A. (2009). The EGFR is required for proper innervation to the skin. Journal of Investigative Dermatology. 129(3), 690-698.
- Fiske, W. H., Threadgill, D., & Coffey, R. J. (2009). ERBBs in the gastrointestinal tract: recent progress and new perspectives. Experimental Cell Research. 315(4), 583-601.
- Lee, T., & Threadgill, D. W. (2009). Generation and validation of mice carrying a conditional allele of the epidermal growth factor receptor. Genesis. 47(2), 85-92.
- Carroll, I. M., Threadgill, D. W., & Threadgill, D. S. (2009). The gastrointestinal microbiome: a malleable, third genome of mammals. MAMMALIAN GENOME. 20(7), 395-403.
- La Merrill, M., Baston, D. S., Denison, M. S., Birnbaum, L. S., Pomp, D., & Threadgill, D. W. (2009). Mouse breast cancer model-dependent changes in metabolic syndrome-associated phenotypes caused by maternal dioxin exposure and dietary fat. American Journal of Physiology: Endocrinology and Metabolism. 296(1), E203-E210.
- Abate-Shen, C., Brown, P. H., Colburn, N. H., Gerner, E. W., Green, J. E., Lipkin, M., Nelson, W. G., & Threadgill, D. (2008). The untapped potential of genetically engineered mouse models in chemoprevention research: opportunities and challenges. Cancer Prevention Research. 1(3), 161-166.
- Chesler, E. J., Miller, D. R., Branstetter, L. R., Galloway, L. D., Jackson, B. L., Philip, V. M., ... Manly, K. F. (2008). The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics. MAMMALIAN GENOME. 19(6), 382-389.
- Barrick, C. J., Yu, M., Chao, H., & Threadgill, D. W. (2008). Chronic pharmacologic inhibition of EGFR leads to cardiac dysfunction in C57BL/6J mice. TOXICOLOGY AND APPLIED PHARMACOLOGY. 228(3), 315-325.
- Dougherty, U., Aluri, L. M., Sehdev, A., Cerda, S. R., Mustafi, R., Kocherginsky, M., ... Bissonnette, M. (2008). 189 EGFR Is Required for Tumor Promotion By Dietary Fat in a Murine Model of Inflammation-Associated Colon Cancer. Gastroenterology. 134(4), a-32-a-33.
- Gordon, R. R., Hunter, K. W., La Merrill, M., Srensen, P., Threadgill, D. W., & Pomp, D. (2008). Genotype X diet interactions in mice predisposed to mammary cancer: II. Tumors and metastasis. MAMMALIAN GENOME. 19(3), 179-189.
- Threadgill, D. W. (2008). Down's syndrome: paradox of a tumour repressor. Nature. 451(7174), 21-22.
- Radiloff, D. R., Rinella, E. S., & Threadgill, D. W. (2008). Modeling cancer patient populations in mice: complex genetic and environmental factors. Drug Discovery Today: Disease Models. 4(2), 83-88.
- Uronis, J. M., Herfarth, H. H., Rubinas, T. C., Bissahoyo, A. C., Hanlon, K., & Threadgill, D. W. (2007). Flat colorectal cancers are genetically determined and progress to invasion without going through a polypoid stage. Cancer Research. 67(24), 11594-11600.
- Dackor, J., Strunk, K. E., Wehmeyer, M. M., & Threadgill, D. W. (2007). Altered trophoblast proliferation is insufficient to account for placental dysfunction in Egfr null embryos. 28(11-12), 1211-1218.
- Huang, H., Eversley, C. D., Threadgill, D. W., & Zou, F. (2007). Bayesian multiple quantitative trait loci mapping for complex traits using markers of the entire genome. Genetics. 176(4), 2529-2540.
- Gatti, D., Maki, A., Chesler, E. J., Kirova, R., Kosyk, O., Lu, L. u., ... Rusyn, I. (2007). Genome-level analysis of genetic regulation of liver gene expression networks. HEPATOLOGY. 46(2), 548-557.
- Kaiser, S., Park, Y., Franklin, J. L., Halberg, R. B., Yu, M., Jessen, W. J., ... Aronow, B. J. (2007). Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. 8(7), R131.
- Roberts, A., McMillan, L., Wang, W., Parker, J., Rusyn, I., & Threadgill, D. (2007). Inferring missing genotypes in large SNP panels using fast nearest-neighbor searches over sliding windows. Bioinformatics. 23(13), i401-i407.
- Roberts, A., Pardo-Manuel de Villena, F., Wang, W., McMillan, L., & Threadgill, D. W. (2007). The polymorphism architecture of mouse genetic resources elucidated using genome-wide resequencing data: implications for QTL discovery and systems genetics. MAMMALIAN GENOME. 18(6-7), 473-481.
- Chi, Y., Ibrahim, J. G., Bissahoyo, A., & Threadgill, D. W. (2007). Bayesian hierarchical modeling for time course microarray experiments. Biometrics. 63(2), 496-504.
- Barrick, C. J., Rojas, M., Schoonhoven, R., Smyth, S. S., & Threadgill, D. W. (2007). Cardiac response to pressure overload in 129S1/SvImJ and C57BL/6J mice: temporal- and background-dependent development of concentric left ventricular hypertrophy. American Journal of Physiology. Heart and Circulatory Physiology. 292(5), H2119-H2130.
- Hsieh, M., Lee, D., Panigone, S., Horner, K., Chen, R., Theologis, A., ... Conti, M. (2007). Luteinizing hormone-dependent activation of the epidermal growth factor network is essential for ovulation. Molecular and Cellular Biology. 27(5), 1914-1924.
- Moy, S. S., Nadler, J. J., Young, N. B., Perez, A., Holloway, L. P., Barbaro, R. P., ... Crawley, J. N. (2007). Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. Behavioural Brain Research. 176(1), 4-20.
- Syed, H. A., & Threadgill, D. W. (2006). Enhanced oligonucleotide microarray labeling and hybridization. BioTechniques. 41(6), 685-686.
- Roberts, R. B., Thompson, C. L., Lee, D., Mankinen, R. W., Sancar, A., & Threadgill, D. W. (2006). Wildtype epidermal growth factor receptor (Egfr) is not required for daily locomotor or masking behavior in mice. Journal of Circadian Rhythms. 4(0), 15-15.
- Nadler, J. J., Zou, F., Huang, H., Moy, S. S., Lauder, J., Crawley, J. N., ... Magnuson, T. R. (2006). Large-scale gene expression differences across brain regions and inbred strains correlate with a behavioral phenotype. Genetics. 174(3), 1229-1236.
- Deloris Alexander, A., Orcutt, R. P., Henry, J. C., Baker, J., Bissahoyo, A. C., & Threadgill, D. W. (2006). Quantitative PCR assays for mouse enteric flora reveal strain-dependent differences in composition that are influenced by the microenvironment. MAMMALIAN GENOME. 17(11), 1093-1104.
- Rinella, E. S., Eversley, C. D., Carroll, I. M., Andrus, J. M., Threadgill, D. W., & Threadgill, D. S. (2006). Human epithelial-specific response to pathogenic Campylobacter jejuni. FEMS Microbiology Letters. 262(2), 236-243.
- Threadgill, D. W. (2006). Meeting report for the 4th annual Complex Trait Consortium meeting: from QTLs to systems genetics. MAMMALIAN GENOME. 17(1), 2-4.
- Fujimoto, N., Wislez, M., Zhang, J., Iwanaga, K., Dackor, J., Hanna, A. E., ... Kurie, J. M. (2005). High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor. Cancer Research. 65(24), 11478-11485.
- Bissahoyo, A., Pearsall, R. S., Hanlon, K., Amann, V., Hicks, D., Godfrey, V. L., & Threadgill, D. W. (2005). Azoxymethane is a genetic background-dependent colorectal tumor initiator and promoter in mice: effects of dose, route, and diet. TOXICOLOGICAL SCIENCES. 88(2), 340-345.
- Threadgill, D. W. (2005). Metastatic potential as a heritable trait. Nature Genetics. 37(10), 1026-1027.
- Genther Williams, S. M., Disbrow, G. L., Schlegel, R., Lee, D., Threadgill, D. W., & Lambert, P. F. (2005). Requirement of epidermal growth factor receptor for hyperplasia induced by E5, a high-risk human papillomavirus oncogene. Cancer Research. 65(15), 6534-6542.
- Zou, F., Gelfond, J., Airey, D. C., Lu, L. u., Manly, K. F., Williams, R. W., & Threadgill, D. W. (2005). Quantitative trait locus analysis using recombinant inbred intercrosses: theoretical and empirical considerations. Genetics. 170(3), 1299-1311.
- Chesler, E. J., Lu, L. u., Shou, S., Qu, Y., Gu, J., Wang, J., ... Williams, R. W. (2005). Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function. Nature Genetics. 37(3), 233-242.
- Franklin, J. L., Yoshiura, K., Dempsey, P. J., Bogatcheva, G., Jeyakumar, L., Meise, K. S., ... Coffey, R. J. (2005). Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein. Experimental Cell Research. 303(2), 457-470.
- Mrosovsky, N., Redlin, U., Roberts, R. B., & Threadgill, D. W. (2005). Masking in waved-2 mice: EGF receptor control of locomotion questioned. Chronobiology International: the journal of biological and medical rhythm research. 22(6), 963-974.
- Hahn, H., Nitzki, F., Schorban, T., Hemmerlein, B., Threadgill, D., & Rosemann, M. (2004). Genetic mapping of a Ptch1-associated rhabdomyosarcoma susceptibility locus on mouse chromosome 2. Genomics. 84(5), 853-858.
- Churchill, G. A., Airey, D. C., Allayee, H., Angel, J. M., Attie, A. D., Beatty, J., ... Complex Trait Consortium. (2004). The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nature Genetics. 36(11), 1133-1137.
- Wilson, W., Pardo-Manuel de Villena, F., Lyn-Cook, B. D., Chatterjee, P. K., Bell, T. A., Detwiler, D. A., ... Grant, D. J. (2004). Characterization of a common deletion polymorphism of the UGT2B17 gene linked to UGT2B15. Genomics. 84(4), 707-714.
- Lee, D., Pearsall, R. S., Das, S., Dey, S. K., Godfrey, V. L., & Threadgill, D. W. (2004). Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damage. Molecular and Cellular Biology. 24(20), 8907-8916.
- Strunk, K. E., Amann, V., & Threadgill, D. W. (2004). Phenotypic variation resulting from a deficiency of epidermal growth factor receptor in mice is caused by extensive genetic heterogeneity that can be genetically and molecularly partitioned. Genetics. 167(4), 1821-1832.
- Lee, D., Cross, S. H., Strunk, K. E., Morgan, J. E., Bailey, C. L., Jackson, I. J., & Threadgill, D. W. (2004). Wa5 is a novel ENU-induced antimorphic allele of the epidermal growth factor receptor. MAMMALIAN GENOME. 15(7), 525-536.
- Lee, D., & Threadgill, D. W. (2004). Investigating gene function using mouse models. Current Opinion in Genetics and Development. 14(3), 246-252.
- Roberts, R. B., Arteaga, C. L., & Threadgill, D. W. (2004). Modeling the cancer patient with genetically engineered mice. Cancer Cell. 5(2), 115-120.
- Roberts, R. B., Arteaga, C. L., & Threadgill, D. W. (2004). Modeling the cancer patient with genetically engineered mice: prediction of toxicity from molecule-targeted therapies. Cancer Cell. 5(2), 115-120.
- Abiola, O., Angel, J. M., Avner, P., Bachmanov, A. A., Belknap, J. K., Bennett, B., ... Complex Trait Consortium. (2003). The nature and identification of quantitative trait loci: a community's view. Nature Reviews Genetics. 4(11), 911-916.
- Williams, R. W., Flaherty, L., & Threadgill, D. W. (2003). The math of making mutant mice. Genes, Brain and Behavior. 2(4), 191-200.
- Fitch, K. R., McGowan, K. A., van Raamsdonk, C. D., Fuchs, H., Lee, D., Puech, A., ... Barsh, G. S. (2003). Genetics of dark skin in mice. Genes and Development. 17(2), 214-228.
- Threadgill, D. W., Hunter, K. W., & Williams, R. W. (2002). Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effort. MAMMALIAN GENOME. 13(4), 175-178.
- Roberts, R. B., Min, L. u., Washington, M. K., Olsen, S. J., Settle, S. H., Coffey, R. J., & Threadgill, D. W. (2002). Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 99(3), 1521-1526.
- Chaurand, P., DaGue, B. B., Pearsall, R. S., Threadgill, D. W., & Caprioli, R. M. (2001). Profiling proteins from azoxymethane-induced colon tumors at the molecular level by matrix-assisted laser desorption/ionization mass spectrometry. Proteomics. 1(10), 1320-1326.
- COFFEYJR, R., ROBERTS, R., SETTLE, S., WHITEHEAD, R., WASHINGTON, K., & THREADGILL, D. (2001). Genetic support for a critical role EGF receptor signaling in intestinal neoplasia in ApcMin mice. Gastroenterology. 120(5), a18-a18.
- Coffey, R. J., Roberts, R., Settle, S. H., Whitehead, R., Washington, K., & Threadgill, D. (2001). Genetic support for a critical role EGF receptor signaling in intestinal neoplasia in ApcMin mice. Gastroenterology. 120(5), a18-A18.
- Reiter, J. L., Threadgill, D. W., Eley, G. D., Strunk, K. E., Danielsen, A. J., Sinclair, C. S., ... Maihle, N. J. (2001). Comparative genomic sequence analysis and isolation of human and mouse alternative EGFR transcripts encoding truncated receptor isoforms. Genomics. 71(1), 1-20.
- Coffey, R. J., & Threadgill, D. (2000). Erratum: Microarray foray (Breast Cancer Research (2000) vol. 2 (8-9)). Breast Cancer Research. 2(2),
- Mcquain, M., Holden, W., McAnich, T., Coffey, R., Threadgill, D., Pearsall, S., & Haselton, F. (2000). Quantitative comparison of DNA attachment chemistries as assessed by hybridization to DNA microarrays. Annals of Biomedical Engineering. 28(SUPPL. 1),
- Denning, M. F., Dlugosz, A. A., Cheng, C., Dempsey, P. J., Coffey, R. J., Threadgill, D. W., Magnuson, T., & Yuspa, S. H. (2000). Cross-talk between epidermal growth factor receptor and protein kinase C during calcium-induced differentiation of keratinocytes. Experimental Dermatology. 9(3), 192-199.
- Coffey, R. J., & Threadgill, D. (2000). Microarray foray. Breast Cancer Research. 2(1), 8-9.
- Coffey, R. J., & Threadgill, D. (1999). Microarray foray. Breast Cancer Research. 2(1),
- Nishimura, H., Yerkes, E., Hohenfellner, K., Miyazaki, Y., Ma, J., Hunley, T. E., ... Ichikawa, I. (1999). Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men. Molecular Cell. 3(1), 1-10.
- Strunk, K. E., & Threadgill, D. W. (1998). Chimeric analysis of epidermal growth factor receptor null cells during embryogenesis. Developmental Biology. 198(1), 181-181.
- Dlugosz, A. A., Hansen, L., Cheng, C., Alexander, N., Denning, M. F., Threadgill, D. W., ... Yuspa, S. H. (1997). Targeted disruption of the epidermal growth factor receptor impairs growth of squamous papillomas expressing the v-ras(Ha) oncogene but does not block in vitro keratinocyte responses to oncogenic ras. Cancer Research. 57(15), 3180-3188.
- Hansen, L. A., Alexander, N., Hogan, M. E., Sundberg, J. P., Dlugosz, A., Threadgill, D. W., Magnuson, T., & Yuspa, S. H. (1997). Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development. American Journal of Pathology. 150(6), 1959-1975.
- Threadgill, D. W., Yee, D., Matin, A., Nadeau, J. H., & Magnuson, T. (1997). Genealogy of the 129 inbred strains: 129/SvJ is a contaminated inbred strain. MAMMALIAN GENOME. 8(6), 390-393.
- Threadgill, D. W., Matin, A., Yee, D., Carrasquillo, M. M., Henry, K. R., Rollins, K. G., Nadeau, J. H., & Magnuson, T. (1997). SSLPs to map genetic differences between the 129 inbred strains and closed-colony, random-bred CD-1 mice. MAMMALIAN GENOME. 8(6), 441-442.
- Tong, B. J., Das, S. K., Threadgill, D., Magnuson, T., & Dey, S. K. (1996). Differential expression of the full-length and truncated forms of the epidermal growth factor receptor in the preimplantation mouse uterus and blastocyst. Molecular Endocrinology. 137(4), 1492-1496.
- Tong, B. J., Das, S. K., Threadgill, D., Magnuson, T., & Dey, S. K. (1996). Differential expression of the full-length and truncated forms of the epidermal growth factor receptor in the preimplantation mouse uterus and blastocyst. ENDOCRINOLOGY. 137(4), 1492-1496.
- Denning, M. F., Dlugosz, A. A., Threadgill, D. W., Magnuson, T., & Yuspa, S. H. (1996). Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C delta. Journal of Biological Chemistry. 271(10), 5325-5331.
- Denning, M. F., Dlugosz, A. A., Cheng, C., Threadgill, D. W., Magnuson, T., & Yuspa, S. H. (1996). Tyrosine phosphorylation of protein kinase C delta during calcium-induced keratinocyte differentiation involves activation of epidermal growth factor receptor. Journal of Investigative Dermatology. 106(4), 618-618.
- Hansen, L. A., Tennenbaum, T., Threadgill, D. W., Magnuson, T., & Yuspa, S. H. (1996). Altered hair follicle morphogenesis in epidermal growth factor receptor deficient mice. Journal of Investigative Dermatology. 106(4), 87-87.
- Dlugosz, A. A., Hansen, L., Cheng, C., Denning, M. F., Threadgill, D. W., Magnuson, T., Coffey, R. J., & Yuspa, S. H. (1996). Targeted disruption of EGFR impairs keratinocyte responses to the v-ras(Ha) oncogene in vitro and in vivo. Journal of Investigative Dermatology. 106(4), 31-31.
- Threadgill, D. W., Dlugosz, A. A., Hansen, L. A., Tennenbaum, T., Lichti, U., Yee, D., ... Harris, R. C. (1995). Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science. 269(5221), 230-234.
- Threadgill, D. S., Threadgill, D. W., Moll, Y. D., Weiss, J. A., Zhang, N., Davey, H. W., Wildeman, A. G., & Womack, J. E. (1994). Syntenic assignment of human chromosome 1 homologous loci in the bovine. Genomics. 22(3), 626-630.
- Gallagher, D. S., Threadgill, D. W., Ryan, A. M., Womack, J. E., & Irwin, D. M. (1993). Physical mapping of the lysozyme gene family in cattle. 4(7), 368-373.
- Dietz, A. B., Georges, M., Threadgill, D. W., Womack, J. E., & Schuler, L. A. (1992). Somatic cell mapping, polymorphism, and linkage analysis of bovine prolactin-related proteins and placental lactogen. Genomics. 14(1), 137-143.
- Zhang, N., Threadgill, D. W., & Womack, J. E. (1992). Synteny mapping in the bovine: genes from human chromosome 4. Genomics. 14(1), 131-136.
- Sharan, S. K., Holdener-Kenny, B., Threadgill, D. W., & Magnuson, T. (1992). Genomic mapping within the albino-deletion complex using individual early postimplantation mouse embryos. MAMMALIAN GENOME. 3(2), 79-83.
- Bishop, M. D., Tavakkol, A., Threadgill, D. W., Simmen, F. A., Simmen, R. C., Davis, M. E., & Womack, J. E. (1991). Somatic cell mapping and restriction fragment length polymorphism analysis of bovine insulin-like growth factor I. Journal of Animal Science. 69(11), 4306-4311.
- GUNAWARDANA, A., SOLINAS, S., SCHOBERLEIN, A., EGGEN, A., THREADGILL, D. W., THREADGILL, D. S., ... STRANZINGER, G. (1991). CHROMOSOMAL ASSIGNMENT OF BOVINE SYNTENIC GROUPS. Cytogenetic and Genome Research. 58(3-4), 2126-2126.
- Georges, M., Gunawardana, A., Threadgill, D. W., Lathrop, M., Olsaker, I., Mishra, A., ... Terry, C. (1991). Characterization of a set of variable number of tandem repeat markers conserved in bovidae. Genomics. 11(1), 24-32.
- Gallagher, D. S., Threadgill, D. W., Jackson, A. P., Parham, P., & Womack, J. E. (1991). Somatic cell mapping of bovine clathrin light chain genes: identification of a new bovine syntenic group. Cytogenetic and Genome Research. 56(3-4), 154-156.
- Threadgill, D. W., & Womack, J. E. (1991). Synteny mapping of human chromosome 8 loci in cattle. Animal Genetics. 22(2), 117-122.
- Threadgill, D. W., & Womack, J. E. (1990). Genomic analysis of the major bovine milk protein genes. Nucleic Acids Research (NAR). 18(23), 6935-6942.
- Threadgill, D. W., & Womack, J. E. (1990). Syntenic conservation between humans and cattle. I. Human chromosome 9. Genomics. 8(1), 22-28.
- Threadgill, D. W., Adkison, L. R., & Womack, J. E. (1990). Syntenic conservation between humans and cattle. II. Human chromosome 12. Genomics. 8(1), 29-34.
- Threadgill, D. W., Wilkmeyer, M., Womack, J. E., & Ledley, F. D. (1990). Localization of the murine methylmalonyl CoA mutase (Mut) locus on chromosome 17 by in situ hybridization. Cytogenetic and Genome Research. 53(2-3), 112-114.
- Threadgill, D. W., Fries, R., Faber, L. K., Vassart, G., Gunawardana, A., Stranzinger, G., & Womack, J. E. (1990). The thyroglobulin gene is syntenic with the MYC and MOS protooncogenes and carbonic anhydrase II and maps to chromosome 14 in cattle. Cytogenetic and Genome Research. 53(1), 32-36.
- THREADGILL, D. W., & WOMACK, J. E. (1989). SYNTENIC ASSIGNMENT OF HSA-9 AND HSA-12 HOMOLOGS IN THE BOVINE - PRELIMINARY EVIDENCE FOR THE ROLE OF FRAGILE SITES IN MAMMALIAN GENOME EVOLUTION. Cytogenetic and Genome Research. 51(1-4), 1091-1091.
- WOMACK, J. E., THREADGILL, D. W., MOLL, Y. D., FABER, L. K., FOREMAN, M. L., DIETZ, A. B., ... ROGERS, D. S. (1989). SYNTENIC MAPPING OF 37 LOCI IN CATTLE - CHROMOSOMAL CONSERVATION WITH MOUSE AND MAN. Cytogenetic and Genome Research. 51(1-4), 1109-1109.
- Threadgill, D. W., & Womack, J. E. (1988). Regional localization of mouse Abl and Mos proto-oncogenes by in situ hybridization. Genomics. 3(1), 82-86.
- Threadgill, D. W. Animal models of autism spectrum disorders: Information for neurotoxicologists
- Threadgill, D. W. Architecture of energy balance traits in emerging lines of the Collaborative Cross
- Threadgill, D. W. Azoxymethane is a genetic background-dependent colorectal tumor initiator and promoter in mice: Effects of dose, route, and diet
- Threadgill, D. W. Bayesian hierarchical modeling for time course microarray experiments
- Threadgill, D. W. Bayesian multiple quantitative trait loci mapping for complex traits using markers of the entire genome
- Threadgill, D. W. Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts
- Threadgill, D. W. Cardiac response to pressure overload in 129S1/SvImJ and C57BL/6J mice: Temporal- and background-dependent development of concentric left ventricular hypertrophy
- Threadgill, D. W. Characterization of a common deletion polymorphism of the UGT2B17 gene linked to UGT2B15
- Threadgill, D. W. Chronic pharmacologic inhibition of EGFR leads to cardiac dysfunction in C57BL/6J mice
- Nagarajan, A., Scoggin, K., Gupta, J., Aminian, M., Adams, L. G., Kirby, M., Threadgill, D., & Andrews-Polymenis, H. Collaborative Cross mice have diverse phenotypic responses to infection with Methicillin-resistant Staphylococcus aureus USA300
- Threadgill, D. W. Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function
- Threadgill, D. W. Conditional inactivation of TNF-converting enzyme in chondrocytes results in an elongated growth plate and shorter long bones
- Threadgill, D. W. Dietary calcium supplementation enhances efficacy but also toxicity of EGFR inhibitor therapy for colon cancer
- Threadgill, D. W. Dietary fat alters body composition, mammary development, and cytochrome P450 induction after maternal TCDD exposure in DBA/2J mice with low-responsive Aryl hydrocarbon receptors
- Threadgill, D. W. Dietary fat alters pulmonary metastasis of mammary cancers through cancer autonomous and non-autonomous changes in gene expression
- Threadgill, D. W. Dietary fat-dependent transcriptional architecture and copy number alterations associated with modifiers of mammary cancer metastasis
- Threadgill, D. W. Down's syndrome: Paradox of a tumour repressor
- Threadgill, D. W. EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis
- Threadgill, D. W. EGFR regulates the expression of keratinocyte-derived granulocyte/ macrophage colony-stimulating factor in vitro and in vivo
- Threadgill, D. W. EGFR signaling promotes TGF-dependent renal fibrosis
- Threadgill, D. W. ERBBs in the gastrointestinal tract: Recent progress and new perspectives
- Threadgill, D. W. Efficacy of EGFR inhibition is modulated by model, sex, genetic background and diet: implications for preclinical cancer prevention and therapy trials
- Threadgill, D. W. Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal
- Threadgill, D. W. Enhanced oligonucleotide microarray labeling and hybridization
- Threadgill, D. W. Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand- dependent terminal keratinocyte differentiation
- Threadgill, D. W. Epidermal growth factor receptor is required for colonic tumor promotion by dietary fat in the azoxymethane/dextran sulfate sodium model: Roles of transforming growth factor- and PTGS2
- Threadgill, D. W. Epidermal growth factor receptor plays an anabolic role in bone metabolism in vivo
- Threadgill, D. W. Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis
- Threadgill, D. W. Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damage
- Threadgill, D. W. Epiregulin-dependent amphiregulin expression and ERBB2 signaling are involved in luteinizing hormone-induced paracrine signaling pathways in mouse ovary
- Threadgill, D. W. Expression quantitative trait loci for extreme host response to influenza A in pre-collaborative cross mice
- Threadgill, D. W. Flat colorectal cancers are genetically determined and progress to invasion without going through a polypoid stage
- Threadgill, D. W. Generation and validation of mice carrying a conditional allele of the epidermal growth factor receptor
- Threadgill, D. W. Genetic analysis of complex traits in the emerging Collaborative Cross
- Threadgill, D. W. Genetic analysis of hematological parameters in incipient lines of the collaborative cross
- Threadgill, D. W. Genetic dissection of complex and quantitative traits: From fantasy to reality via a community effort
- Threadgill, D. W. Genetic mapping and developmental timing of transmission ratio distortion in a mouse interspecific backcross
- Threadgill, D. W. Genetic mapping of a Ptch1-associated rhabdomyosarcoma susceptibility locus on mouse chromosome 2
- Threadgill, D. W. Genetics of dark skin in mice
- Threadgill, D. W. Genome-level analysis of genetic regulation of liver gene expression networks
- Threadgill, D. W. Genome-wide association mapping of loci for antipsychotic-induced extrapyramidal symptoms in mice
- Threadgill, D. W. Genotype x diet interactions in mice predisposed to mammary cancer: II. Tumors and metastasis
- Threadgill, D. W. High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor
- Threadgill, D. W. Human epithelial-specific response to pathogenic Campylobacter jejuni
- Threadgill, D. W. Identification of MAGI-3 as a transforming growth factor- tail binding protein
- Threadgill, D. W. Identification of a novel polymorphism in X-linked sterol-4-alpha-carboxylate 3-dehydrogenase (Nsdhl) associated with reduced high-density lipoprotein cholesterol levels in i/LnJ mice
- Threadgill, D. W. Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis
- Threadgill, D. W. Inferring missing genotypes in large SNP panels using fast nearest-neighbor searches over sliding windows
- Threadgill, D. W. Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice
- Threadgill, D. W. Investigating gene function using mouse models
- Threadgill, D. W. Large-scale gene expression differences across brain regions and inbred strains correlate with a behavioral phenotype
- Threadgill, D. W. Luteinizing hormone-dependent activation of the epidermal growth factor network is essential for ovulation
- Threadgill, D. W. Maternal dioxin exposure combined with a diet high in fat increases mammary cancer incidence in mice
- Threadgill, D. W. Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors
- Threadgill, D. W. Meeting report for the 4th Annual Complex Trait Consortium Meeting: From QTLs to Systems Genetics
- Threadgill, D. W. Metastatic potential as a heritable trait
- Threadgill, D. W. MicroRNA expression in the livers of inbred mice
- Threadgill, D. W. Modeling Host Genetic Regulation of Influenza Pathogenesis in the Collaborative Cross
- Threadgill, D. W. Modeling cancer patient populations in mice: complex genetic and environmental factors
- Threadgill, D. W. Mouse behavioral tasks relevant to autism: Phenotypes of 10 inbred strains
- Threadgill, D. W. Mouse breast cancer model-dependent changes in metabolic syndrome-associated phenotypes caused by maternal dioxin exposure and dietary fat
- Threadgill, D. W. Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans
- Threadgill, D. W. Murine models of colorectal cancer
- Threadgill, D. W. PKC tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1
- Threadgill, D. W. Parent-of-origin effects on cardiac response to pressure overload in mice
- Threadgill, D. W. Phenotypic variation resulting from a deficiency of epidermal growth factor receptor in mice is caused by extensive genetic heterogeneity that can be genetically and molecularly partitioned
- Threadgill, D. W. Placental and embryonic growth restriction in mice with reduced function epidermal growth factor receptor alleles
- Threadgill, D. W. Placental overgrowth and fertility defects in mice with a hypermorphic allele of epidermal growth factor receptor
- Threadgill, D. W. Pleiotropic effects of the trichloroethylene-associated P81S VHL mutation on metabolism, apoptosis, and ATM-mediated DNA damage response
- Threadgill, D. W. Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel
- Wulfridge, P., Davidovich, A., Salvador, A. C., Manno, G. C., Tryggvadottir, R., Idrizi, A., ... Feinberg, A. P. Precision pharmacological reversal of genotype-specific diet-induced metabolic syndrome in mice informed by transcriptional regulation. 4(05-09), 2023.04.25.538156.
- Wulfridge, P., Davidovich, A., Salvador, A. C., Manno, G. C., Tryggvadottir, R., Idrizi, A., ... Feinberg, A. P. Precision pharmacological reversal of strain-specific diet-induced metabolic syndrome in mice informed by epigenetic and transcriptional regulation
- Threadgill, D. W. Quantitative PCR assays for mouse enteric flora reveal strain-dependent differences in composition that are influenced by the microenvironment
- Threadgill, D. W. Quantitative trait locus analysis using recombinant inbred intercrosses: Theoretical and empirical considerations
- Threadgill, D. W. Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice
- Threadgill, D. W. Replication and narrowing of gene expression quantitative trait loci using inbred mice
- Threadgill, D. W. Requirement of epidermal growth factor receptor for hyperplasia induced by E5, a high-risk human papillomavirus oncogene
- Threadgill, D. W. Status and access to the Collaborative Cross population
- Threadgill, D. W. Targeted inactivation of EGF receptor inhibits renal collecting duct development and function
- Threadgill, D. W. Ten years of the collaborative cross
- Threadgill, D. W. The Collaborative Cross at Oak Ridge National Laboratory: Developing a powerful resource for systems genetics
- Threadgill, D. W. The Collaborative Cross, a community resource for the genetic analysis of complex traits
- Threadgill, D. W. The EGFR is required for proper innervation to the skin
- Threadgill, D. W. The gastrointestinal microbiome: A malleable, third genome of mammals
- Threadgill, D. W. The genome architecture of the collaborative cross mouse genetic reference population
- Threadgill, D. W. The nature and identification of quantitative trait loci: A community's view
- Threadgill, D. W. The polymorphism architecture of mouse genetic resources elucidated using genome-wide resequencing data: Implications for QTL discovery and systems genetics
- Threadgill, D. W. The untapped potential of genetically engineered mouse models in chemoprevention research: Opportunities and challenges
- Threadgill, D. W. Toxicogenetics: Population-based testing of drug and chemical safety in mouse models
- Threadgill, D. W. Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer
- Threadgill, D. W. Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK
- Threadgill, D. W. Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium
- Threadgill, D. W. Wildtype epidermal growth factor receptor (Egfr) is not required for daily locomotor or masking behavior in mice
chapter
- Wang, W., McMillan, L., Threadgill, D., & de Villena, F. (2009). Efficient Data-Mining Methods Enabling Genome-Wide Computing. NEXT GENERATION OF DATA MINING. (pp. 49-67). Taylor & Francis.
- Roberts, R. B., & Threadgill, D. W. (2005). THE MOUSE IN BIOMEDICAL RESEARCH. Eisen, E. J. (Eds.), MOUSE IN ANIMAL GENETICS AND BREEDING RESEARCH. (pp. 319-340). PUBLISHED BY IMPERIAL COLLEGE PRESS AND DISTRIBUTED BY WORLD SCIENTIFIC PUBLISHING CO..
- Threadgill, D. W., Hunter, K. W., Zou, F., & Manly, K. F. (2004). Genetic Modifiers. Mouse Models of Human Cancer. Wiley.
- Threadgill, D. W., Yee, D., Thompson, C., & Magnuson, T. (1995). Epidermal Growth Factor Receptor Deficiency Results in Periimplantation Lethality in Mouse. Molecular and Cellular Aspects of Periimplantation Processes. (pp. 231-235). Springer Nature.
conference paper
- Maxwell, S. A., Wallis, D., Zhou, N., Baker, D., Mousavi-Fard, S. H., Loesch, K., ... Sacchettini, J. C. (2022). Development of novel, non-toxic rifamycins that reverse drug resistance. Cancer Research.
- McGill, M. P., Rojas, C. M., & Threadgill, D. W. (2022). ERBB4 mediates IL10-induced growth of EGFR-independent colon tumors. Cancer Research.
- Bokhari, R., Schneider, P., Barrington, W., Falck, A., Mitchell, A., Huggins, S., ... Gaddy, D. (2018). Sex and Diet Specific Differences In Bone Mass of 4 Mouse Strains: Can Mice Tell Us What to Eat for Bone Health?. Journal of Bone and Mineral Research. 413-413.
- Lanier, A., Barrington, W., & Threadgill, D. (2017). Identifying genetic modifiers of PTEN using the Collaborative Cross mouse panel. Cancer Research. 1542-1542.
- Rojas, C. M., Ming, Y. u., & Threadgill, D. (2017). Progression of epidermal growth factor receptor (EGFR)-independent colorectal cancer. Cancer Research. 3400-3400.
- Rojas, C. M., & Threadgill, D. (2017). Progression of colorectal cancer through epidermal growth factor receptor (EGFR)-independent mechanisms. Cancer Research. a15-a15.
- Threadgill, D. (2016). Genetic background-dependent effects of diet on health and production traits. Journal of Animal Science. 5-6.
- Mantilla-Rojas, C., Yu, M., & Threadgill, D. (2016). Genetic dissection of mechanisms underlying epidermal growth factor receptor-independent colorectal cancer development. Cancer Research. lb-039-lb-039.
- Wells, A., Barrington, W., Threadgill, D., Dearth, S., Campagna, S., Saxton, A., & Voy, B. (2016). Gene, Sex and Diet Interact to Control the Tissue Metabolome. The FASEB Journal.
- Warren, M. R., & Threadgill, D. W. (2016). Population Variability and the Teratogenic Effects of Exposure to 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin during Pregnancy. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S78-S78.
- Cichocki, J. A., Furuya, S., Luo, Y. S., Sweet, S., Wade, T., Knap, A., ... Rusyn, I. (2016). Xenobiotic metabolism in a mouse model of non-alcoholic fatty liver disease: A case study of the ubiquitous environmental contaminant tetrachloroethylene. HEPATOLOGY. 800A-800A.
- Wells, A., Barrington, B., Threadgill, D., Campagna, S., & Voy, B. (2015). Investigating Tissue Level Gene-by-diet Interactions with Metabolomics. The FASEB Journal.
- Donohoe, D., Holley, D., Collins, L., Montgomery, S., Whitmore, A., Curry, K., ... Bultman, S. (2015). Abstract PL03-01: A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner. Cancer Prevention Research. pl03-01-pl03-01.
- Donohoe, D., Holley, D., Collins, L., Montgomery, S., Whitmore, A., Hillhouse, A., ... Bultman, S. (2014). Dietary fiber protects against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner. Cancer Research. sy04-02-sy04-02.
- Song, X., Fan, P., Guha, U., Threadgill, D., Varmus, H., & Politi, K. (2013). ERBB3 independent activation of the PI3K pathway in EGFR mutant lung adenocarcinomas. MOLECULAR CANCER THERAPEUTICS. c113-c113.
- Song, X., Fan, P., Guha, U., Threadgill, D., Varmus, H., & Politi, K. (2012). Activation of Putative Compensatory Pathways upon Deletion of Erbb3 in Mutant EGFR-driven Lung Cancer. CLINICAL CANCER RESEARCH. b35-b35.
- Romano, E. A., Menio, J. E., Threadgill, D., & Wheeler, M. D. (2011). Qualitative trait loci analysis of liver fibrosis using CxB recombinant inbreds. The FASEB Journal. 794.9-794.9.
- Dougherty, U., Mustafi, R., Wu, J., Zhu, H., Joseph, L. J., Hart, J., ... Bissonnette, M. (2011). Stromal Cell and Colonocyte EGFR Are Required for Efficient Tumor Xenograft Growth of Colon Cancer Cells. Gastroenterology. S825-S825.
- Bautz, D. J., Uronis, J. M., & Threadgill, D. W. (2010). Quantitative trait locus analysis of tumor morphology in a mouse model of human colorectal cancer. Cancer Research. 2126-2126.
- Mascia, F., Lam, G., Threadgill, D., & Yuspa, S. H. (2010). Abstract 18: Targeted epidermal ablation of EGFR causes local and systemic inflammation. Cancer Research. 18-18.
- Large, M. J., Hartig, S. M., Franco, H. L., Kovanci, E., Mancini, M. A., Threadgill, D. W., ... DeMayo, F. J. (2010). Demonstrating the Critical Role of Uterine Erbb Signaling in Fertility. Biology of Reproduction. 54-55.
- Mascia, F., Lam, G., Threadgill, D., & Yuspa, S. (2010). Epidermal EGFR signaling controls leukocyte infiltration in the skin and prevents systemic disease. Journal of Investigative Dermatology. S3-S3.
- Politi, K. A., Fan, P., Threadgill, D. W., & Varmus, H. (2010). In vivo characterization of the role of Erbb3 in mutant EGFR-induced lung tumorigenesis. JOURNAL OF THORACIC ONCOLOGY. S246-S246.
- DeSimone, M. C., Rathmell, W. K., & Threadgill, D. W. (2010). Role of von-Hippel Lindau Tumor Suppressor Gene Mutations in the Modulation of Susceptibility to Environmental Carcinogens. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 706-706.
- Zhang, Q. i., Wang, W., McMillan, L., Pardo-Manuel De Villena, F., & Threadgill, D. (2009). Inferring genome-wide mosaic structure. Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 150-161.
- Pan, F., McMillan, L., Pardo-Manuel De Villena, F., Threadgill, D., & Wang, W. (2009). TreeQA: quantitative genome wide association mapping using local perfect phylogeny trees. Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 415-426.
- Gordon, R. R., La Merrill, M., Hunter, K. W., Threadgill, D. W., & Pomp, D. (2009). A SYSTEMATIC EVALUATION OF AN F2 MOUSE CROSS PREDISPOSED TO OBESITY AND MAMMARY TUMOR DEVELOPMENT AND FED VARYING LEVELS OF DIETARY FAT. ANNALS OF NUTRITION AND METABOLISM. 547-547.
- DeSimone, M. C., Rathmell, W. K., & Threadgill, D. W. (2009). Elucidating the Functional Consequences of the Trichloroethylene Associated Von-Hippel Lindau Tumor Suppressor Gene Mutation Using a Genetically Engineered Model System. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 562-562.
- Dougherty, U., Cerasi, D., Taylor, I., Mustafi, R., Zhu, H., Hart, J., ... Bissonnette, M. (2009). Stromal Cell EGFR Enhances Colon Cancer Cell Growth in Tumor Xenografts. Gastroenterology. A320-A320.
- Pan, F., Yang, L., McMillan, L., de Villena, F., Threadgill, D., & Wang, W. (2008). Quantitative Association Analysis Using Tree Hierarchies. Proceedings / IEEE International Conference on Data Mining. IEEE International Conference on Data Mining. 971-+.
- ZHANG, Q. I., WANG, W., MCMILLAN, L., PARDO-MANUEL DE VILLENA, F., & THREADGILL, D. (2008). INFERRING GENOME-WIDE MOSAIC STRUCTURE. 150-161.
- PAN, F., MCMILLAN, L., DE VILLENA, F., THREADGILL, D., & WANG, W. (2008). TREEQA: QUANTITATIVE GENOME WIDE ASSOCIATION MAPPING USING LOCAL PERFECT PHYLOGENY TREES. 415-426.
- Threadgill, D. W. (2008). Development of a systems genetics platform using the Collaborative Cross for diseases and therapies with complex etiologies. Biological Psychiatry. 157S-157S.
- Dougherty, U., Aluri, L. M., Sehdev, A., Cerda, S. R., Mustafi, R., Kocherginsky, M., ... Bissonnette, M. (2008). EGFR is required for tumor promotion by dietary fat in a murine model of inflammation-associated colon cancer. Gastroenterology. A32-A33.
- La Merrill, M., Harper, R., Birnbaum, L., Cardiff, R., & Threadgill, D. (2008). Maternal dioxin exposure combined with a diet high in fat increases mammary cancer incidence through induction of estrogen metabolizing genes CYP1B1 and COMT. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 555-555.
- Zhang, Q. i., Wang, W., McMillan, L., Prins, J., de Villena, F., & Threadgill, D. (2008). Genotype Sequence Segmentation: Handling Constraints and Noise. Lecture Notes in Computer Science. 271-283.
- Pan, F., Roberts, A., McMillan, L., de Villena, F., Threadgill, D., & Wang, W. (2007). Sample selection for maximal diversity. Proceedings / IEEE International Conference on Data Mining. IEEE International Conference on Data Mining. 262-271.
- O'Neal, W. K., Livraghi, A., Threadgill, D. W., Hudson, E. J., Mall, M. A., Grubb, B. R., & Boucher, R. C. (2007). Assessment of genetic modifiers for phenotypic severity of beta ENaC transgenic mice. PEDIATRIC PULMONOLOGY. 266-266.
- Barrick, C. J., Rojas, M., Smyth, S., & Threadgill, D. (2006). Cardiac response to pressure-induced hypertrophy is genetic background dependent. The FASEB Journal. A1323-A1323.
- Hsieh, M., Threadgill, D., & Conti, M. (2006). Essential role of the EGF network in LH-induced ovulation. The FASEB Journal. A978-A978.
- Barrick, C. J., Rojas, M., Smyth, S., & Threadgill, D. (2006). Genetic modifiers prevent left ventricular hypertrophy in the Epidermal Growth Factor Receptor (Egfr/ErbB1) waved-2 mouse model for aortic stenosis. The FASEB Journal. A638-A639.
- Yu, M., Lee, T., Syed, H. A., & Threadgill, D. W. (2006). Characterization of EGFR-independent signaling pathways in ApcMin tumors. Cancer Research.
- Eversley, C. D., Barrick, D., Uronis, J., & Threadgill, D. W. (2006). Identifying resistance modifiers of azoxymethane induced colon cancer. Cancer Research.
- Barrick, D. J., Berlin, H., Clore, E. L., Smyth, S., & Threadgill, D. W. (2005). Genetic and pharmaceutical reduction of epidermal growth factor receptor (egfr/erbb1) signaling results in valvular and arterial calcification. Arteriosclerosis, Thrombosis and Vascular Biology. E67-E67.
- Dackor, J., & Threadgill, D. W. (2005). Identifying modifiers of placental development in EGFR deficient mice. Placenta. A21-A21.
- Barrick, D. J., Rojas, M., Smyth, S., & Threadgill, D. (2005). Pharmaceutical and genetic reduction of epidermal growth factor receptor (EGFR/ERBB) signaling impairs cardiac function. The FASEB Journal. A1565-A1565.
- Dackor, J., Strunk, K. E., & Threadgill, D. W. (2005). Proliferation defects in epidermal growth factor receptor null placentae can be rescued in the absence of cyclin-dependent kinase inhibitors. Placenta. A23-A23.
- Christine, K. S., Clore, J. L., Threadgill, D. W., Justice, M. J., & Caron, K. M. (2004). Development of a quantitative, high throughput placental defect screen. Placenta. A62-A62.
- Clore, J. L., Strunk, K. E., Hovick, M. M., & Threadgill, D. W. (2004). Epidermal growth factor receptor null placentae consist of trophoblasts with aberrant cell cycles. Placenta. A13-A13.
- Wood, B. C., Roberts, R. B., Lee, D., & Threadgill, D. W. (2003). Molecular and genetic analysis of a carcinogen-based mouse model for hepatocarcinogenesis. Gastroenterology. A742-A742.
- Breyer, R. M., DeFoe, S. K., Breyer, M. D., Lee, D. K., Young-Seigler, A. C., & Threadgill, D. (2002). Allele insertion mutagenesis at the EP3 receptor locus. The FASEB Journal. A576-A576.
- McQuain, M., Duncave, E., Pearsal, S., Threadgill, D., Coffey, R., & Haselton, F. (1999). Quantitative comparison of protocols for DNA attachment and hybridization to glass. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 850.
- Fries, R., Threadgill, D. W., Hediger, R., Gunawardana, A., Blessing, M., Jorcano, J. L., Stranzinger, G., & Womack, J. E. (1991). Mapping of bovine cytokeratin sequences to four different sites on three chromosomes. Cytogenetic and Genome Research. 135-141.
institutional repository document
- Salvador, A. C., Huda, M. N., Arends, D., Elsaadi, A. M., Gacasan, A. C., Brockmann, G. A., ... Threadgill, D. W. (2023). Analysis of strain, sex, and diet-dependent modulation of gut microbiota reveals candidate keystone organisms driving microbial diversity in response to American and ketogenic diets
- Zhang, X., Xiao, G., Johnson, C., Cai, Y., Horowitz, Z. K., Mennicke, C., ... Ghashghaei, H. T. (2022). Bulk and Mosaic Deletions of Egfr Reveal Regionally Defined Gliogenesis in the Developing Mouse Forebrain
- Gierus, L., Birand, A., Bunting, M. D., Godahewa, G. I., Piltz, S. G., Oh, K. P., ... Thomas, P. Q. (2022). Leveraging a natural murine meiotic drive to suppress invasive populations
- Scoggin, K., Gupta, J., Lynch, R., Nagarajan, A., Aminian, M., Peterson, A., ... Andrews-Polymenis, H. L. (2022). Elucidating Mechanisms of Tolerance to Salmonella Typhimurium Across Long-Term Infections Using the Collaborative Cross
- Nagarajan, A., Scoggin, K., Gupta, J., Threadgill, D. W., & Andrews-Polymenis, H. L. (2022). Using the Collaborative Cross to identify the role of host genetics in defining the murine gut microbiome
- Morgan, A. P., Hughes, J. J., Didion, J. P., Jolley, W. J., Campbell, K. J., Threadgill, D. W., ... de Villena, F. (2022). Population structure and inbreeding in wild house mice (Mus musculus) at different geographic scales
- Scoggin, K., Lynch, R., Gupta, J., Nagarajan, A., Sheffield, M., Elsaadi, A., ... Andrews-Polymenis, H. (2022). Genetic background influences survival of infections with Salmonella enterica serovar Typhimurium in the Collaborative Cross
- Zhang, X., Xiao, G., Johnson, C., Cai, Y., Mennicke, C., Coffey, R., ... Ghashghaei, H. T. (2022). Bulk and Mosaic Deletions of Egfr Reveal Regionally Defined Gliogenesis in the Developing Mouse Forebrain
- Bansal, M., Cuomo, D., Yusi, E. A., Lynch, R. M., & Threadgill, D. (2020). Constitutive WNT Signaling via CTNNB1 Stabilization in the Yolk Sac Epithelium Results in Embryonic Lethality in Mice
- Sigmon, J. S., Blanchard, M. W., Baric, R. S., Bell, T. A., Brennan, J., Brockmann, G. A., ... de Villena, F. (2020). Content and performance of the MiniMUGA genotyping array, a new tool to improve rigor and reproducibility in mouse research
- Sudweeks, J., Hollingsworth, B., Blondel, D. V., Campbell, K. J., Dhole, S., Eisemann, J. D., ... Lloyd, A. L. (2019). Locally Fixed Alleles: A method to localize gene drive to island populations
- Price, A., Okumura, A., Haddock, E., Feldmann, F., Meade-White, K., Sharma, P., ... Rasmussen, A. L. (2019). Transcriptional Correlates of Tolerance and Lethality in Mice Predict Ebola Virus Disease Patient Outcomes
- Didion, J. P., Morgan, A. P., Yadgary, L., Bell, T. A., McMullan, R. C., de Solorzano, L. O., ... de Villena, F. (2015). R2d2 drives selfish sweeps in the house mouse
- Blank, H. M., Hammer, S. E., Boatright, L., Roberts, C., Heyden, K. E., Nagarajan, A., ... Polymenis, M. Late-life dietary folate restriction reduces biosynthetic processes without compromising healthspan in mice

Threadgill, David Professor

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