Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Academic Article

abstract

• Gene targeting was used to create a null allele at the epidermal growth factor receptor locus (Egfr). The phenotype was dependent on genetic background. EGFR deficiency on a CF-1 background resulted in peri-implantation death due to degeneration of the inner cell mass. On a 129/Sv background, homozygous mutants died at mid-gestation due to placental defects; on a CD-1 background, the mutants lived for up to 3 weeks and showed abnormalities in skin, kidney, brain, liver, and gastrointestinal tract. The multiple abnormalities associated with EGFR deficiency indicate that the receptor is involved in a wide range of cellular activities.

authors

• Threadgill, David

published proceedings

• Science

altmetric score

• 12

author list (cited authors)

• Threadgill, D. W., Dlugosz, A. A., Hansen, L. A., Tennenbaum, T., Lichti, U., Yee, D., ... Harris, R. C.

citation count

• 1241

complete list of authors

• Threadgill, DW||Dlugosz, AA||Hansen, LA||Tennenbaum, T||Lichti, U||Yee, D||LaMantia, C||Mourton, T||Herrup, K||Harris, RC

publication date

• July 1995

publisher

• American Association for the Advancement of Science (AAAS)  Publisher

published in

• Science  Journal

keywords

• Abnormalities, Multiple
• Animals
• Base Sequence
• Brain
• Cell Division
• Digestive System
• Digestive System Abnormalities
• Embryonic And Fetal Development
• ErbB Receptors
• Female
• Gene Targeting
• Hair
• Homozygote
• Kidney
• Lung
• Male
• Mice
• Molecular Sequence Data
• Mutation
• Phenotype
• Skin
• Skin Abnormalities

PubMed Central ID

• 7618084

Digital Object Identifier (DOI)

• 10.1126/science.7618084

start page

• 230

end page

• 234

volume

• 269

issue

• 5221

URL

• http://dx.doi.org/10.1126/science.7618084