ERBBs in the gastrointestinal tract: recent progress and new perspectives. Academic Article

abstract

• The gastrointestinal epithelium does much more than provide a physical barrier between the intestinal lumen and our internal milieu. It is actively engaged in absorption and secretion of salt and water via ion transporters, exchangers and selective ion channels. It is also a continuously self-renewing epithelium that undergoes ordered growth and differentiation along its vertical axis. From this dual perspective, we will consider the actions of the ERBB family of ligands and receptors in the maintenance of gastrointestinal homeostasis and discuss instances when the actions of this family go awry such as in cancer and Mntrier's disease.

authors

• Threadgill, David

published proceedings

• Exp Cell Res

author list (cited authors)

• Fiske, W. H., Threadgill, D., & Coffey, R. J.

citation count

• 33

complete list of authors

• Fiske, William H||Threadgill, David||Coffey, Robert J

publication date

• February 2009

publisher

• Elsevier  Publisher

published in

• Experimental Cell Research  Journal

keywords

• ErbB Receptors
• Gastrointestinal Tract
• Homeostasis
• Humans
• Oncogene Proteins V-erbB
• Signal Transduction
• Transcriptional Activation

PubMed Central ID

• 19041864

Digital Object Identifier (DOI)

• 10.1016/j.yexcr.2008.10.043

start page

• 583

end page

• 601

volume

• 315

issue

• 4

URL

• http://dx.doi.org/10.1016/j.yexcr.2008.10.043