Investigating gene function using mouse models. Academic Article

abstract

• Mouse models have become central to investigating and understanding mammalian gene function. Since the development of the first transgenic and knockout models, new methods have been envisioned that both simplify and increase the specificity of mouse models. Combinations of genetic tools have also been applied to dissect gene activities and to provide systems that are both spatially and temporally regulated. Furthermore, novel technologies have been developed that can regulate biological information at each level from creating specific modifications in DNA, to inhibiting gene transcription, to regulating protein activity.

authors

• Threadgill, David

published proceedings

• Curr Opin Genet Dev

author list (cited authors)

• Lee, D., & Threadgill, D. W.

citation count

• 14

complete list of authors

• Lee, Daekee||Threadgill, David W

publication date

• June 2004

publisher

• Elsevier  Publisher

published in

• Current Opinion in Genetics and Development  Journal

keywords

• Alleles
• Animals
• Chimera
• Chromosomes, Artificial, Bacterial
• Enzyme Inhibitors
• Gene Expression Regulation, Developmental
• Gene Silencing
• Mice
• Mice, Knockout
• Mice, Transgenic
• Models, Animal
• Recombination, Genetic

PubMed Central ID

• 15172666

Digital Object Identifier (DOI)

• 10.1016/j.gde.2004.04.013

start page

• 246

end page

• 252

volume

• 14

issue

• 3

URL

• http://dx.doi.org/10.1016/j.gde.2004.04.013