Masking in waved-2 mice: EGF receptor control of locomotion questioned. Academic Article

abstract

• It has been suggested that epidermal growth factors (EGF) are responsible for the inhibition of locomotion by light (i.e., masking) in nocturnal rodents (Kramer et al., 2001). The poor masking response of waved-2 (Egfr(wa2)) mutant mice, with reduced EGF receptor activity, was adduced in support of this idea. In the present work, we studied the responses to light over a large range in illumination levels, in a variety of tests, with pulses of light and with ultradian light-dark cycles in Egfr(wa2) mutant mice. No evidence suggested that normal functioning of epidermal growth factor receptors was required, or even involved, in masking.

authors

• Threadgill, David

published proceedings

• Chronobiol Int

author list (cited authors)

• Mrosovsky, N., Redlin, U., Roberts, R. B., & Threadgill, D. W.

citation count

• 15

complete list of authors

• Mrosovsky, N||Redlin, U||Roberts, RB||Threadgill, DW

publication date

• January 2005

publisher

• Taylor & Francis  Publisher

published in

• Chronobiology International: the journal of biological and medical rhythm research  Journal

keywords

• Animals
• Circadian Rhythm
• DNA Primers
• ErbB Receptors
• Lighting
• Mice
• Mice, Mutant Strains
• Motor Activity
• Polymerase Chain Reaction

PubMed Central ID

• 16393701

Digital Object Identifier (DOI)

• 10.1080/07420520500395086

start page

• 963

end page

• 974

volume

• 22

issue

• 6

URL

• http://dx.doi.org/10.1080/07420520500395086