Case Report: Paucisymptomatic College-Age Population as a Reservoir for Potentially Neutralization-Resistant Severe Acute Respiratory Syndrome Coronavirus 2 Variants.
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To better understand the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant lineage distribution in a college campus population, we carried out viral genome surveillance over a 7-week period from January to March 2021. Among the sequences were three novel viral variants: BV-1 with a B.1.1.7/20I genetic background and an additional spike mutation Q493R, associated with a mild but longer-than-usual COVID-19 case in a college-age person, BV-2 with a T478K mutation on a 20B genetic background, and BV-3, an apparent recombinant lineage. This work highlights the potential of an undervaccinated younger population as a reservoir for the spread and generation of novel variants. This also demonstrates the value of whole genome sequencing as a routine disease surveillance tool.
author list (cited authors)
Neuman, B. W., Brashear, W. A., Brun, M., Chaki, S. P., Fischer, R., Guidry, S. J., ... Zuelke, K.
complete list of authors
Neuman, Benjamin W||Brashear, Wesley A||Brun, Marcel||Chaki, Sankar P||Fischer, Rebecca SB||Guidry, Sierra J||Hill, Joshua E||Hillhouse, Andrew E||Johnson, Charles D||Kahl-McDonagh, Melissa M||Metz, Richard P||Rice-Ficht, Allison C||Shuford, Jennifer A||Skaggs, Tiffany A||Stull, Matthew A||Threadgill, David W||Akpalu, Yao||Zuelke, Kurt