Case Report: Paucisymptomatic College-Age Population as a Reservoir for Potentially Neutralization-Resistant Severe Acute Respiratory Syndrome Coronavirus 2 Variants. Academic Article uri icon


  • To better understand the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant lineage distribution in a college campus population, we carried out viral genome surveillance over a 7-week period from January to March 2021. Among the sequences were three novel viral variants: BV-1 with a B.1.1.7/20I genetic background and an additional spike mutation Q493R, associated with a mild but longer-than-usual COVID-19 case in a college-age person, BV-2 with a T478K mutation on a 20B genetic background, and BV-3, an apparent recombinant lineage. This work highlights the potential of an undervaccinated younger population as a reservoir for the spread and generation of novel variants. This also demonstrates the value of whole genome sequencing as a routine disease surveillance tool.

published proceedings

  • Am J Trop Med Hyg

altmetric score

  • 3.25

author list (cited authors)

  • Neuman, B. W., Brashear, W. A., Brun, M., Chaki, S. P., Fischer, R., Guidry, S. J., ... Zuelke, K.

citation count

  • 2

complete list of authors

  • Neuman, Benjamin W||Brashear, Wesley A||Brun, Marcel||Chaki, Sankar P||Fischer, Rebecca SB||Guidry, Sierra J||Hill, Joshua E||Hillhouse, Andrew E||Johnson, Charles D||Kahl-McDonagh, Melissa M||Metz, Richard P||Rice-Ficht, Allison C||Shuford, Jennifer A||Skaggs, Tiffany A||Stull, Matthew A||Threadgill, David W||Akpalu, Yao||Zuelke, Kurt

publication date

  • September 2021